LeishMANIAdb
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Phosphatidic acid phosphatase protein-like protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Phosphatidic acid phosphatase protein-like protein
Gene product:
phosphatidic acid phosphatase protein-like protein
Species:
Leishmania major
UniProt:
Q4QD76_LEIMA
TriTrypDb:
LmjF.19.1350 , LMJLV39_190019800 * , LMJSD75_190019600
Length:
400

Annotations

LeishMANIAdb annotations

Distinctively related to eukaryotic PLPP enzymes.. This family of protens expanded considerably in Kinetoplastids (might be due to metabolic dependence on host lipids)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 21
NetGPI no yes: 0, no: 21
Cellular components
Term Name Level Count
GO:0016020 membrane 2 22
GO:0110165 cellular anatomical entity 1 22

Expansion

Sequence features

Q4QD76
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD76

Function

Biological processes
Term Name Level Count
GO:0006629 lipid metabolic process 3 22
GO:0006644 phospholipid metabolic process 4 22
GO:0006793 phosphorus metabolic process 3 22
GO:0006796 phosphate-containing compound metabolic process 4 22
GO:0008152 metabolic process 1 22
GO:0009987 cellular process 1 22
GO:0019637 organophosphate metabolic process 3 22
GO:0044237 cellular metabolic process 2 22
GO:0044238 primary metabolic process 2 22
GO:0044255 cellular lipid metabolic process 3 22
GO:0071704 organic substance metabolic process 2 22
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 4
GO:0008195 phosphatidate phosphatase activity 6 4
GO:0016787 hydrolase activity 2 4
GO:0016788 hydrolase activity, acting on ester bonds 3 4
GO:0016791 phosphatase activity 5 4
GO:0042578 phosphoric ester hydrolase activity 4 4

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 374 378 PF00656 0.422
CLV_C14_Caspase3-7 46 50 PF00656 0.351
CLV_NRD_NRD_1 321 323 PF00675 0.565
CLV_NRD_NRD_1 380 382 PF00675 0.747
CLV_NRD_NRD_1 388 390 PF00675 0.701
CLV_PCSK_KEX2_1 352 354 PF00082 0.721
CLV_PCSK_KEX2_1 380 382 PF00082 0.747
CLV_PCSK_KEX2_1 388 390 PF00082 0.701
CLV_PCSK_PC1ET2_1 352 354 PF00082 0.664
DEG_APCC_DBOX_1 143 151 PF00400 0.510
DOC_MAPK_DCC_7 248 258 PF00069 0.292
DOC_PP1_RVXF_1 209 215 PF00149 0.422
DOC_PP4_FxxP_1 92 95 PF00568 0.656
DOC_USP7_MATH_1 106 110 PF00917 0.650
DOC_USP7_MATH_1 325 329 PF00917 0.465
DOC_USP7_MATH_1 340 344 PF00917 0.569
DOC_WW_Pin1_4 360 365 PF00397 0.538
LIG_14-3-3_CanoR_1 211 215 PF00244 0.412
LIG_14-3-3_CanoR_1 242 247 PF00244 0.243
LIG_14-3-3_CanoR_1 358 365 PF00244 0.540
LIG_14-3-3_CanoR_1 43 48 PF00244 0.253
LIG_BIR_III_2 202 206 PF00653 0.423
LIG_BRCT_BRCA1_1 219 223 PF00533 0.281
LIG_BRCT_BRCA1_1 72 76 PF00533 0.334
LIG_DLG_GKlike_1 242 249 PF00625 0.289
LIG_FHA_1 155 161 PF00498 0.505
LIG_FHA_1 245 251 PF00498 0.367
LIG_FHA_2 190 196 PF00498 0.502
LIG_FHA_2 308 314 PF00498 0.425
LIG_FHA_2 372 378 PF00498 0.422
LIG_FHA_2 58 64 PF00498 0.385
LIG_GBD_Chelix_1 24 32 PF00786 0.294
LIG_IRF3_LxIS_1 24 31 PF10401 0.400
LIG_IRF3_LxIS_1 250 257 PF10401 0.300
LIG_LIR_Gen_1 195 205 PF02991 0.451
LIG_LIR_Gen_1 20 29 PF02991 0.332
LIG_LIR_Gen_1 245 254 PF02991 0.361
LIG_LIR_Gen_1 287 296 PF02991 0.408
LIG_LIR_Gen_1 313 324 PF02991 0.448
LIG_LIR_Nem_3 195 200 PF02991 0.445
LIG_LIR_Nem_3 20 24 PF02991 0.332
LIG_LIR_Nem_3 245 249 PF02991 0.310
LIG_LIR_Nem_3 287 292 PF02991 0.365
LIG_LIR_Nem_3 295 299 PF02991 0.451
LIG_LIR_Nem_3 313 319 PF02991 0.331
LIG_LIR_Nem_3 59 64 PF02991 0.293
LIG_LIR_Nem_3 73 79 PF02991 0.240
LIG_LIR_Nem_3 97 101 PF02991 0.584
LIG_LYPXL_S_1 139 143 PF13949 0.373
LIG_LYPXL_yS_3 140 143 PF13949 0.571
LIG_NRBOX 23 29 PF00104 0.411
LIG_PDZ_Wminus1_1 398 400 PF00595 0.532
LIG_Pex14_2 292 296 PF04695 0.326
LIG_Pex14_2 72 76 PF04695 0.372
LIG_Pex14_2 9 13 PF04695 0.589
LIG_PTB_Apo_2 190 197 PF02174 0.553
LIG_PTB_Phospho_1 190 196 PF10480 0.553
LIG_SH2_CRK 197 201 PF00017 0.474
LIG_SH2_NCK_1 115 119 PF00017 0.718
LIG_SH2_SRC 115 118 PF00017 0.744
LIG_SH2_STAP1 180 184 PF00017 0.531
LIG_SH2_STAP1 64 68 PF00017 0.369
LIG_SH2_STAT5 171 174 PF00017 0.483
LIG_SH2_STAT5 197 200 PF00017 0.407
LIG_SH2_STAT5 306 309 PF00017 0.412
LIG_SH2_STAT5 77 80 PF00017 0.277
LIG_SH2_STAT5 83 86 PF00017 0.380
LIG_SH2_STAT5 99 102 PF00017 0.524
LIG_SH3_3 332 338 PF00018 0.514
LIG_SH3_3 376 382 PF00018 0.421
LIG_Sin3_3 25 32 PF02671 0.359
LIG_SUMO_SIM_anti_2 257 262 PF11976 0.429
LIG_SUMO_SIM_anti_2 65 70 PF11976 0.317
LIG_SUMO_SIM_par_1 25 31 PF11976 0.319
LIG_SUMO_SIM_par_1 254 259 PF11976 0.365
LIG_TYR_ITIM 138 143 PF00017 0.599
LIG_TYR_ITIM 314 319 PF00017 0.447
LIG_WRC_WIRS_1 289 294 PF05994 0.355
LIG_WRC_WIRS_1 372 377 PF05994 0.416
MOD_CDK_SPxxK_3 360 367 PF00069 0.530
MOD_CK1_1 154 160 PF00069 0.423
MOD_CK1_1 182 188 PF00069 0.502
MOD_CK1_1 213 219 PF00069 0.412
MOD_CK1_1 328 334 PF00069 0.546
MOD_CK1_1 339 345 PF00069 0.530
MOD_CK1_1 363 369 PF00069 0.501
MOD_CK2_1 2 8 PF00069 0.492
MOD_GlcNHglycan 108 111 PF01048 0.505
MOD_GlcNHglycan 176 179 PF01048 0.288
MOD_GlcNHglycan 215 218 PF01048 0.212
MOD_GlcNHglycan 286 289 PF01048 0.314
MOD_GlcNHglycan 329 333 PF01048 0.671
MOD_GlcNHglycan 338 341 PF01048 0.692
MOD_GlcNHglycan 360 363 PF01048 0.693
MOD_GSK3_1 117 124 PF00069 0.729
MOD_GSK3_1 170 177 PF00069 0.500
MOD_GSK3_1 178 185 PF00069 0.484
MOD_GSK3_1 213 220 PF00069 0.427
MOD_GSK3_1 28 35 PF00069 0.352
MOD_GSK3_1 284 291 PF00069 0.339
MOD_GSK3_1 336 343 PF00069 0.535
MOD_GSK3_1 371 378 PF00069 0.548
MOD_GSK3_1 53 60 PF00069 0.317
MOD_LATS_1 41 47 PF00433 0.305
MOD_N-GLC_1 375 380 PF02516 0.622
MOD_NEK2_1 28 33 PF00069 0.276
MOD_NEK2_1 292 297 PF00069 0.330
MOD_NEK2_1 307 312 PF00069 0.321
MOD_NEK2_1 375 380 PF00069 0.553
MOD_NEK2_2 288 293 PF00069 0.360
MOD_PKA_1 380 386 PF00069 0.421
MOD_PKA_2 210 216 PF00069 0.412
MOD_PKA_2 380 386 PF00069 0.546
MOD_Plk_1 375 381 PF00069 0.556
MOD_Plk_1 48 54 PF00069 0.294
MOD_Plk_1 62 68 PF00069 0.233
MOD_Plk_4 224 230 PF00069 0.267
MOD_Plk_4 256 262 PF00069 0.332
MOD_Plk_4 278 284 PF00069 0.278
MOD_Plk_4 288 294 PF00069 0.276
MOD_Plk_4 380 386 PF00069 0.345
MOD_ProDKin_1 360 366 PF00069 0.535
MOD_SUMO_rev_2 315 325 PF00179 0.391
TRG_DiLeu_BaLyEn_6 245 250 PF01217 0.312
TRG_ENDOCYTIC_2 140 143 PF00928 0.507
TRG_ENDOCYTIC_2 16 19 PF00928 0.298
TRG_ENDOCYTIC_2 197 200 PF00928 0.474
TRG_ENDOCYTIC_2 293 296 PF00928 0.319
TRG_ENDOCYTIC_2 316 319 PF00928 0.445
TRG_ENDOCYTIC_2 77 80 PF00928 0.258
TRG_ER_diArg_1 127 130 PF00400 0.682
TRG_ER_diArg_1 166 169 PF00400 0.417
TRG_ER_diArg_1 379 381 PF00400 0.548
TRG_ER_diArg_1 388 390 PF00400 0.497
TRG_Pf-PMV_PEXEL_1 388 392 PF00026 0.724
TRG_Pf-PMV_PEXEL_1 86 90 PF00026 0.297

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P344 Leptomonas seymouri 58% 100%
A0A0N1I1J3 Leptomonas seymouri 30% 100%
A0A0S4JH63 Bodo saltans 33% 100%
A0A1X0P677 Trypanosomatidae 38% 100%
A0A1X0P6S8 Trypanosomatidae 32% 100%
A0A1X0P729 Trypanosomatidae 30% 100%
A0A3Q8ID01 Leishmania donovani 28% 100%
A0A3Q8IK66 Leishmania donovani 92% 100%
A0A3S5IRX0 Trypanosoma rangeli 40% 100%
A0A422MQK2 Trypanosoma rangeli 35% 100%
A4H9I2 Leishmania braziliensis 30% 100%
A4HA84 Leishmania braziliensis 70% 100%
A4HXR8 Leishmania infantum 28% 100%
A4HYG7 Leishmania infantum 92% 100%
C9ZUG5 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
C9ZZW0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 33% 100%
D0A051 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 31% 100%
E9AS87 Leishmania mexicana (strain MHOM/GT/2001/U1103) 84% 100%
E9AS88 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
O08564 Rattus norvegicus 26% 100%
O14494 Homo sapiens 27% 100%
O88956 Cavia porcellus 28% 100%
P60588 Sus scrofa 27% 100%
Q10022 Caenorhabditis elegans 26% 100%
Q61469 Mus musculus 28% 100%
Q8K593 Rattus norvegicus 24% 100%
Q8LFD1 Arabidopsis thaliana 23% 100%
Q99JY8 Mus musculus 27% 100%
Q9DAX2 Mus musculus 24% 100%
Q9UUA6 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 25% 100%
V5B5J9 Trypanosoma cruzi 37% 100%
V5BM01 Trypanosoma cruzi 34% 100%
V5BWA7 Trypanosoma cruzi 30% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS