Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania major

UniProt:

Q4QD63_LEIMA

TriTrypDb:

LmjF.19.1470 , LMJLV39_190021200 , LMJSD75_190020900

Length:

621

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 22
NetGPI	no	yes: 0, no: 22

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	4
GO:0005737	cytoplasm	2	4
GO:0043226	organelle	2	4
GO:0043227	membrane-bounded organelle	3	4
GO:0043229	intracellular organelle	3	4
GO:0043231	intracellular membrane-bounded organelle	4	4
GO:0110165	cellular anatomical entity	1	4

Expansion

Sequence features

Q4QD63

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD63

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	23
GO:0006793	phosphorus metabolic process	3	23
GO:0006796	phosphate-containing compound metabolic process	4	23
GO:0006807	nitrogen compound metabolic process	2	23
GO:0007165	signal transduction	2	4
GO:0008152	metabolic process	1	23
GO:0009987	cellular process	1	23
GO:0016310	phosphorylation	5	23
GO:0018105	peptidyl-serine phosphorylation	6	3
GO:0018193	peptidyl-amino acid modification	5	3
GO:0018209	peptidyl-serine modification	6	3
GO:0019538	protein metabolic process	3	23
GO:0035556	intracellular signal transduction	3	4
GO:0036211	protein modification process	4	23
GO:0043170	macromolecule metabolic process	3	23
GO:0043412	macromolecule modification	4	23
GO:0044237	cellular metabolic process	2	23
GO:0044238	primary metabolic process	2	23
GO:0046777	protein autophosphorylation	6	3
GO:0050789	regulation of biological process	2	4
GO:0050794	regulation of cellular process	3	4
GO:0065007	biological regulation	1	4
GO:0071704	organic substance metabolic process	2	23
GO:1901564	organonitrogen compound metabolic process	3	23
GO:0000075	cell cycle checkpoint signaling	4	1
GO:0000077	DNA damage checkpoint signaling	5	1
GO:0006950	response to stress	2	1
GO:0006974	DNA damage response	4	1
GO:0007093	mitotic cell cycle checkpoint signaling	4	1
GO:0007346	regulation of mitotic cell cycle	5	1
GO:0010564	regulation of cell cycle process	5	1
GO:0010948	negative regulation of cell cycle process	6	1
GO:0022402	cell cycle process	2	1
GO:0031570	DNA integrity checkpoint signaling	5	1
GO:0033554	cellular response to stress	3	1
GO:0042770	signal transduction in response to DNA damage	4	1
GO:0044773	mitotic DNA damage checkpoint signaling	6	1
GO:0044774	mitotic DNA integrity checkpoint signaling	5	1
GO:0045786	negative regulation of cell cycle	5	1
GO:0045930	negative regulation of mitotic cell cycle	6	1
GO:0048519	negative regulation of biological process	3	1
GO:0048523	negative regulation of cellular process	4	1
GO:0050896	response to stimulus	1	1
GO:0051716	cellular response to stimulus	2	1
GO:0051726	regulation of cell cycle	4	1
GO:1901987	regulation of cell cycle phase transition	6	1
GO:1901988	negative regulation of cell cycle phase transition	7	1
GO:1903047	mitotic cell cycle process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	23
GO:0003824	catalytic activity	1	23
GO:0004672	protein kinase activity	3	23
GO:0004674	protein serine/threonine kinase activity	4	14
GO:0004683	calmodulin-dependent protein kinase activity	5	3
GO:0005488	binding	1	23
GO:0005515	protein binding	2	3
GO:0005516	calmodulin binding	3	3
GO:0005524	ATP binding	5	23
GO:0009931	calcium-dependent protein serine/threonine kinase activity	5	3
GO:0010857	calcium-dependent protein kinase activity	4	3
GO:0016301	kinase activity	4	23
GO:0016740	transferase activity	2	23
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	23
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	23
GO:0017076	purine nucleotide binding	4	23
GO:0030554	adenyl nucleotide binding	5	23
GO:0032553	ribonucleotide binding	3	23
GO:0032555	purine ribonucleotide binding	4	23
GO:0032559	adenyl ribonucleotide binding	5	23
GO:0035639	purine ribonucleoside triphosphate binding	4	23
GO:0036094	small molecule binding	2	23
GO:0043167	ion binding	2	23
GO:0043168	anion binding	3	23
GO:0097159	organic cyclic compound binding	2	23
GO:0097367	carbohydrate derivative binding	2	23
GO:0140096	catalytic activity, acting on a protein	2	23
GO:1901265	nucleoside phosphate binding	3	23
GO:1901363	heterocyclic compound binding	2	23
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	171	175	PF00656	0.404
CLV_C14_Caspase3-7	345	349	PF00656	0.216
CLV_NRD_NRD_1	161	163	PF00675	0.449
CLV_NRD_NRD_1	194	196	PF00675	0.310
CLV_NRD_NRD_1	203	205	PF00675	0.302
CLV_NRD_NRD_1	216	218	PF00675	0.401
CLV_NRD_NRD_1	28	30	PF00675	0.405
CLV_NRD_NRD_1	415	417	PF00675	0.468
CLV_NRD_NRD_1	503	505	PF00675	0.278
CLV_NRD_NRD_1	571	573	PF00675	0.421
CLV_NRD_NRD_1	59	61	PF00675	0.666
CLV_NRD_NRD_1	83	85	PF00675	0.456
CLV_PCSK_KEX2_1	161	163	PF00082	0.455
CLV_PCSK_KEX2_1	203	205	PF00082	0.423
CLV_PCSK_KEX2_1	216	218	PF00082	0.275
CLV_PCSK_KEX2_1	447	449	PF00082	0.333
CLV_PCSK_KEX2_1	503	505	PF00082	0.313
CLV_PCSK_KEX2_1	59	61	PF00082	0.666
CLV_PCSK_KEX2_1	83	85	PF00082	0.456
CLV_PCSK_PC1ET2_1	447	449	PF00082	0.333
CLV_PCSK_SKI1_1	162	166	PF00082	0.359
CLV_PCSK_SKI1_1	268	272	PF00082	0.405
CLV_PCSK_SKI1_1	286	290	PF00082	0.288
CLV_PCSK_SKI1_1	390	394	PF00082	0.353
CLV_PCSK_SKI1_1	417	421	PF00082	0.388
CLV_PCSK_SKI1_1	499	503	PF00082	0.336
DEG_APCC_DBOX_1	267	275	PF00400	0.392
DEG_APCC_DBOX_1	357	365	PF00400	0.310
DEG_SCF_FBW7_1	394	401	PF00400	0.333
DOC_CKS1_1	439	444	PF01111	0.496
DOC_CYCLIN_RxL_1	265	273	PF00134	0.387
DOC_CYCLIN_RxL_1	387	397	PF00134	0.213
DOC_MAPK_gen_1	286	295	PF00069	0.333
DOC_MAPK_gen_1	438	445	PF00069	0.502
DOC_MAPK_gen_1	572	580	PF00069	0.438
DOC_MAPK_MEF2A_6	221	228	PF00069	0.342
DOC_PP4_FxxP_1	404	407	PF00568	0.275
DOC_PP4_FxxP_1	486	489	PF00568	0.314
DOC_USP7_MATH_1	469	473	PF00917	0.308
DOC_USP7_MATH_1	607	611	PF00917	0.655
DOC_USP7_UBL2_3	192	196	PF12436	0.298
DOC_USP7_UBL2_3	26	30	PF12436	0.417
DOC_WW_Pin1_4	349	354	PF00397	0.333
DOC_WW_Pin1_4	394	399	PF00397	0.327
DOC_WW_Pin1_4	438	443	PF00397	0.485
LIG_14-3-3_CanoR_1	195	200	PF00244	0.351
LIG_14-3-3_CanoR_1	29	34	PF00244	0.452
LIG_14-3-3_CanoR_1	427	433	PF00244	0.585
LIG_14-3-3_CanoR_1	552	557	PF00244	0.558
LIG_14-3-3_CanoR_1	565	569	PF00244	0.451
LIG_14-3-3_CanoR_1	60	66	PF00244	0.436
LIG_APCC_ABBAyCdc20_2	281	287	PF00400	0.257
LIG_BIR_III_4	367	371	PF00653	0.216
LIG_BIR_III_4	582	586	PF00653	0.530
LIG_BRCT_BRCA1_1	137	141	PF00533	0.423
LIG_BRCT_BRCA1_1	196	200	PF00533	0.333
LIG_BRCT_BRCA1_1	560	564	PF00533	0.542
LIG_BRCT_BRCA1_1	600	604	PF00533	0.514
LIG_BRCT_MDC1_1	617	621	PF00533	0.484
LIG_CtBP_PxDLS_1	442	446	PF00389	0.370
LIG_deltaCOP1_diTrp_1	575	579	PF00928	0.449
LIG_EVH1_1	361	365	PF00568	0.246
LIG_FHA_1	163	169	PF00498	0.419
LIG_FHA_1	364	370	PF00498	0.187
LIG_FHA_1	455	461	PF00498	0.275
LIG_FHA_2	137	143	PF00498	0.449
LIG_FHA_2	439	445	PF00498	0.404
LIG_FHA_2	461	467	PF00498	0.305
LIG_FHA_2	65	71	PF00498	0.442
LIG_GBD_Chelix_1	168	176	PF00786	0.409
LIG_GBD_Chelix_1	266	274	PF00786	0.275
LIG_LIR_Apic_2	401	407	PF02991	0.357
LIG_LIR_Apic_2	485	489	PF02991	0.333
LIG_LIR_Gen_1	154	164	PF02991	0.496
LIG_LIR_Gen_1	234	244	PF02991	0.344
LIG_LIR_Gen_1	247	257	PF02991	0.366
LIG_LIR_Gen_1	260	267	PF02991	0.352
LIG_LIR_Gen_1	326	337	PF02991	0.285
LIG_LIR_Gen_1	515	525	PF02991	0.246
LIG_LIR_Gen_1	555	564	PF02991	0.513
LIG_LIR_Gen_1	575	583	PF02991	0.512
LIG_LIR_LC3C_4	37	41	PF02991	0.398
LIG_LIR_Nem_3	154	159	PF02991	0.486
LIG_LIR_Nem_3	234	240	PF02991	0.372
LIG_LIR_Nem_3	247	252	PF02991	0.414
LIG_LIR_Nem_3	260	264	PF02991	0.386
LIG_LIR_Nem_3	326	332	PF02991	0.297
LIG_LIR_Nem_3	334	340	PF02991	0.287
LIG_LIR_Nem_3	515	520	PF02991	0.246
LIG_LIR_Nem_3	555	560	PF02991	0.533
LIG_LIR_Nem_3	575	580	PF02991	0.504
LIG_LIR_Nem_3	63	68	PF02991	0.434
LIG_LIR_Nem_3	77	81	PF02991	0.390
LIG_MLH1_MIPbox_1	137	141	PF16413	0.301
LIG_MYND_1	359	363	PF01753	0.226
LIG_Pex14_1	100	104	PF04695	0.387
LIG_Pex14_1	137	141	PF04695	0.331
LIG_REV1ctd_RIR_1	138	148	PF16727	0.324
LIG_RPA_C_Fungi	411	423	PF08784	0.337
LIG_SH2_CRK	156	160	PF00017	0.474
LIG_SH2_CRK	261	265	PF00017	0.333
LIG_SH2_CRK	337	341	PF00017	0.246
LIG_SH2_NCK_1	531	535	PF00017	0.536
LIG_SH2_PTP2	237	240	PF00017	0.388
LIG_SH2_PTP2	329	332	PF00017	0.310
LIG_SH2_SRC	476	479	PF00017	0.187
LIG_SH2_STAP1	261	265	PF00017	0.333
LIG_SH2_STAP1	337	341	PF00017	0.364
LIG_SH2_STAT3	493	496	PF00017	0.333
LIG_SH2_STAT5	106	109	PF00017	0.491
LIG_SH2_STAT5	237	240	PF00017	0.394
LIG_SH2_STAT5	242	245	PF00017	0.382
LIG_SH2_STAT5	329	332	PF00017	0.310
LIG_SH2_STAT5	476	479	PF00017	0.450
LIG_SH2_STAT5	493	496	PF00017	0.333
LIG_SH2_STAT5	531	534	PF00017	0.562
LIG_SH2_STAT5	56	59	PF00017	0.592
LIG_SH3_3	123	129	PF00018	0.414
LIG_SH3_3	356	362	PF00018	0.418
LIG_SH3_3	436	442	PF00018	0.593
LIG_SH3_3	491	497	PF00018	0.258
LIG_SH3_3	83	89	PF00018	0.455
LIG_SUMO_SIM_anti_2	262	267	PF11976	0.333
LIG_SUMO_SIM_anti_2	441	447	PF11976	0.454
LIG_SUMO_SIM_par_1	390	397	PF11976	0.216
LIG_SxIP_EBH_1	583	592	PF03271	0.444
LIG_UBA3_1	172	179	PF00899	0.408
LIG_WW_2	359	362	PF00397	0.226
MOD_CK1_1	32	38	PF00069	0.470
MOD_CK1_1	567	573	PF00069	0.502
MOD_CK1_1	64	70	PF00069	0.457
MOD_CK1_1	9	15	PF00069	0.500
MOD_CK2_1	136	142	PF00069	0.519
MOD_CK2_1	460	466	PF00069	0.275
MOD_CK2_1	469	475	PF00069	0.275
MOD_CK2_1	512	518	PF00069	0.335
MOD_CK2_1	533	539	PF00069	0.646
MOD_CK2_1	593	599	PF00069	0.552
MOD_CK2_1	600	606	PF00069	0.607
MOD_GlcNHglycan	4	7	PF01048	0.539
MOD_GlcNHglycan	410	413	PF01048	0.297
MOD_GlcNHglycan	428	431	PF01048	0.460
MOD_GlcNHglycan	485	489	PF01048	0.399
MOD_GlcNHglycan	514	517	PF01048	0.458
MOD_GlcNHglycan	552	555	PF01048	0.712
MOD_GlcNHglycan	595	598	PF01048	0.603
MOD_GlcNHglycan	617	620	PF01048	0.510
MOD_GSK3_1	194	201	PF00069	0.357
MOD_GSK3_1	2	9	PF00069	0.757
MOD_GSK3_1	25	32	PF00069	0.426
MOD_GSK3_1	315	322	PF00069	0.386
MOD_GSK3_1	394	401	PF00069	0.363
MOD_GSK3_1	422	429	PF00069	0.492
MOD_GSK3_1	529	536	PF00069	0.563
MOD_GSK3_1	560	567	PF00069	0.515
MOD_GSK3_1	598	605	PF00069	0.687
MOD_GSK3_1	60	67	PF00069	0.531
MOD_N-GLC_1	322	327	PF02516	0.226
MOD_N-GLC_1	520	525	PF02516	0.310
MOD_N-GLC_1	550	555	PF02516	0.485
MOD_N-GLC_2	612	614	PF02516	0.460
MOD_NEK2_1	168	173	PF00069	0.612
MOD_NEK2_1	22	27	PF00069	0.526
MOD_NEK2_1	270	275	PF00069	0.292
MOD_NEK2_1	392	397	PF00069	0.379
MOD_NEK2_1	484	489	PF00069	0.359
MOD_NEK2_1	520	525	PF00069	0.296
MOD_NEK2_1	550	555	PF00069	0.566
MOD_NEK2_1	559	564	PF00069	0.504
MOD_NEK2_1	586	591	PF00069	0.522
MOD_NEK2_1	608	613	PF00069	0.539
MOD_NEK2_2	136	141	PF00069	0.381
MOD_NMyristoyl	1	7	PF02799	0.519
MOD_PIKK_1	119	125	PF00454	0.356
MOD_PIKK_1	492	498	PF00454	0.344
MOD_PK_1	552	558	PF00069	0.430
MOD_PKA_1	195	201	PF00069	0.333
MOD_PKA_1	29	35	PF00069	0.453
MOD_PKA_2	194	200	PF00069	0.398
MOD_PKA_2	28	34	PF00069	0.486
MOD_PKA_2	315	321	PF00069	0.215
MOD_PKA_2	426	432	PF00069	0.521
MOD_PKA_2	470	476	PF00069	0.440
MOD_PKA_2	512	518	PF00069	0.360
MOD_PKA_2	564	570	PF00069	0.444
MOD_Plk_1	347	353	PF00069	0.216
MOD_Plk_1	520	526	PF00069	0.320
MOD_Plk_2-3	533	539	PF00069	0.640
MOD_Plk_2-3	600	606	PF00069	0.494
MOD_Plk_4	136	142	PF00069	0.440
MOD_Plk_4	155	161	PF00069	0.389
MOD_Plk_4	195	201	PF00069	0.313
MOD_Plk_4	35	41	PF00069	0.449
MOD_Plk_4	520	526	PF00069	0.280
MOD_Plk_4	552	558	PF00069	0.548
MOD_Plk_4	64	70	PF00069	0.427
MOD_ProDKin_1	349	355	PF00069	0.333
MOD_ProDKin_1	394	400	PF00069	0.327
MOD_ProDKin_1	438	444	PF00069	0.484
MOD_SUMO_for_1	288	291	PF00179	0.357
MOD_SUMO_rev_2	171	181	PF00179	0.587
TRG_DiLeu_BaEn_2	141	147	PF01217	0.325
TRG_DiLeu_BaEn_2	271	277	PF01217	0.246
TRG_DiLeu_BaEn_2	574	580	PF01217	0.512
TRG_DiLeu_BaLyEn_6	388	393	PF01217	0.326
TRG_ENDOCYTIC_2	156	159	PF00928	0.488
TRG_ENDOCYTIC_2	237	240	PF00928	0.416
TRG_ENDOCYTIC_2	261	264	PF00928	0.333
TRG_ENDOCYTIC_2	329	332	PF00928	0.324
TRG_ENDOCYTIC_2	337	340	PF00928	0.346
TRG_ER_diArg_1	160	162	PF00400	0.329
TRG_ER_diArg_1	202	204	PF00400	0.316
TRG_ER_diArg_1	215	217	PF00400	0.278
TRG_ER_diArg_1	502	504	PF00400	0.261
TRG_ER_diArg_1	58	60	PF00400	0.444
TRG_Pf-PMV_PEXEL_1	170	174	PF00026	0.409
TRG_Pf-PMV_PEXEL_1	268	272	PF00026	0.381

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6Q7	Leptomonas seymouri	25%	100%
A0A0N1IM89	Leptomonas seymouri	63%	100%
A0A0S4JQP0	Bodo saltans	23%	100%
A0A0S4KKJ1	Bodo saltans	39%	98%
A0A3S5H5G0	Leishmania donovani	25%	100%
A0A3S7WVR6	Leishmania donovani	94%	100%
A0A3S7WY10	Leishmania donovani	25%	100%
A0A3S7X8Z8	Leishmania donovani	25%	100%
A4H459	Leishmania braziliensis	27%	100%
A4HA97	Leishmania braziliensis	81%	100%
A4HD79	Leishmania braziliensis	25%	100%
A4HFF3	Leishmania braziliensis	25%	100%
A4HSE2	Leishmania infantum	25%	100%
A4HYH7	Leishmania infantum	94%	100%
A4IB02	Leishmania infantum	25%	100%
C9ZX15	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	23%	100%
E9AET0	Leishmania major	26%	100%
E9AH34	Leishmania infantum	25%	100%
E9AKB7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
E9ASA1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
E9B5Y5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	26%	100%
O94547	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	24%	100%
Q4QAV8	Leishmania major	24%	100%
Q4QJJ0	Leishmania major	24%	100%
Q63531	Rattus norvegicus	24%	84%