Cysteine peptidase A (CPA)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

cysteine peptidase A (CPA)

Species:

Leishmania major

UniProt:

Q4QD68_LEIMA

TriTrypDb:

LmjF.19.1420 , LMJLV39_190020600 , LMJSD75_190020300

Length:

354

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 125

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 21

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 37, no: 6
NetGPI	no	yes: 0, no: 43

Cellular components
Term	Name	Level	Count
GO:0000323	lytic vacuole	6	9
GO:0005615	extracellular space	2	9
GO:0005764	lysosome	7	9
GO:0005773	vacuole	5	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0043229	intracellular organelle	3	9
GO:0043231	intracellular membrane-bounded organelle	4	9
GO:0110165	cellular anatomical entity	1	10
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QD68

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD68

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	44
GO:0006807	nitrogen compound metabolic process	2	44
GO:0008152	metabolic process	1	44
GO:0019538	protein metabolic process	3	44
GO:0043170	macromolecule metabolic process	3	44
GO:0044238	primary metabolic process	2	44
GO:0051603	proteolysis involved in protein catabolic process	5	9
GO:0071704	organic substance metabolic process	2	44
GO:1901564	organonitrogen compound metabolic process	3	44

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	44
GO:0004175	endopeptidase activity	4	28
GO:0004197	cysteine-type endopeptidase activity	5	28
GO:0008233	peptidase activity	3	44
GO:0008234	cysteine-type peptidase activity	4	44
GO:0016787	hydrolase activity	2	44
GO:0140096	catalytic activity, acting on a protein	2	44

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	3	5	PF00675	0.554
CLV_PCSK_KEX2_1	298	300	PF00082	0.197
CLV_PCSK_KEX2_1	3	5	PF00082	0.553
CLV_PCSK_PC1ET2_1	298	300	PF00082	0.197
CLV_PCSK_SKI1_1	298	302	PF00082	0.227
DEG_SPOP_SBC_1	349	353	PF00917	0.738
DOC_MAPK_gen_1	114	122	PF00069	0.449
DOC_MAPK_gen_1	258	266	PF00069	0.205
DOC_MAPK_MEF2A_6	258	266	PF00069	0.440
DOC_MAPK_MEF2A_6	318	325	PF00069	0.404
DOC_MAPK_NFAT4_5	318	326	PF00069	0.227
DOC_USP7_MATH_1	218	222	PF00917	0.356
DOC_USP7_MATH_1	324	328	PF00917	0.280
DOC_WW_Pin1_4	139	144	PF00397	0.416
DOC_WW_Pin1_4	223	228	PF00397	0.329
DOC_WW_Pin1_4	26	31	PF00397	0.674
DOC_WW_Pin1_4	92	97	PF00397	0.305
LIG_14-3-3_CanoR_1	48	54	PF00244	0.293
LIG_APCC_ABBAyCdc20_2	117	123	PF00400	0.412
LIG_BIR_II_1	1	5	PF00653	0.678
LIG_BRCT_BRCA1_1	87	91	PF00533	0.426
LIG_EH_1	4	8	PF12763	0.401
LIG_FHA_1	268	274	PF00498	0.378
LIG_FHA_1	336	342	PF00498	0.435
LIG_FHA_1	344	350	PF00498	0.674
LIG_FHA_2	338	344	PF00498	0.380
LIG_FHA_2	93	99	PF00498	0.259
LIG_LIR_Gen_1	240	246	PF02991	0.490
LIG_LIR_Gen_1	317	325	PF02991	0.399
LIG_LIR_Gen_1	88	99	PF02991	0.253
LIG_LIR_Nem_3	240	245	PF02991	0.421
LIG_LIR_Nem_3	269	274	PF02991	0.355
LIG_LIR_Nem_3	317	323	PF02991	0.361
LIG_LIR_Nem_3	39	45	PF02991	0.377
LIG_LIR_Nem_3	88	94	PF02991	0.453
LIG_LIR_Nem_3	98	102	PF02991	0.498
LIG_PDZ_Class_1	349	354	PF00595	0.698
LIG_Pex14_1	271	275	PF04695	0.508
LIG_PTB_Apo_2	102	109	PF02174	0.479
LIG_PTB_Phospho_1	102	108	PF10480	0.482
LIG_SH2_CRK	242	246	PF00017	0.220
LIG_SH2_GRB2like	103	106	PF00017	0.486
LIG_SH2_NCK_1	219	223	PF00017	0.388
LIG_SH2_PTP2	320	323	PF00017	0.361
LIG_SH2_SRC	103	106	PF00017	0.514
LIG_SH2_STAT5	103	106	PF00017	0.479
LIG_SH2_STAT5	255	258	PF00017	0.297
LIG_SH2_STAT5	274	277	PF00017	0.255
LIG_SH2_STAT5	320	323	PF00017	0.361
LIG_SH2_STAT5	74	77	PF00017	0.238
LIG_SUMO_SIM_par_1	172	178	PF11976	0.380
LIG_TRAF2_1	95	98	PF00917	0.287
MOD_CDK_SPxK_1	139	145	PF00069	0.416
MOD_CK1_1	125	131	PF00069	0.527
MOD_CK1_1	172	178	PF00069	0.332
MOD_CK1_1	310	316	PF00069	0.334
MOD_CK1_1	344	350	PF00069	0.680
MOD_CK2_1	172	178	PF00069	0.332
MOD_CK2_1	311	317	PF00069	0.342
MOD_CK2_1	49	55	PF00069	0.464
MOD_CK2_1	92	98	PF00069	0.354
MOD_GlcNHglycan	127	130	PF01048	0.616
MOD_GlcNHglycan	156	159	PF01048	0.476
MOD_GlcNHglycan	22	25	PF01048	0.547
MOD_GlcNHglycan	220	223	PF01048	0.357
MOD_GlcNHglycan	239	242	PF01048	0.294
MOD_GlcNHglycan	38	41	PF01048	0.371
MOD_GlcNHglycan	86	90	PF01048	0.362
MOD_GSK3_1	125	132	PF00069	0.451
MOD_GSK3_1	218	225	PF00069	0.338
MOD_GSK3_1	237	244	PF00069	0.403
MOD_GSK3_1	307	314	PF00069	0.263
MOD_GSK3_1	337	344	PF00069	0.475
MOD_N-GLC_1	169	174	PF02516	0.220
MOD_N-GLC_1	207	212	PF02516	0.444
MOD_N-GLC_1	344	349	PF02516	0.768
MOD_N-GLC_2	328	330	PF02516	0.380
MOD_NEK2_1	149	154	PF00069	0.333
MOD_NEK2_1	283	288	PF00069	0.356
MOD_NEK2_1	36	41	PF00069	0.565
MOD_NEK2_1	75	80	PF00069	0.418
MOD_PIKK_1	161	167	PF00454	0.491
MOD_PKA_2	237	243	PF00069	0.406
MOD_Plk_1	122	128	PF00069	0.706
MOD_Plk_1	169	175	PF00069	0.220
MOD_Plk_1	213	219	PF00069	0.346
MOD_Plk_1	266	272	PF00069	0.361
MOD_Plk_1	344	350	PF00069	0.765
MOD_Plk_4	11	17	PF00069	0.523
MOD_Plk_4	122	128	PF00069	0.518
MOD_Plk_4	169	175	PF00069	0.404
MOD_ProDKin_1	139	145	PF00069	0.416
MOD_ProDKin_1	223	229	PF00069	0.329
MOD_ProDKin_1	26	32	PF00069	0.665
MOD_ProDKin_1	92	98	PF00069	0.305
MOD_SUMO_rev_2	244	252	PF00179	0.274
TRG_ENDOCYTIC_2	242	245	PF00928	0.397
TRG_ENDOCYTIC_2	304	307	PF00928	0.361
TRG_ENDOCYTIC_2	320	323	PF00928	0.361
TRG_ENDOCYTIC_2	42	45	PF00928	0.387
TRG_NLS_MonoExtC_3	297	302	PF00514	0.197

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A072UTP9	Medicago truncatula	35%	100%
A0A0N0P293	Leptomonas seymouri	30%	95%
A0A0N1PA65	Leptomonas seymouri	58%	76%
A0A0S4III3	Bodo saltans	48%	100%
A0A0S4IJE5	Bodo saltans	42%	91%
A0A0S4IMD3	Bodo saltans	45%	95%
A0A0S4ISD8	Bodo saltans	45%	66%
A0A0S4IWQ5	Bodo saltans	38%	100%
A0A0S4IY45	Bodo saltans	38%	100%
A0A0S4J328	Bodo saltans	49%	100%
A0A0S4J3Q7	Bodo saltans	31%	96%
A0A0S4J918	Bodo saltans	36%	100%
A0A0S4J9K9	Bodo saltans	46%	100%
A0A0S4JIQ4	Bodo saltans	28%	100%
A0A0S4JSZ3	Bodo saltans	32%	96%
A0A0S4JV57	Bodo saltans	29%	96%
A0A0S4JXJ3	Bodo saltans	30%	92%
A0A0S4KGP4	Bodo saltans	45%	100%
A0A0S4KI32	Bodo saltans	31%	100%
A0A0S4KJA5	Bodo saltans	44%	76%
A0A1X0NIG8	Trypanosomatidae	31%	82%
A0A1X0NM52	Trypanosomatidae	45%	100%
A0A1X0NXC8	Trypanosomatidae	29%	94%
A0A3R7L7E7	Trypanosoma rangeli	50%	67%
A0A3S5H682	Leishmania donovani	52%	90%
A0A3S5H683	Leishmania donovani	52%	80%
A0A3S5H684	Leishmania donovani	51%	80%
A0A3S5H685	Leishmania donovani	52%	80%
A0A3S7WQD0	Leishmania donovani	52%	80%
A0A6L0WJ22	Leishmania infantum	52%	80%
A0E358	Paramecium tetraurelia	34%	100%
A1E295	Sus scrofa	28%	100%
A1KXI0	Blomia tropicalis	27%	100%
A2XQE8	Oryza sativa subsp. indica	40%	100%
A4H5E4	Leishmania braziliensis	48%	80%
A4H5E5	Leishmania braziliensis	49%	80%
A4H5E6	Leishmania braziliensis	49%	80%
A4HA92	Leishmania braziliensis	69%	74%
A4HH90	Leishmania braziliensis	26%	100%
A4HTP0	Leishmania infantum	49%	93%
A4HYH2	Leishmania infantum	88%	100%
A4I4D6	Leishmania infantum	29%	100%
A5HII1	Actinidia deliciosa	33%	93%
A8DS38	Tabernaemontana divaricata	38%	97%
B2LSD2	Mucuna pruriens	40%	82%
C9ZQB3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	78%
C9ZQB5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	48%	79%
C9ZQB6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	88%
D3ZZ07	Rattus norvegicus	28%	100%
E8NHD8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	99%
E8NHH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	49%	100%
E8NHJ1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	70%
E8NHL3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	66%
E8NHS3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	52%	94%
E9ALZ5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	100%
E9AMH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	97%
E9AMH6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	48%	80%
E9AMH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	47%	99%
E9AS96	Leishmania mexicana (strain MHOM/GT/2001/U1103)	83%	100%
F4JNL3	Arabidopsis thaliana	32%	99%
O10364	Orgyia pseudotsugata multicapsid polyhedrosis virus	35%	100%
O17473	Brugia pahangi	35%	90%
O23791	Ananas comosus	35%	100%
O35186	Rattus norvegicus	36%	100%
O46427	Sus scrofa	33%	100%
O60911	Homo sapiens	36%	100%
O65039	Ricinus communis	43%	98%
O65493	Arabidopsis thaliana	36%	100%
O91466	Cydia pomonella granulosis virus (isolate Mexico/1963)	33%	100%
O97397	Phaedon cochleariae	34%	100%
O97578	Canis lupus familiaris	31%	81%
P00784	Carica papaya	34%	100%
P00785	Actinidia chinensis var. chinensis	33%	93%
P00786	Rattus norvegicus	33%	100%
P00787	Rattus norvegicus	28%	100%
P04988	Dictyostelium discoideum	39%	100%
P04989	Dictyostelium discoideum	37%	94%
P05167	Hordeum vulgare	35%	98%
P05994	Carica papaya	33%	100%
P06797	Mus musculus	40%	100%
P07154	Rattus norvegicus	39%	100%
P07688	Bos taurus	27%	100%
P07711	Homo sapiens	37%	100%
P08176	Dermatophagoides pteronyssinus	32%	100%
P09668	Homo sapiens	33%	100%
P10056	Carica papaya	38%	100%
P12412	Vigna mungo	39%	98%
P13277	Homarus americanus	36%	100%
P14080	Carica papaya	36%	100%
P14658	Trypanosoma brucei brucei	48%	79%
P15242	Rattus norvegicus	34%	100%
P19092	Haemonchus contortus	26%	100%
P22497	Theileria parva	32%	80%
P22895	Glycine max	34%	93%
P25249	Hordeum vulgare	39%	95%
P25250	Hordeum vulgare	39%	95%
P25251	Brassica napus	40%	100%
P25326	Bos taurus	39%	100%
P25773	Felis catus	36%	100%
P25774	Homo sapiens	36%	100%
P25775	Leishmania mexicana	82%	100%
P25776	Oryza sativa subsp. japonica	40%	77%
P25777	Oryza sativa subsp. japonica	40%	76%
P25778	Oryza sativa subsp. japonica	34%	98%
P25779	Trypanosoma cruzi	52%	76%
P25781	Theileria annulata	33%	80%
P25782	Homarus americanus	34%	100%
P25783	Autographa californica nuclear polyhedrosis virus	34%	100%
P25784	Homarus americanus	39%	100%
P25792	Schistosoma mansoni	25%	100%
P25793	Haemonchus contortus	27%	100%
P25802	Ostertagia ostertagi	29%	100%
P25803	Phaseolus vulgaris	39%	98%
P25804	Pisum sativum	39%	98%
P25975	Bos taurus	38%	100%
P35591	Leishmania pifanoi	83%	100%
P36184	Entamoeba histolytica	33%	100%
P36185	Entamoeba histolytica	31%	100%
P36400	Leishmania mexicana	48%	80%
P41715	Choristoneura fumiferana nuclear polyhedrosis virus	33%	100%
P41721	Bombyx mori nuclear polyhedrosis virus	34%	100%
P43156	Hemerocallis sp.	36%	98%
P43157	Schistosoma japonicum	26%	100%
P43233	Gallus gallus	26%	100%
P43234	Homo sapiens	37%	100%
P43235	Homo sapiens	36%	100%
P43236	Oryctolagus cuniculus	34%	100%
P43295	Arabidopsis thaliana	38%	98%
P43296	Arabidopsis thaliana	39%	96%
P43297	Arabidopsis thaliana	39%	77%
P43508	Caenorhabditis elegans	24%	100%
P43509	Caenorhabditis elegans	29%	100%
P43510	Caenorhabditis elegans	24%	93%
P46102	Plasmodium vinckei	29%	70%
P49935	Mus musculus	33%	100%
P53634	Homo sapiens	32%	76%
P54639	Dictyostelium discoideum	33%	80%
P54640	Dictyostelium discoideum	38%	100%
P55097	Mus musculus	35%	100%
P56202	Homo sapiens	32%	94%
P56203	Mus musculus	33%	95%
P61276	Macaca fascicularis	36%	100%
P61277	Macaca mulatta	36%	100%
P80067	Rattus norvegicus	32%	77%
P80884	Ananas comosus	35%	100%
P83205	Ovis aries	28%	100%
P92131	Giardia intestinalis	30%	100%
P92132	Giardia intestinalis	29%	100%
P92133	Giardia intestinalis	30%	100%
P97821	Mus musculus	30%	77%
Q01957	Entamoeba histolytica	30%	100%
Q01958	Entamoeba histolytica	32%	100%
Q05094	Leishmania pifanoi	48%	80%
Q06964	Entamoeba histolytica	34%	100%
Q10716	Zea mays	39%	95%
Q10717	Zea mays	32%	98%
Q1EIQ3	Psoroptes ovis	29%	100%
Q23894	Dictyostelium discoideum	36%	100%
Q24940	Fasciola hepatica	36%	100%
Q26534	Schistosoma mansoni	40%	100%
Q26636	Sarcophaga peregrina	40%	100%
Q28944	Sus scrofa	38%	100%
Q3T0I2	Bos taurus	34%	100%
Q3ZCJ8	Bos taurus	34%	76%
Q3ZKN1	Canis lupus familiaris	35%	100%
Q40143	Solanum lycopersicum	34%	99%
Q4QI61	Leishmania major	51%	80%
Q4QI62	Leishmania major	48%	100%
Q4QI64	Leishmania major	49%	100%
Q4QI65	Leishmania major	49%	100%
Q4QI66	Leishmania major	49%	100%
Q4QI67	Leishmania major	48%	100%
Q4QI68	Leishmania major	49%	100%
Q54TR1	Dictyostelium discoideum	35%	67%
Q5E968	Bos taurus	34%	100%
Q5E998	Bos taurus	38%	100%
Q5RB02	Pongo abelii	32%	76%
Q60HG6	Macaca fascicularis	32%	76%
Q63088	Rattus norvegicus	32%	100%
Q6PN98	Onchocerca volvulus	25%	100%
Q6VTL7	Choristoneura fumiferana defective polyhedrosis virus	33%	100%
Q6YD92	Petrosia ficiformis	31%	100%
Q7F3A8	Oryza sativa subsp. japonica	38%	95%
Q7GDU7	Oryza sativa subsp. japonica	40%	94%
Q7XR52	Oryza sativa subsp. japonica	39%	72%
Q7XWK5	Oryza sativa subsp. japonica	39%	100%
Q80LP4	Adoxophyes honmai nucleopolyhedrovirus	32%	100%
Q80UB0	Mus musculus	35%	100%
Q86GF7	Pandalus borealis	38%	100%
Q8B9D5	Rachiplusia ou multiple nucleopolyhedrovirus (strain R1)	34%	100%
Q8BM88	Mus musculus	35%	100%
Q8H166	Arabidopsis thaliana	36%	99%
Q8HY81	Canis lupus familiaris	37%	100%
Q8HY82	Saimiri boliviensis boliviensis	37%	100%
Q8QLK1	Mamestra configurata nucleopolyhedrovirus	36%	100%
Q8RWQ9	Arabidopsis thaliana	35%	99%
Q8V5U0	Heliothis zea nuclear polyhedrosis virus	36%	96%
Q8VYS0	Arabidopsis thaliana	38%	96%
Q91BH1	Spodoptera litura multicapsid nucleopolyhedrovirus	37%	100%
Q91CL9	Antheraea pernyi nuclear polyhedrosis virus	34%	100%
Q91GE3	Epiphyas postvittana nucleopolyhedrovirus	35%	100%
Q91ZF2	Mus musculus	29%	100%
Q93VC9	Arabidopsis thaliana	30%	98%
Q94503	Dictyostelium discoideum	38%	82%
Q94504	Dictyostelium discoideum	37%	77%
Q94714	Paramecium tetraurelia	34%	100%
Q94715	Paramecium tetraurelia	30%	100%
Q94B08	Arabidopsis thaliana	39%	94%
Q94K85	Arabidopsis thaliana	26%	99%
Q95029	Drosophila melanogaster	42%	95%
Q9BIE1	Leishmania donovani	88%	100%
Q9FGR9	Arabidopsis thaliana	40%	98%
Q9FJ47	Arabidopsis thaliana	36%	100%
Q9FMH8	Arabidopsis thaliana	40%	76%
Q9GKL8	Chlorocebus aethiops	37%	100%
Q9GL24	Canis lupus familiaris	38%	100%
Q9GLE3	Sus scrofa	35%	100%
Q9GQM5	Leishmania donovani	29%	100%
Q9J8B9	Spodoptera exigua nuclear polyhedrosis virus (strain US)	35%	100%
Q9JI81	Mus musculus	32%	100%
Q9JIA9	Mus musculus	33%	100%
Q9JL96	Mus musculus	30%	100%
Q9LM66	Arabidopsis thaliana	41%	99%
Q9LT77	Arabidopsis thaliana	40%	98%
Q9LT78	Arabidopsis thaliana	37%	78%
Q9LXW3	Arabidopsis thaliana	34%	94%
Q9PYY5	Xestia c-nigrum granulosis virus	34%	100%
Q9QZE3	Rattus norvegicus	33%	100%
Q9R013	Mus musculus	37%	77%
Q9R014	Mus musculus	34%	100%
Q9STL4	Arabidopsis thaliana	39%	98%
Q9STL5	Arabidopsis thaliana	41%	97%
Q9SUL1	Arabidopsis thaliana	40%	95%
Q9SUS9	Arabidopsis thaliana	36%	95%
Q9SUT0	Arabidopsis thaliana	36%	97%
Q9TST1	Felis catus	33%	95%
Q9UBX1	Homo sapiens	37%	73%
Q9WGE0	Hyphantria cunea nuclear polyhedrosis virus	33%	100%
Q9YMP9	Lymantria dispar multicapsid nuclear polyhedrosis virus	33%	99%
Q9YWK4	Buzura suppressaria nuclear polyhedrosis virus	32%	100%
V5B261	Trypanosoma cruzi	33%	90%
V5BNL4	Trypanosoma cruzi	26%	100%
V5LU01	Ambrosia artemisiifolia	38%	92%