LeishMANIAdb
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TPT domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
TPT domain-containing protein
Gene product:
Triose-phosphate Transporter family, putative
Species:
Leishmania major
UniProt:
Q4QD58_LEIMA
TriTrypDb:
LmjF.19.1510 , LMJLV39_190021500 , LMJSD75_190021200
Length:
321

Annotations

LeishMANIAdb annotations

Related to plant and animal nucleoside-sugar transporters, often localized to the Golgi apparatus.. An expanded family in kinetoplastids, possibly to cover the need for expanded proteoglycan biosynthesis. Localization: Golgi (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005794 Golgi apparatus 5 2
GO:0016020 membrane 2 12
GO:0043226 organelle 2 2
GO:0043227 membrane-bounded organelle 3 2
GO:0043229 intracellular organelle 3 2
GO:0043231 intracellular membrane-bounded organelle 4 2
GO:0110165 cellular anatomical entity 1 12

Expansion

Sequence features

Q4QD58
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD58

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 2
GO:0005338 nucleotide-sugar transmembrane transporter activity 4 2
GO:0015291 secondary active transmembrane transporter activity 4 2
GO:0015297 antiporter activity 5 2
GO:0015932 nucleobase-containing compound transmembrane transporter activity 3 2
GO:0022804 active transmembrane transporter activity 3 2
GO:0022857 transmembrane transporter activity 2 2
GO:1901505 carbohydrate derivative transmembrane transporter activity 3 2

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_PCSK_KEX2_1 65 67 PF00082 0.226
CLV_PCSK_PC1ET2_1 65 67 PF00082 0.224
CLV_PCSK_SKI1_1 102 106 PF00082 0.249
CLV_PCSK_SKI1_1 27 31 PF00082 0.413
CLV_PCSK_SKI1_1 271 275 PF00082 0.314
CLV_PCSK_SKI1_1 7 11 PF00082 0.263
DEG_APCC_DBOX_1 270 278 PF00400 0.393
DEG_MDM2_SWIB_1 281 289 PF02201 0.298
DOC_CKS1_1 104 109 PF01111 0.249
DOC_CKS1_1 208 213 PF01111 0.305
DOC_CYCLIN_yCln2_LP_2 104 110 PF00134 0.249
DOC_MAPK_gen_1 124 131 PF00069 0.269
DOC_MAPK_gen_1 65 72 PF00069 0.429
DOC_MAPK_MEF2A_6 102 111 PF00069 0.279
DOC_MAPK_MEF2A_6 124 131 PF00069 0.298
DOC_MAPK_MEF2A_6 252 261 PF00069 0.249
DOC_MAPK_MEF2A_6 271 280 PF00069 0.267
DOC_MAPK_MEF2A_6 65 72 PF00069 0.440
DOC_MAPK_MEF2A_6 7 14 PF00069 0.434
DOC_MAPK_NFAT4_5 124 132 PF00069 0.263
DOC_MAPK_NFAT4_5 7 15 PF00069 0.434
DOC_PP1_RVXF_1 25 31 PF00149 0.237
DOC_PP2B_PxIxI_1 213 219 PF00149 0.219
DOC_USP7_MATH_1 16 20 PF00917 0.261
DOC_WW_Pin1_4 103 108 PF00397 0.249
DOC_WW_Pin1_4 207 212 PF00397 0.305
DOC_WW_Pin1_4 238 243 PF00397 0.438
LIG_14-3-3_CanoR_1 32 38 PF00244 0.292
LIG_BIR_II_1 1 5 PF00653 0.602
LIG_BRCT_BRCA1_1 93 97 PF00533 0.238
LIG_FHA_1 104 110 PF00498 0.248
LIG_FHA_1 155 161 PF00498 0.299
LIG_FHA_1 213 219 PF00498 0.233
LIG_FHA_1 23 29 PF00498 0.316
LIG_FHA_1 238 244 PF00498 0.422
LIG_FHA_1 48 54 PF00498 0.324
LIG_FHA_2 138 144 PF00498 0.249
LIG_LIR_Gen_1 178 188 PF02991 0.425
LIG_LIR_Gen_1 232 242 PF02991 0.255
LIG_LIR_Gen_1 244 253 PF02991 0.249
LIG_LIR_Gen_1 89 100 PF02991 0.264
LIG_LIR_LC3C_4 106 111 PF02991 0.342
LIG_LIR_Nem_3 178 183 PF02991 0.425
LIG_LIR_Nem_3 210 216 PF02991 0.301
LIG_LIR_Nem_3 232 237 PF02991 0.292
LIG_LIR_Nem_3 244 248 PF02991 0.319
LIG_LIR_Nem_3 279 284 PF02991 0.467
LIG_LIR_Nem_3 36 40 PF02991 0.257
LIG_LIR_Nem_3 89 95 PF02991 0.327
LIG_NRBOX 154 160 PF00104 0.323
LIG_Pex14_2 281 285 PF04695 0.298
LIG_PTB_Apo_2 203 210 PF02174 0.234
LIG_PTB_Phospho_1 203 209 PF10480 0.234
LIG_SH2_CRK 245 249 PF00017 0.249
LIG_SH2_CRK 37 41 PF00017 0.280
LIG_SH2_CRK 92 96 PF00017 0.216
LIG_SH2_GRB2like 24 27 PF00017 0.393
LIG_SH2_NCK_1 184 188 PF00017 0.319
LIG_SH2_NCK_1 92 96 PF00017 0.224
LIG_SH2_STAP1 24 28 PF00017 0.373
LIG_SH2_STAT5 11 14 PF00017 0.328
LIG_SH2_STAT5 199 202 PF00017 0.278
LIG_SH2_STAT5 209 212 PF00017 0.237
LIG_SH2_STAT5 24 27 PF00017 0.365
LIG_SH2_STAT5 286 289 PF00017 0.293
LIG_SH3_1 208 214 PF00018 0.263
LIG_SH3_3 208 214 PF00018 0.316
LIG_SH3_3 58 64 PF00018 0.480
LIG_SUMO_SIM_anti_2 215 222 PF11976 0.314
LIG_SUMO_SIM_anti_2 39 45 PF11976 0.266
LIG_SUMO_SIM_par_1 108 114 PF11976 0.272
LIG_SUMO_SIM_par_1 151 157 PF11976 0.287
LIG_SUMO_SIM_par_1 215 222 PF11976 0.351
LIG_TYR_ITIM 243 248 PF00017 0.249
LIG_TYR_ITIM 9 14 PF00017 0.319
LIG_TYR_ITIM 90 95 PF00017 0.264
LIG_UBA3_1 233 239 PF00899 0.279
LIG_Vh1_VBS_1 148 166 PF01044 0.257
MOD_CK1_1 139 145 PF00069 0.372
MOD_CK1_1 241 247 PF00069 0.413
MOD_CK1_1 36 42 PF00069 0.234
MOD_GlcNHglycan 121 124 PF01048 0.234
MOD_GlcNHglycan 143 147 PF01048 0.461
MOD_GlcNHglycan 221 224 PF01048 0.308
MOD_GSK3_1 125 132 PF00069 0.268
MOD_GSK3_1 137 144 PF00069 0.186
MOD_GSK3_1 154 161 PF00069 0.230
MOD_GSK3_1 237 244 PF00069 0.433
MOD_N-GLC_1 229 234 PF02516 0.322
MOD_N-GLC_1 86 91 PF02516 0.249
MOD_NEK2_1 127 132 PF00069 0.334
MOD_NEK2_1 148 153 PF00069 0.301
MOD_NEK2_1 158 163 PF00069 0.252
MOD_NEK2_1 284 289 PF00069 0.297
MOD_NEK2_1 46 51 PF00069 0.276
MOD_Plk_1 229 235 PF00069 0.277
MOD_Plk_1 86 92 PF00069 0.249
MOD_Plk_4 111 117 PF00069 0.249
MOD_Plk_4 148 154 PF00069 0.264
MOD_Plk_4 212 218 PF00069 0.236
MOD_Plk_4 36 42 PF00069 0.217
MOD_Plk_4 86 92 PF00069 0.283
MOD_ProDKin_1 103 109 PF00069 0.249
MOD_ProDKin_1 207 213 PF00069 0.305
MOD_ProDKin_1 238 244 PF00069 0.438
MOD_SUMO_rev_2 315 321 PF00179 0.693
TRG_DiLeu_BaEn_3 297 303 PF01217 0.514
TRG_ENDOCYTIC_2 11 14 PF00928 0.283
TRG_ENDOCYTIC_2 245 248 PF00928 0.249
TRG_ENDOCYTIC_2 286 289 PF00928 0.249
TRG_ENDOCYTIC_2 37 40 PF00928 0.259
TRG_ENDOCYTIC_2 92 95 PF00928 0.216
TRG_ENDOCYTIC_2 98 101 PF00928 0.242

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P8N6 Leptomonas seymouri 71% 99%
A0A0N1PAW1 Leptomonas seymouri 36% 99%
A0A0S4IKV6 Bodo saltans 22% 91%
A0A0S4IKX4 Bodo saltans 63% 100%
A0A0S4JRZ1 Bodo saltans 58% 100%
A0A1X0P276 Trypanosomatidae 36% 100%
A0A1X0P5Z4 Trypanosomatidae 61% 100%
A0A3R7NGZ9 Trypanosoma rangeli 38% 100%
A0A3S7WVL9 Leishmania donovani 95% 100%
A0A3S7X3R1 Leishmania donovani 36% 99%
A0A422NUS0 Trypanosoma rangeli 58% 100%
A2AKQ0 Mus musculus 22% 90%
A2VE55 Bos taurus 22% 90%
A4HAA0 Leishmania braziliensis 79% 100%
A4HYI0 Leishmania infantum 95% 100%
A4I5U5 Leishmania infantum 36% 99%
A4IFK2 Bos taurus 45% 100%
A9UUB8 Monosiga brevicollis 22% 96%
C9ZR66 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 35% 100%
E9ASA4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 91% 100%
E9B140 Leishmania mexicana (strain MHOM/GT/2001/U1103) 34% 99%
F4IHS9 Arabidopsis thaliana 35% 94%
O94695 Schizosaccharomyces pombe (strain 972 / ATCC 24843) 22% 71%
P0C6B1 Rattus norvegicus 24% 78%
P0CK96 Homo sapiens 23% 79%
Q15B89 Sus scrofa 22% 94%
Q1JQ66 Danio rerio 46% 100%
Q3E6T0 Arabidopsis thaliana 24% 92%
Q4Q726 Leishmania major 35% 100%
Q550W6 Dictyostelium discoideum 24% 87%
Q5RDC9 Pongo abelii 22% 90%
Q5RKL7 Rattus norvegicus 25% 92%
Q5XF09 Arabidopsis thaliana 26% 100%
Q6DBP3 Arabidopsis thaliana 24% 100%
Q6ICL7 Homo sapiens 26% 92%
Q6PGC7 Mus musculus 43% 100%
Q76EJ3 Homo sapiens 23% 95%
Q7Z769 Homo sapiens 44% 100%
Q8C811 Mus musculus 22% 79%
Q8CD26 Mus musculus 24% 78%
Q8GUJ1 Arabidopsis thaliana 36% 91%
Q8H184 Arabidopsis thaliana 24% 78%
Q8RWW7 Arabidopsis thaliana 32% 95%
Q8RXL8 Arabidopsis thaliana 35% 90%
Q94B65 Arabidopsis thaliana 24% 99%
Q94EI9 Arabidopsis thaliana 23% 94%
Q96K37 Homo sapiens 22% 78%
Q9C521 Arabidopsis thaliana 27% 96%
Q9C8M1 Arabidopsis thaliana 22% 97%
Q9FDZ5 Arabidopsis thaliana 30% 96%
Q9FG70 Arabidopsis thaliana 26% 81%
Q9FIH5 Arabidopsis thaliana 32% 92%
Q9FYE5 Arabidopsis thaliana 24% 100%
Q9LDH3 Arabidopsis thaliana 26% 89%
Q9LFN3 Arabidopsis thaliana 22% 91%
Q9LPU2 Arabidopsis thaliana 32% 92%
Q9LRP2 Arabidopsis thaliana 24% 86%
Q9LU76 Arabidopsis thaliana 32% 82%
Q9NTN3 Homo sapiens 22% 90%
Q9SFE9 Arabidopsis thaliana 28% 94%
Q9SKJ7 Arabidopsis thaliana 22% 93%
Q9SRE4 Arabidopsis thaliana 32% 93%
Q9SS40 Arabidopsis thaliana 23% 90%
Q9SUV2 Arabidopsis thaliana 22% 92%
Q9SZ96 Arabidopsis thaliana 31% 96%
Q9VHT4 Drosophila melanogaster 24% 95%
V5BJU5 Trypanosoma cruzi 22% 83%
V5BMW3 Trypanosoma cruzi 40% 100%
V5D4Q6 Trypanosoma cruzi 58% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS