Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QD85_LEIMA

TriTrypDb:

LmjF.19.1300 , LMJLV39_190018700 , LMJSD75_190018700

Length:

851

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 4
NetGPI	no	yes: 0, no: 4

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QD85

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD85

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	5
GO:0006793	phosphorus metabolic process	3	5
GO:0006796	phosphate-containing compound metabolic process	4	5
GO:0006807	nitrogen compound metabolic process	2	5
GO:0008152	metabolic process	1	5
GO:0009987	cellular process	1	5
GO:0016310	phosphorylation	5	5
GO:0019538	protein metabolic process	3	5
GO:0036211	protein modification process	4	5
GO:0043170	macromolecule metabolic process	3	5
GO:0043412	macromolecule modification	4	5
GO:0044237	cellular metabolic process	2	5
GO:0044238	primary metabolic process	2	5
GO:0071704	organic substance metabolic process	2	5
GO:1901564	organonitrogen compound metabolic process	3	5

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	5
GO:0003824	catalytic activity	1	5
GO:0004672	protein kinase activity	3	5
GO:0005488	binding	1	5
GO:0005524	ATP binding	5	5
GO:0016301	kinase activity	4	5
GO:0016740	transferase activity	2	5
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	5
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	5
GO:0017076	purine nucleotide binding	4	5
GO:0030554	adenyl nucleotide binding	5	5
GO:0032553	ribonucleotide binding	3	5
GO:0032555	purine ribonucleotide binding	4	5
GO:0032559	adenyl ribonucleotide binding	5	5
GO:0035639	purine ribonucleoside triphosphate binding	4	5
GO:0036094	small molecule binding	2	5
GO:0043167	ion binding	2	5
GO:0043168	anion binding	3	5
GO:0097159	organic cyclic compound binding	2	5
GO:0097367	carbohydrate derivative binding	2	5
GO:0140096	catalytic activity, acting on a protein	2	5
GO:1901265	nucleoside phosphate binding	3	5
GO:1901363	heterocyclic compound binding	2	5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	217	221	PF00656	0.753
CLV_C14_Caspase3-7	566	570	PF00656	0.667
CLV_C14_Caspase3-7	599	603	PF00656	0.606
CLV_C14_Caspase3-7	659	663	PF00656	0.593
CLV_NRD_NRD_1	135	137	PF00675	0.667
CLV_NRD_NRD_1	161	163	PF00675	0.562
CLV_NRD_NRD_1	225	227	PF00675	0.654
CLV_PCSK_FUR_1	133	137	PF00082	0.528
CLV_PCSK_KEX2_1	135	137	PF00082	0.667
CLV_PCSK_KEX2_1	161	163	PF00082	0.562
CLV_PCSK_KEX2_1	225	227	PF00082	0.654
CLV_PCSK_SKI1_1	135	139	PF00082	0.664
CLV_PCSK_SKI1_1	225	229	PF00082	0.540
CLV_PCSK_SKI1_1	286	290	PF00082	0.524
CLV_PCSK_SKI1_1	307	311	PF00082	0.562
CLV_PCSK_SKI1_1	370	374	PF00082	0.602
CLV_PCSK_SKI1_1	595	599	PF00082	0.600
CLV_PCSK_SKI1_1	86	90	PF00082	0.521
CLV_Separin_Metazoa	756	760	PF03568	0.618
DEG_APCC_DBOX_1	594	602	PF00400	0.600
DEG_APCC_DBOX_1	707	715	PF00400	0.595
DEG_APCC_DBOX_1	85	93	PF00400	0.519
DEG_SCF_FBW7_1	256	262	PF00400	0.609
DEG_SPOP_SBC_1	116	120	PF00917	0.670
DOC_CKS1_1	176	181	PF01111	0.649
DOC_CKS1_1	256	261	PF01111	0.608
DOC_CKS1_1	308	313	PF01111	0.550
DOC_CYCLIN_RxL_1	367	374	PF00134	0.601
DOC_CYCLIN_RxL_1	681	692	PF00134	0.614
DOC_CYCLIN_RxL_1	697	706	PF00134	0.460
DOC_CYCLIN_RxL_1	707	715	PF00134	0.504
DOC_CYCLIN_yClb5_NLxxxL_5	338	347	PF00134	0.521
DOC_CYCLIN_yCln2_LP_2	24	27	PF00134	0.634
DOC_CYCLIN_yCln2_LP_2	718	724	PF00134	0.585
DOC_MAPK_gen_1	456	465	PF00069	0.543
DOC_MAPK_gen_1	520	529	PF00069	0.637
DOC_MAPK_gen_1	787	795	PF00069	0.596
DOC_MAPK_MEF2A_6	749	757	PF00069	0.562
DOC_MAPK_MEF2A_6	759	766	PF00069	0.569
DOC_PP1_RVXF_1	585	591	PF00149	0.610
DOC_PP2B_LxvP_1	155	158	PF13499	0.626
DOC_PP2B_LxvP_1	23	26	PF13499	0.641
DOC_PP2B_LxvP_1	755	758	PF13499	0.584
DOC_PP4_FxxP_1	28	31	PF00568	0.580
DOC_PP4_FxxP_1	308	311	PF00568	0.552
DOC_USP7_MATH_1	160	164	PF00917	0.646
DOC_USP7_MATH_1	169	173	PF00917	0.693
DOC_USP7_MATH_1	278	282	PF00917	0.607
DOC_USP7_MATH_1	388	392	PF00917	0.633
DOC_USP7_MATH_1	537	541	PF00917	0.724
DOC_USP7_MATH_1	729	733	PF00917	0.652
DOC_USP7_MATH_1	785	789	PF00917	0.612
DOC_USP7_MATH_1	828	832	PF00917	0.688
DOC_WW_Pin1_4	117	122	PF00397	0.777
DOC_WW_Pin1_4	175	180	PF00397	0.672
DOC_WW_Pin1_4	186	191	PF00397	0.553
DOC_WW_Pin1_4	211	216	PF00397	0.730
DOC_WW_Pin1_4	255	260	PF00397	0.610
DOC_WW_Pin1_4	307	312	PF00397	0.648
DOC_WW_Pin1_4	336	341	PF00397	0.565
DOC_WW_Pin1_4	506	511	PF00397	0.692
DOC_WW_Pin1_4	571	576	PF00397	0.545
DOC_WW_Pin1_4	627	632	PF00397	0.600
DOC_WW_Pin1_4	695	700	PF00397	0.509
DOC_WW_Pin1_4	749	754	PF00397	0.522
DOC_WW_Pin1_4	810	815	PF00397	0.649
LIG_14-3-3_CanoR_1	161	167	PF00244	0.569
LIG_14-3-3_CanoR_1	346	352	PF00244	0.601
LIG_14-3-3_CanoR_1	449	458	PF00244	0.698
LIG_14-3-3_CanoR_1	587	597	PF00244	0.706
LIG_14-3-3_CanoR_1	614	621	PF00244	0.521
LIG_14-3-3_CanoR_1	789	794	PF00244	0.590
LIG_Actin_WH2_2	196	212	PF00022	0.633
LIG_AP2alpha_1	795	799	PF02296	0.564
LIG_BIR_III_4	569	573	PF00653	0.667
LIG_BRCT_BRCA1_1	141	145	PF00533	0.639
LIG_BRCT_BRCA1_1	660	664	PF00533	0.627
LIG_BRCT_BRCA1_1	791	795	PF00533	0.517
LIG_CaM_IQ_9	735	751	PF13499	0.583
LIG_Clathr_ClatBox_1	711	715	PF01394	0.594
LIG_CtBP_PxDLS_1	126	130	PF00389	0.569
LIG_CtBP_PxDLS_1	557	563	PF00389	0.625
LIG_deltaCOP1_diTrp_1	471	479	PF00928	0.565
LIG_deltaCOP1_diTrp_1	658	664	PF00928	0.623
LIG_FHA_1	256	262	PF00498	0.535
LIG_FHA_1	406	412	PF00498	0.567
LIG_FHA_1	572	578	PF00498	0.543
LIG_FHA_1	618	624	PF00498	0.625
LIG_FHA_1	681	687	PF00498	0.603
LIG_FHA_1	689	695	PF00498	0.554
LIG_FHA_1	750	756	PF00498	0.591
LIG_FHA_1	761	767	PF00498	0.484
LIG_FHA_2	240	246	PF00498	0.573
LIG_FHA_2	33	39	PF00498	0.551
LIG_FHA_2	431	437	PF00498	0.639
LIG_FHA_2	58	64	PF00498	0.583
LIG_FHA_2	614	620	PF00498	0.717
LIG_Integrin_RGD_1	66	68	PF01839	0.581
LIG_LIR_Gen_1	596	605	PF02991	0.609
LIG_LIR_Gen_1	60	70	PF02991	0.581
LIG_LIR_Gen_1	698	709	PF02991	0.492
LIG_LIR_Gen_1	726	736	PF02991	0.593
LIG_LIR_Nem_3	185	191	PF02991	0.652
LIG_LIR_Nem_3	29	33	PF02991	0.559
LIG_LIR_Nem_3	304	308	PF02991	0.562
LIG_LIR_Nem_3	596	600	PF02991	0.598
LIG_LIR_Nem_3	60	65	PF02991	0.584
LIG_LIR_Nem_3	650	655	PF02991	0.576
LIG_LIR_Nem_3	698	704	PF02991	0.498
LIG_LIR_Nem_3	726	731	PF02991	0.595
LIG_LIR_Nem_3	797	802	PF02991	0.561
LIG_NRBOX	713	719	PF00104	0.593
LIG_PCNA_yPIPBox_3	395	405	PF02747	0.603
LIG_Pex14_1	473	477	PF04695	0.541
LIG_Pex14_1	660	664	PF04695	0.627
LIG_Pex14_2	795	799	PF04695	0.564
LIG_PTB_Apo_2	471	478	PF02174	0.532
LIG_SH2_CRK	366	370	PF00017	0.608
LIG_SH2_STAT3	781	784	PF00017	0.606
LIG_SH2_STAT5	191	194	PF00017	0.657
LIG_SH2_STAT5	480	483	PF00017	0.548
LIG_SH2_STAT5	655	658	PF00017	0.588
LIG_SH2_STAT5	848	851	PF00017	0.632
LIG_SH3_1	187	193	PF00018	0.654
LIG_SH3_3	176	182	PF00018	0.664
LIG_SH3_3	187	193	PF00018	0.541
LIG_SH3_3	45	51	PF00018	0.629
LIG_SH3_3	638	644	PF00018	0.597
LIG_SH3_3	66	72	PF00018	0.662
LIG_SH3_3	662	668	PF00018	0.637
LIG_SH3_3	809	815	PF00018	0.742
LIG_SH3_CIN85_PxpxPR_1	156	161	PF14604	0.540
LIG_SUMO_SIM_anti_2	35	43	PF11976	0.588
LIG_SUMO_SIM_anti_2	596	602	PF11976	0.600
LIG_SUMO_SIM_anti_2	761	766	PF11976	0.597
LIG_SUMO_SIM_par_1	125	130	PF11976	0.597
LIG_SUMO_SIM_par_1	29	35	PF11976	0.551
LIG_SUMO_SIM_par_1	710	715	PF11976	0.623
LIG_TRAF2_1	193	196	PF00917	0.656
LIG_TRAF2_1	242	245	PF00917	0.567
LIG_TRAF2_1	780	783	PF00917	0.626
LIG_TRAF2_2	537	542	PF00917	0.658
LIG_UBA3_1	711	719	PF00899	0.481
MOD_CDK_SPK_2	211	216	PF00069	0.730
MOD_CDK_SPK_2	695	700	PF00069	0.509
MOD_CDK_SPxK_1	117	123	PF00069	0.668
MOD_CK1_1	171	177	PF00069	0.674
MOD_CK1_1	450	456	PF00069	0.702
MOD_CK1_1	571	577	PF00069	0.647
MOD_CK1_1	788	794	PF00069	0.619
MOD_CK2_1	239	245	PF00069	0.564
MOD_CK2_1	57	63	PF00069	0.559
MOD_CK2_1	613	619	PF00069	0.721
MOD_Cter_Amidation	223	226	PF01082	0.676
MOD_DYRK1A_RPxSP_1	749	753	PF00069	0.506
MOD_GlcNHglycan	129	132	PF01048	0.681
MOD_GlcNHglycan	171	174	PF01048	0.673
MOD_GlcNHglycan	293	296	PF01048	0.520
MOD_GlcNHglycan	378	381	PF01048	0.670
MOD_GlcNHglycan	390	393	PF01048	0.453
MOD_GlcNHglycan	401	404	PF01048	0.489
MOD_GlcNHglycan	412	415	PF01048	0.502
MOD_GlcNHglycan	441	444	PF01048	0.728
MOD_GlcNHglycan	569	573	PF01048	0.593
MOD_GlcNHglycan	691	694	PF01048	0.626
MOD_GlcNHglycan	733	736	PF01048	0.561
MOD_GlcNHglycan	739	742	PF01048	0.492
MOD_GSK3_1	115	122	PF00069	0.724
MOD_GSK3_1	171	178	PF00069	0.670
MOD_GSK3_1	182	189	PF00069	0.560
MOD_GSK3_1	255	262	PF00069	0.626
MOD_GSK3_1	40	47	PF00069	0.700
MOD_GSK3_1	613	620	PF00069	0.628
MOD_GSK3_1	656	663	PF00069	0.618
MOD_GSK3_1	785	792	PF00069	0.685
MOD_N-GLC_1	291	296	PF02516	0.521
MOD_N-GLC_1	336	341	PF02516	0.563
MOD_N-GLC_1	388	393	PF02516	0.604
MOD_N-GLC_1	695	700	PF02516	0.509
MOD_N-GLC_2	547	549	PF02516	0.572
MOD_NEK2_1	12	17	PF00069	0.610
MOD_NEK2_1	127	132	PF00069	0.570
MOD_NEK2_1	301	306	PF00069	0.533
MOD_NEK2_1	32	37	PF00069	0.539
MOD_NEK2_1	399	404	PF00069	0.592
MOD_NEK2_1	40	45	PF00069	0.563
MOD_NEK2_1	405	410	PF00069	0.547
MOD_NEK2_1	516	521	PF00069	0.626
MOD_NEK2_1	588	593	PF00069	0.681
MOD_NEK2_1	656	661	PF00069	0.657
MOD_NEK2_1	688	693	PF00069	0.517
MOD_NEK2_1	737	742	PF00069	0.573
MOD_NEK2_1	766	771	PF00069	0.576
MOD_NEK2_2	447	452	PF00069	0.704
MOD_NEK2_2	617	622	PF00069	0.516
MOD_PIKK_1	182	188	PF00454	0.657
MOD_PIKK_1	405	411	PF00454	0.657
MOD_PIKK_1	743	749	PF00454	0.588
MOD_PKA_2	12	18	PF00069	0.638
MOD_PKA_2	160	166	PF00069	0.578
MOD_PKA_2	345	351	PF00069	0.574
MOD_PKA_2	613	619	PF00069	0.637
MOD_PKA_2	656	662	PF00069	0.506
MOD_PKA_2	688	694	PF00069	0.599
MOD_PKA_2	788	794	PF00069	0.591
MOD_PKB_1	787	795	PF00069	0.591
MOD_Plk_1	405	411	PF00069	0.594
MOD_Plk_1	760	766	PF00069	0.579
MOD_Plk_4	233	239	PF00069	0.522
MOD_Plk_4	660	666	PF00069	0.736
MOD_Plk_4	760	766	PF00069	0.572
MOD_ProDKin_1	117	123	PF00069	0.780
MOD_ProDKin_1	175	181	PF00069	0.673
MOD_ProDKin_1	186	192	PF00069	0.554
MOD_ProDKin_1	211	217	PF00069	0.732
MOD_ProDKin_1	255	261	PF00069	0.613
MOD_ProDKin_1	307	313	PF00069	0.642
MOD_ProDKin_1	336	342	PF00069	0.560
MOD_ProDKin_1	506	512	PF00069	0.691
MOD_ProDKin_1	571	577	PF00069	0.542
MOD_ProDKin_1	627	633	PF00069	0.599
MOD_ProDKin_1	695	701	PF00069	0.508
MOD_ProDKin_1	749	755	PF00069	0.519
MOD_ProDKin_1	810	816	PF00069	0.647
TRG_DiLeu_BaEn_1	202	207	PF01217	0.622
TRG_DiLeu_BaEn_1	406	411	PF01217	0.569
TRG_DiLeu_BaEn_1	619	624	PF01217	0.625
TRG_DiLeu_BaEn_1	713	718	PF01217	0.591
TRG_DiLeu_BaLyEn_6	584	589	PF01217	0.611
TRG_DiLeu_BaLyEn_6	707	712	PF01217	0.595
TRG_DiLeu_BaLyEn_6	813	818	PF01217	0.606
TRG_ENDOCYTIC_2	191	194	PF00928	0.657
TRG_ENDOCYTIC_2	305	308	PF00928	0.561
TRG_ENDOCYTIC_2	366	369	PF00928	0.608
TRG_ENDOCYTIC_2	480	483	PF00928	0.548
TRG_ER_diArg_1	132	135	PF00400	0.685
TRG_ER_diArg_1	160	162	PF00400	0.560
TRG_ER_diArg_1	225	227	PF00400	0.642
TRG_ER_diArg_1	249	252	PF00400	0.519
TRG_ER_diArg_1	525	528	PF00400	0.543
TRG_ER_diArg_1	707	710	PF00400	0.598
TRG_Pf-PMV_PEXEL_1	102	107	PF00026	0.648
TRG_Pf-PMV_PEXEL_1	370	374	PF00026	0.686
TRG_Pf-PMV_PEXEL_1	449	454	PF00026	0.804
TRG_Pf-PMV_PEXEL_1	676	680	PF00026	0.676
TRG_Pf-PMV_PEXEL_1	710	715	PF00026	0.593
TRG_Pf-PMV_PEXEL_1	772	776	PF00026	0.581

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7WVK3	Leishmania donovani	90%	100%
A4HYE8	Leishmania infantum	89%	100%
E9AS81	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%