Eukaryotic translation initiation factor-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

eukaryotic translation initiation factor-like protein

Species:

Leishmania major

UniProt:

Q4QD60_LEIMA

TriTrypDb:

LmjF.19.1480 , LMJLV39_190021300 , LMJSD75_190021000

Length:

281

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016281	eukaryotic translation initiation factor 4F complex	2	2
GO:0032991	protein-containing complex	1	2
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QD60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD60

Function

Biological processes
Term	Name	Level	Count
GO:0006413	translational initiation	3	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0044237	cellular metabolic process	2	2

Molecular functions
Term	Name	Level	Count
GO:0000339	RNA cap binding	5	2
GO:0000340	RNA 7-methylguanosine cap binding	6	2
GO:0000342	RNA cap 4 binding	6	2
GO:0003676	nucleic acid binding	3	12
GO:0003723	RNA binding	4	12
GO:0003743	translation initiation factor activity	4	12
GO:0005488	binding	1	12
GO:0008135	translation factor activity, RNA binding	3	12
GO:0045182	translation regulator activity	1	12
GO:0090079	translation regulator activity, nucleic acid binding	2	12
GO:0097159	organic cyclic compound binding	2	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	190	192	PF00675	0.318
CLV_NRD_NRD_1	83	85	PF00675	0.248
CLV_NRD_NRD_1	97	99	PF00675	0.223
CLV_PCSK_KEX2_1	97	99	PF00082	0.258
CLV_Separin_Metazoa	217	221	PF03568	0.573
DEG_Nend_UBRbox_2	1	3	PF02207	0.657
DOC_CYCLIN_RxL_1	189	200	PF00134	0.458
DOC_MAPK_gen_1	267	276	PF00069	0.513
DOC_MAPK_gen_1	97	106	PF00069	0.420
DOC_MAPK_MEF2A_6	267	276	PF00069	0.438
DOC_PP2B_LxvP_1	196	199	PF13499	0.371
DOC_USP7_MATH_1	110	114	PF00917	0.474
DOC_USP7_MATH_1	76	80	PF00917	0.512
DOC_WW_Pin1_4	218	223	PF00397	0.712
LIG_14-3-3_CanoR_1	152	157	PF00244	0.452
LIG_14-3-3_CanoR_1	267	273	PF00244	0.529
LIG_deltaCOP1_diTrp_1	167	173	PF00928	0.420
LIG_deltaCOP1_diTrp_1	59	65	PF00928	0.512
LIG_FHA_1	124	130	PF00498	0.484
LIG_FHA_1	160	166	PF00498	0.430
LIG_FHA_1	269	275	PF00498	0.553
LIG_FHA_1	41	47	PF00498	0.481
LIG_FHA_2	212	218	PF00498	0.556
LIG_GBD_Chelix_1	186	194	PF00786	0.312
LIG_LIR_Gen_1	121	132	PF02991	0.420
LIG_LIR_Gen_1	26	32	PF02991	0.409
LIG_LIR_Nem_3	121	127	PF02991	0.416
LIG_LIR_Nem_3	59	65	PF02991	0.435
LIG_LIR_Nem_3	79	83	PF02991	0.420
LIG_PCNA_yPIPBox_3	180	190	PF02747	0.435
LIG_PDZ_Class_3	276	281	PF00595	0.522
LIG_Pex14_1	102	106	PF04695	0.409
LIG_Pex14_2	61	65	PF04695	0.512
LIG_SH2_STAP1	270	274	PF00017	0.489
LIG_SH2_STAT5	189	192	PF00017	0.480
LIG_SH2_STAT5	242	245	PF00017	0.295
LIG_SH2_STAT5	270	273	PF00017	0.493
LIG_SH2_STAT5	81	84	PF00017	0.451
LIG_SH3_2	219	224	PF14604	0.611
LIG_SH3_3	216	222	PF00018	0.631
LIG_SUMO_SIM_par_1	270	275	PF11976	0.424
LIG_TRAF2_1	251	254	PF00917	0.441
MOD_CDC14_SPxK_1	221	224	PF00782	0.608
MOD_CDK_SPxK_1	218	224	PF00069	0.611
MOD_CDK_SPxxK_3	222	229	PF00069	0.703
MOD_CK1_1	10	16	PF00069	0.635
MOD_CK1_1	163	169	PF00069	0.441
MOD_CK1_1	238	244	PF00069	0.481
MOD_CK2_1	108	114	PF00069	0.497
MOD_CK2_1	211	217	PF00069	0.755
MOD_CMANNOS	22	25	PF00535	0.209
MOD_GlcNHglycan	129	132	PF01048	0.312
MOD_GlcNHglycan	157	160	PF01048	0.280
MOD_GlcNHglycan	162	165	PF01048	0.282
MOD_GlcNHglycan	175	178	PF01048	0.353
MOD_GlcNHglycan	208	211	PF01048	0.728
MOD_GlcNHglycan	232	236	PF01048	0.519
MOD_GlcNHglycan	237	240	PF01048	0.398
MOD_GlcNHglycan	56	59	PF01048	0.277
MOD_GlcNHglycan	9	12	PF01048	0.492
MOD_GSK3_1	104	111	PF00069	0.452
MOD_GSK3_1	123	130	PF00069	0.500
MOD_GSK3_1	155	162	PF00069	0.552
MOD_GSK3_1	197	204	PF00069	0.725
MOD_GSK3_1	218	225	PF00069	0.619
MOD_GSK3_1	231	238	PF00069	0.667
MOD_GSK3_1	36	43	PF00069	0.480
MOD_GSK3_1	65	72	PF00069	0.415
MOD_N-GLC_1	65	70	PF02516	0.292
MOD_N-GLC_1	76	81	PF02516	0.249
MOD_N-GLC_2	4	6	PF02516	0.718
MOD_NEK2_1	127	132	PF00069	0.521
MOD_NEK2_1	65	70	PF00069	0.512
MOD_PIKK_1	179	185	PF00454	0.433
MOD_PIKK_1	69	75	PF00454	0.433
MOD_PKA_2	179	185	PF00069	0.451
MOD_PKB_1	150	158	PF00069	0.430
MOD_Plk_1	65	71	PF00069	0.476
MOD_Plk_2-3	211	217	PF00069	0.584
MOD_Plk_4	16	22	PF00069	0.527
MOD_Plk_4	211	217	PF00069	0.600
MOD_Plk_4	238	244	PF00069	0.372
MOD_Plk_4	65	71	PF00069	0.514
MOD_Plk_4	76	82	PF00069	0.513
MOD_ProDKin_1	218	224	PF00069	0.713
MOD_SUMO_for_1	251	254	PF00179	0.533
MOD_SUMO_rev_2	163	170	PF00179	0.457
MOD_SUMO_rev_2	200	209	PF00179	0.564
TRG_DiLeu_BaEn_1	211	216	PF01217	0.606
TRG_ENDOCYTIC_2	80	83	PF00928	0.420
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P3S7	Leptomonas seymouri	25%	81%
A0A0N0P8A8	Leptomonas seymouri	66%	100%
A0A0N0P8F2	Leptomonas seymouri	24%	100%
A0A0S4KG92	Bodo saltans	44%	96%
A0A1U8GR65	Capsicum annuum	27%	100%
A0A1X0P6Z9	Trypanosomatidae	36%	100%
A0A3Q7FGP1	Solanum lycopersicum	30%	100%
A0A3Q7I7R4	Solanum lycopersicum	26%	100%
A0A3Q8IE78	Leishmania donovani	23%	100%
A0A3S5H774	Leishmania donovani	94%	100%
A0A3S5IRX1	Trypanosoma rangeli	36%	97%
A4HA98	Leishmania braziliensis	82%	100%
A4HFT8	Leishmania braziliensis	25%	100%
A4HYH8	Leishmania infantum	95%	100%
A4I2V4	Leishmania infantum	23%	100%
A6NMX2	Homo sapiens	26%	100%
C6ZJZ3	Glycine max	30%	100%
D0A0V2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9ASA2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
E9AZ65	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
O81481	Zea mays	30%	100%
P07260	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	28%	100%
P29557	Triticum aestivum	30%	100%
P48598	Drosophila melanogaster	30%	100%
Q0GRC4	Pisum sativum	29%	100%
Q21693	Caenorhabditis elegans	28%	100%
Q66WU1	Nicotiana tabacum	27%	100%
V5AP07	Trypanosoma cruzi	42%	100%
V7BSD0	Phaseolus vulgaris	29%	100%