TATA box-binding protein-like 1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TATA-box-binding protein

Species:

Leishmania major

UniProt:

Q4QD71_LEIMA

TriTrypDb:

LmjF.19.1390 , LMJLV39_190020300 , LMJSD75_190020000

Length:

293

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QD71

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD71

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	11
GO:0006352	DNA-templated transcription initiation	6	11
GO:0006725	cellular aromatic compound metabolic process	3	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009058	biosynthetic process	2	11
GO:0009059	macromolecule biosynthetic process	4	11
GO:0009987	cellular process	1	11
GO:0016070	RNA metabolic process	5	11
GO:0018130	heterocycle biosynthetic process	4	11
GO:0019438	aromatic compound biosynthetic process	4	11
GO:0032774	RNA biosynthetic process	5	11
GO:0034641	cellular nitrogen compound metabolic process	3	11
GO:0034654	nucleobase-containing compound biosynthetic process	4	11
GO:0043170	macromolecule metabolic process	3	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044249	cellular biosynthetic process	3	11
GO:0044271	cellular nitrogen compound biosynthetic process	4	11
GO:0046483	heterocycle metabolic process	3	11
GO:0071704	organic substance metabolic process	2	11
GO:0090304	nucleic acid metabolic process	4	11
GO:1901360	organic cyclic compound metabolic process	3	11
GO:1901362	organic cyclic compound biosynthetic process	4	11
GO:1901576	organic substance biosynthetic process	3	11

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	11
GO:0003677	DNA binding	4	11
GO:0003743	translation initiation factor activity	4	7
GO:0005488	binding	1	11
GO:0008135	translation factor activity, RNA binding	3	7
GO:0016251	RNA polymerase II general transcription initiation factor activity	2	2
GO:0045182	translation regulator activity	1	7
GO:0090079	translation regulator activity, nucleic acid binding	2	7
GO:0097159	organic cyclic compound binding	2	11
GO:0140223	general transcription initiation factor activity	1	2
GO:1901363	heterocyclic compound binding	2	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	243	247	PF00656	0.471
CLV_NRD_NRD_1	173	175	PF00675	0.217
CLV_NRD_NRD_1	289	291	PF00675	0.545
CLV_PCSK_SKI1_1	174	178	PF00082	0.300
CLV_PCSK_SKI1_1	273	277	PF00082	0.294
DEG_Nend_UBRbox_2	1	3	PF02207	0.522
DOC_CYCLIN_RxL_1	171	183	PF00134	0.521
DOC_MAPK_gen_1	171	181	PF00069	0.511
DOC_MAPK_MEF2A_6	174	181	PF00069	0.535
DOC_MAPK_NFAT4_5	174	182	PF00069	0.513
DOC_MAPK_RevD_3	278	291	PF00069	0.471
DOC_PP2B_LxvP_1	74	77	PF13499	0.537
DOC_PP4_FxxP_1	24	27	PF00568	0.559
DOC_SPAK_OSR1_1	194	198	PF12202	0.438
DOC_USP7_MATH_1	101	105	PF00917	0.512
DOC_USP7_MATH_1	157	161	PF00917	0.450
DOC_USP7_MATH_1	213	217	PF00917	0.497
DOC_WW_Pin1_4	196	201	PF00397	0.520
LIG_14-3-3_CterR_2	290	293	PF00244	0.578
LIG_Actin_WH2_2	257	275	PF00022	0.525
LIG_BIR_III_2	91	95	PF00653	0.492
LIG_BRCT_BRCA1_1	182	186	PF00533	0.393
LIG_deltaCOP1_diTrp_1	246	256	PF00928	0.448
LIG_FHA_1	116	122	PF00498	0.430
LIG_FHA_1	131	137	PF00498	0.417
LIG_FHA_1	138	144	PF00498	0.417
LIG_FHA_1	256	262	PF00498	0.426
LIG_FHA_1	36	42	PF00498	0.609
LIG_Integrin_RGD_1	244	246	PF01839	0.311
LIG_LIR_Gen_1	2	13	PF02991	0.579
LIG_LIR_Nem_3	2	8	PF02991	0.589
LIG_LIR_Nem_3	30	34	PF02991	0.639
LIG_LIR_Nem_3	91	96	PF02991	0.487
LIG_PCNA_yPIPBox_3	230	239	PF02747	0.511
LIG_RPA_C_Fungi	158	170	PF08784	0.385
LIG_SH3_3	194	200	PF00018	0.298
LIG_SH3_3	31	37	PF00018	0.699
LIG_TRFH_1	209	213	PF08558	0.330
MOD_CDC14_SPxK_1	199	202	PF00782	0.385
MOD_CDK_SPxK_1	196	202	PF00069	0.385
MOD_CK1_1	115	121	PF00069	0.264
MOD_CK1_1	44	50	PF00069	0.688
MOD_CK2_1	155	161	PF00069	0.272
MOD_CK2_1	265	271	PF00069	0.254
MOD_GlcNHglycan	130	133	PF01048	0.326
MOD_GlcNHglycan	147	150	PF01048	0.266
MOD_GlcNHglycan	43	46	PF01048	0.636
MOD_GSK3_1	145	152	PF00069	0.333
MOD_GSK3_1	247	254	PF00069	0.284
MOD_N-GLC_1	179	184	PF02516	0.465
MOD_N-GLC_2	196	198	PF02516	0.385
MOD_N-GLC_2	232	234	PF02516	0.385
MOD_NEK2_1	145	150	PF00069	0.337
MOD_NEK2_1	179	184	PF00069	0.354
MOD_NEK2_2	130	135	PF00069	0.272
MOD_PK_1	187	193	PF00069	0.272
MOD_Plk_1	179	185	PF00069	0.371
MOD_Plk_4	149	155	PF00069	0.333
MOD_Plk_4	251	257	PF00069	0.272
MOD_ProDKin_1	196	202	PF00069	0.399
MOD_SUMO_rev_2	288	293	PF00179	0.555
TRG_DiLeu_BaEn_1	9	14	PF01217	0.693
TRG_ENDOCYTIC_2	5	8	PF00928	0.606
TRG_ER_diArg_1	186	189	PF00400	0.261
TRG_Pf-PMV_PEXEL_1	285	289	PF00026	0.446

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HSM2	Leptomonas seymouri	79%	100%
A0A0S4IM21	Bodo saltans	46%	100%
A0A1X0P6C1	Trypanosomatidae	58%	100%
A0A3Q8IBD3	Leishmania donovani	99%	100%
A0A3R7KKB8	Trypanosoma rangeli	49%	100%
A4HA89	Leishmania braziliensis	91%	100%
A4HYG9	Leishmania infantum	99%	100%
A7UFC2	Entamoeba histolytica	25%	100%
C4M7H7	Entamoeba histolytica	28%	100%
D0A0T9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	60%	100%
E9AS93	Leishmania mexicana (strain MHOM/GT/2001/U1103)	97%	100%
O17488	Artemia franciscana	31%	100%
P20227	Drosophila melanogaster	30%	83%
P52653	Entamoeba histolytica	28%	100%
Q12731	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	28%	100%
Q9NHP5	Drosophila virilis	27%	84%