Uncharacterized protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

membrane-bound O-acyltransferase, putative

Species:

Leishmania major

UniProt:

Q4QD77_LEIMA

TriTrypDb:

LmjF.19.1347 , LMJLV39_190019600 , LMJSD75_190019500

Length:

734

Annotations

LeishMANIAdb annotations

Membrane-bound O-acyltransferase involved in the remodeling of glycosylphosphatidylinositol (GPI) anchors. Related to fungal GUP1 proteins.

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Show entries

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005783	endoplasmic reticulum	5	2
GO:0016020	membrane	2	8
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	8

Previous1Next

Expansion

Sequence features

Q4QD77

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD77

Function

Could not find GO biological_process term for this entry.

Show entries

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016740	transferase activity	2	3
GO:0016746	acyltransferase activity	3	3

Previous1Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	17	21	PF00656	0.667
CLV_C14_Caspase3-7	281	285	PF00656	0.348
CLV_C14_Caspase3-7	43	47	PF00656	0.627
CLV_MEL_PAP_1	243	249	PF00089	0.272
CLV_NRD_NRD_1	141	143	PF00675	0.360
CLV_NRD_NRD_1	144	146	PF00675	0.350
CLV_NRD_NRD_1	199	201	PF00675	0.382
CLV_NRD_NRD_1	321	323	PF00675	0.555
CLV_NRD_NRD_1	414	416	PF00675	0.336
CLV_PCSK_FUR_1	142	146	PF00082	0.353

Previous1 2 3 4 5…24Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0S4IRP6	Bodo saltans	31%	100%
A0A3S5IRW9	Trypanosoma rangeli	36%	100%
A0A3S7WVM5	Leishmania donovani	89%	100%
A4HYG3	Leishmania infantum	90%	100%
E9AGT2	Leishmania infantum	28%	100%
E9AS86	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	97%

Previous1Next