Oxidoreductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

oxidoreductase-like protein

Species:

Leishmania major

UniProt:

Q4QD65_LEIMA

TriTrypDb:

LmjF.19.1450 , LMJLV39_190021000 , LMJSD75_190020700

Length:

584

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005829	cytosol	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QD65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD65

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	2
GO:0003824	catalytic activity	1	10
GO:0004497	monooxygenase activity	3	5
GO:0004517	nitric-oxide synthase activity	5	5
GO:0005488	binding	1	2
GO:0010181	FMN binding	4	2
GO:0016491	oxidoreductase activity	2	10
GO:0016705	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen	3	5
GO:0016709	oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen	4	5
GO:0032553	ribonucleotide binding	3	2
GO:0036094	small molecule binding	2	2
GO:0043167	ion binding	2	2
GO:0043168	anion binding	3	2
GO:0050660	flavin adenine dinucleotide binding	4	2
GO:0097159	organic cyclic compound binding	2	2
GO:0097367	carbohydrate derivative binding	2	2
GO:1901265	nucleoside phosphate binding	3	2
GO:1901363	heterocyclic compound binding	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	2	4	PF00675	0.586
CLV_NRD_NRD_1	298	300	PF00675	0.550
CLV_NRD_NRD_1	325	327	PF00675	0.609
CLV_NRD_NRD_1	447	449	PF00675	0.361
CLV_PCSK_KEX2_1	2	4	PF00082	0.531
CLV_PCSK_KEX2_1	298	300	PF00082	0.593
CLV_PCSK_KEX2_1	325	327	PF00082	0.609
CLV_PCSK_KEX2_1	447	449	PF00082	0.363
CLV_PCSK_SKI1_1	125	129	PF00082	0.659
CLV_PCSK_SKI1_1	185	189	PF00082	0.583
CLV_PCSK_SKI1_1	375	379	PF00082	0.707
CLV_PCSK_SKI1_1	479	483	PF00082	0.308
CLV_PCSK_SKI1_1	505	509	PF00082	0.294
CLV_PCSK_SKI1_1	88	92	PF00082	0.647
CLV_Separin_Metazoa	476	480	PF03568	0.424
DEG_Nend_UBRbox_1	1	4	PF02207	0.346
DEG_ODPH_VHL_1	434	446	PF01847	0.444
DEG_SPOP_SBC_1	226	230	PF00917	0.590
DOC_CYCLIN_RxL_1	151	159	PF00134	0.414
DOC_CYCLIN_yCln2_LP_2	183	189	PF00134	0.376
DOC_CYCLIN_yCln2_LP_2	412	418	PF00134	0.455
DOC_CYCLIN_yCln2_LP_2	421	427	PF00134	0.310
DOC_MAPK_RevD_3	283	299	PF00069	0.356
DOC_MAPK_RevD_3	310	326	PF00069	0.282
DOC_PP1_RVXF_1	569	575	PF00149	0.599
DOC_PP2B_PxIxI_1	110	116	PF00149	0.426
DOC_USP7_MATH_1	245	249	PF00917	0.428
DOC_USP7_MATH_1	324	328	PF00917	0.421
DOC_USP7_MATH_1	373	377	PF00917	0.431
DOC_USP7_MATH_1	452	456	PF00917	0.541
DOC_USP7_MATH_1	536	540	PF00917	0.518
DOC_WW_Pin1_4	104	109	PF00397	0.436
DOC_WW_Pin1_4	166	171	PF00397	0.361
DOC_WW_Pin1_4	229	234	PF00397	0.550
DOC_WW_Pin1_4	261	266	PF00397	0.440
DOC_WW_Pin1_4	310	315	PF00397	0.445
DOC_WW_Pin1_4	331	336	PF00397	0.360
DOC_WW_Pin1_4	420	425	PF00397	0.460
DOC_WW_Pin1_4	73	78	PF00397	0.477
LIG_14-3-3_CanoR_1	216	223	PF00244	0.396
LIG_14-3-3_CanoR_1	298	303	PF00244	0.351
LIG_14-3-3_CanoR_1	325	331	PF00244	0.455
LIG_14-3-3_CanoR_1	447	457	PF00244	0.545
LIG_Actin_WH2_2	434	449	PF00022	0.485
LIG_Actin_WH2_2	470	485	PF00022	0.424
LIG_APCC_ABBA_1	215	220	PF00400	0.447
LIG_BRCT_BRCA1_1	422	426	PF00533	0.361
LIG_BRCT_BRCA1_1	454	458	PF00533	0.583
LIG_Clathr_ClatBox_1	563	567	PF01394	0.645
LIG_CSL_BTD_1	179	182	PF09270	0.357
LIG_deltaCOP1_diTrp_1	575	583	PF00928	0.596
LIG_eIF4E_1	390	396	PF01652	0.339
LIG_FHA_1	16	22	PF00498	0.361
LIG_FHA_1	307	313	PF00498	0.431
LIG_FHA_1	482	488	PF00498	0.575
LIG_FHA_1	506	512	PF00498	0.505
LIG_FHA_1	517	523	PF00498	0.591
LIG_FHA_1	577	583	PF00498	0.638
LIG_FHA_2	466	472	PF00498	0.556
LIG_LIR_Gen_1	194	204	PF02991	0.367
LIG_LIR_Gen_1	209	218	PF02991	0.372
LIG_LIR_Gen_1	23	32	PF02991	0.331
LIG_LIR_Gen_1	276	285	PF02991	0.372
LIG_LIR_Gen_1	392	401	PF02991	0.438
LIG_LIR_Gen_1	471	482	PF02991	0.424
LIG_LIR_Nem_3	194	199	PF02991	0.342
LIG_LIR_Nem_3	209	214	PF02991	0.314
LIG_LIR_Nem_3	23	29	PF02991	0.331
LIG_LIR_Nem_3	276	281	PF02991	0.367
LIG_LIR_Nem_3	392	396	PF02991	0.429
LIG_LIR_Nem_3	471	477	PF02991	0.565
LIG_LYPXL_yS_3	268	271	PF13949	0.361
LIG_NRBOX	188	194	PF00104	0.416
LIG_NRBOX	254	260	PF00104	0.332
LIG_Pex14_1	22	26	PF04695	0.308
LIG_Pex14_2	211	215	PF04695	0.370
LIG_PTB_Apo_2	395	402	PF02174	0.437
LIG_SH2_NCK_1	300	304	PF00017	0.425
LIG_SH2_PTP2	196	199	PF00017	0.351
LIG_SH2_PTP2	65	68	PF00017	0.446
LIG_SH2_SRC	196	199	PF00017	0.351
LIG_SH2_SRC	474	477	PF00017	0.583
LIG_SH2_SRC	490	493	PF00017	0.551
LIG_SH2_SRC	65	68	PF00017	0.416
LIG_SH2_STAP1	26	30	PF00017	0.348
LIG_SH2_STAP1	474	478	PF00017	0.577
LIG_SH2_STAP1	490	494	PF00017	0.415
LIG_SH2_STAT5	196	199	PF00017	0.304
LIG_SH2_STAT5	204	207	PF00017	0.310
LIG_SH2_STAT5	390	393	PF00017	0.350
LIG_SH2_STAT5	506	509	PF00017	0.531
LIG_SH2_STAT5	65	68	PF00017	0.403
LIG_SH3_3	1	7	PF00018	0.311
LIG_SH3_3	105	111	PF00018	0.456
LIG_SH3_3	167	173	PF00018	0.357
LIG_SH3_3	176	182	PF00018	0.328
LIG_SH3_3	278	284	PF00018	0.375
LIG_SH3_3	288	294	PF00018	0.293
LIG_SH3_3	308	314	PF00018	0.309
LIG_SH3_3	527	533	PF00018	0.561
LIG_SH3_3	66	72	PF00018	0.443
LIG_SUMO_SIM_anti_2	131	138	PF11976	0.439
LIG_SUMO_SIM_anti_2	270	276	PF11976	0.414
LIG_SUMO_SIM_par_1	270	276	PF11976	0.414
LIG_SUMO_SIM_par_1	286	292	PF11976	0.202
LIG_SUMO_SIM_par_1	562	568	PF11976	0.593
LIG_TRAF2_1	48	51	PF00917	0.595
LIG_TRAF2_1	495	498	PF00917	0.461
LIG_TRAF2_1	557	560	PF00917	0.638
LIG_TYR_ITIM	24	29	PF00017	0.336
LIG_TYR_ITIM	266	271	PF00017	0.393
LIG_TYR_ITIM	472	477	PF00017	0.424
LIG_UBA3_1	214	222	PF00899	0.412
LIG_UBA3_1	255	261	PF00899	0.474
LIG_WRC_WIRS_1	277	282	PF05994	0.388
LIG_WRC_WIRS_1	390	395	PF05994	0.410
MOD_CK1_1	100	106	PF00069	0.450
MOD_CK1_1	140	146	PF00069	0.516
MOD_CK1_1	15	21	PF00069	0.339
MOD_CK1_1	200	206	PF00069	0.375
MOD_CK1_1	221	227	PF00069	0.505
MOD_CK1_1	228	234	PF00069	0.493
MOD_CK1_1	248	254	PF00069	0.236
MOD_CK1_1	260	266	PF00069	0.445
MOD_CK1_1	420	426	PF00069	0.418
MOD_CK2_1	206	212	PF00069	0.394
MOD_CK2_1	45	51	PF00069	0.593
MOD_CK2_1	465	471	PF00069	0.527
MOD_CK2_1	492	498	PF00069	0.462
MOD_CK2_1	554	560	PF00069	0.583
MOD_CK2_1	73	79	PF00069	0.480
MOD_GlcNHglycan	120	123	PF01048	0.691
MOD_GlcNHglycan	14	17	PF01048	0.508
MOD_GlcNHglycan	193	196	PF01048	0.596
MOD_GlcNHglycan	224	227	PF01048	0.774
MOD_GlcNHglycan	290	294	PF01048	0.577
MOD_GlcNHglycan	326	329	PF01048	0.615
MOD_GlcNHglycan	379	382	PF01048	0.699
MOD_GlcNHglycan	454	457	PF01048	0.391
MOD_GSK3_1	206	213	PF00069	0.382
MOD_GSK3_1	218	225	PF00069	0.380
MOD_GSK3_1	227	234	PF00069	0.475
MOD_GSK3_1	257	264	PF00069	0.467
MOD_GSK3_1	294	301	PF00069	0.393
MOD_GSK3_1	306	313	PF00069	0.402
MOD_GSK3_1	373	380	PF00069	0.404
MOD_GSK3_1	448	455	PF00069	0.565
MOD_GSK3_1	97	104	PF00069	0.368
MOD_NEK2_1	118	123	PF00069	0.441
MOD_NEK2_1	206	211	PF00069	0.355
MOD_NEK2_1	259	264	PF00069	0.460
MOD_NEK2_1	289	294	PF00069	0.353
MOD_NEK2_1	363	368	PF00069	0.390
MOD_NEK2_1	377	382	PF00069	0.466
MOD_NEK2_1	389	394	PF00069	0.290
MOD_NEK2_1	396	401	PF00069	0.271
MOD_NEK2_2	101	106	PF00069	0.405
MOD_NEK2_2	536	541	PF00069	0.596
MOD_PIKK_1	140	146	PF00454	0.524
MOD_PIKK_1	43	49	PF00454	0.574
MOD_PIKK_1	439	445	PF00454	0.395
MOD_PKA_1	298	304	PF00069	0.334
MOD_PKA_2	298	304	PF00069	0.379
MOD_PKA_2	324	330	PF00069	0.441
MOD_Plk_1	554	560	PF00069	0.568
MOD_Plk_2-3	554	560	PF00069	0.568
MOD_Plk_4	101	107	PF00069	0.404
MOD_Plk_4	200	206	PF00069	0.346
MOD_Plk_4	210	216	PF00069	0.317
MOD_Plk_4	267	273	PF00069	0.374
MOD_Plk_4	396	402	PF00069	0.421
MOD_Plk_4	57	63	PF00069	0.384
MOD_ProDKin_1	104	110	PF00069	0.435
MOD_ProDKin_1	166	172	PF00069	0.359
MOD_ProDKin_1	229	235	PF00069	0.538
MOD_ProDKin_1	261	267	PF00069	0.430
MOD_ProDKin_1	310	316	PF00069	0.438
MOD_ProDKin_1	331	337	PF00069	0.356
MOD_ProDKin_1	420	426	PF00069	0.449
MOD_ProDKin_1	73	79	PF00069	0.473
MOD_SUMO_for_1	488	491	PF00179	0.591
MOD_SUMO_rev_2	219	224	PF00179	0.444
MOD_SUMO_rev_2	79	87	PF00179	0.451
TRG_DiLeu_BaEn_1	238	243	PF01217	0.432
TRG_DiLeu_BaEn_1	560	565	PF01217	0.603
TRG_DiLeu_BaEn_2	275	281	PF01217	0.393
TRG_DiLeu_BaEn_2	524	530	PF01217	0.536
TRG_DiLeu_BaLyEn_6	254	259	PF01217	0.444
TRG_DiLeu_BaLyEn_6	284	289	PF01217	0.331
TRG_DiLeu_BaLyEn_6	433	438	PF01217	0.427
TRG_DiLeu_BaLyEn_6	559	564	PF01217	0.662
TRG_DiLeu_LyEn_5	238	243	PF01217	0.418
TRG_ENDOCYTIC_2	196	199	PF00928	0.342
TRG_ENDOCYTIC_2	26	29	PF00928	0.391
TRG_ENDOCYTIC_2	268	271	PF00928	0.378
TRG_ENDOCYTIC_2	390	393	PF00928	0.413
TRG_ENDOCYTIC_2	474	477	PF00928	0.424
TRG_ER_diArg_1	1	3	PF00400	0.336
TRG_ER_diArg_1	298	300	PF00400	0.359
TRG_ER_diArg_1	446	448	PF00400	0.563
TRG_ER_diArg_1	569	572	PF00400	0.606
TRG_NES_CRM1_1	273	286	PF08389	0.394
TRG_Pf-PMV_PEXEL_1	562	567	PF00026	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IB19	Leptomonas seymouri	60%	100%
A0A0S4INF0	Bodo saltans	26%	100%
A0A1X0P608	Trypanosomatidae	38%	94%
A0A3Q8IK79	Leishmania donovani	95%	100%
A4HA95	Leishmania braziliensis	84%	100%
A4HYH5	Leishmania infantum	95%	100%
D0A0U9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	37%	93%
E9AS99	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%