LeishMANIAdb
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Putative glycerol uptake protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative glycerol uptake protein
Gene product:
glycerol uptake protein, putative
Species:
Leishmania major
UniProt:
Q4QD80_LEIMA
TriTrypDb:
LmjF.19.1330 , LMJLV39_190019400 , LMJSD75_190019100 * , LMJSD75_190019300
Length:
743

Annotations

LeishMANIAdb annotations

Membrane-bound O-acyltransferase involved in the remodeling of glycosylphosphatidylinositol (GPI) anchors. Related to fungal GUP1 proteins.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 30
NetGPI no yes: 0, no: 30
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 5
GO:0005783 endoplasmic reticulum 5 5
GO:0016020 membrane 2 31
GO:0043226 organelle 2 5
GO:0043227 membrane-bounded organelle 3 5
GO:0043229 intracellular organelle 3 5
GO:0043231 intracellular membrane-bounded organelle 4 5
GO:0110165 cellular anatomical entity 1 31

Expansion

Sequence features

Q4QD80
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD80

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 6
GO:0016740 transferase activity 2 6
GO:0016746 acyltransferase activity 3 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 268 272 PF00656 0.379
CLV_C14_Caspase3-7 687 691 PF00656 0.429
CLV_NRD_NRD_1 425 427 PF00675 0.323
CLV_NRD_NRD_1 636 638 PF00675 0.363
CLV_PCSK_KEX2_1 636 638 PF00082 0.384
CLV_PCSK_PC7_1 632 638 PF00082 0.419
CLV_PCSK_SKI1_1 113 117 PF00082 0.275
CLV_PCSK_SKI1_1 130 134 PF00082 0.398
CLV_PCSK_SKI1_1 430 434 PF00082 0.322
CLV_PCSK_SKI1_1 544 548 PF00082 0.448
CLV_PCSK_SKI1_1 624 628 PF00082 0.407
CLV_PCSK_SKI1_1 700 704 PF00082 0.553
CLV_PCSK_SKI1_1 73 77 PF00082 0.573
DEG_APCC_DBOX_1 429 437 PF00400 0.447
DEG_APCC_DBOX_1 543 551 PF00400 0.432
DEG_APCC_DBOX_1 623 631 PF00400 0.610
DEG_MDM2_SWIB_1 76 83 PF02201 0.332
DEG_SCF_FBW7_1 702 707 PF00400 0.356
DEG_SPOP_SBC_1 418 422 PF00917 0.568
DOC_CDC14_PxL_1 448 456 PF14671 0.427
DOC_CKS1_1 135 140 PF01111 0.567
DOC_CKS1_1 169 174 PF01111 0.574
DOC_CYCLIN_RxL_1 127 137 PF00134 0.429
DOC_CYCLIN_yCln2_LP_2 200 206 PF00134 0.478
DOC_CYCLIN_yCln2_LP_2 396 402 PF00134 0.393
DOC_MAPK_DCC_7 544 554 PF00069 0.344
DOC_MAPK_gen_1 303 312 PF00069 0.416
DOC_MAPK_gen_1 426 435 PF00069 0.517
DOC_MAPK_gen_1 542 549 PF00069 0.480
DOC_MAPK_MEF2A_6 113 122 PF00069 0.399
DOC_MAPK_MEF2A_6 542 549 PF00069 0.566
DOC_MAPK_NFAT4_5 113 121 PF00069 0.263
DOC_PP1_RVXF_1 18 24 PF00149 0.660
DOC_PP1_RVXF_1 285 292 PF00149 0.451
DOC_PP1_RVXF_1 316 323 PF00149 0.306
DOC_PP1_SILK_1 433 438 PF00149 0.386
DOC_PP2B_LxvP_1 396 399 PF13499 0.393
DOC_PP4_FxxP_1 226 229 PF00568 0.343
DOC_PP4_FxxP_1 23 26 PF00568 0.637
DOC_USP7_MATH_1 144 148 PF00917 0.807
DOC_USP7_MATH_1 149 153 PF00917 0.663
DOC_USP7_MATH_1 367 371 PF00917 0.298
DOC_USP7_MATH_1 405 409 PF00917 0.348
DOC_USP7_MATH_1 411 415 PF00917 0.501
DOC_USP7_MATH_1 419 423 PF00917 0.501
DOC_USP7_MATH_1 622 626 PF00917 0.602
DOC_USP7_MATH_1 698 702 PF00917 0.334
DOC_USP7_UBL2_3 174 178 PF12436 0.569
DOC_WW_Pin1_4 134 139 PF00397 0.632
DOC_WW_Pin1_4 168 173 PF00397 0.591
DOC_WW_Pin1_4 185 190 PF00397 0.679
DOC_WW_Pin1_4 22 27 PF00397 0.700
DOC_WW_Pin1_4 3 8 PF00397 0.784
DOC_WW_Pin1_4 636 641 PF00397 0.659
DOC_WW_Pin1_4 700 705 PF00397 0.439
LIG_14-3-3_CanoR_1 130 136 PF00244 0.605
LIG_14-3-3_CanoR_1 305 311 PF00244 0.395
LIG_14-3-3_CanoR_1 313 318 PF00244 0.367
LIG_14-3-3_CanoR_1 417 425 PF00244 0.624
LIG_14-3-3_CanoR_1 43 48 PF00244 0.619
LIG_14-3-3_CanoR_1 437 446 PF00244 0.252
LIG_14-3-3_CanoR_1 463 467 PF00244 0.329
LIG_14-3-3_CanoR_1 544 550 PF00244 0.449
LIG_14-3-3_CanoR_1 632 640 PF00244 0.693
LIG_14-3-3_CanoR_1 729 735 PF00244 0.552
LIG_Actin_WH2_2 303 320 PF00022 0.326
LIG_Actin_WH2_2 469 485 PF00022 0.323
LIG_BRCT_BRCA1_1 308 312 PF00533 0.358
LIG_BRCT_BRCA1_1 455 459 PF00533 0.319
LIG_BRCT_BRCA1_1 490 494 PF00533 0.596
LIG_BRCT_BRCA1_1 583 587 PF00533 0.432
LIG_CSL_BTD_1 169 172 PF09270 0.620
LIG_CtBP_PxDLS_1 503 507 PF00389 0.489
LIG_deltaCOP1_diTrp_1 102 108 PF00928 0.332
LIG_deltaCOP1_diTrp_1 522 530 PF00928 0.508
LIG_EH_1 85 89 PF12763 0.335
LIG_eIF4E_1 391 397 PF01652 0.441
LIG_FHA_1 195 201 PF00498 0.637
LIG_FHA_1 25 31 PF00498 0.680
LIG_FHA_1 314 320 PF00498 0.379
LIG_FHA_1 344 350 PF00498 0.376
LIG_FHA_1 511 517 PF00498 0.495
LIG_FHA_1 655 661 PF00498 0.420
LIG_FHA_1 705 711 PF00498 0.432
LIG_FHA_1 730 736 PF00498 0.597
LIG_FHA_2 26 32 PF00498 0.721
LIG_FHA_2 463 469 PF00498 0.329
LIG_FHA_2 687 693 PF00498 0.449
LIG_Integrin_isoDGR_2 614 616 PF01839 0.476
LIG_LIR_Apic_2 134 138 PF02991 0.538
LIG_LIR_Gen_1 114 123 PF02991 0.367
LIG_LIR_Gen_1 36 44 PF02991 0.715
LIG_LIR_Gen_1 385 394 PF02991 0.292
LIG_LIR_Gen_1 407 416 PF02991 0.393
LIG_LIR_Gen_1 441 451 PF02991 0.409
LIG_LIR_Gen_1 456 467 PF02991 0.280
LIG_LIR_Gen_1 491 502 PF02991 0.571
LIG_LIR_Gen_1 732 741 PF02991 0.538
LIG_LIR_Gen_1 77 88 PF02991 0.417
LIG_LIR_Nem_3 102 108 PF02991 0.322
LIG_LIR_Nem_3 110 115 PF02991 0.325
LIG_LIR_Nem_3 126 132 PF02991 0.446
LIG_LIR_Nem_3 36 40 PF02991 0.644
LIG_LIR_Nem_3 385 391 PF02991 0.300
LIG_LIR_Nem_3 407 412 PF02991 0.410
LIG_LIR_Nem_3 414 418 PF02991 0.490
LIG_LIR_Nem_3 441 446 PF02991 0.397
LIG_LIR_Nem_3 456 462 PF02991 0.243
LIG_LIR_Nem_3 491 497 PF02991 0.577
LIG_LIR_Nem_3 644 650 PF02991 0.602
LIG_LIR_Nem_3 69 75 PF02991 0.386
LIG_LIR_Nem_3 732 737 PF02991 0.574
LIG_LIR_Nem_3 77 83 PF02991 0.390
LIG_LYPXL_S_1 40 44 PF13949 0.473
LIG_LYPXL_yS_3 41 44 PF13949 0.607
LIG_NRBOX 117 123 PF00104 0.412
LIG_PAM2_1 636 648 PF00658 0.563
LIG_Pex14_1 278 282 PF04695 0.454
LIG_Pex14_1 308 312 PF04695 0.335
LIG_Pex14_1 523 527 PF04695 0.499
LIG_Pex14_1 530 534 PF04695 0.499
LIG_Pex14_2 484 488 PF04695 0.346
LIG_Pex14_2 519 523 PF04695 0.501
LIG_Pex14_2 555 559 PF04695 0.358
LIG_Pex14_2 76 80 PF04695 0.336
LIG_PTB_Apo_2 83 90 PF02174 0.346
LIG_REV1ctd_RIR_1 86 95 PF16727 0.350
LIG_SH2_CRK 129 133 PF00017 0.533
LIG_SH2_CRK 135 139 PF00017 0.590
LIG_SH2_CRK 210 214 PF00017 0.345
LIG_SH2_CRK 37 41 PF00017 0.689
LIG_SH2_CRK 386 390 PF00017 0.291
LIG_SH2_CRK 415 419 PF00017 0.535
LIG_SH2_CRK 443 447 PF00017 0.445
LIG_SH2_CRK 457 461 PF00017 0.320
LIG_SH2_CRK 534 538 PF00017 0.499
LIG_SH2_GRB2like 97 100 PF00017 0.317
LIG_SH2_NCK_1 135 139 PF00017 0.562
LIG_SH2_NCK_1 210 214 PF00017 0.363
LIG_SH2_NCK_1 37 41 PF00017 0.648
LIG_SH2_SRC 97 100 PF00017 0.323
LIG_SH2_STAP1 37 41 PF00017 0.731
LIG_SH2_STAP1 391 395 PF00017 0.386
LIG_SH2_STAP1 431 435 PF00017 0.506
LIG_SH2_STAP1 457 461 PF00017 0.323
LIG_SH2_STAP1 715 719 PF00017 0.320
LIG_SH2_STAP1 97 101 PF00017 0.365
LIG_SH2_STAT3 277 280 PF00017 0.434
LIG_SH2_STAT5 210 213 PF00017 0.364
LIG_SH2_STAT5 237 240 PF00017 0.423
LIG_SH2_STAT5 265 268 PF00017 0.482
LIG_SH2_STAT5 281 284 PF00017 0.414
LIG_SH2_STAT5 394 397 PF00017 0.361
LIG_SH2_STAT5 401 404 PF00017 0.343
LIG_SH2_STAT5 443 446 PF00017 0.344
LIG_SH2_STAT5 49 52 PF00017 0.341
LIG_SH2_STAT5 536 539 PF00017 0.499
LIG_SH2_STAT5 734 737 PF00017 0.550
LIG_SH3_3 166 172 PF00018 0.655
LIG_SH3_3 218 224 PF00018 0.466
LIG_SH3_3 294 300 PF00018 0.542
LIG_SH3_3 392 398 PF00018 0.504
LIG_SH3_3 446 452 PF00018 0.427
LIG_SH3_CIN85_PxpxPR_1 189 194 PF14604 0.572
LIG_SUMO_SIM_anti_2 258 265 PF11976 0.300
LIG_SUMO_SIM_par_1 265 271 PF11976 0.520
LIG_TRFH_1 394 398 PF08558 0.447
LIG_TYR_ITIM 413 418 PF00017 0.470
LIG_TYR_ITIM 477 482 PF00017 0.417
LIG_TYR_ITIM 532 537 PF00017 0.342
LIG_UBA3_1 476 483 PF00899 0.386
LIG_WRC_WIRS_1 112 117 PF05994 0.222
LIG_WRC_WIRS_1 406 411 PF05994 0.348
LIG_WRC_WIRS_1 67 72 PF05994 0.382
LIG_WW_1 398 401 PF00397 0.393
MOD_CDK_SPxK_1 168 174 PF00069 0.439
MOD_CK1_1 134 140 PF00069 0.590
MOD_CK1_1 151 157 PF00069 0.484
MOD_CK1_1 25 31 PF00069 0.719
MOD_CK1_1 686 692 PF00069 0.710
MOD_CK2_1 344 350 PF00069 0.452
MOD_CK2_1 462 468 PF00069 0.453
MOD_CMANNOS 520 523 PF00535 0.348
MOD_DYRK1A_RPxSP_1 168 172 PF00069 0.443
MOD_DYRK1A_RPxSP_1 3 7 PF00069 0.455
MOD_DYRK1A_RPxSP_1 700 704 PF00069 0.337
MOD_GlcNHglycan 125 128 PF01048 0.464
MOD_GlcNHglycan 138 141 PF01048 0.490
MOD_GlcNHglycan 153 156 PF01048 0.533
MOD_GlcNHglycan 189 192 PF01048 0.719
MOD_GlcNHglycan 360 363 PF01048 0.528
MOD_GlcNHglycan 497 500 PF01048 0.441
MOD_GlcNHglycan 606 610 PF01048 0.539
MOD_GlcNHglycan 633 636 PF01048 0.461
MOD_GlcNHglycan 686 689 PF01048 0.694
MOD_GlcNHglycan 717 720 PF01048 0.411
MOD_GSK3_1 10 17 PF00069 0.539
MOD_GSK3_1 107 114 PF00069 0.328
MOD_GSK3_1 134 141 PF00069 0.625
MOD_GSK3_1 144 151 PF00069 0.559
MOD_GSK3_1 153 160 PF00069 0.520
MOD_GSK3_1 255 262 PF00069 0.316
MOD_GSK3_1 52 59 PF00069 0.484
MOD_GSK3_1 700 707 PF00069 0.522
MOD_NEK2_1 1 6 PF00069 0.644
MOD_NEK2_1 133 138 PF00069 0.569
MOD_NEK2_1 145 150 PF00069 0.761
MOD_NEK2_1 153 158 PF00069 0.461
MOD_NEK2_1 256 261 PF00069 0.324
MOD_NEK2_1 306 311 PF00069 0.404
MOD_NEK2_1 312 317 PF00069 0.384
MOD_NEK2_1 462 467 PF00069 0.364
MOD_NEK2_1 482 487 PF00069 0.259
MOD_NEK2_1 510 515 PF00069 0.367
MOD_NEK2_1 641 646 PF00069 0.505
MOD_NEK2_1 713 718 PF00069 0.409
MOD_PK_1 43 49 PF00069 0.520
MOD_PKA_2 306 312 PF00069 0.483
MOD_PKA_2 338 344 PF00069 0.486
MOD_PKA_2 462 468 PF00069 0.386
MOD_PKA_2 631 637 PF00069 0.547
MOD_Plk_1 344 350 PF00069 0.453
MOD_Plk_1 35 41 PF00069 0.519
MOD_Plk_1 441 447 PF00069 0.499
MOD_Plk_1 97 103 PF00069 0.416
MOD_Plk_4 111 117 PF00069 0.268
MOD_Plk_4 208 214 PF00069 0.492
MOD_Plk_4 259 265 PF00069 0.362
MOD_Plk_4 36 42 PF00069 0.691
MOD_Plk_4 411 417 PF00069 0.286
MOD_Plk_4 431 437 PF00069 0.386
MOD_Plk_4 441 447 PF00069 0.433
MOD_Plk_4 462 468 PF00069 0.418
MOD_Plk_4 545 551 PF00069 0.455
MOD_Plk_4 56 62 PF00069 0.257
MOD_Plk_4 641 647 PF00069 0.567
MOD_Plk_4 655 661 PF00069 0.316
MOD_Plk_4 730 736 PF00069 0.411
MOD_ProDKin_1 134 140 PF00069 0.538
MOD_ProDKin_1 168 174 PF00069 0.475
MOD_ProDKin_1 185 191 PF00069 0.596
MOD_ProDKin_1 22 28 PF00069 0.636
MOD_ProDKin_1 3 9 PF00069 0.743
MOD_ProDKin_1 636 642 PF00069 0.565
MOD_ProDKin_1 700 706 PF00069 0.532
TRG_DiLeu_BaEn_2 467 473 PF01217 0.432
TRG_DiLeu_BaLyEn_6 226 231 PF01217 0.418
TRG_DiLeu_BaLyEn_6 315 320 PF01217 0.463
TRG_ENDOCYTIC_2 112 115 PF00928 0.383
TRG_ENDOCYTIC_2 129 132 PF00928 0.285
TRG_ENDOCYTIC_2 210 213 PF00928 0.334
TRG_ENDOCYTIC_2 237 240 PF00928 0.370
TRG_ENDOCYTIC_2 249 252 PF00928 0.322
TRG_ENDOCYTIC_2 37 40 PF00928 0.552
TRG_ENDOCYTIC_2 386 389 PF00928 0.340
TRG_ENDOCYTIC_2 394 397 PF00928 0.353
TRG_ENDOCYTIC_2 41 44 PF00928 0.546
TRG_ENDOCYTIC_2 415 418 PF00928 0.454
TRG_ENDOCYTIC_2 443 446 PF00928 0.360
TRG_ENDOCYTIC_2 457 460 PF00928 0.343
TRG_ENDOCYTIC_2 479 482 PF00928 0.383
TRG_ENDOCYTIC_2 534 537 PF00928 0.345
TRG_ENDOCYTIC_2 647 650 PF00928 0.380
TRG_ENDOCYTIC_2 72 75 PF00928 0.501
TRG_ENDOCYTIC_2 734 737 PF00928 0.444
TRG_ENDOCYTIC_2 738 741 PF00928 0.405
TRG_ER_diArg_1 305 308 PF00400 0.461
TRG_ER_diArg_1 542 545 PF00400 0.377
TRG_ER_diArg_1 636 638 PF00400 0.426

Homologs

Protein Taxonomy Sequence identity Coverage
A0A1X0P614 Trypanosomatidae 32% 100%
A0A1X0P616 Trypanosomatidae 40% 100%
A0A3Q8IAC1 Leishmania donovani 89% 96%
A0A3Q8IBC3 Leishmania donovani 81% 100%
A0A3Q8IBE0 Leishmania donovani 73% 89%
A0A3Q8IDD7 Leishmania donovani 89% 96%
A0A3S5H769 Leishmania donovani 89% 100%
A0A3S5IRW9 Trypanosoma rangeli 36% 100%
A0A3S7WVJ2 Leishmania donovani 73% 88%
A0A3S7WVK4 Leishmania donovani 92% 96%
A4HA75 Leishmania braziliensis 61% 100%
A4HA76 Leishmania braziliensis 60% 100%
A4HA77 Leishmania braziliensis 67% 100%
A4HA80 Leishmania braziliensis 58% 80%
A4HA81 Leishmania braziliensis 66% 100%
A4HA82 Leishmania braziliensis 66% 99%
D0A0T4 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
E8NHJ2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 87% 100%
E9AGT0 Leishmania infantum 73% 88%
E9AGT1 Leishmania infantum 91% 100%
E9AGT2 Leishmania infantum 88% 100%
E9AGT3 Leishmania infantum 91% 96%
E9AGT4 Leishmania infantum 89% 96%
E9AS84 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
E9AS85 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 96%
E9AS86 Leishmania mexicana (strain MHOM/GT/2001/U1103) 30% 99%
Q4QD78 Leishmania major 94% 100%
Q4QD79 Leishmania major 98% 100%
Q4QD81 Leishmania major 75% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS