Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QD51_LEIMA

TriTrypDb:

LmjF.19.1580 , LMJLV39_190022500 , LMJSD75_190022000

Length:

394

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QD51

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD51

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	268	272	PF00656	0.591
CLV_C14_Caspase3-7	281	285	PF00656	0.581
CLV_NRD_NRD_1	13	15	PF00675	0.534
CLV_NRD_NRD_1	235	237	PF00675	0.719
CLV_NRD_NRD_1	77	79	PF00675	0.559
CLV_NRD_NRD_1	86	88	PF00675	0.475
CLV_PCSK_KEX2_1	15	17	PF00082	0.516
CLV_PCSK_KEX2_1	2	4	PF00082	0.516
CLV_PCSK_KEX2_1	235	237	PF00082	0.719
CLV_PCSK_KEX2_1	77	79	PF00082	0.559
CLV_PCSK_KEX2_1	86	88	PF00082	0.475
CLV_PCSK_PC1ET2_1	15	17	PF00082	0.516
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.516
CLV_PCSK_SKI1_1	358	362	PF00082	0.635
CLV_PCSK_SKI1_1	365	369	PF00082	0.558
CLV_PCSK_SKI1_1	60	64	PF00082	0.541
DEG_APCC_DBOX_1	59	67	PF00400	0.541
DEG_Nend_UBRbox_1	1	4	PF02207	0.504
DOC_ANK_TNKS_1	279	286	PF00023	0.609
DOC_CYCLIN_yCln2_LP_2	248	254	PF00134	0.566
DOC_MAPK_gen_1	14	24	PF00069	0.508
DOC_MAPK_gen_1	232	240	PF00069	0.531
DOC_MAPK_gen_1	86	94	PF00069	0.535
DOC_PP2B_LxvP_1	200	203	PF13499	0.475
DOC_PP4_FxxP_1	317	320	PF00568	0.510
DOC_USP7_MATH_1	265	269	PF00917	0.556
DOC_USP7_MATH_1	343	347	PF00917	0.534
DOC_USP7_MATH_1	49	53	PF00917	0.538
DOC_WW_Pin1_4	219	224	PF00397	0.579
DOC_WW_Pin1_4	250	255	PF00397	0.566
DOC_WW_Pin1_4	335	340	PF00397	0.571
LIG_14-3-3_CanoR_1	16	25	PF00244	0.510
LIG_14-3-3_CanoR_1	342	352	PF00244	0.555
LIG_14-3-3_CanoR_1	365	370	PF00244	0.590
LIG_14-3-3_CanoR_1	372	382	PF00244	0.617
LIG_14-3-3_CanoR_1	86	90	PF00244	0.603
LIG_Actin_WH2_2	316	331	PF00022	0.550
LIG_BRCT_BRCA1_1	184	188	PF00533	0.527
LIG_Clathr_ClatBox_1	68	72	PF01394	0.597
LIG_FHA_1	17	23	PF00498	0.459
LIG_FHA_1	2	8	PF00498	0.515
LIG_FHA_1	210	216	PF00498	0.502
LIG_FHA_1	383	389	PF00498	0.591
LIG_FHA_2	375	381	PF00498	0.595
LIG_GBD_Chelix_1	241	249	PF00786	0.672
LIG_LIR_Gen_1	111	121	PF02991	0.529
LIG_LIR_Gen_1	212	221	PF02991	0.576
LIG_LIR_Gen_1	262	270	PF02991	0.563
LIG_LIR_Nem_3	111	117	PF02991	0.532
LIG_LIR_Nem_3	185	191	PF02991	0.524
LIG_LIR_Nem_3	212	216	PF02991	0.584
LIG_LIR_Nem_3	262	267	PF02991	0.567
LIG_LIR_Nem_3	88	92	PF02991	0.602
LIG_NRBOX	65	71	PF00104	0.592
LIG_SH3_3	125	131	PF00018	0.561
LIG_SH3_3	191	197	PF00018	0.532
LIG_SH3_3	248	254	PF00018	0.581
LIG_SH3_3	264	270	PF00018	0.565
LIG_SUMO_SIM_anti_2	168	174	PF11976	0.531
LIG_SUMO_SIM_anti_2	64	70	PF11976	0.527
LIG_SUMO_SIM_par_1	117	122	PF11976	0.712
LIG_SUMO_SIM_par_1	40	46	PF11976	0.586
LIG_SUMO_SIM_par_1	67	72	PF11976	0.595
LIG_TRAF2_1	279	282	PF00917	0.611
LIG_TRAF2_1	377	380	PF00917	0.649
LIG_UBA3_1	68	73	PF00899	0.492
MOD_CDC14_SPxK_1	222	225	PF00782	0.549
MOD_CDK_SPK_2	250	255	PF00069	0.511
MOD_CDK_SPxK_1	219	225	PF00069	0.544
MOD_CDK_SPxxK_3	335	342	PF00069	0.565
MOD_CK1_1	243	249	PF00069	0.499
MOD_CK1_1	253	259	PF00069	0.601
MOD_CK1_1	307	313	PF00069	0.620
MOD_CK1_1	338	344	PF00069	0.557
MOD_CK1_1	383	389	PF00069	0.589
MOD_CK2_1	244	250	PF00069	0.601
MOD_CK2_1	256	262	PF00069	0.478
MOD_CK2_1	295	301	PF00069	0.642
MOD_CK2_1	374	380	PF00069	0.557
MOD_CK2_1	49	55	PF00069	0.575
MOD_GlcNHglycan	184	187	PF01048	0.530
MOD_GlcNHglycan	242	245	PF01048	0.485
MOD_GlcNHglycan	297	300	PF01048	0.598
MOD_GlcNHglycan	382	385	PF01048	0.644
MOD_GSK3_1	211	218	PF00069	0.652
MOD_GSK3_1	240	247	PF00069	0.510
MOD_GSK3_1	284	291	PF00069	0.622
MOD_GSK3_1	295	302	PF00069	0.577
MOD_GSK3_1	370	377	PF00069	0.580
MOD_GSK3_1	378	385	PF00069	0.546
MOD_GSK3_1	72	79	PF00069	0.553
MOD_NEK2_1	1	6	PF00069	0.512
MOD_NEK2_1	119	124	PF00069	0.479
MOD_NEK2_1	240	245	PF00069	0.491
MOD_NEK2_1	324	329	PF00069	0.592
MOD_NEK2_1	382	387	PF00069	0.582
MOD_NEK2_2	49	54	PF00069	0.538
MOD_PK_1	18	24	PF00069	0.471
MOD_PKA_2	299	305	PF00069	0.543
MOD_PKA_2	76	82	PF00069	0.576
MOD_PKA_2	85	91	PF00069	0.528
MOD_PKA_2	97	103	PF00069	0.496
MOD_PKB_1	14	22	PF00069	0.510
MOD_Plk_1	256	262	PF00069	0.583
MOD_Plk_4	108	114	PF00069	0.596
MOD_Plk_4	119	125	PF00069	0.539
MOD_Plk_4	160	166	PF00069	0.606
MOD_Plk_4	195	201	PF00069	0.466
MOD_Plk_4	244	250	PF00069	0.530
MOD_Plk_4	64	70	PF00069	0.523
MOD_ProDKin_1	219	225	PF00069	0.577
MOD_ProDKin_1	250	256	PF00069	0.565
MOD_ProDKin_1	335	341	PF00069	0.568
TRG_DiLeu_BaEn_1	168	173	PF01217	0.529
TRG_DiLeu_BaEn_1	64	69	PF01217	0.589
TRG_DiLeu_BaLyEn_6	20	25	PF01217	0.517
TRG_ER_diArg_1	14	17	PF00400	0.517
TRG_ER_diArg_1	177	180	PF00400	0.578
TRG_ER_diArg_1	235	237	PF00400	0.712
TRG_ER_diArg_1	95	98	PF00400	0.544
TRG_NES_CRM1_1	350	364	PF08389	0.463
TRG_NLS_Bipartite_1	2	19	PF00514	0.538
TRG_NLS_MonoExtC_3	13	18	PF00514	0.487
TRG_NLS_MonoExtN_4	14	19	PF00514	0.507
TRG_Pf-PMV_PEXEL_1	30	34	PF00026	0.523
TRG_Pf-PMV_PEXEL_1	342	347	PF00026	0.579
TRG_PTS2	1	11	PF00400	0.486

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IB12	Leptomonas seymouri	33%	100%
A0A3S7WVS2	Leishmania donovani	92%	100%
A4HAA7	Leishmania braziliensis	72%	99%
A4HYI7	Leishmania infantum	92%	100%
E9ASB1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%