LeishMANIAdb
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Secreted protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Secreted protein
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QD59_LEIMA
TriTrypDb:
LmjF.19.1505 , LMJSD75_190021100
Length:
114

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 13
NetGPI no yes: 0, no: 13
Cellular components
Term Name Level Count
GO:0005737 cytoplasm 2 2
GO:0110165 cellular anatomical entity 1 2

Expansion

Sequence features

Q4QD59
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD59

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_NRD_NRD_1 4 6 PF00675 0.468
CLV_PCSK_KEX2_1 4 6 PF00082 0.468
DEG_Nend_Nbox_1 1 3 PF02207 0.498
DEG_SPOP_SBC_1 37 41 PF00917 0.487
DOC_MAPK_DCC_7 30 38 PF00069 0.509
DOC_MAPK_MEF2A_6 30 38 PF00069 0.488
DOC_PP4_MxPP_1 31 34 PF00568 0.591
DOC_USP7_MATH_1 52 56 PF00917 0.484
DOC_WW_Pin1_4 21 26 PF00397 0.487
DOC_WW_Pin1_4 66 71 PF00397 0.578
DOC_WW_Pin1_4 77 82 PF00397 0.550
LIG_14-3-3_CanoR_1 19 25 PF00244 0.479
LIG_14-3-3_CanoR_1 4 13 PF00244 0.425
LIG_14-3-3_CanoR_1 96 105 PF00244 0.432
LIG_Actin_WH2_2 81 98 PF00022 0.492
LIG_FHA_1 102 108 PF00498 0.369
LIG_FHA_1 37 43 PF00498 0.686
LIG_FHA_1 78 84 PF00498 0.523
LIG_FHA_1 90 96 PF00498 0.405
LIG_LIR_Gen_1 104 113 PF02991 0.449
LIG_LIR_Gen_1 50 58 PF02991 0.530
LIG_LIR_Nem_3 104 108 PF02991 0.432
LIG_LIR_Nem_3 50 56 PF02991 0.497
LIG_MYND_1 33 37 PF01753 0.626
LIG_NRBOX 72 78 PF00104 0.576
LIG_SH2_CRK 105 109 PF00017 0.437
LIG_SH2_CRK 17 21 PF00017 0.441
LIG_SH2_STAP1 105 109 PF00017 0.462
LIG_SH3_3 31 37 PF00018 0.579
LIG_SUMO_SIM_anti_2 106 111 PF11976 0.499
MOD_CK1_1 47 53 PF00069 0.622
MOD_Cter_Amidation 2 5 PF01082 0.543
MOD_GlcNHglycan 46 49 PF01048 0.611
MOD_GSK3_1 38 45 PF00069 0.530
MOD_NEK2_1 20 25 PF00069 0.408
MOD_Plk_4 103 109 PF00069 0.350
MOD_Plk_4 52 58 PF00069 0.634
MOD_Plk_4 72 78 PF00069 0.440
MOD_Plk_4 89 95 PF00069 0.477
MOD_ProDKin_1 21 27 PF00069 0.487
MOD_ProDKin_1 66 72 PF00069 0.572
MOD_ProDKin_1 77 83 PF00069 0.550
TRG_ENDOCYTIC_2 105 108 PF00928 0.405
TRG_ENDOCYTIC_2 17 20 PF00928 0.409
TRG_ER_diArg_1 4 6 PF00400 0.468
TRG_Pf-PMV_PEXEL_1 96 100 PF00026 0.391

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I123 Leptomonas seymouri 71% 100%
A0A0S4IR74 Bodo saltans 33% 70%
A0A0S4KIC6 Bodo saltans 42% 100%
A0A1X0P673 Trypanosomatidae 53% 100%
A0A1X0P697 Trypanosomatidae 40% 91%
A0A3Q8IBH0 Leishmania donovani 38% 93%
A0A3Q8IBJ2 Leishmania donovani 97% 100%
A0A422NUP2 Trypanosoma rangeli 49% 100%
A4HA99 Leishmania braziliensis 83% 100%
A4HYH9 Leishmania infantum 97% 100%
D0A0V3 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 91%
E9ASA3 Leishmania mexicana (strain MHOM/GT/2001/U1103) 96% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS