Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QD84_LEIMA

TriTrypDb:

LmjF.19.1310 , LMJLV39_190018800 , LMJSD75_190018800

Length:

976

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QD84

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD84

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	222	226	PF00656	0.705
CLV_C14_Caspase3-7	234	238	PF00656	0.631
CLV_C14_Caspase3-7	321	325	PF00656	0.610
CLV_C14_Caspase3-7	439	443	PF00656	0.670
CLV_C14_Caspase3-7	598	602	PF00656	0.645
CLV_C14_Caspase3-7	757	761	PF00656	0.704
CLV_C14_Caspase3-7	889	893	PF00656	0.678
CLV_NRD_NRD_1	154	156	PF00675	0.744
CLV_NRD_NRD_1	160	162	PF00675	0.670
CLV_NRD_NRD_1	287	289	PF00675	0.627
CLV_NRD_NRD_1	363	365	PF00675	0.750
CLV_NRD_NRD_1	417	419	PF00675	0.751
CLV_NRD_NRD_1	546	548	PF00675	0.576
CLV_NRD_NRD_1	579	581	PF00675	0.781
CLV_NRD_NRD_1	64	66	PF00675	0.716
CLV_NRD_NRD_1	868	870	PF00675	0.693
CLV_PCSK_KEX2_1	107	109	PF00082	0.640
CLV_PCSK_KEX2_1	287	289	PF00082	0.627
CLV_PCSK_KEX2_1	363	365	PF00082	0.750
CLV_PCSK_KEX2_1	417	419	PF00082	0.751
CLV_PCSK_KEX2_1	546	548	PF00082	0.576
CLV_PCSK_KEX2_1	579	581	PF00082	0.781
CLV_PCSK_KEX2_1	630	632	PF00082	0.587
CLV_PCSK_KEX2_1	64	66	PF00082	0.716
CLV_PCSK_KEX2_1	749	751	PF00082	0.705
CLV_PCSK_KEX2_1	868	870	PF00082	0.693
CLV_PCSK_PC1ET2_1	107	109	PF00082	0.640
CLV_PCSK_PC1ET2_1	630	632	PF00082	0.585
CLV_PCSK_PC1ET2_1	749	751	PF00082	0.705
CLV_PCSK_SKI1_1	364	368	PF00082	0.750
CLV_PCSK_SKI1_1	379	383	PF00082	0.550
CLV_PCSK_SKI1_1	579	583	PF00082	0.775
CLV_PCSK_SKI1_1	637	641	PF00082	0.563
CLV_PCSK_SKI1_1	772	776	PF00082	0.634
DEG_APCC_DBOX_1	668	676	PF00400	0.658
DEG_COP1_1	43	52	PF00400	0.636
DEG_Nend_UBRbox_2	1	3	PF02207	0.750
DEG_SPOP_SBC_1	246	250	PF00917	0.657
DEG_SPOP_SBC_1	406	410	PF00917	0.586
DEG_SPOP_SBC_1	934	938	PF00917	0.635
DOC_ANK_TNKS_1	205	212	PF00023	0.657
DOC_ANK_TNKS_1	63	70	PF00023	0.707
DOC_CYCLIN_RxL_1	576	585	PF00134	0.685
DOC_CYCLIN_RxL_1	769	778	PF00134	0.686
DOC_CYCLIN_yCln2_LP_2	381	387	PF00134	0.566
DOC_CYCLIN_yCln2_LP_2	918	924	PF00134	0.721
DOC_MAPK_MEF2A_6	448	456	PF00069	0.583
DOC_PP1_RVXF_1	954	961	PF00149	0.651
DOC_PP2B_LxvP_1	109	112	PF13499	0.603
DOC_PP2B_LxvP_1	456	459	PF13499	0.569
DOC_PP2B_LxvP_1	736	739	PF13499	0.684
DOC_USP7_MATH_1	150	154	PF00917	0.740
DOC_USP7_MATH_1	196	200	PF00917	0.608
DOC_USP7_MATH_1	215	219	PF00917	0.529
DOC_USP7_MATH_1	245	249	PF00917	0.666
DOC_USP7_MATH_1	369	373	PF00917	0.670
DOC_USP7_MATH_1	42	46	PF00917	0.768
DOC_USP7_MATH_1	433	437	PF00917	0.619
DOC_USP7_MATH_1	48	52	PF00917	0.701
DOC_USP7_MATH_1	551	555	PF00917	0.735
DOC_USP7_MATH_1	655	659	PF00917	0.564
DOC_USP7_MATH_1	711	715	PF00917	0.732
DOC_USP7_MATH_1	787	791	PF00917	0.707
DOC_USP7_MATH_1	908	912	PF00917	0.585
DOC_USP7_MATH_1	928	932	PF00917	0.580
DOC_USP7_MATH_1	934	938	PF00917	0.694
DOC_USP7_MATH_1	952	956	PF00917	0.501
DOC_USP7_MATH_1	967	971	PF00917	0.467
DOC_USP7_UBL2_3	626	630	PF12436	0.570
DOC_WW_Pin1_4	160	165	PF00397	0.755
DOC_WW_Pin1_4	172	177	PF00397	0.611
DOC_WW_Pin1_4	235	240	PF00397	0.738
DOC_WW_Pin1_4	268	273	PF00397	0.620
DOC_WW_Pin1_4	348	353	PF00397	0.721
DOC_WW_Pin1_4	355	360	PF00397	0.677
DOC_WW_Pin1_4	380	385	PF00397	0.711
DOC_WW_Pin1_4	389	394	PF00397	0.630
DOC_WW_Pin1_4	441	446	PF00397	0.690
DOC_WW_Pin1_4	448	453	PF00397	0.665
DOC_WW_Pin1_4	51	56	PF00397	0.765
DOC_WW_Pin1_4	520	525	PF00397	0.599
DOC_WW_Pin1_4	906	911	PF00397	0.729
DOC_WW_Pin1_4	936	941	PF00397	0.713
DOC_WW_Pin1_4	946	951	PF00397	0.611
DOC_WW_Pin1_4	97	102	PF00397	0.701
DOC_WW_Pin1_4	971	976	PF00397	0.676
LIG_14-3-3_CanoR_1	155	165	PF00244	0.748
LIG_14-3-3_CanoR_1	206	210	PF00244	0.701
LIG_14-3-3_CanoR_1	240	245	PF00244	0.591
LIG_14-3-3_CanoR_1	357	367	PF00244	0.618
LIG_14-3-3_CanoR_1	463	472	PF00244	0.599
LIG_14-3-3_CanoR_1	643	651	PF00244	0.680
LIG_14-3-3_CanoR_1	725	731	PF00244	0.652
LIG_14-3-3_CanoR_1	735	739	PF00244	0.617
LIG_BIR_III_2	442	446	PF00653	0.677
LIG_BRCT_BRCA1_1	16	20	PF00533	0.573
LIG_BRCT_BRCA1_1	969	973	PF00533	0.607
LIG_deltaCOP1_diTrp_1	587	596	PF00928	0.548
LIG_eIF4E_1	270	276	PF01652	0.634
LIG_FHA_1	211	217	PF00498	0.592
LIG_FHA_1	408	414	PF00498	0.749
LIG_FHA_1	427	433	PF00498	0.500
LIG_FHA_1	646	652	PF00498	0.567
LIG_FHA_1	841	847	PF00498	0.660
LIG_FHA_1	90	96	PF00498	0.693
LIG_FHA_2	19	25	PF00498	0.598
LIG_FHA_2	217	223	PF00498	0.605
LIG_FHA_2	269	275	PF00498	0.650
LIG_FHA_2	437	443	PF00498	0.665
LIG_FHA_2	475	481	PF00498	0.686
LIG_FHA_2	482	488	PF00498	0.627
LIG_FHA_2	659	665	PF00498	0.690
LIG_FHA_2	669	675	PF00498	0.568
LIG_FHA_2	757	763	PF00498	0.703
LIG_FHA_2	937	943	PF00498	0.667
LIG_FHA_2	961	967	PF00498	0.628
LIG_LIR_Gen_1	966	976	PF02991	0.656
LIG_LIR_LC3C_4	273	277	PF02991	0.626
LIG_LIR_Nem_3	19	25	PF02991	0.627
LIG_LIR_Nem_3	460	465	PF02991	0.719
LIG_LIR_Nem_3	575	581	PF02991	0.685
LIG_LIR_Nem_3	594	599	PF02991	0.510
LIG_LIR_Nem_3	966	971	PF02991	0.636
LIG_MYND_3	49	53	PF01753	0.613
LIG_PDZ_Class_1	971	976	PF00595	0.676
LIG_SH2_CRK	578	582	PF00017	0.686
LIG_SH2_STAP1	22	26	PF00017	0.643
LIG_SH2_STAP1	793	797	PF00017	0.654
LIG_SH2_STAP1	968	972	PF00017	0.648
LIG_SH2_STAT5	270	273	PF00017	0.648
LIG_SH2_STAT5	350	353	PF00017	0.700
LIG_SH3_2	59	64	PF14604	0.711
LIG_SH3_3	171	177	PF00018	0.638
LIG_SH3_3	233	239	PF00018	0.734
LIG_SH3_3	54	60	PF00018	0.763
LIG_SH3_3	77	83	PF00018	0.691
LIG_SH3_3	913	919	PF00018	0.692
LIG_SH3_3	922	928	PF00018	0.626
LIG_SUMO_SIM_par_1	670	678	PF11976	0.715
LIG_TRAF2_1	485	488	PF00917	0.582
LIG_TRAF2_1	500	503	PF00917	0.544
LIG_WW_2	916	919	PF00397	0.665
MOD_CDC14_SPxK_1	909	912	PF00782	0.665
MOD_CDK_SPK_2	235	240	PF00069	0.684
MOD_CDK_SPxK_1	389	395	PF00069	0.693
MOD_CDK_SPxK_1	906	912	PF00069	0.665
MOD_CDK_SPxxK_3	441	448	PF00069	0.721
MOD_CK1_1	172	178	PF00069	0.603
MOD_CK1_1	256	262	PF00069	0.578
MOD_CK1_1	294	300	PF00069	0.683
MOD_CK1_1	353	359	PF00069	0.720
MOD_CK1_1	380	386	PF00069	0.657
MOD_CK1_1	405	411	PF00069	0.698
MOD_CK1_1	426	432	PF00069	0.721
MOD_CK1_1	436	442	PF00069	0.599
MOD_CK1_1	51	57	PF00069	0.638
MOD_CK1_1	554	560	PF00069	0.743
MOD_CK1_1	645	651	PF00069	0.687
MOD_CK1_1	658	664	PF00069	0.557
MOD_CK1_1	677	683	PF00069	0.763
MOD_CK1_1	712	718	PF00069	0.702
MOD_CK1_1	726	732	PF00069	0.582
MOD_CK1_1	734	740	PF00069	0.649
MOD_CK1_1	836	842	PF00069	0.752
MOD_CK1_1	85	91	PF00069	0.691
MOD_CK1_1	886	892	PF00069	0.730
MOD_CK1_1	936	942	PF00069	0.659
MOD_CK2_1	18	24	PF00069	0.605
MOD_CK2_1	196	202	PF00069	0.677
MOD_CK2_1	300	306	PF00069	0.716
MOD_CK2_1	391	397	PF00069	0.666
MOD_CK2_1	481	487	PF00069	0.583
MOD_CK2_1	497	503	PF00069	0.541
MOD_CK2_1	556	562	PF00069	0.680
MOD_CK2_1	621	627	PF00069	0.725
MOD_CK2_1	658	664	PF00069	0.674
MOD_CK2_1	668	674	PF00069	0.621
MOD_CK2_1	677	683	PF00069	0.542
MOD_CK2_1	698	704	PF00069	0.735
MOD_CK2_1	756	762	PF00069	0.704
MOD_CK2_1	936	942	PF00069	0.699
MOD_Cter_Amidation	415	418	PF01082	0.758
MOD_Cter_Amidation	747	750	PF01082	0.671
MOD_GlcNHglycan	12	15	PF01048	0.712
MOD_GlcNHglycan	145	149	PF01048	0.730
MOD_GlcNHglycan	158	161	PF01048	0.614
MOD_GlcNHglycan	16	19	PF01048	0.648
MOD_GlcNHglycan	177	180	PF01048	0.525
MOD_GlcNHglycan	186	189	PF01048	0.593
MOD_GlcNHglycan	229	232	PF01048	0.715
MOD_GlcNHglycan	249	252	PF01048	0.579
MOD_GlcNHglycan	258	261	PF01048	0.559
MOD_GlcNHglycan	309	312	PF01048	0.713
MOD_GlcNHglycan	352	355	PF01048	0.754
MOD_GlcNHglycan	404	407	PF01048	0.746
MOD_GlcNHglycan	414	417	PF01048	0.658
MOD_GlcNHglycan	465	468	PF01048	0.620
MOD_GlcNHglycan	528	531	PF01048	0.599
MOD_GlcNHglycan	534	537	PF01048	0.578
MOD_GlcNHglycan	550	554	PF01048	0.621
MOD_GlcNHglycan	623	626	PF01048	0.675
MOD_GlcNHglycan	731	734	PF01048	0.598
MOD_GlcNHglycan	740	743	PF01048	0.545
MOD_GlcNHglycan	885	888	PF01048	0.738
MOD_GlcNHglycan	950	953	PF01048	0.701
MOD_GSK3_1	10	17	PF00069	0.665
MOD_GSK3_1	117	124	PF00069	0.710
MOD_GSK3_1	156	163	PF00069	0.757
MOD_GSK3_1	175	182	PF00069	0.534
MOD_GSK3_1	223	230	PF00069	0.682
MOD_GSK3_1	25	32	PF00069	0.461
MOD_GSK3_1	307	314	PF00069	0.733
MOD_GSK3_1	353	360	PF00069	0.728
MOD_GSK3_1	398	405	PF00069	0.615
MOD_GSK3_1	407	414	PF00069	0.621
MOD_GSK3_1	457	464	PF00069	0.627
MOD_GSK3_1	51	58	PF00069	0.691
MOD_GSK3_1	532	539	PF00069	0.613
MOD_GSK3_1	551	558	PF00069	0.668
MOD_GSK3_1	645	652	PF00069	0.668
MOD_GSK3_1	673	680	PF00069	0.787
MOD_GSK3_1	734	741	PF00069	0.632
MOD_GSK3_1	830	837	PF00069	0.736
MOD_GSK3_1	85	92	PF00069	0.670
MOD_GSK3_1	929	936	PF00069	0.637
MOD_GSK3_1	944	951	PF00069	0.629
MOD_GSK3_1	967	974	PF00069	0.651
MOD_N-GLC_1	348	353	PF02516	0.725
MOD_N-GLC_1	712	717	PF02516	0.702
MOD_N-GLC_1	723	728	PF02516	0.585
MOD_N-GLC_1	883	888	PF02516	0.586
MOD_NEK2_1	118	123	PF00069	0.771
MOD_NEK2_1	255	260	PF00069	0.677
MOD_NEK2_1	526	531	PF00069	0.677
MOD_NEK2_1	555	560	PF00069	0.636
MOD_NEK2_1	675	680	PF00069	0.665
MOD_NEK2_1	728	733	PF00069	0.652
MOD_NEK2_1	792	797	PF00069	0.717
MOD_NEK2_2	150	155	PF00069	0.716
MOD_NEK2_2	196	201	PF00069	0.659
MOD_NEK2_2	300	305	PF00069	0.555
MOD_NEK2_2	433	438	PF00069	0.567
MOD_NEK2_2	615	620	PF00069	0.578
MOD_OFUCOSY	849	854	PF10250	0.528
MOD_PIKK_1	396	402	PF00454	0.705
MOD_PIKK_1	497	503	PF00454	0.703
MOD_PKA_1	155	161	PF00069	0.719
MOD_PKA_2	194	200	PF00069	0.715
MOD_PKA_2	205	211	PF00069	0.641
MOD_PKA_2	223	229	PF00069	0.543
MOD_PKA_2	307	313	PF00069	0.599
MOD_PKA_2	497	503	PF00069	0.703
MOD_PKA_2	642	648	PF00069	0.619
MOD_PKA_2	668	674	PF00069	0.629
MOD_PKA_2	734	740	PF00069	0.704
MOD_PKA_2	819	825	PF00069	0.613
MOD_Plk_1	150	156	PF00069	0.626
MOD_Plk_1	18	24	PF00069	0.497
MOD_Plk_1	300	306	PF00069	0.643
MOD_Plk_1	311	317	PF00069	0.630
MOD_Plk_1	424	430	PF00069	0.647
MOD_Plk_1	482	488	PF00069	0.661
MOD_Plk_1	645	651	PF00069	0.679
MOD_Plk_1	726	732	PF00069	0.602
MOD_Plk_1	944	950	PF00069	0.683
MOD_Plk_2-3	474	480	PF00069	0.684
MOD_Plk_4	205	211	PF00069	0.684
MOD_Plk_4	377	383	PF00069	0.639
MOD_Plk_4	433	439	PF00069	0.701
MOD_Plk_4	457	463	PF00069	0.725
MOD_Plk_4	572	578	PF00069	0.687
MOD_Plk_4	591	597	PF00069	0.503
MOD_Plk_4	615	621	PF00069	0.576
MOD_Plk_4	645	651	PF00069	0.566
MOD_Plk_4	668	674	PF00069	0.708
MOD_Plk_4	787	793	PF00069	0.620
MOD_Plk_4	836	842	PF00069	0.723
MOD_Plk_4	967	973	PF00069	0.647
MOD_ProDKin_1	160	166	PF00069	0.749
MOD_ProDKin_1	172	178	PF00069	0.613
MOD_ProDKin_1	235	241	PF00069	0.740
MOD_ProDKin_1	268	274	PF00069	0.616
MOD_ProDKin_1	348	354	PF00069	0.722
MOD_ProDKin_1	355	361	PF00069	0.677
MOD_ProDKin_1	380	386	PF00069	0.713
MOD_ProDKin_1	389	395	PF00069	0.632
MOD_ProDKin_1	441	447	PF00069	0.691
MOD_ProDKin_1	448	454	PF00069	0.666
MOD_ProDKin_1	51	57	PF00069	0.764
MOD_ProDKin_1	520	526	PF00069	0.602
MOD_ProDKin_1	906	912	PF00069	0.730
MOD_ProDKin_1	936	942	PF00069	0.713
MOD_ProDKin_1	946	952	PF00069	0.606
MOD_ProDKin_1	97	103	PF00069	0.699
MOD_SUMO_rev_2	372	381	PF00179	0.642
MOD_SUMO_rev_2	464	473	PF00179	0.664
TRG_DiLeu_BaEn_2	805	811	PF01217	0.603
TRG_DiLeu_BaLyEn_6	505	510	PF01217	0.687
TRG_DiLeu_BaLyEn_6	770	775	PF01217	0.691
TRG_DiLeu_BaLyEn_6	793	798	PF01217	0.656
TRG_ENDOCYTIC_2	578	581	PF00928	0.688
TRG_ENDOCYTIC_2	968	971	PF00928	0.645
TRG_ER_diArg_1	171	174	PF00400	0.607
TRG_ER_diArg_1	286	288	PF00400	0.617
TRG_ER_diArg_1	545	547	PF00400	0.574
TRG_ER_diArg_1	578	580	PF00400	0.783
TRG_ER_diArg_1	64	66	PF00400	0.716
TRG_Pf-PMV_PEXEL_1	579	584	PF00026	0.683
TRG_Pf-PMV_PEXEL_1	796	801	PF00026	0.660

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S5H768	Leishmania donovani	86%	100%
A4HA78	Leishmania braziliensis	58%	100%
A4HYE9	Leishmania infantum	85%	100%
E9AS82	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%