LeishMANIAdb
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Oxidoreductase-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Oxidoreductase-like protein
Gene product:
oxidoreductase-like protein
Species:
Leishmania major
UniProt:
Q4QD65_LEIMA
TriTrypDb:
LmjF.19.1450 , LMJLV39_190021000 , LMJSD75_190020700
Length:
584

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 9
NetGPI no yes: 0, no: 9
Cellular components
TermNameLevelCount
GO:0005654 nucleoplasm 2 2
GO:0005829 cytosol 2 2
GO:0110165 cellular anatomical entity 1 2
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Expansion

Sequence features

Q4QD65
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD65

Function

Could not find GO biological_process term for this entry.
Molecular functions
TermNameLevelCount
GO:0000166 nucleotide binding 3 2
GO:0003824 catalytic activity 1 10
GO:0004497 monooxygenase activity 3 5
GO:0004517 nitric-oxide synthase activity 5 5
GO:0005488 binding 1 2
GO:0010181 FMN binding 4 2
GO:0016491 oxidoreductase activity 2 10
GO:0016705 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen 3 5
GO:0016709 oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, NAD(P)H as one donor, and incorporation of one atom of oxygen 4 5
GO:0032553 ribonucleotide binding 3 2
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Putative motif mimicry

LeishmaniaFromToDomain/MotifScore
CLV_NRD_NRD_1 2 4 PF00675 0.586
CLV_NRD_NRD_1 298 300 PF00675 0.550
CLV_NRD_NRD_1 325 327 PF00675 0.609
CLV_NRD_NRD_1 447 449 PF00675 0.361
CLV_PCSK_KEX2_1 2 4 PF00082 0.531
CLV_PCSK_KEX2_1 298 300 PF00082 0.593
CLV_PCSK_KEX2_1 325 327 PF00082 0.609
CLV_PCSK_KEX2_1 447 449 PF00082 0.363
CLV_PCSK_SKI1_1 125 129 PF00082 0.659
CLV_PCSK_SKI1_1 185 189 PF00082 0.583
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Homologs

ProteinTaxonomySequence identityCoverage
A0A0N1IB19 Leptomonas seymouri 60% 100%
A0A0S4INF0 Bodo saltans 26% 100%
A0A1X0P608 Trypanosomatidae 38% 94%
A0A3Q8IK79 Leishmania donovani 95% 100%
A4HA95 Leishmania braziliensis 84% 100%
A4HYH5 Leishmania infantum 95% 100%
D0A0U9 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 37% 93%
E9AS99 Leishmania mexicana (strain MHOM/GT/2001/U1103) 94% 100%
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Download

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS