Putative cation transporter

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cation transporter, putative

Species:

Leishmania major

UniProt:

Q4QD72_LEIMA

TriTrypDb:

LmjF.19.1380 , LMJLV39_190020200 , LMJSD75_190019900

Length:

613

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

Q4QD72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD72

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	12
GO:0008324	monoatomic cation transmembrane transporter activity	4	12
GO:0015075	monoatomic ion transmembrane transporter activity	3	12
GO:0022857	transmembrane transporter activity	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	591	595	PF00656	0.761
CLV_NRD_NRD_1	104	106	PF00675	0.381
CLV_NRD_NRD_1	173	175	PF00675	0.525
CLV_NRD_NRD_1	255	257	PF00675	0.338
CLV_NRD_NRD_1	438	440	PF00675	0.508
CLV_PCSK_KEX2_1	173	175	PF00082	0.525
CLV_PCSK_KEX2_1	255	257	PF00082	0.287
CLV_PCSK_KEX2_1	393	395	PF00082	0.468
CLV_PCSK_KEX2_1	438	440	PF00082	0.508
CLV_PCSK_PC1ET2_1	393	395	PF00082	0.342
CLV_PCSK_SKI1_1	247	251	PF00082	0.287
CLV_PCSK_SKI1_1	553	557	PF00082	0.442
DEG_APCC_DBOX_1	341	349	PF00400	0.622
DEG_SPOP_SBC_1	479	483	PF00917	0.670
DEG_SPOP_SBC_1	7	11	PF00917	0.775
DOC_CYCLIN_RxL_1	244	254	PF00134	0.413
DOC_MAPK_gen_1	105	117	PF00069	0.581
DOC_MAPK_gen_1	393	400	PF00069	0.694
DOC_MAPK_HePTP_8	390	402	PF00069	0.709
DOC_MAPK_MEF2A_6	393	402	PF00069	0.648
DOC_PP1_RVXF_1	245	252	PF00149	0.413
DOC_PP4_FxxP_1	542	545	PF00568	0.677
DOC_USP7_MATH_1	195	199	PF00917	0.597
DOC_USP7_MATH_1	240	244	PF00917	0.413
DOC_USP7_MATH_1	365	369	PF00917	0.770
DOC_USP7_MATH_1	370	374	PF00917	0.791
DOC_USP7_MATH_1	381	385	PF00917	0.664
DOC_USP7_MATH_1	437	441	PF00917	0.600
DOC_USP7_MATH_1	479	483	PF00917	0.803
DOC_USP7_MATH_1	496	500	PF00917	0.624
DOC_USP7_MATH_1	505	509	PF00917	0.690
DOC_USP7_MATH_1	592	596	PF00917	0.755
DOC_USP7_MATH_1	609	613	PF00917	0.772
DOC_USP7_MATH_1	74	78	PF00917	0.317
DOC_WW_Pin1_4	185	190	PF00397	0.533
DOC_WW_Pin1_4	374	379	PF00397	0.818
DOC_WW_Pin1_4	512	517	PF00397	0.745
LIG_14-3-3_CanoR_1	180	189	PF00244	0.491
LIG_14-3-3_CanoR_1	438	442	PF00244	0.683
LIG_14-3-3_CanoR_1	531	537	PF00244	0.663
LIG_14-3-3_CanoR_1	547	551	PF00244	0.680
LIG_14-3-3_CanoR_1	553	558	PF00244	0.604
LIG_Actin_WH2_2	333	348	PF00022	0.666
LIG_BRCT_BRCA1_1	498	502	PF00533	0.732
LIG_BRCT_BRCA1_1	581	585	PF00533	0.547
LIG_FHA_1	239	245	PF00498	0.387
LIG_FHA_1	252	258	PF00498	0.438
LIG_FHA_1	412	418	PF00498	0.596
LIG_FHA_1	446	452	PF00498	0.645
LIG_FHA_1	468	474	PF00498	0.633
LIG_FHA_1	513	519	PF00498	0.789
LIG_FHA_1	541	547	PF00498	0.700
LIG_FHA_1	87	93	PF00498	0.404
LIG_FHA_2	220	226	PF00498	0.410
LIG_FHA_2	589	595	PF00498	0.721
LIG_FHA_2	605	611	PF00498	0.601
LIG_LIR_Apic_2	454	459	PF02991	0.583
LIG_LIR_Apic_2	541	545	PF02991	0.701
LIG_LIR_Gen_1	145	156	PF02991	0.329
LIG_LIR_Gen_1	216	223	PF02991	0.497
LIG_LIR_Gen_1	445	452	PF02991	0.612
LIG_LIR_Gen_1	538	546	PF02991	0.675
LIG_LIR_Gen_1	83	93	PF02991	0.279
LIG_LIR_Gen_1	97	103	PF02991	0.344
LIG_LIR_Nem_3	145	151	PF02991	0.350
LIG_LIR_Nem_3	323	327	PF02991	0.552
LIG_LIR_Nem_3	445	450	PF02991	0.609
LIG_LIR_Nem_3	538	542	PF02991	0.602
LIG_LIR_Nem_3	60	66	PF02991	0.367
LIG_LIR_Nem_3	83	88	PF02991	0.288
LIG_LIR_Nem_3	97	101	PF02991	0.344
LIG_PCNA_yPIPBox_3	229	237	PF02747	0.347
LIG_Pex14_2	397	401	PF04695	0.650
LIG_SH2_GRB2like	327	330	PF00017	0.662
LIG_SH2_NCK_1	418	422	PF00017	0.664
LIG_SH2_PTP2	98	101	PF00017	0.396
LIG_SH2_SRC	327	330	PF00017	0.662
LIG_SH2_STAP1	409	413	PF00017	0.574
LIG_SH2_STAT5	456	459	PF00017	0.754
LIG_SH2_STAT5	98	101	PF00017	0.364
LIG_SUMO_SIM_anti_2	428	435	PF11976	0.619
LIG_SUMO_SIM_anti_2	77	83	PF11976	0.287
LIG_SUMO_SIM_par_1	413	420	PF11976	0.608
LIG_SUMO_SIM_par_1	448	454	PF11976	0.693
LIG_TRAF2_1	202	205	PF00917	0.568
LIG_TRAF2_1	535	538	PF00917	0.668
LIG_TRAF2_1	549	552	PF00917	0.481
LIG_TYR_ITIM	416	421	PF00017	0.654
LIG_TYR_ITIM	96	101	PF00017	0.328
LIG_WRC_WIRS_1	539	544	PF05994	0.695
MOD_CK1_1	185	191	PF00069	0.577
MOD_CK1_1	374	380	PF00069	0.788
MOD_CK1_1	454	460	PF00069	0.695
MOD_CK1_1	483	489	PF00069	0.794
MOD_CK1_1	508	514	PF00069	0.731
MOD_CK1_1	559	565	PF00069	0.666
MOD_CK1_1	599	605	PF00069	0.800
MOD_CK2_1	199	205	PF00069	0.605
MOD_CK2_1	219	225	PF00069	0.282
MOD_CK2_1	317	323	PF00069	0.464
MOD_CK2_1	365	371	PF00069	0.781
MOD_CK2_1	380	386	PF00069	0.734
MOD_CK2_1	532	538	PF00069	0.664
MOD_CK2_1	546	552	PF00069	0.467
MOD_CK2_1	568	574	PF00069	0.664
MOD_GlcNHglycan	121	125	PF01048	0.372
MOD_GlcNHglycan	184	187	PF01048	0.777
MOD_GlcNHglycan	278	281	PF01048	0.329
MOD_GlcNHglycan	3	6	PF01048	0.575
MOD_GlcNHglycan	331	336	PF01048	0.482
MOD_GlcNHglycan	367	370	PF01048	0.565
MOD_GlcNHglycan	42	45	PF01048	0.437
MOD_GlcNHglycan	421	424	PF01048	0.459
MOD_GlcNHglycan	482	485	PF01048	0.589
MOD_GlcNHglycan	498	501	PF01048	0.385
MOD_GlcNHglycan	509	513	PF01048	0.489
MOD_GlcNHglycan	581	584	PF01048	0.457
MOD_GlcNHglycan	586	589	PF01048	0.522
MOD_GlcNHglycan	594	597	PF01048	0.543
MOD_GlcNHglycan	598	601	PF01048	0.548
MOD_GlcNHglycan	72	75	PF01048	0.519
MOD_GSK3_1	150	157	PF00069	0.327
MOD_GSK3_1	181	188	PF00069	0.559
MOD_GSK3_1	195	202	PF00069	0.599
MOD_GSK3_1	370	377	PF00069	0.787
MOD_GSK3_1	479	486	PF00069	0.748
MOD_GSK3_1	496	503	PF00069	0.640
MOD_GSK3_1	508	515	PF00069	0.653
MOD_GSK3_1	553	560	PF00069	0.635
MOD_GSK3_1	584	591	PF00069	0.678
MOD_GSK3_1	592	599	PF00069	0.674
MOD_GSK3_1	70	77	PF00069	0.337
MOD_GSK3_1	8	15	PF00069	0.727
MOD_N-GLC_1	181	186	PF02516	0.723
MOD_N-GLC_1	454	459	PF02516	0.512
MOD_N-GLC_1	467	472	PF02516	0.540
MOD_NEK2_1	120	125	PF00069	0.540
MOD_NEK2_1	154	159	PF00069	0.342
MOD_NEK2_1	251	256	PF00069	0.476
MOD_NEK2_1	303	308	PF00069	0.328
MOD_NEK2_1	317	322	PF00069	0.476
MOD_NEK2_1	451	456	PF00069	0.706
MOD_NEK2_1	64	69	PF00069	0.387
MOD_PIKK_1	356	362	PF00454	0.651
MOD_PKA_2	251	257	PF00069	0.465
MOD_PKA_2	437	443	PF00069	0.624
MOD_PKA_2	546	552	PF00069	0.681
MOD_Plk_1	331	337	PF00069	0.639
MOD_Plk_1	386	392	PF00069	0.777
MOD_Plk_1	460	466	PF00069	0.711
MOD_Plk_1	551	557	PF00069	0.668
MOD_Plk_2-3	568	574	PF00069	0.647
MOD_Plk_4	150	156	PF00069	0.369
MOD_Plk_4	240	246	PF00069	0.385
MOD_Plk_4	317	323	PF00069	0.467
MOD_Plk_4	411	417	PF00069	0.564
MOD_Plk_4	446	452	PF00069	0.644
MOD_ProDKin_1	185	191	PF00069	0.536
MOD_ProDKin_1	374	380	PF00069	0.819
MOD_ProDKin_1	512	518	PF00069	0.745
TRG_DiLeu_BaEn_1	428	433	PF01217	0.666
TRG_DiLeu_BaLyEn_6	576	581	PF01217	0.614
TRG_ENDOCYTIC_2	314	317	PF00928	0.334
TRG_ENDOCYTIC_2	418	421	PF00928	0.664
TRG_ENDOCYTIC_2	98	101	PF00928	0.344
TRG_ER_diArg_1	109	112	PF00400	0.465
TRG_ER_diArg_1	255	257	PF00400	0.562
TRG_NLS_MonoExtC_3	104	109	PF00514	0.581
TRG_Pf-PMV_PEXEL_1	439	444	PF00026	0.498

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IHD4	Leptomonas seymouri	61%	97%
A0A0S4IWL9	Bodo saltans	36%	100%
A0A1X0P615	Trypanosomatidae	49%	100%
A0A3Q8IBF0	Leishmania donovani	94%	100%
A0A3R7MPI1	Trypanosoma rangeli	44%	100%
A4HA88	Leishmania braziliensis	78%	100%
A4HYG8	Leishmania infantum	94%	100%
D0A0T8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	100%
E9AS92	Leishmania mexicana (strain MHOM/GT/2001/U1103)	91%	100%
V5B132	Trypanosoma cruzi	45%	100%