SRP19

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

SRP19

Gene product:

SRP19 protein, putative

Species:

Leishmania major

UniProt:

Q4QD49_LEIMA

TriTrypDb:

LmjF.19.1600 , LMJLV39_190022700 , LMJSD75_190022200

Length:

166

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005786	signal recognition particle, endoplasmic reticulum targeting	4	10
GO:0032991	protein-containing complex	1	10
GO:0048500	signal recognition particle	3	10
GO:1990904	ribonucleoprotein complex	2	10

Expansion

Sequence features

Q4QD49

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD49

Function

Biological processes
Term	Name	Level	Count
GO:0006617	SRP-dependent cotranslational protein targeting to membrane, signal sequence recognition	6	2
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	2
GO:0022607	cellular component assembly	4	2
GO:0043933	protein-containing complex organization	4	2
GO:0065003	protein-containing complex assembly	5	2
GO:0071840	cellular component organization or biogenesis	2	2
GO:0006605	protein targeting	5	8
GO:0006612	protein targeting to membrane	5	8
GO:0006613	cotranslational protein targeting to membrane	6	8
GO:0006614	SRP-dependent cotranslational protein targeting to membrane	7	8
GO:0006810	transport	3	8
GO:0006886	intracellular protein transport	4	8
GO:0008104	protein localization	4	8
GO:0015031	protein transport	4	8
GO:0033036	macromolecule localization	2	8
GO:0033365	protein localization to organelle	5	8
GO:0045047	protein targeting to ER	6	8
GO:0045184	establishment of protein localization	3	8
GO:0046907	intracellular transport	3	8
GO:0051179	localization	1	8
GO:0051234	establishment of localization	2	8
GO:0051641	cellular localization	2	8
GO:0051649	establishment of localization in cell	3	8
GO:0051668	localization within membrane	3	8
GO:0070727	cellular macromolecule localization	3	8
GO:0070972	protein localization to endoplasmic reticulum	6	8
GO:0071702	organic substance transport	4	8
GO:0071705	nitrogen compound transport	4	8
GO:0072594	establishment of protein localization to organelle	4	8
GO:0072599	establishment of protein localization to endoplasmic reticulum	5	8
GO:0072657	protein localization to membrane	4	8
GO:0090150	establishment of protein localization to membrane	4	8

Molecular functions
Term	Name	Level	Count
GO:0003676	nucleic acid binding	3	10
GO:0003723	RNA binding	4	10
GO:0005488	binding	1	10
GO:0008312	7S RNA binding	5	10
GO:0097159	organic cyclic compound binding	2	10
GO:1901363	heterocyclic compound binding	2	10

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	130	132	PF00675	0.212
CLV_NRD_NRD_1	39	41	PF00675	0.212
CLV_PCSK_KEX2_1	130	132	PF00082	0.212
CLV_PCSK_KEX2_1	39	41	PF00082	0.217
CLV_PCSK_SKI1_1	39	43	PF00082	0.245
CLV_Separin_Metazoa	127	131	PF03568	0.412
DEG_APCC_DBOX_1	142	150	PF00400	0.527
DEG_Nend_UBRbox_3	1	3	PF02207	0.577
DEG_SCF_FBW7_2	96	102	PF00400	0.459
DOC_CKS1_1	32	37	PF01111	0.466
DOC_CKS1_1	96	101	PF01111	0.459
DOC_MAPK_MEF2A_6	89	96	PF00069	0.412
DOC_USP7_MATH_1	71	75	PF00917	0.489
DOC_USP7_UBL2_3	93	97	PF12436	0.418
DOC_WW_Pin1_4	156	161	PF00397	0.612
DOC_WW_Pin1_4	31	36	PF00397	0.447
DOC_WW_Pin1_4	95	100	PF00397	0.479
LIG_14-3-3_CanoR_1	40	50	PF00244	0.429
LIG_14-3-3_CanoR_1	77	87	PF00244	0.441
LIG_Actin_WH2_1	115	132	PF00022	0.459
LIG_FHA_2	122	128	PF00498	0.514
LIG_FHA_2	32	38	PF00498	0.429
LIG_FHA_2	49	55	PF00498	0.496
LIG_FHA_2	96	102	PF00498	0.459
LIG_GBD_Chelix_1	132	140	PF00786	0.227
LIG_LIR_Apic_2	30	35	PF02991	0.427
LIG_LIR_Nem_3	23	28	PF02991	0.454
LIG_LIR_Nem_3	81	87	PF02991	0.459
LIG_SH2_CRK	21	25	PF00017	0.247
LIG_SH2_SRC	28	31	PF00017	0.412
LIG_SH2_STAP1	16	20	PF00017	0.460
LIG_SH2_STAT5	104	107	PF00017	0.412
LIG_SH2_STAT5	28	31	PF00017	0.419
LIG_SH2_STAT5	32	35	PF00017	0.420
LIG_SH3_3	138	144	PF00018	0.504
LIG_SH3_3	44	50	PF00018	0.412
LIG_SH3_3	82	88	PF00018	0.437
LIG_TRAF2_1	124	127	PF00917	0.429
LIG_TRAF2_1	51	54	PF00917	0.481
LIG_TYR_ITIM	62	67	PF00017	0.496
MOD_CDK_SPxxK_3	156	163	PF00069	0.502
MOD_CK1_1	31	37	PF00069	0.501
MOD_CK1_1	78	84	PF00069	0.485
MOD_CK2_1	121	127	PF00069	0.429
MOD_CK2_1	31	37	PF00069	0.456
MOD_CK2_1	48	54	PF00069	0.457
MOD_Cter_Amidation	37	40	PF01082	0.212
MOD_GlcNHglycan	115	118	PF01048	0.243
MOD_GSK3_1	105	112	PF00069	0.417
MOD_GSK3_1	71	78	PF00069	0.456
MOD_NEK2_1	41	46	PF00069	0.452
MOD_NEK2_2	20	25	PF00069	0.381
MOD_PIKK_1	109	115	PF00454	0.429
MOD_PIKK_1	41	47	PF00454	0.429
MOD_PIKK_1	75	81	PF00454	0.414
MOD_PKA_1	39	45	PF00069	0.412
MOD_PKA_2	39	45	PF00069	0.412
MOD_Plk_2-3	48	54	PF00069	0.496
MOD_Plk_4	20	26	PF00069	0.247
MOD_Plk_4	28	34	PF00069	0.445
MOD_ProDKin_1	156	162	PF00069	0.615
MOD_ProDKin_1	31	37	PF00069	0.447
MOD_ProDKin_1	95	101	PF00069	0.479
MOD_SUMO_rev_2	15	20	PF00179	0.473
TRG_ENDOCYTIC_2	21	24	PF00928	0.367
TRG_ENDOCYTIC_2	64	67	PF00928	0.429
TRG_ER_diArg_1	129	131	PF00400	0.412
TRG_ER_diArg_1	39	41	PF00400	0.414

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IMF8	Leptomonas seymouri	68%	100%
A0A0S4J7U0	Bodo saltans	56%	95%
A0A1X0P851	Trypanosomatidae	59%	100%
A0A3R7MSQ5	Trypanosoma rangeli	59%	100%
A0A3S7WVQ7	Leishmania donovani	98%	100%
A4HAA9	Leishmania braziliensis	86%	100%
A4HYI9	Leishmania infantum	98%	100%
E9ASB3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
Q554G7	Dictyostelium discoideum	29%	93%