LeishMANIAdb
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PIH1 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
PIH1 domain-containing protein
Gene product:
pre-RNA processing PIH1/Nop17, putative
Species:
Leishmania major
UniProt:
Q4QD67_LEIMA
TriTrypDb:
LmjF.19.1430 , LMJLV39_190020800 * , LMJSD75_190020500
Length:
365

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 yes yes: 2, no: 9
NetGPI no yes: 0, no: 11
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QD67
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD67

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 172 176 PF00656 0.677
CLV_NRD_NRD_1 157 159 PF00675 0.694
CLV_NRD_NRD_1 165 167 PF00675 0.545
CLV_NRD_NRD_1 179 181 PF00675 0.570
CLV_PCSK_KEX2_1 71 73 PF00082 0.270
CLV_PCSK_PC1ET2_1 71 73 PF00082 0.270
CLV_PCSK_SKI1_1 104 108 PF00082 0.366
CLV_PCSK_SKI1_1 203 207 PF00082 0.521
CLV_PCSK_SKI1_1 258 262 PF00082 0.796
CLV_PCSK_SKI1_1 348 352 PF00082 0.463
DEG_Nend_Nbox_1 1 3 PF02207 0.476
DEG_ODPH_VHL_1 307 320 PF01847 0.503
DOC_CKS1_1 139 144 PF01111 0.438
DOC_CKS1_1 196 201 PF01111 0.689
DOC_CYCLIN_yCln2_LP_2 58 64 PF00134 0.466
DOC_MAPK_gen_1 348 358 PF00069 0.410
DOC_MAPK_MEF2A_6 297 306 PF00069 0.497
DOC_PP2B_LxvP_1 336 339 PF13499 0.511
DOC_PP2B_LxvP_1 58 61 PF13499 0.466
DOC_PP4_FxxP_1 275 278 PF00568 0.566
DOC_PP4_FxxP_1 306 309 PF00568 0.534
DOC_SPAK_OSR1_1 292 296 PF12202 0.620
DOC_USP7_MATH_1 18 22 PF00917 0.562
DOC_USP7_MATH_1 216 220 PF00917 0.641
DOC_USP7_UBL2_3 261 265 PF12436 0.793
DOC_WW_Pin1_4 138 143 PF00397 0.583
DOC_WW_Pin1_4 195 200 PF00397 0.603
DOC_WW_Pin1_4 252 257 PF00397 0.664
LIG_BRCT_BRCA1_1 271 275 PF00533 0.563
LIG_CtBP_PxDLS_1 234 238 PF00389 0.508
LIG_deltaCOP1_diTrp_1 286 293 PF00928 0.679
LIG_EH1_1 52 60 PF00400 0.515
LIG_FHA_1 100 106 PF00498 0.455
LIG_FHA_1 196 202 PF00498 0.657
LIG_FHA_1 21 27 PF00498 0.409
LIG_FHA_1 324 330 PF00498 0.469
LIG_FHA_1 340 346 PF00498 0.360
LIG_FHA_1 351 357 PF00498 0.369
LIG_FHA_1 83 89 PF00498 0.523
LIG_FHA_2 15 21 PF00498 0.398
LIG_FHA_2 170 176 PF00498 0.694
LIG_Integrin_RGD_1 72 74 PF01839 0.214
LIG_LIR_Apic_2 272 278 PF02991 0.565
LIG_LIR_Gen_1 287 295 PF02991 0.648
LIG_LIR_LC3C_4 353 358 PF02991 0.379
LIG_LIR_Nem_3 287 293 PF02991 0.644
LIG_PCNA_yPIPBox_3 188 196 PF02747 0.717
LIG_PTB_Apo_2 128 135 PF02174 0.519
LIG_PTB_Phospho_1 128 134 PF10480 0.522
LIG_SH2_SRC 49 52 PF00017 0.553
LIG_SH2_STAP1 75 79 PF00017 0.537
LIG_SH2_STAT5 134 137 PF00017 0.431
LIG_SH2_STAT5 24 27 PF00017 0.525
LIG_SH2_STAT5 49 52 PF00017 0.501
LIG_SH2_STAT5 77 80 PF00017 0.581
LIG_SH3_3 136 142 PF00018 0.481
LIG_SH3_3 31 37 PF00018 0.524
LIG_SH3_3 61 67 PF00018 0.503
LIG_SUMO_SIM_anti_2 353 359 PF11976 0.499
LIG_SUMO_SIM_par_1 102 109 PF11976 0.561
LIG_SUMO_SIM_par_1 353 359 PF11976 0.483
LIG_SUMO_SIM_par_1 360 365 PF11976 0.504
LIG_SUMO_SIM_par_1 60 66 PF11976 0.537
LIG_UBA3_1 97 104 PF00899 0.581
MOD_CDC14_SPxK_1 255 258 PF00782 0.525
MOD_CDK_SPK_2 138 143 PF00069 0.423
MOD_CDK_SPxK_1 252 258 PF00069 0.701
MOD_CDK_SPxxK_3 195 202 PF00069 0.624
MOD_CK1_1 144 150 PF00069 0.584
MOD_CK1_1 160 166 PF00069 0.763
MOD_CK1_1 220 226 PF00069 0.666
MOD_CK1_1 311 317 PF00069 0.534
MOD_CK2_1 14 20 PF00069 0.442
MOD_CK2_1 144 150 PF00069 0.641
MOD_CK2_1 233 239 PF00069 0.626
MOD_CK2_1 60 66 PF00069 0.566
MOD_GlcNHglycan 271 274 PF01048 0.777
MOD_GlcNHglycan 319 323 PF01048 0.574
MOD_GlcNHglycan 4 7 PF01048 0.498
MOD_GSK3_1 14 21 PF00069 0.445
MOD_GSK3_1 216 223 PF00069 0.640
MOD_GSK3_1 252 259 PF00069 0.632
MOD_GSK3_1 291 298 PF00069 0.474
MOD_N-GLC_1 160 165 PF02516 0.635
MOD_N-GLC_1 329 334 PF02516 0.602
MOD_N-GLC_2 27 29 PF02516 0.259
MOD_NEK2_1 2 7 PF00069 0.549
MOD_NEK2_1 356 361 PF00069 0.388
MOD_NEK2_1 38 43 PF00069 0.553
MOD_NEK2_2 256 261 PF00069 0.748
MOD_PIKK_1 331 337 PF00454 0.574
MOD_PKA_1 89 95 PF00069 0.414
MOD_PKA_2 157 163 PF00069 0.715
MOD_PKA_2 291 297 PF00069 0.626
MOD_Plk_1 135 141 PF00069 0.501
MOD_Plk_2-3 169 175 PF00069 0.744
MOD_Plk_4 144 150 PF00069 0.584
MOD_Plk_4 20 26 PF00069 0.477
MOD_Plk_4 271 277 PF00069 0.756
MOD_Plk_4 82 88 PF00069 0.538
MOD_ProDKin_1 138 144 PF00069 0.584
MOD_ProDKin_1 195 201 PF00069 0.599
MOD_ProDKin_1 252 258 PF00069 0.668
MOD_SUMO_rev_2 63 70 PF00179 0.562
TRG_DiLeu_BaLyEn_6 187 192 PF01217 0.555
TRG_DiLeu_BaLyEn_6 93 98 PF01217 0.574
TRG_ER_diArg_1 240 243 PF00400 0.468
TRG_NES_CRM1_1 99 111 PF08389 0.538
TRG_Pf-PMV_PEXEL_1 305 310 PF00026 0.547

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I2M6 Leptomonas seymouri 55% 100%
A0A0S4KEM5 Bodo saltans 34% 75%
A0A1X0P5Z2 Trypanosomatidae 37% 100%
A0A3S5H773 Leishmania donovani 89% 100%
A0A422NUP7 Trypanosoma rangeli 38% 100%
A4HA93 Leishmania braziliensis 72% 100%
A4HYH3 Leishmania infantum 90% 100%
D0A0U7 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 100%
E9AS97 Leishmania mexicana (strain MHOM/GT/2001/U1103) 88% 100%
V5D4Q0 Trypanosoma cruzi 39% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS