LeishMANIAdb
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Putative glycerol uptake protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative glycerol uptake protein
Gene product:
glycerol uptake protein, putative
Species:
Leishmania major
UniProt:
Q4QD82_LEIMA
TriTrypDb:
LmjF.19.1320 , LMJLV39_190019000 , LMJSD75_190019000 * , LMJSD75_190019100
Length:
378

Annotations

LeishMANIAdb annotations

Membrane-bound O-acyltransferase involved in the remodeling of glycosylphosphatidylinositol (GPI) anchors. Related to fungal GUP1 proteins.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0005783 endoplasmic reticulum 5 2
GO:0016020 membrane 2 10
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 10

Expansion

Sequence features

Q4QD82
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD82

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 2
GO:0016740 transferase activity 2 2
GO:0016746 acyltransferase activity 3 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 16 20 PF00656 0.376
CLV_MEL_PAP_1 331 337 PF00089 0.281
CLV_NRD_NRD_1 173 175 PF00675 0.256
CLV_NRD_NRD_1 255 257 PF00675 0.250
CLV_PCSK_KEX2_1 255 257 PF00082 0.250
CLV_PCSK_SKI1_1 178 182 PF00082 0.268
CLV_PCSK_SKI1_1 292 296 PF00082 0.402
DEG_APCC_DBOX_1 177 185 PF00400 0.401
DEG_APCC_DBOX_1 291 299 PF00400 0.529
DEG_SPOP_SBC_1 166 170 PF00917 0.541
DOC_CDC14_PxL_1 196 204 PF14671 0.419
DOC_CYCLIN_yCln2_LP_2 144 150 PF00134 0.300
DOC_MAPK_DCC_7 292 302 PF00069 0.294
DOC_MAPK_gen_1 174 183 PF00069 0.401
DOC_MAPK_gen_1 290 297 PF00069 0.449
DOC_MAPK_gen_1 51 60 PF00069 0.344
DOC_MAPK_MEF2A_6 290 297 PF00069 0.511
DOC_PP1_RVXF_1 33 40 PF00149 0.354
DOC_PP1_RVXF_1 64 71 PF00149 0.273
DOC_PP1_SILK_1 181 186 PF00149 0.377
DOC_PP2B_LxvP_1 144 147 PF13499 0.300
DOC_USP7_MATH_1 115 119 PF00917 0.250
DOC_USP7_MATH_1 153 157 PF00917 0.300
DOC_USP7_MATH_1 159 163 PF00917 0.456
DOC_USP7_MATH_1 167 171 PF00917 0.456
LIG_14-3-3_CanoR_1 165 173 PF00244 0.541
LIG_14-3-3_CanoR_1 185 194 PF00244 0.146
LIG_14-3-3_CanoR_1 211 215 PF00244 0.311
LIG_14-3-3_CanoR_1 292 298 PF00244 0.402
LIG_14-3-3_CanoR_1 358 367 PF00244 0.602
LIG_14-3-3_CanoR_1 53 59 PF00244 0.338
LIG_14-3-3_CanoR_1 61 66 PF00244 0.283
LIG_Actin_WH2_2 217 233 PF00022 0.249
LIG_Actin_WH2_2 51 68 PF00022 0.317
LIG_BRCT_BRCA1_1 203 207 PF00533 0.311
LIG_BRCT_BRCA1_1 238 242 PF00533 0.531
LIG_BRCT_BRCA1_1 331 335 PF00533 0.354
LIG_BRCT_BRCA1_1 56 60 PF00533 0.278
LIG_CtBP_PxDLS_1 251 255 PF00389 0.456
LIG_deltaCOP1_diTrp_1 270 278 PF00928 0.467
LIG_eIF4E_1 139 145 PF01652 0.341
LIG_FHA_1 259 265 PF00498 0.580
LIG_FHA_1 62 68 PF00498 0.360
LIG_FHA_1 92 98 PF00498 0.315
LIG_FHA_2 211 217 PF00498 0.311
LIG_LIR_Gen_1 133 142 PF02991 0.256
LIG_LIR_Gen_1 155 164 PF02991 0.300
LIG_LIR_Gen_1 189 199 PF02991 0.396
LIG_LIR_Gen_1 204 215 PF02991 0.187
LIG_LIR_Gen_1 239 250 PF02991 0.524
LIG_LIR_Nem_3 133 139 PF02991 0.256
LIG_LIR_Nem_3 155 160 PF02991 0.435
LIG_LIR_Nem_3 162 166 PF02991 0.446
LIG_LIR_Nem_3 189 194 PF02991 0.453
LIG_LIR_Nem_3 204 210 PF02991 0.187
LIG_LIR_Nem_3 239 245 PF02991 0.524
LIG_Pex14_1 26 30 PF04695 0.444
LIG_Pex14_1 271 275 PF04695 0.452
LIG_Pex14_1 278 282 PF04695 0.452
LIG_Pex14_1 56 60 PF04695 0.335
LIG_Pex14_2 232 236 PF04695 0.300
LIG_Pex14_2 267 271 PF04695 0.456
LIG_Pex14_2 303 307 PF04695 0.319
LIG_SH2_CRK 134 138 PF00017 0.256
LIG_SH2_CRK 163 167 PF00017 0.432
LIG_SH2_CRK 191 195 PF00017 0.377
LIG_SH2_CRK 205 209 PF00017 0.196
LIG_SH2_CRK 282 286 PF00017 0.452
LIG_SH2_STAP1 139 143 PF00017 0.311
LIG_SH2_STAP1 179 183 PF00017 0.410
LIG_SH2_STAP1 205 209 PF00017 0.364
LIG_SH2_STAT3 25 28 PF00017 0.422
LIG_SH2_STAT5 13 16 PF00017 0.406
LIG_SH2_STAT5 142 145 PF00017 0.314
LIG_SH2_STAT5 149 152 PF00017 0.322
LIG_SH2_STAT5 191 194 PF00017 0.296
LIG_SH2_STAT5 284 287 PF00017 0.452
LIG_SH2_STAT5 29 32 PF00017 0.324
LIG_SH2_STAT5 375 378 PF00017 0.546
LIG_SH3_3 140 146 PF00018 0.326
LIG_SH3_3 194 200 PF00018 0.419
LIG_SH3_3 42 48 PF00018 0.358
LIG_SUMO_SIM_anti_2 6 13 PF11976 0.277
LIG_SUMO_SIM_par_1 13 19 PF11976 0.388
LIG_TRFH_1 142 146 PF08558 0.419
LIG_TYR_ITIM 161 166 PF00017 0.540
LIG_TYR_ITIM 225 230 PF00017 0.325
LIG_TYR_ITIM 280 285 PF00017 0.452
LIG_UBA3_1 224 231 PF00899 0.377
LIG_WRC_WIRS_1 154 159 PF05994 0.300
LIG_WW_1 146 149 PF00397 0.419
MOD_CK1_1 361 367 PF00069 0.583
MOD_CK2_1 210 216 PF00069 0.256
MOD_CK2_1 92 98 PF00069 0.308
MOD_CMANNOS 268 271 PF00535 0.256
MOD_GlcNHglycan 108 111 PF01048 0.609
MOD_GlcNHglycan 245 248 PF01048 0.341
MOD_GlcNHglycan 331 334 PF01048 0.326
MOD_GSK3_1 3 10 PF00069 0.264
MOD_GSK3_1 361 368 PF00069 0.592
MOD_NEK2_1 210 215 PF00069 0.247
MOD_NEK2_1 230 235 PF00069 0.156
MOD_NEK2_1 258 263 PF00069 0.452
MOD_NEK2_1 4 9 PF00069 0.281
MOD_NEK2_1 54 59 PF00069 0.342
MOD_NEK2_1 60 65 PF00069 0.315
MOD_NEK2_2 365 370 PF00069 0.535
MOD_PIKK_1 358 364 PF00454 0.572
MOD_PKA_2 210 216 PF00069 0.311
MOD_PKA_2 365 371 PF00069 0.749
MOD_PKA_2 54 60 PF00069 0.319
MOD_PKA_2 86 92 PF00069 0.321
MOD_Plk_1 189 195 PF00069 0.377
MOD_Plk_1 92 98 PF00069 0.308
MOD_Plk_4 159 165 PF00069 0.403
MOD_Plk_4 179 185 PF00069 0.401
MOD_Plk_4 189 195 PF00069 0.377
MOD_Plk_4 210 216 PF00069 0.331
MOD_Plk_4 293 299 PF00069 0.402
MOD_Plk_4 371 377 PF00069 0.585
MOD_Plk_4 7 13 PF00069 0.310
TRG_DiLeu_BaEn_2 215 221 PF01217 0.329
TRG_DiLeu_BaLyEn_6 63 68 PF01217 0.360
TRG_ENDOCYTIC_2 134 137 PF00928 0.256
TRG_ENDOCYTIC_2 142 145 PF00928 0.300
TRG_ENDOCYTIC_2 163 166 PF00928 0.540
TRG_ENDOCYTIC_2 191 194 PF00928 0.304
TRG_ENDOCYTIC_2 205 208 PF00928 0.314
TRG_ENDOCYTIC_2 227 230 PF00928 0.324
TRG_ENDOCYTIC_2 282 285 PF00928 0.452
TRG_ER_diArg_1 254 256 PF00400 0.450
TRG_ER_diArg_1 290 293 PF00400 0.511
TRG_ER_diArg_1 53 56 PF00400 0.421

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3R7KT56 Trypanosoma rangeli 51% 94%
A0A3R7NNW7 Trypanosoma rangeli 48% 86%
A0A3S7WVS3 Leishmania donovani 94% 92%
A4HA77 Leishmania braziliensis 75% 67%
A4HA79 Leishmania braziliensis 77% 77%
E9AGS9 Leishmania infantum 88% 92%
E9AGT2 Leishmania infantum 89% 69%
E9AS84 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 77%
P53154 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) 31% 68%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS