LeishMANIAdb
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Uncharacterized protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Uncharacterized protein
Gene product:
membrane-bound O-acyltransferase, putative
Species:
Leishmania major
UniProt:
Q4QD77_LEIMA
TriTrypDb:
LmjF.19.1347 * , LMJLV39_190019600 * , LMJSD75_190019500 *
Length:
734

Annotations

LeishMANIAdb annotations

Membrane-bound O-acyltransferase involved in the remodeling of glycosylphosphatidylinositol (GPI) anchors. Related to fungal GUP1 proteins.

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 7
NetGPI no yes: 0, no: 7
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0005783 endoplasmic reticulum 5 2
GO:0016020 membrane 2 8
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 8

Expansion

Sequence features

Q4QD77
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD77

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 3
GO:0016740 transferase activity 2 3
GO:0016746 acyltransferase activity 3 3

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 17 21 PF00656 0.667
CLV_C14_Caspase3-7 281 285 PF00656 0.348
CLV_C14_Caspase3-7 43 47 PF00656 0.627
CLV_MEL_PAP_1 243 249 PF00089 0.272
CLV_NRD_NRD_1 141 143 PF00675 0.360
CLV_NRD_NRD_1 144 146 PF00675 0.350
CLV_NRD_NRD_1 199 201 PF00675 0.382
CLV_NRD_NRD_1 321 323 PF00675 0.555
CLV_NRD_NRD_1 414 416 PF00675 0.336
CLV_PCSK_FUR_1 142 146 PF00082 0.353
CLV_PCSK_FUR_1 645 649 PF00082 0.352
CLV_PCSK_KEX2_1 141 143 PF00082 0.356
CLV_PCSK_KEX2_1 144 146 PF00082 0.347
CLV_PCSK_KEX2_1 245 247 PF00082 0.357
CLV_PCSK_KEX2_1 321 323 PF00082 0.555
CLV_PCSK_KEX2_1 414 416 PF00082 0.327
CLV_PCSK_KEX2_1 647 649 PF00082 0.364
CLV_PCSK_PC1ET2_1 245 247 PF00082 0.357
CLV_PCSK_PC1ET2_1 647 649 PF00082 0.356
CLV_PCSK_SKI1_1 150 154 PF00082 0.383
CLV_PCSK_SKI1_1 614 618 PF00082 0.487
DEG_APCC_DBOX_1 414 422 PF00400 0.494
DEG_APCC_DBOX_1 57 65 PF00400 0.537
DEG_APCC_KENBOX_2 93 97 PF00400 0.363
DEG_MDM2_SWIB_1 604 611 PF02201 0.282
DEG_ODPH_VHL_1 240 253 PF01847 0.401
DEG_SCF_FBW7_1 439 446 PF00400 0.375
DEG_SPOP_SBC_1 4 8 PF00917 0.671
DEG_SPOP_SBC_1 444 448 PF00917 0.366
DEG_SPOP_SBC_1 475 479 PF00917 0.394
DEG_SPOP_SBC_1 491 495 PF00917 0.407
DOC_CKS1_1 440 445 PF01111 0.373
DOC_CYCLIN_yCln2_LP_2 97 103 PF00134 0.320
DOC_MAPK_DCC_7 594 603 PF00069 0.289
DOC_MAPK_gen_1 200 208 PF00069 0.536
DOC_MAPK_gen_1 411 420 PF00069 0.508
DOC_MAPK_MEF2A_6 190 199 PF00069 0.618
DOC_MAPK_MEF2A_6 274 282 PF00069 0.274
DOC_MAPK_RevD_3 128 142 PF00069 0.333
DOC_PP1_RVXF_1 243 250 PF00149 0.476
DOC_PP1_RVXF_1 301 308 PF00149 0.262
DOC_PP1_RVXF_1 612 619 PF00149 0.291
DOC_PP2B_LxvP_1 239 242 PF13499 0.385
DOC_PP2B_LxvP_1 97 100 PF13499 0.352
DOC_PP2B_PxIxI_1 627 633 PF00149 0.308
DOC_PP4_FxxP_1 381 384 PF00568 0.282
DOC_PP4_FxxP_1 549 552 PF00568 0.481
DOC_USP7_MATH_1 346 350 PF00917 0.377
DOC_USP7_MATH_1 390 394 PF00917 0.287
DOC_USP7_MATH_1 396 400 PF00917 0.472
DOC_USP7_MATH_1 4 8 PF00917 0.661
DOC_USP7_MATH_1 443 447 PF00917 0.486
DOC_USP7_MATH_1 47 51 PF00917 0.614
DOC_USP7_MATH_2 351 357 PF00917 0.329
DOC_USP7_UBL2_3 324 328 PF12436 0.350
DOC_USP7_UBL2_3 94 98 PF12436 0.371
DOC_WW_Pin1_4 285 290 PF00397 0.359
DOC_WW_Pin1_4 439 444 PF00397 0.383
DOC_WW_Pin1_4 496 501 PF00397 0.422
DOC_WW_Pin1_4 646 651 PF00397 0.553
LIG_14-3-3_CanoR_1 190 194 PF00244 0.596
LIG_14-3-3_CanoR_1 246 250 PF00244 0.554
LIG_14-3-3_CanoR_1 303 308 PF00244 0.349
LIG_14-3-3_CanoR_1 321 327 PF00244 0.350
LIG_14-3-3_CanoR_1 344 352 PF00244 0.420
LIG_14-3-3_CanoR_1 423 427 PF00244 0.307
LIG_14-3-3_CanoR_1 58 62 PF00244 0.522
LIG_Actin_WH2_2 598 616 PF00022 0.333
LIG_BIR_II_1 1 5 PF00653 0.792
LIG_BIR_III_3 1 5 PF00653 0.633
LIG_BRCT_BRCA1_1 65 69 PF00533 0.261
LIG_CSL_BTD_1 286 289 PF09270 0.359
LIG_deltaCOP1_diTrp_1 284 293 PF00928 0.345
LIG_deltaCOP1_diTrp_1 534 543 PF00928 0.333
LIG_deltaCOP1_diTrp_1 571 579 PF00928 0.460
LIG_EH1_1 227 235 PF00400 0.482
LIG_eIF4E_1 132 138 PF01652 0.333
LIG_FHA_1 149 155 PF00498 0.533
LIG_FHA_1 194 200 PF00498 0.698
LIG_FHA_1 31 37 PF00498 0.692
LIG_FHA_1 504 510 PF00498 0.381
LIG_FHA_1 591 597 PF00498 0.487
LIG_FHA_1 679 685 PF00498 0.406
LIG_FHA_1 695 701 PF00498 0.377
LIG_FHA_2 330 336 PF00498 0.379
LIG_FHA_2 41 47 PF00498 0.630
LIG_FHA_2 57 63 PF00498 0.469
LIG_LIR_Apic_2 547 552 PF02991 0.491
LIG_LIR_Gen_1 309 317 PF02991 0.306
LIG_LIR_Gen_1 593 603 PF02991 0.258
LIG_LIR_Gen_1 6 15 PF02991 0.607
LIG_LIR_Gen_1 66 76 PF02991 0.382
LIG_LIR_Nem_3 284 290 PF02991 0.355
LIG_LIR_Nem_3 309 315 PF02991 0.315
LIG_LIR_Nem_3 374 379 PF02991 0.306
LIG_LIR_Nem_3 392 397 PF02991 0.329
LIG_LIR_Nem_3 399 403 PF02991 0.517
LIG_LIR_Nem_3 534 540 PF02991 0.325
LIG_LIR_Nem_3 593 598 PF02991 0.350
LIG_LIR_Nem_3 6 12 PF02991 0.607
LIG_LIR_Nem_3 66 72 PF02991 0.391
LIG_LIR_Nem_3 697 701 PF02991 0.287
LIG_Pex14_1 293 297 PF04695 0.286
LIG_Pex14_1 572 576 PF04695 0.454
LIG_Pex14_1 579 583 PF04695 0.454
LIG_Pex14_2 539 543 PF04695 0.486
LIG_Pex14_2 568 572 PF04695 0.454
LIG_Pex14_2 595 599 PF04695 0.309
LIG_Pex14_2 604 608 PF04695 0.268
LIG_Pex14_2 701 705 PF04695 0.233
LIG_REV1ctd_RIR_1 537 545 PF16727 0.450
LIG_SH2_CRK 244 248 PF00017 0.478
LIG_SH2_CRK 583 587 PF00017 0.454
LIG_SH2_CRK 76 80 PF00017 0.333
LIG_SH2_NCK_1 76 80 PF00017 0.308
LIG_SH2_PTP2 433 436 PF00017 0.339
LIG_SH2_SRC 132 135 PF00017 0.233
LIG_SH2_SRC 238 241 PF00017 0.487
LIG_SH2_SRC 433 436 PF00017 0.339
LIG_SH2_STAP1 297 301 PF00017 0.222
LIG_SH2_STAP1 76 80 PF00017 0.333
LIG_SH2_STAT3 722 725 PF00017 0.557
LIG_SH2_STAT3 731 734 PF00017 0.496
LIG_SH2_STAT5 121 124 PF00017 0.333
LIG_SH2_STAT5 132 135 PF00017 0.220
LIG_SH2_STAT5 238 241 PF00017 0.499
LIG_SH2_STAT5 376 379 PF00017 0.286
LIG_SH2_STAT5 382 385 PF00017 0.289
LIG_SH2_STAT5 397 400 PF00017 0.468
LIG_SH2_STAT5 433 436 PF00017 0.350
LIG_SH2_STAT5 55 58 PF00017 0.543
LIG_SH2_STAT5 585 588 PF00017 0.454
LIG_SH2_STAT5 63 66 PF00017 0.247
LIG_SH2_STAT5 706 709 PF00017 0.344
LIG_SH3_3 121 127 PF00018 0.333
LIG_SUMO_SIM_anti_2 298 303 PF11976 0.218
LIG_SUMO_SIM_anti_2 506 511 PF11976 0.372
LIG_SUMO_SIM_anti_2 661 667 PF11976 0.333
LIG_SUMO_SIM_par_1 505 511 PF11976 0.380
LIG_SUMO_SIM_par_1 664 669 PF11976 0.258
LIG_SUMO_SIM_par_1 71 77 PF11976 0.333
LIG_TYR_ITIM 380 385 PF00017 0.339
LIG_TYR_ITIM 581 586 PF00017 0.287
LIG_TYR_ITIM 74 79 PF00017 0.333
LIG_UBA3_1 239 245 PF00899 0.392
LIG_UBA3_1 690 699 PF00899 0.308
LIG_WRC_WIRS_1 304 309 PF05994 0.346
LIG_WRC_WIRS_1 391 396 PF05994 0.390
MOD_CK1_1 172 178 PF00069 0.591
MOD_CK1_1 306 312 PF00069 0.443
MOD_CK1_1 404 410 PF00069 0.396
MOD_CK1_1 422 428 PF00069 0.185
MOD_CK1_1 492 498 PF00069 0.736
MOD_CK1_1 57 63 PF00069 0.418
MOD_CK1_1 677 683 PF00069 0.552
MOD_CK1_1 7 13 PF00069 0.665
MOD_CK2_1 313 319 PF00069 0.408
MOD_CK2_1 505 511 PF00069 0.376
MOD_CK2_1 56 62 PF00069 0.422
MOD_CMANNOS 569 572 PF00535 0.287
MOD_GlcNHglycan 168 172 PF01048 0.586
MOD_GlcNHglycan 202 206 PF01048 0.330
MOD_GlcNHglycan 373 376 PF01048 0.372
MOD_GlcNHglycan 403 406 PF01048 0.434
MOD_GlcNHglycan 447 450 PF01048 0.665
MOD_GlcNHglycan 454 457 PF01048 0.557
MOD_GlcNHglycan 48 52 PF01048 0.453
MOD_GlcNHglycan 708 711 PF01048 0.263
MOD_GSK3_1 146 153 PF00069 0.485
MOD_GSK3_1 184 191 PF00069 0.583
MOD_GSK3_1 245 252 PF00069 0.431
MOD_GSK3_1 291 298 PF00069 0.256
MOD_GSK3_1 3 10 PF00069 0.708
MOD_GSK3_1 422 429 PF00069 0.494
MOD_GSK3_1 439 446 PF00069 0.478
MOD_GSK3_1 490 497 PF00069 0.681
MOD_GSK3_1 513 520 PF00069 0.395
MOD_GSK3_1 590 597 PF00069 0.326
MOD_GSK3_1 630 637 PF00069 0.301
MOD_GSK3_1 674 681 PF00069 0.534
MOD_N-GLC_1 155 160 PF02516 0.445
MOD_NEK2_1 137 142 PF00069 0.353
MOD_NEK2_1 249 254 PF00069 0.370
MOD_NEK2_1 278 283 PF00069 0.519
MOD_NEK2_1 311 316 PF00069 0.388
MOD_NEK2_1 371 376 PF00069 0.364
MOD_NEK2_1 426 431 PF00069 0.314
MOD_NEK2_1 467 472 PF00069 0.461
MOD_NEK2_1 474 479 PF00069 0.432
MOD_NEK2_1 490 495 PF00069 0.527
MOD_NEK2_1 522 527 PF00069 0.284
MOD_NEK2_1 56 61 PF00069 0.462
MOD_NEK2_1 588 593 PF00069 0.339
MOD_PIKK_1 292 298 PF00454 0.381
MOD_PIKK_1 658 664 PF00454 0.333
MOD_PK_1 594 600 PF00069 0.339
MOD_PKA_1 245 251 PF00069 0.427
MOD_PKA_2 189 195 PF00069 0.553
MOD_PKA_2 245 251 PF00069 0.427
MOD_PKA_2 40 46 PF00069 0.643
MOD_PKA_2 422 428 PF00069 0.233
MOD_PKA_2 57 63 PF00069 0.296
MOD_Plk_1 184 190 PF00069 0.567
MOD_Plk_1 201 207 PF00069 0.511
MOD_Plk_1 369 375 PF00069 0.377
MOD_Plk_1 4 10 PF00069 0.496
MOD_Plk_1 666 672 PF00069 0.333
MOD_Plk_2-3 313 319 PF00069 0.308
MOD_Plk_2-3 718 724 PF00069 0.314
MOD_Plk_4 150 156 PF00069 0.569
MOD_Plk_4 193 199 PF00069 0.506
MOD_Plk_4 251 257 PF00069 0.368
MOD_Plk_4 278 284 PF00069 0.531
MOD_Plk_4 32 38 PF00069 0.748
MOD_Plk_4 422 428 PF00069 0.502
MOD_Plk_4 505 511 PF00069 0.514
MOD_Plk_4 517 523 PF00069 0.277
MOD_Plk_4 594 600 PF00069 0.346
MOD_Plk_4 63 69 PF00069 0.321
MOD_Plk_4 630 636 PF00069 0.285
MOD_ProDKin_1 285 291 PF00069 0.427
MOD_ProDKin_1 439 445 PF00069 0.478
MOD_ProDKin_1 496 502 PF00069 0.522
MOD_ProDKin_1 646 652 PF00069 0.426
MOD_SUMO_rev_2 404 413 PF00179 0.415
TRG_DiLeu_BaLyEn_6 286 291 PF01217 0.428
TRG_DiLeu_BaLyEn_6 416 421 PF01217 0.404
TRG_DiLeu_BaLyEn_6 611 616 PF01217 0.333
TRG_ENDOCYTIC_2 104 107 PF00928 0.420
TRG_ENDOCYTIC_2 120 123 PF00928 0.204
TRG_ENDOCYTIC_2 244 247 PF00928 0.438
TRG_ENDOCYTIC_2 382 385 PF00928 0.320
TRG_ENDOCYTIC_2 433 436 PF00928 0.394
TRG_ENDOCYTIC_2 583 586 PF00928 0.287
TRG_ENDOCYTIC_2 76 79 PF00928 0.434
TRG_ER_diArg_1 141 144 PF00400 0.357
TRG_ER_diArg_1 413 415 PF00400 0.387
TRG_NES_CRM1_1 534 547 PF08389 0.465
TRG_NES_CRM1_1 553 566 PF08389 0.235
TRG_Pf-PMV_PEXEL_1 657 662 PF00026 0.333

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0S4IRP6 Bodo saltans 31% 100%
A0A3S5IRW9 Trypanosoma rangeli 36% 100%
A0A3S7WVM5 Leishmania donovani 89% 100%
A4HYG3 Leishmania infantum 90% 100%
E9AGT2 Leishmania infantum 28% 100%
E9AS86 Leishmania mexicana (strain MHOM/GT/2001/U1103) 81% 97%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS