NTP_transf_2 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QD73_LEIMA

TriTrypDb:

LmjF.19.1370 , LMJLV39_190020100 , LMJSD75_190019800

Length:

740

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QD73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD73

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	11	15	PF00656	0.654
CLV_C14_Caspase3-7	412	416	PF00656	0.559
CLV_NRD_NRD_1	292	294	PF00675	0.635
CLV_NRD_NRD_1	323	325	PF00675	0.756
CLV_NRD_NRD_1	400	402	PF00675	0.599
CLV_PCSK_FUR_1	398	402	PF00082	0.520
CLV_PCSK_KEX2_1	323	325	PF00082	0.756
CLV_PCSK_KEX2_1	400	402	PF00082	0.616
CLV_PCSK_KEX2_1	407	409	PF00082	0.418
CLV_PCSK_KEX2_1	487	489	PF00082	0.435
CLV_PCSK_PC1ET2_1	407	409	PF00082	0.551
CLV_PCSK_PC1ET2_1	487	489	PF00082	0.435
CLV_PCSK_SKI1_1	257	261	PF00082	0.573
CLV_PCSK_SKI1_1	407	411	PF00082	0.551
CLV_PCSK_SKI1_1	475	479	PF00082	0.589
CLV_PCSK_SKI1_1	623	627	PF00082	0.646
CLV_PCSK_SKI1_1	723	727	PF00082	0.523
DEG_APCC_DBOX_1	111	119	PF00400	0.586
DEG_APCC_DBOX_1	507	515	PF00400	0.672
DEG_APCC_DBOX_1	526	534	PF00400	0.339
DEG_APCC_DBOX_1	577	585	PF00400	0.503
DOC_CKS1_1	461	466	PF01111	0.628
DOC_CYCLIN_RxL_1	472	479	PF00134	0.566
DOC_CYCLIN_yCln2_LP_2	728	731	PF00134	0.509
DOC_MAPK_gen_1	508	516	PF00069	0.568
DOC_MAPK_gen_1	718	727	PF00069	0.507
DOC_MAPK_MEF2A_6	527	535	PF00069	0.528
DOC_MAPK_MEF2A_6	578	585	PF00069	0.456
DOC_MAPK_MEF2A_6	67	76	PF00069	0.535
DOC_MAPK_MEF2A_6	721	729	PF00069	0.508
DOC_MIT_MIM_1	506	514	PF04212	0.530
DOC_PP2B_LxvP_1	286	289	PF13499	0.709
DOC_PP2B_LxvP_1	727	730	PF13499	0.502
DOC_PP2B_PxIxI_1	540	546	PF00149	0.503
DOC_PP4_FxxP_1	352	355	PF00568	0.577
DOC_USP7_MATH_1	144	148	PF00917	0.671
DOC_USP7_MATH_1	169	173	PF00917	0.745
DOC_USP7_MATH_1	175	179	PF00917	0.768
DOC_USP7_MATH_1	182	186	PF00917	0.722
DOC_USP7_MATH_1	225	229	PF00917	0.679
DOC_USP7_MATH_1	300	304	PF00917	0.663
DOC_USP7_MATH_1	347	351	PF00917	0.837
DOC_USP7_MATH_1	367	371	PF00917	0.517
DOC_USP7_MATH_1	451	455	PF00917	0.660
DOC_USP7_MATH_1	680	684	PF00917	0.622
DOC_USP7_MATH_1	734	738	PF00917	0.568
DOC_WW_Pin1_4	147	152	PF00397	0.695
DOC_WW_Pin1_4	154	159	PF00397	0.641
DOC_WW_Pin1_4	165	170	PF00397	0.553
DOC_WW_Pin1_4	229	234	PF00397	0.681
DOC_WW_Pin1_4	332	337	PF00397	0.827
DOC_WW_Pin1_4	377	382	PF00397	0.669
DOC_WW_Pin1_4	383	388	PF00397	0.603
DOC_WW_Pin1_4	460	465	PF00397	0.644
DOC_WW_Pin1_4	617	622	PF00397	0.635
DOC_WW_Pin1_4	659	664	PF00397	0.564
DOC_WW_Pin1_4	684	689	PF00397	0.748
LIG_14-3-3_CanoR_1	112	116	PF00244	0.500
LIG_14-3-3_CanoR_1	193	203	PF00244	0.656
LIG_14-3-3_CanoR_1	257	262	PF00244	0.603
LIG_14-3-3_CanoR_1	475	485	PF00244	0.579
LIG_14-3-3_CanoR_1	521	531	PF00244	0.533
LIG_14-3-3_CanoR_1	546	551	PF00244	0.496
LIG_14-3-3_CanoR_1	669	674	PF00244	0.635
LIG_Actin_WH2_2	416	431	PF00022	0.602
LIG_Actin_WH2_2	532	550	PF00022	0.511
LIG_Actin_WH2_2	707	725	PF00022	0.482
LIG_APCC_ABBA_1	7	12	PF00400	0.678
LIG_BIR_II_1	1	5	PF00653	0.716
LIG_BRCT_BRCA1_1	231	235	PF00533	0.559
LIG_BRCT_MDC1_1	736	740	PF00533	0.612
LIG_Clathr_ClatBox_1	530	534	PF01394	0.511
LIG_CSL_BTD_1	384	387	PF09270	0.620
LIG_FHA_1	258	264	PF00498	0.699
LIG_FHA_1	307	313	PF00498	0.582
LIG_FHA_1	355	361	PF00498	0.572
LIG_FHA_1	377	383	PF00498	0.606
LIG_FHA_1	58	64	PF00498	0.389
LIG_FHA_1	724	730	PF00498	0.611
LIG_FHA_2	444	450	PF00498	0.722
LIG_FHA_2	498	504	PF00498	0.538
LIG_GBD_Chelix_1	391	399	PF00786	0.602
LIG_GBD_Chelix_1	470	478	PF00786	0.520
LIG_Integrin_RGD_1	467	469	PF01839	0.616
LIG_LIR_Apic_2	349	355	PF02991	0.588
LIG_LIR_Apic_2	384	388	PF02991	0.610
LIG_LIR_Gen_1	57	63	PF02991	0.539
LIG_LIR_Nem_3	403	409	PF02991	0.587
LIG_LIR_Nem_3	483	489	PF02991	0.586
LIG_LIR_Nem_3	549	554	PF02991	0.518
LIG_LIR_Nem_3	57	62	PF02991	0.548
LIG_NRBOX	57	63	PF00104	0.394
LIG_Pex14_2	604	608	PF04695	0.608
LIG_Pex14_2	689	693	PF04695	0.622
LIG_RPA_C_Fungi	639	651	PF08784	0.639
LIG_SH2_CRK	486	490	PF00017	0.520
LIG_SH2_PTP2	582	585	PF00017	0.386
LIG_SH2_SRC	517	520	PF00017	0.567
LIG_SH2_STAP1	522	526	PF00017	0.551
LIG_SH2_STAP1	55	59	PF00017	0.551
LIG_SH2_STAT3	592	595	PF00017	0.530
LIG_SH2_STAT5	554	557	PF00017	0.489
LIG_SH2_STAT5	582	585	PF00017	0.386
LIG_SH2_STAT5	706	709	PF00017	0.549
LIG_SH3_3	17	23	PF00018	0.635
LIG_SH3_3	219	225	PF00018	0.720
LIG_SH3_3	338	344	PF00018	0.604
LIG_SH3_3	375	381	PF00018	0.667
LIG_SH3_3	458	464	PF00018	0.659
LIG_SH3_3	513	519	PF00018	0.563
LIG_SH3_3	535	541	PF00018	0.533
LIG_SUMO_SIM_anti_2	724	729	PF11976	0.504
LIG_SUMO_SIM_par_1	258	264	PF11976	0.692
LIG_SUMO_SIM_par_1	59	65	PF11976	0.385
LIG_TRAF2_1	446	449	PF00917	0.621
LIG_TRAF2_1	500	503	PF00917	0.548
LIG_TYR_ITIM	707	712	PF00017	0.521
LIG_UBA3_1	58	67	PF00899	0.527
LIG_WRC_WIRS_1	690	695	PF05994	0.605
MOD_CDC14_SPxK_1	620	623	PF00782	0.646
MOD_CDC14_SPxK_1	662	665	PF00782	0.526
MOD_CDK_SPK_2	147	152	PF00069	0.641
MOD_CDK_SPxK_1	617	623	PF00069	0.638
MOD_CDK_SPxK_1	659	665	PF00069	0.531
MOD_CDK_SPxxK_3	460	467	PF00069	0.634
MOD_CK1_1	143	149	PF00069	0.695
MOD_CK1_1	165	171	PF00069	0.674
MOD_CK1_1	194	200	PF00069	0.664
MOD_CK1_1	287	293	PF00069	0.589
MOD_CK1_1	377	383	PF00069	0.709
MOD_CK1_1	574	580	PF00069	0.504
MOD_CK2_1	300	306	PF00069	0.711
MOD_CK2_1	443	449	PF00069	0.720
MOD_CK2_1	497	503	PF00069	0.562
MOD_CK2_1	506	512	PF00069	0.461
MOD_GlcNHglycan	118	121	PF01048	0.622
MOD_GlcNHglycan	140	143	PF01048	0.566
MOD_GlcNHglycan	185	188	PF01048	0.773
MOD_GlcNHglycan	257	260	PF01048	0.748
MOD_GlcNHglycan	268	271	PF01048	0.615
MOD_GlcNHglycan	286	289	PF01048	0.536
MOD_GlcNHglycan	336	339	PF01048	0.727
MOD_GlcNHglycan	591	595	PF01048	0.390
MOD_GlcNHglycan	682	685	PF01048	0.639
MOD_GlcNHglycan	694	697	PF01048	0.519
MOD_GlcNHglycan	736	739	PF01048	0.602
MOD_GSK3_1	140	147	PF00069	0.596
MOD_GSK3_1	165	172	PF00069	0.790
MOD_GSK3_1	191	198	PF00069	0.611
MOD_GSK3_1	212	219	PF00069	0.708
MOD_GSK3_1	225	232	PF00069	0.610
MOD_GSK3_1	280	287	PF00069	0.614
MOD_GSK3_1	29	36	PF00069	0.460
MOD_GSK3_1	330	337	PF00069	0.807
MOD_GSK3_1	373	380	PF00069	0.692
MOD_GSK3_1	476	483	PF00069	0.579
MOD_GSK3_1	57	64	PF00069	0.394
MOD_GSK3_1	586	593	PF00069	0.374
MOD_GSK3_1	655	662	PF00069	0.663
MOD_GSK3_1	680	687	PF00069	0.753
MOD_GSK3_1	688	695	PF00069	0.631
MOD_N-GLC_1	152	157	PF02516	0.609
MOD_NEK2_1	111	116	PF00069	0.498
MOD_NEK2_1	16	21	PF00069	0.572
MOD_NEK2_1	191	196	PF00069	0.657
MOD_NEK2_1	61	66	PF00069	0.518
MOD_NEK2_1	679	684	PF00069	0.616
MOD_NEK2_1	689	694	PF00069	0.549
MOD_PIKK_1	162	168	PF00454	0.656
MOD_PIKK_1	205	211	PF00454	0.633
MOD_PIKK_1	48	54	PF00454	0.520
MOD_PKA_2	111	117	PF00069	0.540
MOD_PKA_2	176	182	PF00069	0.699
MOD_PKA_2	192	198	PF00069	0.528
MOD_PKA_2	449	455	PF00069	0.664
MOD_PKA_2	668	674	PF00069	0.617
MOD_PKB_1	721	729	PF00069	0.484
MOD_Plk_1	191	197	PF00069	0.672
MOD_Plk_1	374	380	PF00069	0.575
MOD_Plk_1	419	425	PF00069	0.588
MOD_Plk_1	623	629	PF00069	0.813
MOD_Plk_1	723	729	PF00069	0.564
MOD_Plk_2-3	45	51	PF00069	0.562
MOD_Plk_4	199	205	PF00069	0.704
MOD_Plk_4	257	263	PF00069	0.695
MOD_Plk_4	26	32	PF00069	0.505
MOD_Plk_4	355	361	PF00069	0.572
MOD_Plk_4	723	729	PF00069	0.504
MOD_ProDKin_1	147	153	PF00069	0.695
MOD_ProDKin_1	154	160	PF00069	0.642
MOD_ProDKin_1	165	171	PF00069	0.556
MOD_ProDKin_1	229	235	PF00069	0.679
MOD_ProDKin_1	332	338	PF00069	0.828
MOD_ProDKin_1	377	383	PF00069	0.665
MOD_ProDKin_1	460	466	PF00069	0.636
MOD_ProDKin_1	617	623	PF00069	0.638
MOD_ProDKin_1	659	665	PF00069	0.564
MOD_ProDKin_1	684	690	PF00069	0.749
MOD_SUMO_for_1	130	133	PF00179	0.634
MOD_SUMO_for_1	151	154	PF00179	0.661
MOD_SUMO_rev_2	403	409	PF00179	0.474
TRG_DiLeu_BaEn_4	502	508	PF01217	0.541
TRG_DiLeu_BaLyEn_6	526	531	PF01217	0.568
TRG_ENDOCYTIC_2	486	489	PF00928	0.625
TRG_ENDOCYTIC_2	55	58	PF00928	0.552
TRG_ENDOCYTIC_2	582	585	PF00928	0.465
TRG_ENDOCYTIC_2	709	712	PF00928	0.513
TRG_ER_diArg_1	323	325	PF00400	0.641
TRG_ER_diArg_1	398	401	PF00400	0.630
TRG_ER_diArg_1	507	510	PF00400	0.589
TRG_ER_diArg_1	545	548	PF00400	0.485
TRG_NES_CRM1_1	599	612	PF08389	0.597
TRG_NES_CRM1_1	705	719	PF08389	0.482
TRG_Pf-PMV_PEXEL_1	408	412	PF00026	0.602

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IBI1	Leishmania donovani	88%	99%
A4HA87	Leishmania braziliensis	64%	99%
A4HYG4	Leishmania infantum	88%	99%
E9AS91	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%