ELMO domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ELMO/CED-12 family, putative

Species:

Leishmania major

UniProt:

Q4QD52_LEIMA

TriTrypDb:

LmjF.19.1570 , LMJLV39_190022400 , LMJSD75_190021900

Length:

248

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QD52

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD52

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	148	152	PF00082	0.360
CLV_PCSK_SKI1_1	181	185	PF00082	0.300
CLV_PCSK_SKI1_1	233	237	PF00082	0.407
CLV_PCSK_SKI1_1	71	75	PF00082	0.363
DEG_Nend_UBRbox_2	1	3	PF02207	0.431
DOC_CKS1_1	131	136	PF01111	0.341
DOC_CKS1_1	6	11	PF01111	0.368
DOC_MAPK_gen_1	212	220	PF00069	0.363
DOC_MAPK_MEF2A_6	181	190	PF00069	0.297
DOC_PP1_RVXF_1	231	237	PF00149	0.395
DOC_PP1_RVXF_1	69	75	PF00149	0.363
DOC_WW_Pin1_4	130	135	PF00397	0.283
DOC_WW_Pin1_4	28	33	PF00397	0.479
DOC_WW_Pin1_4	5	10	PF00397	0.480
LIG_14-3-3_CanoR_1	148	153	PF00244	0.363
LIG_14-3-3_CanoR_1	194	201	PF00244	0.297
LIG_14-3-3_CanoR_1	209	218	PF00244	0.385
LIG_14-3-3_CanoR_1	49	57	PF00244	0.345
LIG_BRCT_BRCA1_1	102	106	PF00533	0.376
LIG_deltaCOP1_diTrp_1	90	97	PF00928	0.269
LIG_eIF4E_1	6	12	PF01652	0.466
LIG_FHA_1	144	150	PF00498	0.355
LIG_FHA_1	190	196	PF00498	0.273
LIG_FHA_1	212	218	PF00498	0.390
LIG_FHA_1	6	12	PF00498	0.368
LIG_FHA_1	74	80	PF00498	0.331
LIG_FHA_2	227	233	PF00498	0.382
LIG_FHA_2	238	244	PF00498	0.280
LIG_LIR_Apic_2	4	9	PF02991	0.421
LIG_LIR_Apic_2	45	50	PF02991	0.304
LIG_LIR_Gen_1	126	136	PF02991	0.345
LIG_LIR_Gen_1	225	236	PF02991	0.337
LIG_LIR_Nem_3	126	131	PF02991	0.335
LIG_LIR_Nem_3	225	231	PF02991	0.340
LIG_LIR_Nem_3	23	27	PF02991	0.395
LIG_NRBOX	230	236	PF00104	0.399
LIG_PCNA_yPIPBox_3	215	228	PF02747	0.341
LIG_PDZ_Class_1	243	248	PF00595	0.418
LIG_Pex14_2	24	28	PF04695	0.351
LIG_SH2_CRK	47	51	PF00017	0.345
LIG_SH2_STAT3	7	10	PF00017	0.434
LIG_SH2_STAT5	119	122	PF00017	0.304
LIG_SH2_STAT5	199	202	PF00017	0.304
LIG_SH2_STAT5	228	231	PF00017	0.402
LIG_SH2_STAT5	27	30	PF00017	0.477
LIG_SH2_STAT5	7	10	PF00017	0.418
LIG_SH3_3	26	32	PF00018	0.427
LIG_SUMO_SIM_anti_2	58	63	PF11976	0.345
LIG_TRAF2_1	240	243	PF00917	0.334
MOD_CAAXbox	245	248	PF01239	0.433
MOD_CK1_1	165	171	PF00069	0.395
MOD_CK1_1	226	232	PF00069	0.285
MOD_CK2_1	168	174	PF00069	0.451
MOD_CK2_1	237	243	PF00069	0.406
MOD_GlcNHglycan	126	131	PF01048	0.320
MOD_GlcNHglycan	170	173	PF01048	0.352
MOD_GlcNHglycan	40	43	PF01048	0.430
MOD_GlcNHglycan	51	54	PF01048	0.391
MOD_GlcNHglycan	81	84	PF01048	0.375
MOD_GSK3_1	1	8	PF00069	0.543
MOD_GSK3_1	126	133	PF00069	0.302
MOD_GSK3_1	161	168	PF00069	0.328
MOD_GSK3_1	189	196	PF00069	0.372
MOD_GSK3_1	222	229	PF00069	0.409
MOD_GSK3_1	97	104	PF00069	0.363
MOD_N-GLC_1	143	148	PF02516	0.269
MOD_N-GLC_1	155	160	PF02516	0.303
MOD_NEK2_1	1	6	PF00069	0.510
MOD_NEK2_1	143	148	PF00069	0.304
MOD_NEK2_1	162	167	PF00069	0.374
MOD_NEK2_1	211	216	PF00069	0.381
MOD_NEK2_1	79	84	PF00069	0.471
MOD_PIKK_1	189	195	PF00454	0.273
MOD_PKA_2	193	199	PF00069	0.333
MOD_PKA_2	211	217	PF00069	0.376
MOD_Plk_1	1	7	PF00069	0.509
MOD_Plk_1	126	132	PF00069	0.379
MOD_Plk_1	143	149	PF00069	0.268
MOD_Plk_1	155	161	PF00069	0.303
MOD_Plk_1	22	28	PF00069	0.443
MOD_Plk_1	84	90	PF00069	0.200
MOD_Plk_4	148	154	PF00069	0.314
MOD_Plk_4	162	168	PF00069	0.418
MOD_Plk_4	223	229	PF00069	0.244
MOD_ProDKin_1	130	136	PF00069	0.283
MOD_ProDKin_1	28	34	PF00069	0.484
MOD_ProDKin_1	5	11	PF00069	0.473
TRG_DiLeu_BaEn_1	230	235	PF01217	0.415
TRG_DiLeu_BaEn_1	243	248	PF01217	0.305
TRG_DiLeu_BaEn_3	126	132	PF01217	0.200
TRG_DiLeu_BaLyEn_6	201	206	PF01217	0.363
TRG_DiLeu_LyEn_5	230	235	PF01217	0.398
TRG_ENDOCYTIC_2	208	211	PF00928	0.345
TRG_ENDOCYTIC_2	228	231	PF00928	0.179
TRG_Pf-PMV_PEXEL_1	181	185	PF00026	0.281
TRG_Pf-PMV_PEXEL_1	215	219	PF00026	0.394

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I9A9	Leptomonas seymouri	62%	66%
A0A0S4IWN1	Bodo saltans	34%	73%
A0A1X0P699	Trypanosomatidae	40%	85%
A0A3S7WVN6	Leishmania donovani	96%	100%
A4HAA6	Leishmania braziliensis	74%	78%
A4HYI6	Leishmania infantum	96%	100%
E9ASB0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	78%
Q08DZ3	Bos taurus	27%	85%
Q0IIE6	Bos taurus	23%	76%
Q3V1U8	Mus musculus	23%	76%
Q5NVD7	Pongo abelii	23%	76%
Q8BGF6	Mus musculus	28%	85%
Q8IZ81	Homo sapiens	29%	85%
Q8N336	Homo sapiens	22%	74%