LeishMANIAdb
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Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Transmembrane protein
Gene product:
hypothetical protein, unknown function
Species:
Leishmania major
UniProt:
Q4QD75_LEIMA
TriTrypDb:
LmjF.19.1360 , LMJLV39_190019900 , LMJSD75_190019700
Length:
88

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 4
NetGPI no yes: 0, no: 4
Cellular components
Term Name Level Count
GO:0016020 membrane 2 4
GO:0110165 cellular anatomical entity 1 4

Expansion

Sequence features

Q4QD75
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD75

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_SKI1_1 6 10 PF00082 0.402
DEG_APCC_DBOX_1 3 11 PF00400 0.594
DOC_CYCLIN_yCln2_LP_2 59 65 PF00134 0.394
DOC_MAPK_MEF2A_6 48 57 PF00069 0.491
DOC_PP1_RVXF_1 4 10 PF00149 0.469
LIG_FHA_2 32 38 PF00498 0.418
LIG_Pex14_2 64 68 PF04695 0.456
LIG_SH2_PTP2 76 79 PF00017 0.471
LIG_SH2_SRC 76 79 PF00017 0.394
LIG_SH2_STAP1 23 27 PF00017 0.296
LIG_SH2_STAT5 76 79 PF00017 0.471
LIG_TRAF2_1 39 42 PF00917 0.570
LIG_TYR_ITIM 74 79 PF00017 0.394
MOD_GSK3_1 80 87 PF00069 0.442
MOD_Plk_4 23 29 PF00069 0.394
MOD_Plk_4 81 87 PF00069 0.604
TRG_DiLeu_BaLyEn_6 3 8 PF01217 0.638
TRG_ENDOCYTIC_2 76 79 PF00928 0.471
TRG_ER_diArg_1 4 7 PF00400 0.708

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3S5H771 Leishmania donovani 89% 100%
A4HA85 Leishmania braziliensis 62% 100%
A4HYG6 Leishmania infantum 89% 100%

Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS