Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania major

UniProt:

Q4QD54_LEIMA

TriTrypDb:

LmjF.19.1550 , LMJLV39_190022200 , LMJSD75_190021700

Length:

401

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005840	ribosome	5	10
GO:0032991	protein-containing complex	1	10
GO:0043226	organelle	2	10
GO:0043228	non-membrane-bounded organelle	3	10
GO:0043229	intracellular organelle	3	10
GO:0043232	intracellular non-membrane-bounded organelle	4	10
GO:0110165	cellular anatomical entity	1	10
GO:1990904	ribonucleoprotein complex	2	10

Expansion

Sequence features

Q4QD54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD54

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0032182	ubiquitin-like protein binding	3	2
GO:0043130	ubiquitin binding	4	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	339	343	PF00656	0.575
CLV_MEL_PAP_1	297	303	PF00089	0.409
CLV_PCSK_KEX2_1	14	16	PF00082	0.608
CLV_PCSK_PC1ET2_1	14	16	PF00082	0.603
CLV_PCSK_SKI1_1	27	31	PF00082	0.440
CLV_PCSK_SKI1_1	316	320	PF00082	0.385
CLV_PCSK_SKI1_1	338	342	PF00082	0.502
CLV_PCSK_SKI1_1	390	394	PF00082	0.367
DEG_Nend_Nbox_1	1	3	PF02207	0.739
DOC_CYCLIN_RxL_1	24	32	PF00134	0.439
DOC_MAPK_gen_1	207	216	PF00069	0.476
DOC_MAPK_gen_1	242	252	PF00069	0.559
DOC_MAPK_gen_1	374	381	PF00069	0.464
DOC_MAPK_MEF2A_6	191	200	PF00069	0.475
DOC_PP2B_LxvP_1	152	155	PF13499	0.538
DOC_PP4_FxxP_1	261	264	PF00568	0.408
DOC_USP7_MATH_1	157	161	PF00917	0.507
DOC_USP7_MATH_1	177	181	PF00917	0.563
DOC_USP7_MATH_1	196	200	PF00917	0.361
DOC_USP7_MATH_1	3	7	PF00917	0.574
DOC_WW_Pin1_4	132	137	PF00397	0.636
LIG_14-3-3_CanoR_1	215	221	PF00244	0.444
LIG_14-3-3_CanoR_1	300	307	PF00244	0.447
LIG_Actin_WH2_2	343	360	PF00022	0.524
LIG_ActinCP_TwfCPI_2	261	270	PF01115	0.462
LIG_deltaCOP1_diTrp_1	35	45	PF00928	0.424
LIG_FHA_1	211	217	PF00498	0.483
LIG_FHA_1	326	332	PF00498	0.486
LIG_FHA_1	69	75	PF00498	0.563
LIG_FHA_2	30	36	PF00498	0.372
LIG_FHA_2	337	343	PF00498	0.534
LIG_HP1_1	196	200	PF01393	0.466
LIG_LIR_Apic_2	258	264	PF02991	0.402
LIG_LIR_Gen_1	28	39	PF02991	0.447
LIG_LIR_Gen_1	42	52	PF02991	0.364
LIG_LIR_Nem_3	28	34	PF02991	0.444
LIG_LIR_Nem_3	42	48	PF02991	0.341
LIG_Pex14_2	34	38	PF04695	0.358
LIG_PTAP_UEV_1	136	141	PF05743	0.458
LIG_SH2_CRK	170	174	PF00017	0.575
LIG_SH2_CRK	332	336	PF00017	0.424
LIG_SH2_GRB2like	231	234	PF00017	0.400
LIG_SH2_SRC	231	234	PF00017	0.400
LIG_SH2_SRC	294	297	PF00017	0.407
LIG_SH2_STAT5	296	299	PF00017	0.417
LIG_SH2_STAT5	31	34	PF00017	0.390
LIG_SH3_2	202	207	PF14604	0.572
LIG_SH3_3	134	140	PF00018	0.703
LIG_SH3_3	199	205	PF00018	0.475
LIG_SH3_3	261	267	PF00018	0.497
LIG_SH3_3	71	77	PF00018	0.580
LIG_TRAF2_1	353	356	PF00917	0.458
LIG_TYR_ITIM	292	297	PF00017	0.413
LIG_UBA3_1	238	245	PF00899	0.447
MOD_CK1_1	103	109	PF00069	0.442
MOD_CK1_1	144	150	PF00069	0.579
MOD_CK1_1	302	308	PF00069	0.408
MOD_CK1_1	4	10	PF00069	0.663
MOD_CK1_1	90	96	PF00069	0.621
MOD_CK2_1	271	277	PF00069	0.395
MOD_CK2_1	4	10	PF00069	0.642
MOD_GlcNHglycan	137	140	PF01048	0.596
MOD_GlcNHglycan	170	173	PF01048	0.330
MOD_GlcNHglycan	3	6	PF01048	0.770
MOD_GlcNHglycan	320	323	PF01048	0.383
MOD_GlcNHglycan	7	10	PF01048	0.697
MOD_GlcNHglycan	93	96	PF01048	0.663
MOD_GlcNHglycan	97	100	PF01048	0.670
MOD_GSK3_1	1	8	PF00069	0.764
MOD_GSK3_1	127	134	PF00069	0.603
MOD_GSK3_1	177	184	PF00069	0.606
MOD_GSK3_1	25	32	PF00069	0.478
MOD_GSK3_1	302	309	PF00069	0.429
MOD_GSK3_1	381	388	PF00069	0.374
MOD_GSK3_1	87	94	PF00069	0.550
MOD_GSK3_1	95	102	PF00069	0.653
MOD_N-GLC_1	100	105	PF02516	0.448
MOD_N-GLC_1	108	113	PF02516	0.515
MOD_N-GLC_1	372	377	PF02516	0.481
MOD_N-GLC_1	87	92	PF02516	0.555
MOD_NEK2_1	1	6	PF00069	0.772
MOD_NEK2_1	120	125	PF00069	0.499
MOD_NEK2_1	127	132	PF00069	0.509
MOD_NEK2_1	271	276	PF00069	0.374
MOD_NEK2_1	29	34	PF00069	0.420
MOD_NEK2_1	385	390	PF00069	0.366
MOD_NEK2_1	392	397	PF00069	0.371
MOD_NEK2_1	91	96	PF00069	0.726
MOD_NEK2_2	336	341	PF00069	0.505
MOD_NEK2_2	56	61	PF00069	0.437
MOD_PIKK_1	240	246	PF00454	0.502
MOD_PK_1	181	187	PF00069	0.594
MOD_PKA_1	14	20	PF00069	0.536
MOD_PKA_2	14	20	PF00069	0.548
MOD_PKA_2	168	174	PF00069	0.594
MOD_PKA_2	190	196	PF00069	0.529
MOD_PKA_2	299	305	PF00069	0.412
MOD_Plk_1	100	106	PF00069	0.448
MOD_Plk_1	108	114	PF00069	0.398
MOD_Plk_1	127	133	PF00069	0.550
MOD_Plk_1	325	331	PF00069	0.371
MOD_Plk_1	336	342	PF00069	0.446
MOD_Plk_1	385	391	PF00069	0.373
MOD_Plk_1	87	93	PF00069	0.591
MOD_Plk_4	147	153	PF00069	0.521
MOD_Plk_4	157	163	PF00069	0.479
MOD_Plk_4	25	31	PF00069	0.488
MOD_Plk_4	302	308	PF00069	0.395
MOD_Plk_4	56	62	PF00069	0.459
MOD_ProDKin_1	132	138	PF00069	0.642
MOD_SUMO_rev_2	232	239	PF00179	0.397
TRG_ENDOCYTIC_2	294	297	PF00928	0.407
TRG_ENDOCYTIC_2	31	34	PF00928	0.390
TRG_Pf-PMV_PEXEL_1	245	249	PF00026	0.457
TRG_Pf-PMV_PEXEL_1	310	314	PF00026	0.393
TRG_Pf-PMV_PEXEL_1	338	342	PF00026	0.427

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PF14	Leptomonas seymouri	82%	100%
A0A0S4IXZ3	Bodo saltans	65%	100%
A0A1X0P6T7	Trypanosomatidae	67%	100%
A0A3R7NXE0	Trypanosoma rangeli	67%	100%
A0A3S7WVM1	Leishmania donovani	97%	100%
A4HAA4	Leishmania braziliensis	91%	100%
A4HYI4	Leishmania infantum	96%	100%
A4QNE6	Xenopus tropicalis	43%	100%
A8J3F6	Chlamydomonas reinhardtii	45%	100%
D0A0V7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	69%	100%
E9ASA8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
Q29RZ9	Bos taurus	44%	100%
Q54E33	Dictyostelium discoideum	20%	100%
Q561Y0	Danio rerio	42%	100%
Q5M7F6	Xenopus laevis	44%	100%
Q8BGF3	Mus musculus	45%	100%
Q96MX6	Homo sapiens	44%	100%
V5B8V8	Trypanosoma cruzi	69%	100%