Peptidylprolyl isomerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

FK506-binding protein (FKBP)-type peptidyl-prolyl isomerase, putative

Species:

Leishmania major

UniProt:

Q4QD56_LEIMA

TriTrypDb:

LmjF.19.1530 , LMJLV39_190021700 , LMJSD75_190021400

Length:

432

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 12

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	yes	yes: 5

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 5

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	3
GO:0016020	membrane	2	1

Expansion

Sequence features

Q4QD56

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD56

Function

Biological processes
Term	Name	Level	Count
GO:0000413	protein peptidyl-prolyl isomerization	7	2
GO:0006457	protein folding	2	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0018193	peptidyl-amino acid modification	5	2
GO:0018208	peptidyl-proline modification	6	2
GO:0019538	protein metabolic process	3	2
GO:0036211	protein modification process	4	2
GO:0043170	macromolecule metabolic process	3	2
GO:0043412	macromolecule modification	4	2
GO:0044238	primary metabolic process	2	2
GO:0061077	chaperone-mediated protein folding	3	2
GO:0071704	organic substance metabolic process	2	2
GO:1901564	organonitrogen compound metabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003755	peptidyl-prolyl cis-trans isomerase activity	3	12
GO:0003824	catalytic activity	1	12
GO:0016853	isomerase activity	2	12
GO:0016859	cis-trans isomerase activity	3	12
GO:0140096	catalytic activity, acting on a protein	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	292	296	PF00656	0.578
CLV_C14_Caspase3-7	66	70	PF00656	0.447
CLV_NRD_NRD_1	225	227	PF00675	0.398
CLV_NRD_NRD_1	288	290	PF00675	0.397
CLV_NRD_NRD_1	310	312	PF00675	0.379
CLV_NRD_NRD_1	358	360	PF00675	0.476
CLV_PCSK_KEX2_1	227	229	PF00082	0.450
CLV_PCSK_KEX2_1	288	290	PF00082	0.411
CLV_PCSK_KEX2_1	310	312	PF00082	0.359
CLV_PCSK_PC1ET2_1	227	229	PF00082	0.450
CLV_PCSK_PC1ET2_1	288	290	PF00082	0.539
CLV_PCSK_SKI1_1	108	112	PF00082	0.364
CLV_PCSK_SKI1_1	359	363	PF00082	0.476
CLV_PCSK_SKI1_1	370	374	PF00082	0.319
CLV_PCSK_SKI1_1	42	46	PF00082	0.399
CLV_PCSK_SKI1_1	424	428	PF00082	0.557
CLV_PCSK_SKI1_1	55	59	PF00082	0.326
DEG_SPOP_SBC_1	5	9	PF00917	0.632
DOC_MAPK_gen_1	153	161	PF00069	0.547
DOC_MAPK_gen_1	307	315	PF00069	0.348
DOC_PP4_FxxP_1	247	250	PF00568	0.465
DOC_USP7_MATH_1	248	252	PF00917	0.529
DOC_USP7_MATH_1	5	9	PF00917	0.659
DOC_USP7_UBL2_3	108	112	PF12436	0.187
DOC_USP7_UBL2_3	424	428	PF12436	0.495
DOC_USP7_UBL2_3	94	98	PF12436	0.334
DOC_WW_Pin1_4	111	116	PF00397	0.380
DOC_WW_Pin1_4	121	126	PF00397	0.311
DOC_WW_Pin1_4	194	199	PF00397	0.605
LIG_14-3-3_CanoR_1	348	357	PF00244	0.386
LIG_14-3-3_CanoR_1	359	365	PF00244	0.458
LIG_Actin_WH2_2	96	114	PF00022	0.345
LIG_APCC_ABBA_1	214	219	PF00400	0.367
LIG_BIR_II_1	1	5	PF00653	0.683
LIG_BIR_III_2	242	246	PF00653	0.576
LIG_BRCT_BRCA1_1	353	357	PF00533	0.455
LIG_Clathr_ClatBox_1	135	139	PF01394	0.345
LIG_EH1_1	61	69	PF00400	0.379
LIG_FHA_1	142	148	PF00498	0.453
LIG_FHA_1	176	182	PF00498	0.418
LIG_FHA_1	259	265	PF00498	0.399
LIG_FHA_1	367	373	PF00498	0.455
LIG_FHA_1	41	47	PF00498	0.419
LIG_FHA_2	199	205	PF00498	0.537
LIG_FHA_2	64	70	PF00498	0.402
LIG_Integrin_RGD_1	79	81	PF01839	0.455
LIG_LIR_Apic_2	167	171	PF02991	0.459
LIG_LIR_Apic_2	246	250	PF02991	0.479
LIG_LIR_Nem_3	194	199	PF02991	0.649
LIG_LIR_Nem_3	203	208	PF02991	0.557
LIG_Pex14_2	427	431	PF04695	0.590
LIG_PTB_Apo_2	167	174	PF02174	0.551
LIG_SH2_CRK	196	200	PF00017	0.618
LIG_SH2_CRK	41	45	PF00017	0.435
LIG_SH2_GRB2like	168	171	PF00017	0.486
LIG_SH2_NCK_1	168	172	PF00017	0.449
LIG_SH2_SRC	117	120	PF00017	0.455
LIG_SH2_SRC	168	171	PF00017	0.486
LIG_SH2_STAP1	351	355	PF00017	0.469
LIG_SH2_STAT5	184	187	PF00017	0.456
LIG_SH2_STAT5	196	199	PF00017	0.555
LIG_SH2_STAT5	262	265	PF00017	0.390
LIG_SH2_STAT5	351	354	PF00017	0.340
LIG_SH2_STAT5	63	66	PF00017	0.372
LIG_SH3_3	123	129	PF00018	0.311
LIG_SH3_3	20	26	PF00018	0.549
LIG_SH3_3	28	34	PF00018	0.503
LIG_SUMO_SIM_par_1	261	268	PF11976	0.421
LIG_SUMO_SIM_par_1	360	366	PF11976	0.382
LIG_SUMO_SIM_par_1	394	399	PF11976	0.376
LIG_SUMO_SIM_par_1	42	47	PF11976	0.463
LIG_UBA3_1	158	163	PF00899	0.526
LIG_UBA3_1	372	377	PF00899	0.455
MOD_CDK_SPxK_1	194	200	PF00069	0.601
MOD_CK1_1	124	130	PF00069	0.404
MOD_CK1_1	175	181	PF00069	0.491
MOD_CK1_1	267	273	PF00069	0.594
MOD_CK1_1	363	369	PF00069	0.334
MOD_CK1_1	8	14	PF00069	0.646
MOD_CK2_1	248	254	PF00069	0.498
MOD_GlcNHglycan	148	152	PF01048	0.457
MOD_GlcNHglycan	229	232	PF01048	0.506
MOD_GlcNHglycan	251	254	PF01048	0.466
MOD_GlcNHglycan	291	294	PF01048	0.550
MOD_GlcNHglycan	353	356	PF01048	0.379
MOD_GlcNHglycan	8	11	PF01048	0.743
MOD_GSK3_1	153	160	PF00069	0.493
MOD_GSK3_1	194	201	PF00069	0.624
MOD_GSK3_1	267	274	PF00069	0.484
MOD_GSK3_1	351	358	PF00069	0.415
MOD_GSK3_1	4	11	PF00069	0.681
MOD_GSK3_1	68	75	PF00069	0.320
MOD_GSK3_1	98	105	PF00069	0.291
MOD_N-GLC_1	130	135	PF02516	0.351
MOD_N-GLC_1	366	371	PF02516	0.311
MOD_NEK2_1	157	162	PF00069	0.579
MOD_NEK2_1	173	178	PF00069	0.343
MOD_NEK2_1	322	327	PF00069	0.449
MOD_NEK2_1	40	45	PF00069	0.386
MOD_NEK2_1	68	73	PF00069	0.404
MOD_NEK2_1	83	88	PF00069	0.226
MOD_NEK2_2	57	62	PF00069	0.394
MOD_NEK2_2	99	104	PF00069	0.345
MOD_PIKK_1	14	20	PF00454	0.593
MOD_PIKK_1	48	54	PF00454	0.484
MOD_PKA_1	227	233	PF00069	0.484
MOD_PKA_1	289	295	PF00069	0.465
MOD_PKA_2	227	233	PF00069	0.429
MOD_Plk_1	130	136	PF00069	0.351
MOD_Plk_1	153	159	PF00069	0.393
MOD_Plk_1	173	179	PF00069	0.388
MOD_Plk_1	258	264	PF00069	0.434
MOD_Plk_1	267	273	PF00069	0.385
MOD_Plk_1	322	328	PF00069	0.564
MOD_Plk_1	83	89	PF00069	0.335
MOD_Plk_2-3	415	421	PF00069	0.363
MOD_Plk_2-3	69	75	PF00069	0.243
MOD_Plk_4	130	136	PF00069	0.326
MOD_Plk_4	153	159	PF00069	0.397
MOD_Plk_4	258	264	PF00069	0.377
MOD_Plk_4	40	46	PF00069	0.392
MOD_Plk_4	422	428	PF00069	0.610
MOD_Plk_4	63	69	PF00069	0.447
MOD_ProDKin_1	111	117	PF00069	0.380
MOD_ProDKin_1	121	127	PF00069	0.311
MOD_ProDKin_1	194	200	PF00069	0.598
MOD_SUMO_for_1	326	329	PF00179	0.596
MOD_SUMO_rev_2	203	208	PF00179	0.525
TRG_ENDOCYTIC_2	196	199	PF00928	0.475
TRG_ENDOCYTIC_2	41	44	PF00928	0.429
TRG_ER_diArg_1	225	228	PF00400	0.447
TRG_ER_diArg_1	309	311	PF00400	0.359
TRG_ER_diArg_1	332	335	PF00400	0.523
TRG_ER_diLys_1	428	432	PF00400	0.555

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDU7	Leptomonas seymouri	74%	100%
A0A0S4IT01	Bodo saltans	45%	100%
A0A1X0P656	Trypanosomatidae	51%	100%
A0A3R7L7K6	Trypanosoma rangeli	55%	100%
A0A3S7WVP4	Leishmania donovani	96%	100%
A4HAA2	Leishmania braziliensis	87%	100%
A4HYI1	Leishmania infantum	96%	100%
D0A0V5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	52%	100%
E9ASA6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
P27124	Oryctolagus cuniculus	33%	94%
P30416	Mus musculus	34%	94%
Q02790	Homo sapiens	32%	94%
Q13451	Homo sapiens	31%	95%
Q38931	Arabidopsis thaliana	29%	78%
Q43207	Triticum aestivum	30%	77%
Q5RF88	Pongo abelii	31%	95%
Q64378	Mus musculus	31%	95%
Q7DMA9	Arabidopsis thaliana	25%	68%
Q95L05	Chlorocebus aethiops	31%	95%
Q9FJL3	Arabidopsis thaliana	29%	75%
Q9QVC8	Rattus norvegicus	33%	94%
Q9TRY0	Bos taurus	33%	94%
Q9VL78	Drosophila melanogaster	31%	98%
Q9XSH5	Saimiri boliviensis boliviensis	31%	95%
Q9XSI2	Saguinus oedipus	31%	95%
Q9XT11	Aotus nancymaae	31%	95%
V5AP12	Trypanosoma cruzi	50%	90%