Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QD57_LEIMA

TriTrypDb:

LmjF.19.1520 , LMJLV39_190021600 , LMJSD75_190021300

Length:

785

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

Q4QD57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD57

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	19	23	PF00656	0.621
CLV_NRD_NRD_1	136	138	PF00675	0.626
CLV_NRD_NRD_1	190	192	PF00675	0.690
CLV_NRD_NRD_1	323	325	PF00675	0.571
CLV_NRD_NRD_1	358	360	PF00675	0.419
CLV_NRD_NRD_1	454	456	PF00675	0.434
CLV_NRD_NRD_1	617	619	PF00675	0.583
CLV_NRD_NRD_1	758	760	PF00675	0.545
CLV_PCSK_FUR_1	134	138	PF00082	0.711
CLV_PCSK_FUR_1	756	760	PF00082	0.666
CLV_PCSK_KEX2_1	136	138	PF00082	0.650
CLV_PCSK_KEX2_1	190	192	PF00082	0.648
CLV_PCSK_KEX2_1	322	324	PF00082	0.574
CLV_PCSK_KEX2_1	337	339	PF00082	0.362
CLV_PCSK_KEX2_1	454	456	PF00082	0.434
CLV_PCSK_KEX2_1	546	548	PF00082	0.497
CLV_PCSK_KEX2_1	707	709	PF00082	0.503
CLV_PCSK_KEX2_1	758	760	PF00082	0.546
CLV_PCSK_PC1ET2_1	337	339	PF00082	0.362
CLV_PCSK_PC1ET2_1	546	548	PF00082	0.497
CLV_PCSK_PC1ET2_1	707	709	PF00082	0.503
CLV_PCSK_SKI1_1	338	342	PF00082	0.527
CLV_PCSK_SKI1_1	513	517	PF00082	0.400
CLV_PCSK_SKI1_1	647	651	PF00082	0.484
CLV_PCSK_SKI1_1	747	751	PF00082	0.495
DEG_SCF_FBW7_1	401	408	PF00400	0.588
DEG_SPOP_SBC_1	57	61	PF00917	0.603
DOC_CKS1_1	402	407	PF01111	0.589
DOC_CKS1_1	528	533	PF01111	0.461
DOC_MAPK_gen_1	196	205	PF00069	0.580
DOC_MAPK_gen_1	357	366	PF00069	0.394
DOC_MAPK_gen_1	451	459	PF00069	0.441
DOC_MAPK_gen_1	474	482	PF00069	0.467
DOC_MAPK_gen_1	546	552	PF00069	0.397
DOC_MAPK_gen_1	618	628	PF00069	0.559
DOC_MAPK_gen_1	645	653	PF00069	0.484
DOC_MAPK_gen_1	707	713	PF00069	0.505
DOC_MAPK_MEF2A_6	454	461	PF00069	0.464
DOC_MAPK_MEF2A_6	488	495	PF00069	0.426
DOC_MAPK_MEF2A_6	518	525	PF00069	0.401
DOC_MAPK_MEF2A_6	645	653	PF00069	0.484
DOC_MAPK_NFAT4_5	454	462	PF00069	0.430
DOC_PP1_RVXF_1	603	610	PF00149	0.392
DOC_PP4_FxxP_1	385	388	PF00568	0.529
DOC_PP4_FxxP_1	528	531	PF00568	0.409
DOC_PP4_FxxP_1	7	10	PF00568	0.572
DOC_USP7_MATH_1	142	146	PF00917	0.667
DOC_USP7_MATH_1	197	201	PF00917	0.700
DOC_USP7_MATH_1	236	240	PF00917	0.725
DOC_USP7_MATH_1	241	245	PF00917	0.714
DOC_USP7_MATH_1	3	7	PF00917	0.663
DOC_USP7_MATH_1	392	396	PF00917	0.562
DOC_USP7_MATH_1	405	409	PF00917	0.557
DOC_USP7_MATH_1	57	61	PF00917	0.665
DOC_USP7_MATH_1	63	67	PF00917	0.593
DOC_USP7_MATH_1	690	694	PF00917	0.594
DOC_USP7_MATH_1	76	80	PF00917	0.445
DOC_USP7_MATH_1	8	12	PF00917	0.665
DOC_USP7_UBL2_3	615	619	PF12436	0.526
DOC_WW_Pin1_4	279	284	PF00397	0.665
DOC_WW_Pin1_4	401	406	PF00397	0.764
DOC_WW_Pin1_4	527	532	PF00397	0.475
DOC_WW_Pin1_4	576	581	PF00397	0.432
DOC_WW_Pin1_4	585	590	PF00397	0.417
DOC_WW_Pin1_4	59	64	PF00397	0.586
DOC_WW_Pin1_4	6	11	PF00397	0.684
DOC_WW_Pin1_4	68	73	PF00397	0.596
DOC_WW_Pin1_4	719	724	PF00397	0.605
LIG_14-3-3_CanoR_1	148	156	PF00244	0.603
LIG_14-3-3_CanoR_1	240	247	PF00244	0.656
LIG_14-3-3_CanoR_1	33	37	PF00244	0.728
LIG_14-3-3_CanoR_1	578	587	PF00244	0.418
LIG_14-3-3_CanoR_1	677	681	PF00244	0.544
LIG_14-3-3_CanoR_1	731	741	PF00244	0.656
LIG_APCC_ABBAyCdc20_2	122	128	PF00400	0.533
LIG_BIR_II_1	1	5	PF00653	0.539
LIG_BRCT_BRCA1_1	142	146	PF00533	0.685
LIG_BRCT_BRCA1_1	93	97	PF00533	0.676
LIG_EH1_1	368	376	PF00400	0.385
LIG_FHA_1	346	352	PF00498	0.530
LIG_FHA_1	353	359	PF00498	0.478
LIG_FHA_1	40	46	PF00498	0.625
LIG_FHA_1	766	772	PF00498	0.704
LIG_FHA_1	91	97	PF00498	0.666
LIG_FHA_2	182	188	PF00498	0.525
LIG_FHA_2	402	408	PF00498	0.725
LIG_FHA_2	528	534	PF00498	0.435
LIG_FHA_2	725	731	PF00498	0.585
LIG_FHA_2	76	82	PF00498	0.553
LIG_Integrin_RGD_1	667	669	PF01839	0.543
LIG_LIR_Apic_2	5	10	PF02991	0.570
LIG_LIR_Apic_2	526	531	PF02991	0.410
LIG_LIR_Gen_1	143	154	PF02991	0.606
LIG_LIR_Gen_1	377	387	PF02991	0.435
LIG_LIR_Gen_1	563	573	PF02991	0.382
LIG_LIR_Gen_1	606	616	PF02991	0.486
LIG_LIR_Nem_3	123	129	PF02991	0.561
LIG_LIR_Nem_3	143	149	PF02991	0.616
LIG_LIR_Nem_3	314	319	PF02991	0.582
LIG_LIR_Nem_3	377	382	PF02991	0.391
LIG_LIR_Nem_3	533	538	PF02991	0.363
LIG_LIR_Nem_3	563	568	PF02991	0.400
LIG_LIR_Nem_3	606	612	PF02991	0.383
LIG_PTB_Apo_2	222	229	PF02174	0.577
LIG_SH2_GRB2like	319	322	PF00017	0.530
LIG_SH2_NCK_1	178	182	PF00017	0.643
LIG_SH2_NCK_1	565	569	PF00017	0.355
LIG_SH2_SRC	178	181	PF00017	0.643
LIG_SH2_SRC	565	568	PF00017	0.454
LIG_SH2_SRC	571	574	PF00017	0.356
LIG_SH2_STAP1	178	182	PF00017	0.643
LIG_SH2_STAP1	565	569	PF00017	0.420
LIG_SH2_STAT3	182	185	PF00017	0.643
LIG_SH2_STAT3	734	737	PF00017	0.528
LIG_SH2_STAT5	36	39	PF00017	0.597
LIG_SH2_STAT5	365	368	PF00017	0.404
LIG_SH2_STAT5	571	574	PF00017	0.395
LIG_SH2_STAT5	608	611	PF00017	0.398
LIG_SH2_STAT5	655	658	PF00017	0.494
LIG_SH2_STAT5	734	737	PF00017	0.673
LIG_SH3_3	223	229	PF00018	0.583
LIG_SH3_3	277	283	PF00018	0.661
LIG_SH3_3	395	401	PF00018	0.588
LIG_SH3_3	479	485	PF00018	0.503
LIG_SH3_3	581	587	PF00018	0.418
LIG_SH3_3	66	72	PF00018	0.599
LIG_SH3_3	667	673	PF00018	0.550
LIG_SH3_3	720	726	PF00018	0.620
LIG_TRAF2_1	184	187	PF00917	0.565
LIG_TRAF2_1	426	429	PF00917	0.531
LIG_TRAF2_1	72	75	PF00917	0.692
LIG_UBA3_1	541	546	PF00899	0.431
LIG_UBA3_1	652	658	PF00899	0.485
LIG_WW_3	119	123	PF00397	0.511
MOD_CDK_SPK_2	527	532	PF00069	0.416
MOD_CDK_SPK_2	576	581	PF00069	0.436
MOD_CK1_1	189	195	PF00069	0.597
MOD_CK1_1	239	245	PF00069	0.582
MOD_CK1_1	278	284	PF00069	0.648
MOD_CK1_1	39	45	PF00069	0.654
MOD_CK1_1	449	455	PF00069	0.507
MOD_CK1_1	579	585	PF00069	0.420
MOD_CK1_1	59	65	PF00069	0.680
MOD_CK1_1	6	12	PF00069	0.608
MOD_CK1_1	679	685	PF00069	0.539
MOD_CK1_1	688	694	PF00069	0.519
MOD_CK2_1	181	187	PF00069	0.519
MOD_CK2_1	239	245	PF00069	0.614
MOD_CK2_1	346	352	PF00069	0.643
MOD_CK2_1	401	407	PF00069	0.755
MOD_CK2_1	527	533	PF00069	0.416
MOD_CK2_1	68	74	PF00069	0.668
MOD_CK2_1	690	696	PF00069	0.552
MOD_CK2_1	75	81	PF00069	0.547
MOD_CK2_1	770	776	PF00069	0.680
MOD_Cter_Amidation	134	137	PF01082	0.621
MOD_Cter_Amidation	705	708	PF01082	0.509
MOD_GlcNHglycan	1	4	PF01048	0.651
MOD_GlcNHglycan	10	13	PF01048	0.694
MOD_GlcNHglycan	255	258	PF01048	0.690
MOD_GlcNHglycan	259	262	PF01048	0.645
MOD_GlcNHglycan	326	331	PF01048	0.562
MOD_GSK3_1	197	204	PF00069	0.664
MOD_GSK3_1	227	234	PF00069	0.704
MOD_GSK3_1	236	243	PF00069	0.648
MOD_GSK3_1	253	260	PF00069	0.561
MOD_GSK3_1	275	282	PF00069	0.707
MOD_GSK3_1	31	38	PF00069	0.668
MOD_GSK3_1	401	408	PF00069	0.746
MOD_GSK3_1	523	530	PF00069	0.410
MOD_GSK3_1	572	579	PF00069	0.391
MOD_GSK3_1	58	65	PF00069	0.667
MOD_GSK3_1	6	13	PF00069	0.700
MOD_GSK3_1	676	683	PF00069	0.536
MOD_GSK3_1	770	777	PF00069	0.720
MOD_GSK3_1	92	99	PF00069	0.543
MOD_LATS_1	157	163	PF00433	0.559
MOD_LATS_1	238	244	PF00433	0.617
MOD_N-GLC_1	236	241	PF02516	0.578
MOD_N-GLC_1	409	414	PF02516	0.467
MOD_N-GLC_1	523	528	PF02516	0.357
MOD_N-GLC_1	629	634	PF02516	0.534
MOD_NEK2_1	129	134	PF00069	0.711
MOD_NEK2_1	676	681	PF00069	0.540
MOD_NEK2_1	732	737	PF00069	0.648
MOD_NEK2_2	92	97	PF00069	0.610
MOD_PIKK_1	129	135	PF00454	0.616
MOD_PIKK_1	181	187	PF00454	0.625
MOD_PIKK_1	189	195	PF00454	0.672
MOD_PIKK_1	409	415	PF00454	0.619
MOD_PIKK_1	446	452	PF00454	0.566
MOD_PIKK_1	724	730	PF00454	0.666
MOD_PKA_1	359	365	PF00069	0.404
MOD_PKA_2	189	195	PF00069	0.768
MOD_PKA_2	239	245	PF00069	0.614
MOD_PKA_2	275	281	PF00069	0.684
MOD_PKA_2	300	306	PF00069	0.724
MOD_PKA_2	32	38	PF00069	0.683
MOD_PKA_2	676	682	PF00069	0.542
MOD_Plk_1	326	332	PF00069	0.577
MOD_Plk_1	774	780	PF00069	0.572
MOD_Plk_4	159	165	PF00069	0.710
MOD_Plk_4	275	281	PF00069	0.660
MOD_Plk_4	359	365	PF00069	0.404
MOD_Plk_4	537	543	PF00069	0.401
MOD_Plk_4	92	98	PF00069	0.524
MOD_ProDKin_1	279	285	PF00069	0.663
MOD_ProDKin_1	401	407	PF00069	0.766
MOD_ProDKin_1	527	533	PF00069	0.476
MOD_ProDKin_1	576	582	PF00069	0.438
MOD_ProDKin_1	585	591	PF00069	0.418
MOD_ProDKin_1	59	65	PF00069	0.587
MOD_ProDKin_1	6	12	PF00069	0.684
MOD_ProDKin_1	68	74	PF00069	0.595
MOD_ProDKin_1	719	725	PF00069	0.599
MOD_SUMO_for_1	336	339	PF00179	0.339
MOD_SUMO_for_1	626	629	PF00179	0.565
MOD_SUMO_rev_2	742	749	PF00179	0.476
TRG_ENDOCYTIC_2	126	129	PF00928	0.565
TRG_ENDOCYTIC_2	565	568	PF00928	0.384
TRG_ER_diArg_1	134	137	PF00400	0.669
TRG_ER_diArg_1	322	324	PF00400	0.443
TRG_ER_diArg_1	380	383	PF00400	0.402
TRG_ER_diArg_1	454	456	PF00400	0.433
TRG_ER_diArg_1	756	759	PF00400	0.676
TRG_NES_CRM1_1	467	478	PF08389	0.453
TRG_NES_CRM1_1	742	754	PF08389	0.544
TRG_NLS_MonoExtN_4	615	622	PF00514	0.473
TRG_Pf-PMV_PEXEL_1	14	19	PF00026	0.697
TRG_Pf-PMV_PEXEL_1	599	604	PF00026	0.395

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8A9	Leptomonas seymouri	69%	85%
A0A0S4JN96	Bodo saltans	46%	100%
A0A1X0P5Z6	Trypanosomatidae	54%	100%
A0A3Q8IBG1	Leishmania donovani	96%	100%
A0A3S5IRX2	Trypanosoma rangeli	51%	100%
A4HAA1	Leishmania braziliensis	85%	90%
A4HYI2	Leishmania infantum	96%	100%
D0A0V4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	53%	98%
E9ASA5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5B4C3	Trypanosoma cruzi	51%	87%