Putative glycerol uptake protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

glycerol uptake protein, putative

Species:

Leishmania major

UniProt:

Q4QD81_LEIMA

TriTrypDb:

LmjF.19.1000 , LMJLV39_190019000 , LMJSD75_190019100 , LMJSD75_190019200

Length:

691

Annotations

LeishMANIAdb annotations

Membrane-bound O-acyltransferase involved in the remodeling of glycosylphosphatidylinositol (GPI) anchors. Related to fungal GUP1 proteins.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 32
NetGPI	no	yes: 0, no: 32

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	5
GO:0005783	endoplasmic reticulum	5	5
GO:0016020	membrane	2	33
GO:0043226	organelle	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0043229	intracellular organelle	3	5
GO:0043231	intracellular membrane-bounded organelle	4	5
GO:0110165	cellular anatomical entity	1	33

Expansion

Sequence features

Q4QD81

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD81

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	6
GO:0016740	transferase activity	2	6
GO:0016746	acyltransferase activity	3	6

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	204	208	PF00656	0.373
CLV_NRD_NRD_1	109	111	PF00675	0.412
CLV_NRD_NRD_1	361	363	PF00675	0.335
CLV_NRD_NRD_1	443	445	PF00675	0.299
CLV_NRD_NRD_1	572	574	PF00675	0.354
CLV_PCSK_KEX2_1	109	111	PF00082	0.412
CLV_PCSK_KEX2_1	443	445	PF00082	0.299
CLV_PCSK_KEX2_1	572	574	PF00082	0.373
CLV_PCSK_PC7_1	568	574	PF00082	0.414
CLV_PCSK_SKI1_1	133	137	PF00082	0.346
CLV_PCSK_SKI1_1	15	19	PF00082	0.571
CLV_PCSK_SKI1_1	366	370	PF00082	0.334
CLV_PCSK_SKI1_1	480	484	PF00082	0.460
CLV_PCSK_SKI1_1	560	564	PF00082	0.406
DEG_APCC_DBOX_1	365	373	PF00400	0.453
DEG_APCC_DBOX_1	479	487	PF00400	0.562
DEG_APCC_DBOX_1	559	567	PF00400	0.609
DEG_Nend_Nbox_1	1	3	PF02207	0.308
DEG_SPOP_SBC_1	354	358	PF00917	0.568
DEG_SPOP_SBC_1	86	90	PF00917	0.604
DOC_CKS1_1	112	117	PF01111	0.601
DOC_CKS1_1	26	31	PF01111	0.284
DOC_CKS1_1	637	642	PF01111	0.283
DOC_CYCLIN_yCln2_LP_2	332	338	PF00134	0.411
DOC_MAPK_DCC_7	23	32	PF00069	0.291
DOC_MAPK_DCC_7	480	490	PF00069	0.343
DOC_MAPK_gen_1	239	248	PF00069	0.421
DOC_MAPK_gen_1	362	371	PF00069	0.527
DOC_MAPK_gen_1	478	485	PF00069	0.489
DOC_MAPK_gen_1	72	82	PF00069	0.522
DOC_MAPK_MEF2A_6	478	485	PF00069	0.573
DOC_MAPK_MEF2A_6	56	64	PF00069	0.416
DOC_PP1_RVXF_1	221	228	PF00149	0.460
DOC_PP1_RVXF_1	252	259	PF00149	0.305
DOC_PP1_SILK_1	369	374	PF00149	0.376
DOC_PP2B_LxvP_1	332	335	PF13499	0.411
DOC_PP4_FxxP_1	162	165	PF00568	0.357
DOC_USP7_MATH_1	303	307	PF00917	0.435
DOC_USP7_MATH_1	341	345	PF00917	0.346
DOC_USP7_MATH_1	347	351	PF00917	0.500
DOC_USP7_MATH_1	355	359	PF00917	0.500
DOC_USP7_MATH_1	558	562	PF00917	0.594
DOC_USP7_MATH_1	86	90	PF00917	0.815
DOC_WW_Pin1_4	111	116	PF00397	0.654
DOC_WW_Pin1_4	25	30	PF00397	0.291
DOC_WW_Pin1_4	572	577	PF00397	0.653
DOC_WW_Pin1_4	636	641	PF00397	0.452
DOC_WW_Pin1_4	682	687	PF00397	0.687
DOC_WW_Pin1_4	75	80	PF00397	0.621
DOC_WW_Pin1_4	82	87	PF00397	0.674
LIG_14-3-3_CanoR_1	138	142	PF00244	0.552
LIG_14-3-3_CanoR_1	241	247	PF00244	0.377
LIG_14-3-3_CanoR_1	249	254	PF00244	0.353
LIG_14-3-3_CanoR_1	353	361	PF00244	0.583
LIG_14-3-3_CanoR_1	373	382	PF00244	0.248
LIG_14-3-3_CanoR_1	399	403	PF00244	0.321
LIG_14-3-3_CanoR_1	480	486	PF00244	0.450
LIG_14-3-3_CanoR_1	568	576	PF00244	0.691
LIG_14-3-3_CanoR_1	633	642	PF00244	0.443
LIG_14-3-3_CanoR_1	75	79	PF00244	0.656
LIG_Actin_WH2_2	239	256	PF00022	0.338
LIG_Actin_WH2_2	383	401	PF00022	0.197
LIG_Actin_WH2_2	405	421	PF00022	0.332
LIG_Actin_WH2_2	664	680	PF00022	0.478
LIG_BRCT_BRCA1_1	244	248	PF00533	0.312
LIG_BRCT_BRCA1_1	426	430	PF00533	0.601
LIG_BRCT_BRCA1_1	519	523	PF00533	0.433
LIG_BRCT_BRCA1_1	592	596	PF00533	0.257
LIG_CtBP_PxDLS_1	439	443	PF00389	0.502
LIG_deltaCOP1_diTrp_1	44	50	PF00928	0.347
LIG_deltaCOP1_diTrp_1	458	466	PF00928	0.504
LIG_eIF4E_1	19	25	PF01652	0.300
LIG_eIF4E_1	327	333	PF01652	0.442
LIG_FHA_1	130	136	PF00498	0.736
LIG_FHA_1	250	256	PF00498	0.379
LIG_FHA_1	280	286	PF00498	0.369
LIG_FHA_1	375	381	PF00498	0.343
LIG_FHA_1	447	453	PF00498	0.491
LIG_FHA_1	642	648	PF00498	0.444
LIG_FHA_2	399	405	PF00498	0.321
LIG_FHA_2	618	624	PF00498	0.446
LIG_FHA_2	683	689	PF00498	0.627
LIG_GBD_Chelix_1	600	608	PF00786	0.223
LIG_Integrin_isoDGR_2	550	552	PF01839	0.469
LIG_LIR_Gen_1	28	39	PF02991	0.391
LIG_LIR_Gen_1	321	330	PF02991	0.304
LIG_LIR_Gen_1	343	352	PF02991	0.377
LIG_LIR_Gen_1	377	387	PF02991	0.424
LIG_LIR_Gen_1	392	403	PF02991	0.289
LIG_LIR_Gen_1	427	438	PF02991	0.564
LIG_LIR_Gen_1	593	604	PF02991	0.406
LIG_LIR_Nem_3	28	34	PF02991	0.357
LIG_LIR_Nem_3	321	327	PF02991	0.312
LIG_LIR_Nem_3	343	348	PF02991	0.382
LIG_LIR_Nem_3	350	354	PF02991	0.486
LIG_LIR_Nem_3	36	42	PF02991	0.305
LIG_LIR_Nem_3	377	382	PF02991	0.412
LIG_LIR_Nem_3	392	398	PF02991	0.249
LIG_LIR_Nem_3	427	433	PF02991	0.583
LIG_LIR_Nem_3	44	50	PF02991	0.336
LIG_LIR_Nem_3	593	599	PF02991	0.382
LIG_OCRL_FandH_1	11	23	PF00620	0.274
LIG_Pex14_1	141	145	PF04695	0.197
LIG_Pex14_1	214	218	PF04695	0.441
LIG_Pex14_1	244	248	PF04695	0.331
LIG_Pex14_1	459	463	PF04695	0.498
LIG_Pex14_1	466	470	PF04695	0.498
LIG_Pex14_1	638	642	PF04695	0.264
LIG_Pex14_2	420	424	PF04695	0.353
LIG_Pex14_2	455	459	PF04695	0.500
LIG_Pex14_2	491	495	PF04695	0.353
LIG_SH2_CRK	146	150	PF00017	0.337
LIG_SH2_CRK	322	326	PF00017	0.304
LIG_SH2_CRK	351	355	PF00017	0.550
LIG_SH2_CRK	470	474	PF00017	0.498
LIG_SH2_CRK	54	58	PF00017	0.223
LIG_SH2_GRB2like	39	42	PF00017	0.334
LIG_SH2_NCK_1	146	150	PF00017	0.354
LIG_SH2_PTP2	379	382	PF00017	0.288
LIG_SH2_STAP1	327	331	PF00017	0.376
LIG_SH2_STAP1	367	371	PF00017	0.488
LIG_SH2_STAP1	54	58	PF00017	0.224
LIG_SH2_STAT3	213	216	PF00017	0.423
LIG_SH2_STAT5	146	149	PF00017	0.363
LIG_SH2_STAT5	173	176	PF00017	0.427
LIG_SH2_STAT5	201	204	PF00017	0.495
LIG_SH2_STAT5	217	220	PF00017	0.416
LIG_SH2_STAT5	330	333	PF00017	0.359
LIG_SH2_STAT5	337	340	PF00017	0.346
LIG_SH2_STAT5	379	382	PF00017	0.359
LIG_SH2_STAT5	472	475	PF00017	0.498
LIG_SH2_STAT5	651	654	PF00017	0.310
LIG_SH3_3	112	118	PF00018	0.618
LIG_SH3_3	154	160	PF00018	0.450
LIG_SH3_3	230	236	PF00018	0.542
LIG_SH3_3	328	334	PF00018	0.453
LIG_Sin3_3	59	66	PF02671	0.206
LIG_SUMO_SIM_anti_2	194	201	PF11976	0.312
LIG_SUMO_SIM_anti_2	654	660	PF11976	0.420
LIG_SUMO_SIM_par_1	201	207	PF11976	0.531
LIG_SUMO_SIM_par_1	646	652	PF11976	0.375
LIG_SxIP_EBH_1	138	148	PF03271	0.406
LIG_TRFH_1	330	334	PF08558	0.459
LIG_TYR_ITIM	349	354	PF00017	0.482
LIG_TYR_ITIM	413	418	PF00017	0.432
LIG_TYR_ITIM	468	473	PF00017	0.341
LIG_UBA3_1	412	419	PF00899	0.376
LIG_UBA3_1	667	676	PF00899	0.501
LIG_WRC_WIRS_1	342	347	PF05994	0.365
LIG_WW_1	334	337	PF00397	0.411
MOD_CDK_SPK_2	572	577	PF00069	0.379
MOD_CDK_SPxxK_3	572	579	PF00069	0.352
MOD_CK1_1	575	581	PF00069	0.373
MOD_CK1_1	611	617	PF00069	0.504
MOD_CK1_1	636	642	PF00069	0.405
MOD_CK1_1	649	655	PF00069	0.273
MOD_CK1_1	682	688	PF00069	0.657
MOD_CK1_1	74	80	PF00069	0.546
MOD_CK1_1	85	91	PF00069	0.585
MOD_CK1_1	92	98	PF00069	0.556
MOD_CK2_1	280	286	PF00069	0.489
MOD_CK2_1	398	404	PF00069	0.454
MOD_CK2_1	617	623	PF00069	0.458
MOD_CK2_1	677	683	PF00069	0.438
MOD_CMANNOS	456	459	PF00535	0.346
MOD_CMANNOS	638	641	PF00535	0.308
MOD_DYRK1A_RPxSP_1	75	79	PF00069	0.398
MOD_GlcNHglycan	296	299	PF01048	0.512
MOD_GlcNHglycan	433	436	PF01048	0.442
MOD_GlcNHglycan	519	522	PF01048	0.368
MOD_GlcNHglycan	542	546	PF01048	0.530
MOD_GlcNHglycan	569	572	PF01048	0.447
MOD_GlcNHglycan	611	614	PF01048	0.549
MOD_GlcNHglycan	67	70	PF01048	0.471
MOD_GlcNHglycan	679	682	PF01048	0.531
MOD_GSK3_1	121	128	PF00069	0.690
MOD_GSK3_1	191	198	PF00069	0.329
MOD_GSK3_1	604	611	PF00069	0.498
MOD_GSK3_1	618	625	PF00069	0.537
MOD_GSK3_1	71	78	PF00069	0.518
MOD_GSK3_1	81	88	PF00069	0.623
MOD_GSK3_1	89	96	PF00069	0.537
MOD_N-GLC_1	40	45	PF02516	0.352
MOD_N-GLC_1	609	614	PF02516	0.369
MOD_N-GLC_1	677	682	PF02516	0.474
MOD_N-GLC_1	80	85	PF02516	0.466
MOD_NEK2_1	136	141	PF00069	0.528
MOD_NEK2_1	192	197	PF00069	0.345
MOD_NEK2_1	242	247	PF00069	0.394
MOD_NEK2_1	248	253	PF00069	0.377
MOD_NEK2_1	398	403	PF00069	0.364
MOD_NEK2_1	418	423	PF00069	0.249
MOD_NEK2_1	446	451	PF00069	0.357
MOD_NEK2_1	608	613	PF00069	0.472
MOD_NEK2_1	646	651	PF00069	0.377
MOD_NEK2_1	677	682	PF00069	0.409
MOD_NEK2_1	80	85	PF00069	0.696
MOD_NEK2_1	87	92	PF00069	0.775
MOD_NEK2_2	591	596	PF00069	0.305
MOD_PIKK_1	633	639	PF00454	0.335
MOD_PIKK_1	89	95	PF00454	0.493
MOD_PKA_2	129	135	PF00069	0.538
MOD_PKA_2	137	143	PF00069	0.382
MOD_PKA_2	242	248	PF00069	0.442
MOD_PKA_2	274	280	PF00069	0.470
MOD_PKA_2	398	404	PF00069	0.376
MOD_PKA_2	567	573	PF00069	0.552
MOD_PKA_2	71	77	PF00069	0.411
MOD_Plk_1	280	286	PF00069	0.477
MOD_Plk_4	137	143	PF00069	0.587
MOD_Plk_4	144	150	PF00069	0.445
MOD_Plk_4	195	201	PF00069	0.377
MOD_Plk_4	347	353	PF00069	0.298
MOD_Plk_4	367	373	PF00069	0.399
MOD_Plk_4	398	404	PF00069	0.407
MOD_Plk_4	481	487	PF00069	0.420
MOD_Plk_4	591	597	PF00069	0.333
MOD_Plk_4	646	652	PF00069	0.293
MOD_Plk_4	666	672	PF00069	0.406
MOD_ProDKin_1	111	117	PF00069	0.559
MOD_ProDKin_1	25	31	PF00069	0.326
MOD_ProDKin_1	572	578	PF00069	0.558
MOD_ProDKin_1	636	642	PF00069	0.550
MOD_ProDKin_1	682	688	PF00069	0.613
MOD_ProDKin_1	75	81	PF00069	0.528
MOD_ProDKin_1	82	88	PF00069	0.589
TRG_DiLeu_BaEn_2	403	409	PF01217	0.424
TRG_DiLeu_BaLyEn_6	162	167	PF01217	0.407
TRG_DiLeu_BaLyEn_6	251	256	PF01217	0.464
TRG_ENDOCYTIC_2	146	149	PF00928	0.347
TRG_ENDOCYTIC_2	173	176	PF00928	0.355
TRG_ENDOCYTIC_2	185	188	PF00928	0.320
TRG_ENDOCYTIC_2	322	325	PF00928	0.349
TRG_ENDOCYTIC_2	330	333	PF00928	0.344
TRG_ENDOCYTIC_2	351	354	PF00928	0.456
TRG_ENDOCYTIC_2	379	382	PF00928	0.374
TRG_ENDOCYTIC_2	39	42	PF00928	0.398
TRG_ENDOCYTIC_2	415	418	PF00928	0.400
TRG_ENDOCYTIC_2	470	473	PF00928	0.343
TRG_ENDOCYTIC_2	54	57	PF00928	0.373
TRG_ER_diArg_1	109	111	PF00400	0.804
TRG_ER_diArg_1	241	244	PF00400	0.452
TRG_ER_diArg_1	442	444	PF00400	0.346
TRG_ER_diArg_1	478	481	PF00400	0.368
TRG_ER_diArg_1	572	574	PF00400	0.413
TRG_ER_diArg_1	576	579	PF00400	0.352

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IRP6	Bodo saltans	35%	100%
A0A1X0P614	Trypanosomatidae	33%	100%
A0A1X0P616	Trypanosomatidae	42%	100%
A0A3Q8IAC1	Leishmania donovani	68%	89%
A0A3Q8IBC3	Leishmania donovani	66%	100%
A0A3Q8IBE0	Leishmania donovani	89%	83%
A0A3Q8IDD7	Leishmania donovani	68%	89%
A0A3S5H769	Leishmania donovani	68%	100%
A0A3S5IRW9	Trypanosoma rangeli	38%	100%
A0A3S7WVJ2	Leishmania donovani	89%	82%
A0A3S7WVK4	Leishmania donovani	71%	89%
A4HA75	Leishmania braziliensis	61%	95%
A4HA76	Leishmania braziliensis	64%	100%
A4HA77	Leishmania braziliensis	61%	100%
A4HA79	Leishmania braziliensis	68%	100%
A4HA80	Leishmania braziliensis	61%	75%
A4HA81	Leishmania braziliensis	63%	100%
A4HA82	Leishmania braziliensis	61%	92%
D0A0T4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	100%
E8NHJ2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
E9AGT0	Leishmania infantum	89%	82%
E9AGT1	Leishmania infantum	75%	100%
E9AGT2	Leishmania infantum	71%	100%
E9AGT3	Leishmania infantum	71%	89%
E9AGT4	Leishmania infantum	68%	89%
E9AS84	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
E9AS85	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	89%
E9AS86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	30%	92%
Q4QD78	Leishmania major	72%	100%
Q4QD79	Leishmania major	75%	100%
Q4QD80	Leishmania major	75%	100%