Protein kinase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

protein kinase, putative

Species:

Leishmania major

UniProt:

Q4QD48_LEIMA

TriTrypDb:

LmjF.19.1610 , LMJLV39_190022800 , LMJSD75_190022300

Length:

278

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QD48

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD48

Function

Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	8
GO:0006793	phosphorus metabolic process	3	8
GO:0006796	phosphate-containing compound metabolic process	4	8
GO:0006807	nitrogen compound metabolic process	2	8
GO:0008152	metabolic process	1	8
GO:0009987	cellular process	1	8
GO:0016310	phosphorylation	5	8
GO:0019538	protein metabolic process	3	8
GO:0036211	protein modification process	4	8
GO:0043170	macromolecule metabolic process	3	8
GO:0043412	macromolecule modification	4	8
GO:0044237	cellular metabolic process	2	8
GO:0044238	primary metabolic process	2	8
GO:0071704	organic substance metabolic process	2	8
GO:1901564	organonitrogen compound metabolic process	3	8

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	8
GO:0003824	catalytic activity	1	8
GO:0004672	protein kinase activity	3	8
GO:0004674	protein serine/threonine kinase activity	4	2
GO:0005488	binding	1	8
GO:0005524	ATP binding	5	8
GO:0016301	kinase activity	4	8
GO:0016740	transferase activity	2	8
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	8
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	8
GO:0017076	purine nucleotide binding	4	8
GO:0030554	adenyl nucleotide binding	5	8
GO:0032553	ribonucleotide binding	3	8
GO:0032555	purine ribonucleotide binding	4	8
GO:0032559	adenyl ribonucleotide binding	5	8
GO:0035639	purine ribonucleoside triphosphate binding	4	8
GO:0036094	small molecule binding	2	8
GO:0043167	ion binding	2	8
GO:0043168	anion binding	3	8
GO:0097159	organic cyclic compound binding	2	8
GO:0097367	carbohydrate derivative binding	2	8
GO:0140096	catalytic activity, acting on a protein	2	8
GO:1901265	nucleoside phosphate binding	3	8
GO:1901363	heterocyclic compound binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	107	109	PF00675	0.489
CLV_NRD_NRD_1	4	6	PF00675	0.556
CLV_NRD_NRD_1	9	11	PF00675	0.495
CLV_PCSK_FUR_1	7	11	PF00082	0.578
CLV_PCSK_KEX2_1	100	102	PF00082	0.442
CLV_PCSK_KEX2_1	107	109	PF00082	0.404
CLV_PCSK_KEX2_1	4	6	PF00082	0.556
CLV_PCSK_KEX2_1	9	11	PF00082	0.495
CLV_PCSK_PC1ET2_1	100	102	PF00082	0.393
CLV_PCSK_PC7_1	5	11	PF00082	0.584
CLV_PCSK_SKI1_1	103	107	PF00082	0.146
CLV_PCSK_SKI1_1	108	112	PF00082	0.339
CLV_PCSK_SKI1_1	246	250	PF00082	0.477
CLV_PCSK_SKI1_1	86	90	PF00082	0.386
DEG_APCC_DBOX_1	106	114	PF00400	0.351
DEG_APCC_DBOX_1	4	12	PF00400	0.594
DEG_ODPH_VHL_1	179	190	PF01847	0.399
DOC_CKS1_1	89	94	PF01111	0.360
DOC_CYCLIN_RxL_1	103	114	PF00134	0.400
DOC_MAPK_gen_1	107	113	PF00069	0.438
DOC_MAPK_gen_1	243	251	PF00069	0.477
DOC_PP1_RVXF_1	7	14	PF00149	0.572
DOC_PP4_FxxP_1	166	169	PF00568	0.477
DOC_USP7_MATH_1	125	129	PF00917	0.477
DOC_USP7_MATH_1	206	210	PF00917	0.320
DOC_USP7_MATH_1	3	7	PF00917	0.556
DOC_USP7_MATH_1	51	55	PF00917	0.325
DOC_WW_Pin1_4	132	137	PF00397	0.399
DOC_WW_Pin1_4	148	153	PF00397	0.224
DOC_WW_Pin1_4	236	241	PF00397	0.477
DOC_WW_Pin1_4	88	93	PF00397	0.453
LIG_14-3-3_CanoR_1	118	122	PF00244	0.484
LIG_APCC_ABBA_1	121	126	PF00400	0.399
LIG_APCC_ABBA_1	179	184	PF00400	0.477
LIG_APCC_ABBA_1	64	69	PF00400	0.496
LIG_APCC_ABBA_1	94	99	PF00400	0.360
LIG_BIR_II_1	1	5	PF00653	0.636
LIG_BRCT_BRCA1_1	162	166	PF00533	0.477
LIG_Clathr_ClatBox_1	110	114	PF01394	0.405
LIG_CSL_BTD_1	12	15	PF09270	0.335
LIG_deltaCOP1_diTrp_1	183	188	PF00928	0.405
LIG_deltaCOP1_diTrp_1	215	220	PF00928	0.386
LIG_FHA_1	195	201	PF00498	0.477
LIG_FHA_1	32	38	PF00498	0.539
LIG_FHA_1	89	95	PF00498	0.447
LIG_LIR_Apic_2	163	169	PF02991	0.351
LIG_LIR_Gen_1	201	210	PF02991	0.435
LIG_LIR_Gen_1	215	224	PF02991	0.359
LIG_LIR_Gen_1	62	68	PF02991	0.553
LIG_LIR_Nem_3	201	207	PF02991	0.441
LIG_LIR_Nem_3	214	220	PF02991	0.356
LIG_LIR_Nem_3	62	66	PF02991	0.406
LIG_MLH1_MIPbox_1	162	166	PF16413	0.321
LIG_MYND_1	92	96	PF01753	0.243
LIG_SH2_CRK	193	197	PF00017	0.405
LIG_SH2_CRK	233	237	PF00017	0.243
LIG_SH2_SRC	122	125	PF00017	0.477
LIG_SH2_STAT5	122	125	PF00017	0.468
LIG_SH2_STAT5	164	167	PF00017	0.412
LIG_SH2_STAT5	59	62	PF00017	0.401
LIG_SH2_STAT5	63	66	PF00017	0.410
LIG_SH3_3	175	181	PF00018	0.477
LIG_SH3_3	197	203	PF00018	0.477
LIG_SUMO_SIM_anti_2	34	42	PF11976	0.497
LIG_SUMO_SIM_par_1	109	114	PF11976	0.477
LIG_SUMO_SIM_par_1	18	24	PF11976	0.522
LIG_TYR_ITIM	191	196	PF00017	0.477
MOD_CDK_SPxxK_3	236	243	PF00069	0.477
MOD_CK1_1	135	141	PF00069	0.477
MOD_CK1_1	211	217	PF00069	0.447
MOD_CK1_1	239	245	PF00069	0.477
MOD_CK2_1	262	268	PF00069	0.405
MOD_GlcNHglycan	1	4	PF01048	0.623
MOD_GlcNHglycan	157	160	PF01048	0.284
MOD_GlcNHglycan	264	267	PF01048	0.405
MOD_GlcNHglycan	53	56	PF01048	0.329
MOD_GSK3_1	131	138	PF00069	0.419
MOD_GSK3_1	194	201	PF00069	0.454
MOD_GSK3_1	77	84	PF00069	0.464
MOD_NEK2_1	270	275	PF00069	0.477
MOD_NEK2_1	77	82	PF00069	0.417
MOD_PKA_2	117	123	PF00069	0.484
MOD_PKA_2	242	248	PF00069	0.427
MOD_PKA_2	262	268	PF00069	0.146
MOD_PKA_2	3	9	PF00069	0.471
MOD_Plk_1	125	131	PF00069	0.354
MOD_Plk_4	117	123	PF00069	0.457
MOD_Plk_4	160	166	PF00069	0.317
MOD_Plk_4	270	276	PF00069	0.477
MOD_Plk_4	90	96	PF00069	0.476
MOD_ProDKin_1	132	138	PF00069	0.399
MOD_ProDKin_1	148	154	PF00069	0.224
MOD_ProDKin_1	236	242	PF00069	0.477
MOD_ProDKin_1	88	94	PF00069	0.453
TRG_DiLeu_BaEn_2	246	252	PF01217	0.477
TRG_ENDOCYTIC_2	164	167	PF00928	0.477
TRG_ENDOCYTIC_2	193	196	PF00928	0.405
TRG_ENDOCYTIC_2	217	220	PF00928	0.477
TRG_ENDOCYTIC_2	233	236	PF00928	0.212
TRG_ENDOCYTIC_2	63	66	PF00928	0.444
TRG_ER_diArg_1	106	108	PF00400	0.438
TRG_ER_diArg_1	4	7	PF00400	0.511
TRG_ER_diArg_1	45	48	PF00400	0.457
TRG_ER_diArg_1	8	10	PF00400	0.455
TRG_NES_CRM1_1	17	31	PF08389	0.573

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8N2	Leptomonas seymouri	45%	89%
A0A1X0PAW2	Trypanosomatidae	26%	78%
A0A3Q8IEN2	Leishmania donovani	94%	100%
A0A3R7KMF0	Trypanosoma rangeli	25%	79%
A4HAB0	Leishmania braziliensis	85%	100%
A4HYJ0	Leishmania infantum	94%	100%
A9RWC9	Physcomitrium patens	29%	79%
A9SR33	Physcomitrium patens	27%	81%
C9ZW68	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	79%
D0A0W4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	82%
E9ASB4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
O14047	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	27%	89%
Q00771	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	30%	67%
Q07250	Malus domestica	29%	67%
Q5QN75	Oryza sativa subsp. japonica	28%	78%
Q94A06	Arabidopsis thaliana	25%	79%
Q9S7U9	Arabidopsis thaliana	29%	77%