Terminal uridylyltransferases 3

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Cid1 family poly A polymerase, putative

Species:

Leishmania major

UniProt:

Q4QD69_LEIMA

TriTrypDb:

LmjF.19.1410 , LMJLV39_190020500 , LMJSD75_190020200

Length:

933

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

Q4QD69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD69

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	7
GO:0006396	RNA processing	6	7
GO:0006725	cellular aromatic compound metabolic process	3	7
GO:0006807	nitrogen compound metabolic process	2	7
GO:0008152	metabolic process	1	7
GO:0009987	cellular process	1	7
GO:0016070	RNA metabolic process	5	7
GO:0031123	RNA 3'-end processing	7	7
GO:0034641	cellular nitrogen compound metabolic process	3	7
GO:0043170	macromolecule metabolic process	3	7
GO:0044237	cellular metabolic process	2	7
GO:0044238	primary metabolic process	2	7
GO:0046483	heterocycle metabolic process	3	7
GO:0071076	RNA 3' uridylation	8	7
GO:0071704	organic substance metabolic process	2	7
GO:0090304	nucleic acid metabolic process	4	7
GO:1901360	organic cyclic compound metabolic process	3	7

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0016740	transferase activity	2	7
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	7
GO:0016779	nucleotidyltransferase activity	4	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7
GO:0050265	RNA uridylyltransferase activity	4	7
GO:0070569	uridylyltransferase activity	5	7
GO:0140098	catalytic activity, acting on RNA	3	7
GO:0140640	catalytic activity, acting on a nucleic acid	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	333	337	PF00656	0.548
CLV_C14_Caspase3-7	636	640	PF00656	0.467
CLV_NRD_NRD_1	179	181	PF00675	0.527
CLV_NRD_NRD_1	266	268	PF00675	0.347
CLV_NRD_NRD_1	345	347	PF00675	0.394
CLV_NRD_NRD_1	358	360	PF00675	0.404
CLV_NRD_NRD_1	384	386	PF00675	0.303
CLV_NRD_NRD_1	432	434	PF00675	0.519
CLV_NRD_NRD_1	577	579	PF00675	0.743
CLV_NRD_NRD_1	595	597	PF00675	0.516
CLV_NRD_NRD_1	681	683	PF00675	0.681
CLV_NRD_NRD_1	756	758	PF00675	0.683
CLV_PCSK_FUR_1	266	270	PF00082	0.419
CLV_PCSK_FUR_1	343	347	PF00082	0.321
CLV_PCSK_KEX2_1	234	236	PF00082	0.342
CLV_PCSK_KEX2_1	266	268	PF00082	0.351
CLV_PCSK_KEX2_1	345	347	PF00082	0.384
CLV_PCSK_KEX2_1	358	360	PF00082	0.373
CLV_PCSK_KEX2_1	384	386	PF00082	0.352
CLV_PCSK_KEX2_1	432	434	PF00082	0.519
CLV_PCSK_KEX2_1	577	579	PF00082	0.647
CLV_PCSK_KEX2_1	597	599	PF00082	0.507
CLV_PCSK_KEX2_1	681	683	PF00082	0.681
CLV_PCSK_KEX2_1	756	758	PF00082	0.683
CLV_PCSK_KEX2_1	787	789	PF00082	0.613
CLV_PCSK_KEX2_1	859	861	PF00082	0.589
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.342
CLV_PCSK_PC1ET2_1	268	270	PF00082	0.438
CLV_PCSK_PC1ET2_1	345	347	PF00082	0.411
CLV_PCSK_PC1ET2_1	597	599	PF00082	0.568
CLV_PCSK_PC1ET2_1	787	789	PF00082	0.613
CLV_PCSK_PC1ET2_1	859	861	PF00082	0.589
CLV_PCSK_PC7_1	855	861	PF00082	0.584
CLV_PCSK_SKI1_1	483	487	PF00082	0.480
CLV_PCSK_SKI1_1	552	556	PF00082	0.527
CLV_PCSK_SKI1_1	806	810	PF00082	0.626
CLV_PCSK_SKI1_1	899	903	PF00082	0.636
CLV_Separin_Metazoa	273	277	PF03568	0.614
DEG_APCC_DBOX_1	106	114	PF00400	0.535
DEG_MDM2_SWIB_1	299	307	PF02201	0.489
DOC_CDC14_PxL_1	886	894	PF14671	0.471
DOC_CKS1_1	592	597	PF01111	0.415
DOC_CYCLIN_RxL_1	319	333	PF00134	0.573
DOC_CYCLIN_RxL_1	745	755	PF00134	0.459
DOC_CYCLIN_yCln2_LP_2	723	726	PF00134	0.495
DOC_MAPK_gen_1	323	331	PF00069	0.568
DOC_MAPK_gen_1	432	439	PF00069	0.297
DOC_MAPK_gen_1	859	867	PF00069	0.404
DOC_MAPK_MEF2A_6	250	258	PF00069	0.578
DOC_MAPK_MEF2A_6	323	331	PF00069	0.544
DOC_MAPK_MEF2A_6	522	530	PF00069	0.324
DOC_MAPK_MEF2A_6	558	566	PF00069	0.312
DOC_MAPK_RevD_3	254	269	PF00069	0.578
DOC_MAPK_RevD_3	500	516	PF00069	0.224
DOC_MIT_MIM_1	654	662	PF04212	0.357
DOC_PP1_RVXF_1	411	417	PF00149	0.473
DOC_PP1_RVXF_1	514	521	PF00149	0.224
DOC_PP2B_LxvP_1	154	157	PF13499	0.634
DOC_PP2B_LxvP_1	329	332	PF13499	0.558
DOC_PP2B_LxvP_1	723	726	PF13499	0.477
DOC_PP4_FxxP_1	146	149	PF00568	0.518
DOC_PP4_FxxP_1	438	441	PF00568	0.312
DOC_PP4_FxxP_1	592	595	PF00568	0.391
DOC_USP7_MATH_1	13	17	PF00917	0.650
DOC_USP7_MATH_1	281	285	PF00917	0.610
DOC_USP7_MATH_1	505	509	PF00917	0.273
DOC_USP7_MATH_1	71	75	PF00917	0.694
DOC_USP7_MATH_1	726	730	PF00917	0.479
DOC_USP7_MATH_1	771	775	PF00917	0.486
DOC_USP7_UBL2_3	401	405	PF12436	0.510
DOC_WW_Pin1_4	357	362	PF00397	0.606
DOC_WW_Pin1_4	552	557	PF00397	0.324
DOC_WW_Pin1_4	583	588	PF00397	0.442
DOC_WW_Pin1_4	591	596	PF00397	0.349
DOC_WW_Pin1_4	684	689	PF00397	0.476
LIG_14-3-3_CanoR_1	323	328	PF00244	0.614
LIG_14-3-3_CanoR_1	378	382	PF00244	0.488
LIG_14-3-3_CanoR_1	606	611	PF00244	0.389
LIG_14-3-3_CanoR_1	613	621	PF00244	0.408
LIG_14-3-3_CanoR_1	681	685	PF00244	0.522
LIG_14-3-3_CanoR_1	806	812	PF00244	0.400
LIG_14-3-3_CanoR_1	860	866	PF00244	0.469
LIG_Actin_WH2_2	418	434	PF00022	0.309
LIG_Actin_WH2_2	600	615	PF00022	0.440
LIG_Actin_WH2_2	817	834	PF00022	0.398
LIG_BRCT_BRCA1_1	364	368	PF00533	0.501
LIG_FHA_1	473	479	PF00498	0.330
LIG_FHA_1	523	529	PF00498	0.283
LIG_FHA_1	607	613	PF00498	0.366
LIG_FHA_1	61	67	PF00498	0.532
LIG_FHA_1	685	691	PF00498	0.446
LIG_FHA_1	701	707	PF00498	0.495
LIG_FHA_1	816	822	PF00498	0.384
LIG_FHA_2	512	518	PF00498	0.273
LIG_FHA_2	692	698	PF00498	0.511
LIG_Integrin_RGD_1	843	845	PF01839	0.620
LIG_LIR_Apic_2	143	149	PF02991	0.511
LIG_LIR_Apic_2	435	441	PF02991	0.311
LIG_LIR_Apic_2	683	689	PF02991	0.524
LIG_LIR_Gen_1	141	152	PF02991	0.521
LIG_LIR_Gen_1	423	431	PF02991	0.309
LIG_LIR_Gen_1	532	543	PF02991	0.266
LIG_LIR_Gen_1	586	595	PF02991	0.412
LIG_LIR_Gen_1	672	679	PF02991	0.479
LIG_LIR_Gen_1	697	706	PF02991	0.529
LIG_LIR_Gen_1	869	879	PF02991	0.382
LIG_LIR_Gen_1	905	912	PF02991	0.437
LIG_LIR_Nem_3	135	139	PF02991	0.542
LIG_LIR_Nem_3	141	147	PF02991	0.487
LIG_LIR_Nem_3	196	201	PF02991	0.683
LIG_LIR_Nem_3	423	429	PF02991	0.309
LIG_LIR_Nem_3	455	461	PF02991	0.360
LIG_LIR_Nem_3	532	538	PF02991	0.299
LIG_LIR_Nem_3	586	592	PF02991	0.414
LIG_LIR_Nem_3	697	701	PF02991	0.530
LIG_LIR_Nem_3	869	875	PF02991	0.396
LIG_LIR_Nem_3	905	911	PF02991	0.440
LIG_LIR_Nem_3	97	103	PF02991	0.603
LIG_MYND_1	275	279	PF01753	0.587
LIG_MYND_1	67	71	PF01753	0.554
LIG_NRBOX	109	115	PF00104	0.526
LIG_NRBOX	477	483	PF00104	0.398
LIG_Pex14_2	299	303	PF04695	0.493
LIG_Pex14_2	364	368	PF04695	0.501
LIG_Pex14_2	399	403	PF04695	0.496
LIG_Rb_pABgroove_1	586	594	PF01858	0.397
LIG_SH2_CRK	152	156	PF00017	0.653
LIG_SH2_CRK	608	612	PF00017	0.462
LIG_SH2_CRK	686	690	PF00017	0.461
LIG_SH2_NCK_1	152	156	PF00017	0.653
LIG_SH2_PTP2	458	461	PF00017	0.325
LIG_SH2_SRC	886	889	PF00017	0.513
LIG_SH2_STAP1	420	424	PF00017	0.309
LIG_SH2_STAP1	544	548	PF00017	0.273
LIG_SH2_STAP1	608	612	PF00017	0.462
LIG_SH2_STAP1	759	763	PF00017	0.435
LIG_SH2_STAP1	872	876	PF00017	0.339
LIG_SH2_STAT3	386	389	PF00017	0.501
LIG_SH2_STAT3	800	803	PF00017	0.477
LIG_SH2_STAT5	125	128	PF00017	0.497
LIG_SH2_STAT5	152	155	PF00017	0.593
LIG_SH2_STAT5	386	389	PF00017	0.575
LIG_SH2_STAT5	428	431	PF00017	0.337
LIG_SH2_STAT5	458	461	PF00017	0.325
LIG_SH2_STAT5	487	490	PF00017	0.268
LIG_SH2_STAT5	608	611	PF00017	0.448
LIG_SH2_STAT5	648	651	PF00017	0.334
LIG_SH2_STAT5	686	689	PF00017	0.515
LIG_SH2_STAT5	886	889	PF00017	0.456
LIG_SH3_1	64	70	PF00018	0.560
LIG_SH3_1	686	692	PF00018	0.474
LIG_SH3_2	67	72	PF14604	0.579
LIG_SH3_3	198	204	PF00018	0.633
LIG_SH3_3	442	448	PF00018	0.371
LIG_SH3_3	454	460	PF00018	0.379
LIG_SH3_3	462	468	PF00018	0.287
LIG_SH3_3	59	65	PF00018	0.593
LIG_SH3_3	686	692	PF00018	0.474
LIG_SH3_3	779	785	PF00018	0.487
LIG_SH3_3	864	870	PF00018	0.413
LIG_SH3_3	876	882	PF00018	0.482
LIG_SH3_3	887	893	PF00018	0.460
LIG_SUMO_SIM_anti_2	252	260	PF11976	0.579
LIG_SUMO_SIM_anti_2	523	530	PF11976	0.324
LIG_SUMO_SIM_anti_2	827	832	PF11976	0.343
LIG_TRAF2_1	270	273	PF00917	0.674
LIG_TYR_ITIM	456	461	PF00017	0.382
LIG_UBA3_1	853	859	PF00899	0.441
LIG_WRC_WIRS_1	82	87	PF05994	0.440
LIG_WW_2	67	70	PF00397	0.436
LIG_WW_3	273	277	PF00397	0.437
LIG_WW_3	69	73	PF00397	0.452
MOD_CDK_SPK_2	591	596	PF00069	0.497
MOD_CDK_SPxK_1	552	558	PF00069	0.376
MOD_CDK_SPxK_1	591	597	PF00069	0.501
MOD_CDK_SPxxK_3	591	598	PF00069	0.504
MOD_CK1_1	12	18	PF00069	0.551
MOD_CK1_1	129	135	PF00069	0.355
MOD_CK1_1	223	229	PF00069	0.537
MOD_CK1_1	472	478	PF00069	0.312
MOD_CK2_1	169	175	PF00069	0.761
MOD_CK2_1	188	194	PF00069	0.501
MOD_CK2_1	26	32	PF00069	0.658
MOD_CK2_1	691	697	PF00069	0.730
MOD_Cter_Amidation	178	181	PF01082	0.689
MOD_GlcNHglycan	11	14	PF01048	0.621
MOD_GlcNHglycan	201	204	PF01048	0.662
MOD_GlcNHglycan	28	31	PF01048	0.376
MOD_GlcNHglycan	308	311	PF01048	0.352
MOD_GlcNHglycan	471	474	PF01048	0.336
MOD_GlcNHglycan	507	510	PF01048	0.313
MOD_GlcNHglycan	788	791	PF01048	0.592
MOD_GlcNHglycan	916	919	PF01048	0.606
MOD_GSK3_1	169	176	PF00069	0.647
MOD_GSK3_1	222	229	PF00069	0.552
MOD_GSK3_1	302	309	PF00069	0.455
MOD_GSK3_1	416	423	PF00069	0.309
MOD_GSK3_1	494	501	PF00069	0.311
MOD_GSK3_1	520	527	PF00069	0.348
MOD_GSK3_1	680	687	PF00069	0.606
MOD_GSK3_1	9	16	PF00069	0.612
MOD_GSK3_1	903	910	PF00069	0.547
MOD_LATS_1	321	327	PF00433	0.426
MOD_LATS_1	604	610	PF00433	0.420
MOD_N-GLC_1	409	414	PF02516	0.386
MOD_NEK2_1	126	131	PF00069	0.386
MOD_NEK2_1	256	261	PF00069	0.441
MOD_NEK2_1	368	373	PF00069	0.336
MOD_NEK2_1	399	404	PF00069	0.488
MOD_NEK2_1	416	421	PF00069	0.253
MOD_NEK2_1	572	577	PF00069	0.381
MOD_NEK2_1	752	757	PF00069	0.586
MOD_NEK2_1	786	791	PF00069	0.600
MOD_NEK2_1	861	866	PF00069	0.505
MOD_NEK2_1	9	14	PF00069	0.575
MOD_NEK2_1	907	912	PF00069	0.581
MOD_PIKK_1	220	226	PF00454	0.586
MOD_PIKK_1	71	77	PF00454	0.640
MOD_PKA_2	377	383	PF00069	0.328
MOD_PKA_2	612	618	PF00069	0.633
MOD_PKA_2	680	686	PF00069	0.648
MOD_PKA_2	71	77	PF00069	0.552
MOD_PKA_2	813	819	PF00069	0.536
MOD_Plk_1	142	148	PF00069	0.422
MOD_Plk_1	187	193	PF00069	0.664
MOD_Plk_1	409	415	PF00069	0.382
MOD_Plk_2-3	188	194	PF00069	0.578
MOD_Plk_2-3	362	368	PF00069	0.349
MOD_Plk_2-3	76	82	PF00069	0.452
MOD_Plk_4	126	132	PF00069	0.359
MOD_Plk_4	223	229	PF00069	0.517
MOD_Plk_4	281	287	PF00069	0.462
MOD_Plk_4	377	383	PF00069	0.328
MOD_Plk_4	420	426	PF00069	0.289
MOD_Plk_4	477	483	PF00069	0.311
MOD_Plk_4	524	530	PF00069	0.381
MOD_Plk_4	57	63	PF00069	0.444
MOD_Plk_4	606	612	PF00069	0.430
MOD_Plk_4	903	909	PF00069	0.535
MOD_ProDKin_1	357	363	PF00069	0.483
MOD_ProDKin_1	552	558	PF00069	0.376
MOD_ProDKin_1	583	589	PF00069	0.544
MOD_ProDKin_1	591	597	PF00069	0.420
MOD_ProDKin_1	684	690	PF00069	0.593
MOD_SUMO_for_1	230	233	PF00179	0.416
TRG_DiLeu_BaEn_1	252	257	PF01217	0.446
TRG_DiLeu_BaEn_1	5	10	PF01217	0.569
TRG_DiLeu_BaEn_4	187	193	PF01217	0.552
TRG_DiLeu_BaLyEn_6	109	114	PF01217	0.376
TRG_ENDOCYTIC_2	428	431	PF00928	0.309
TRG_ENDOCYTIC_2	458	461	PF00928	0.382
TRG_ENDOCYTIC_2	535	538	PF00928	0.309
TRG_ENDOCYTIC_2	608	611	PF00928	0.497
TRG_ENDOCYTIC_2	872	875	PF00928	0.426
TRG_ER_diArg_1	265	267	PF00400	0.383
TRG_ER_diArg_1	383	385	PF00400	0.421
TRG_ER_diArg_1	431	433	PF00400	0.346
TRG_ER_diArg_1	595	598	PF00400	0.446
TRG_ER_diArg_1	928	931	PF00400	0.605
TRG_NLS_MonoExtN_4	343	349	PF00514	0.378
TRG_Pf-PMV_PEXEL_1	385	389	PF00026	0.382
TRG_Pf-PMV_PEXEL_1	552	557	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HZT3	Leptomonas seymouri	48%	94%
A0A3Q8IEM2	Leishmania donovani	94%	100%
A4HA91	Leishmania braziliensis	70%	100%
A4HYH1	Leishmania infantum	94%	100%
E9AS95	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%