Inosine-5'-monophosphate dehydrogenase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inosine-5'-monophosphate dehydrogenase

Species:

Leishmania major

UniProt:

Q4QD53_LEIMA

TriTrypDb:

LmjF.19.1560 , LMJLV39_190022300 , LMJSD75_190021800

Length:

514

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Show entries

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12

Previous1Next

Expansion

Sequence features

Q4QD53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD53

Function

Show entries

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006163	purine nucleotide metabolic process	5	12
GO:0006164	purine nucleotide biosynthetic process	6	12
GO:0006177	GMP biosynthetic process	8	12
GO:0006183	GTP biosynthetic process	8	2
GO:0006725	cellular aromatic compound metabolic process	3	12
GO:0006753	nucleoside phosphate metabolic process	4	12
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	12

Previous1 2 3 4 5 6 7Next

Show entries

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0003938	IMP dehydrogenase activity	5	12
GO:0005488	binding	1	12
GO:0016491	oxidoreductase activity	2	12
GO:0016614	oxidoreductase activity, acting on CH-OH group of donors	3	12
GO:0016616	oxidoreductase activity, acting on the CH-OH group of donors, NAD or NADP as acceptor	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043169	cation binding	3	12

Previous1 2Next

Putative motif mimicry

Show entries


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	12	16	PF00656	0.425
CLV_C14_Caspase3-7	219	223	PF00656	0.449
CLV_NRD_NRD_1	177	179	PF00675	0.274
CLV_NRD_NRD_1	220	222	PF00675	0.249
CLV_NRD_NRD_1	254	256	PF00675	0.354
CLV_NRD_NRD_1	488	490	PF00675	0.278
CLV_PCSK_KEX2_1	177	179	PF00082	0.267
CLV_PCSK_KEX2_1	220	222	PF00082	0.247
CLV_PCSK_KEX2_1	253	255	PF00082	0.337
CLV_PCSK_KEX2_1	424	426	PF00082	0.249

Previous1 2 3 4 5…15Next

Homologs

Show entries


Protein	Taxonomy	Sequence identity	Coverage
A0A0B5L585	Penicillium brevicompactum	46%	94%
A0A0N0P602	Leptomonas seymouri	35%	100%
A0A0N1I2L9	Leptomonas seymouri	87%	100%
A0A0S4ISB5	Bodo saltans	73%	100%
A0A0S4KKC7	Bodo saltans	34%	94%
A0A1X0NTH3	Trypanosomatidae	36%	100%
A0A1X0P5Z8	Trypanosomatidae	77%	100%
A0A3Q8IBE3	Leishmania donovani	99%	100%
A0A3R7MPJ5	Trypanosoma rangeli	78%	100%
A0A3S7WUI0	Leishmania donovani	35%	100%

Previous1 2 3 4 5…12Next