Putative potassium voltage-gated channel

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

potassium voltage-gated channel, putative

Species:

Leishmania major

UniProt:

Q4QD47_LEIMA

TriTrypDb:

LmjF.19.1620 , LMJLV39_190022900 , LMJSD75_190022400

Length:

308

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 9

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005739	mitochondrion	5	2
GO:0008076	voltage-gated potassium channel complex	4	2
GO:0016020	membrane	2	2
GO:0032991	protein-containing complex	1	2
GO:0034702	monoatomic ion channel complex	4	2
GO:0034703	cation channel complex	5	2
GO:0034705	potassium channel complex	6	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0098796	membrane protein complex	2	2
GO:0098797	plasma membrane protein complex	3	2
GO:0110165	cellular anatomical entity	1	2
GO:1902495	transmembrane transporter complex	3	2
GO:1990351	transporter complex	2	2

Expansion

Sequence features

Q4QD47

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD47

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	2
GO:0006811	monoatomic ion transport	4	2
GO:0006812	monoatomic cation transport	5	2
GO:0006813	potassium ion transport	7	2
GO:0009987	cellular process	1	12
GO:0016043	cellular component organization	3	12
GO:0022607	cellular component assembly	4	12
GO:0030001	metal ion transport	6	2
GO:0043933	protein-containing complex organization	4	12
GO:0051179	localization	1	2
GO:0051234	establishment of localization	2	2
GO:0051259	protein complex oligomerization	6	12
GO:0051260	protein homooligomerization	7	12
GO:0065003	protein-containing complex assembly	5	12
GO:0071840	cellular component organization or biogenesis	2	12

Molecular functions
Term	Name	Level	Count
GO:0005215	transporter activity	1	2
GO:0005216	monoatomic ion channel activity	4	2
GO:0005242	inward rectifier potassium channel activity	7	2
GO:0005244	voltage-gated monoatomic ion channel activity	4	2
GO:0005249	voltage-gated potassium channel activity	6	2
GO:0005261	monoatomic cation channel activity	5	2
GO:0005267	potassium channel activity	6	2
GO:0008324	monoatomic cation transmembrane transporter activity	4	2
GO:0015075	monoatomic ion transmembrane transporter activity	3	2
GO:0015079	potassium ion transmembrane transporter activity	6	2
GO:0015267	channel activity	4	2
GO:0015272	ATP-activated inward rectifier potassium channel activity	8	2
GO:0015276	ligand-gated monoatomic ion channel activity	5	2
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	2
GO:0022803	passive transmembrane transporter activity	3	2
GO:0022832	voltage-gated channel activity	6	2
GO:0022834	ligand-gated channel activity	6	2
GO:0022836	gated channel activity	5	2
GO:0022843	voltage-gated monoatomic cation channel activity	5	2
GO:0022857	transmembrane transporter activity	2	2
GO:0022890	inorganic cation transmembrane transporter activity	4	2
GO:0046873	metal ion transmembrane transporter activity	5	2
GO:0099094	ligand-gated monoatomic cation channel activity	6	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	109	113	PF00656	0.690
CLV_NRD_NRD_1	159	161	PF00675	0.404
CLV_NRD_NRD_1	167	169	PF00675	0.361
CLV_NRD_NRD_1	249	251	PF00675	0.387
CLV_PCSK_KEX2_1	144	146	PF00082	0.396
CLV_PCSK_KEX2_1	167	169	PF00082	0.406
CLV_PCSK_KEX2_1	249	251	PF00082	0.387
CLV_PCSK_PC1ET2_1	144	146	PF00082	0.396
CLV_PCSK_SKI1_1	160	164	PF00082	0.467
CLV_PCSK_SKI1_1	187	191	PF00082	0.376
CLV_PCSK_SKI1_1	3	7	PF00082	0.395
DEG_APCC_DBOX_1	121	129	PF00400	0.374
DEG_APCC_DBOX_1	249	257	PF00400	0.571
DOC_CYCLIN_RxL_1	66	76	PF00134	0.428
DOC_MAPK_DCC_7	122	130	PF00069	0.420
DOC_MAPK_gen_1	144	150	PF00069	0.381
DOC_MAPK_gen_1	75	83	PF00069	0.415
DOC_MAPK_MEF2A_6	122	130	PF00069	0.465
DOC_MAPK_MEF2A_6	75	83	PF00069	0.435
DOC_PP1_RVXF_1	285	291	PF00149	0.666
DOC_PP1_RVXF_1	67	74	PF00149	0.435
DOC_PP2B_LxvP_1	46	49	PF13499	0.398
DOC_USP7_MATH_1	25	29	PF00917	0.395
DOC_USP7_MATH_1	37	41	PF00917	0.433
DOC_USP7_MATH_1	52	56	PF00917	0.486
DOC_WW_Pin1_4	228	233	PF00397	0.423
DOC_WW_Pin1_4	290	295	PF00397	0.634
DOC_WW_Pin1_4	44	49	PF00397	0.451
LIG_14-3-3_CanoR_1	17	22	PF00244	0.414
LIG_BIR_III_2	61	65	PF00653	0.393
LIG_FHA_1	161	167	PF00498	0.375
LIG_FHA_1	191	197	PF00498	0.381
LIG_FHA_1	203	209	PF00498	0.388
LIG_FHA_1	214	220	PF00498	0.445
LIG_FHA_1	223	229	PF00498	0.245
LIG_FHA_1	37	43	PF00498	0.474
LIG_FHA_1	74	80	PF00498	0.302
LIG_FHA_2	51	57	PF00498	0.428
LIG_LIR_Gen_1	225	235	PF02991	0.432
LIG_LIR_Gen_1	26	37	PF02991	0.379
LIG_LIR_Gen_1	273	283	PF02991	0.630
LIG_LIR_Gen_1	65	74	PF02991	0.367
LIG_LIR_Gen_1	98	107	PF02991	0.379
LIG_LIR_Nem_3	176	182	PF02991	0.396
LIG_LIR_Nem_3	225	230	PF02991	0.406
LIG_LIR_Nem_3	273	278	PF02991	0.637
LIG_LIR_Nem_3	65	70	PF02991	0.367
LIG_MYND_1	44	48	PF01753	0.228
LIG_MYND_3	253	257	PF01753	0.607
LIG_NRBOX	17	23	PF00104	0.435
LIG_PCNA_yPIPBox_3	12	22	PF02747	0.435
LIG_Pex14_2	29	33	PF04695	0.400
LIG_PTB_Apo_2	242	249	PF02174	0.347
LIG_SH2_GRB2like	275	278	PF00017	0.623
LIG_SH2_PTP2	227	230	PF00017	0.403
LIG_SH2_STAT5	13	16	PF00017	0.441
LIG_SH2_STAT5	227	230	PF00017	0.403
LIG_SH3_2	282	287	PF14604	0.629
LIG_SH3_3	248	254	PF00018	0.487
LIG_SH3_3	279	285	PF00018	0.580
LIG_SH3_3	291	297	PF00018	0.618
LIG_SH3_3	46	52	PF00018	0.368
MOD_CDC14_SPxK_1	293	296	PF00782	0.652
MOD_CDK_SPxK_1	290	296	PF00069	0.672
MOD_CK1_1	226	232	PF00069	0.497
MOD_CK2_1	50	56	PF00069	0.443
MOD_GlcNHglycan	108	111	PF01048	0.593
MOD_GlcNHglycan	39	42	PF01048	0.426
MOD_GSK3_1	13	20	PF00069	0.308
MOD_GSK3_1	202	209	PF00069	0.405
MOD_GSK3_1	222	229	PF00069	0.384
MOD_NEK2_1	148	153	PF00069	0.389
MOD_NEK2_1	174	179	PF00069	0.399
MOD_NEK2_1	190	195	PF00069	0.438
MOD_NEK2_1	204	209	PF00069	0.398
MOD_NEK2_1	223	228	PF00069	0.575
MOD_NEK2_1	36	41	PF00069	0.433
MOD_NEK2_1	73	78	PF00069	0.307
MOD_PIKK_1	160	166	PF00454	0.374
MOD_PIKK_1	206	212	PF00454	0.400
MOD_PKA_1	160	166	PF00069	0.411
MOD_PKA_2	16	22	PF00069	0.435
MOD_Plk_1	25	31	PF00069	0.395
MOD_Plk_1	260	266	PF00069	0.638
MOD_Plk_4	17	23	PF00069	0.319
MOD_Plk_4	174	180	PF00069	0.393
MOD_Plk_4	223	229	PF00069	0.404
MOD_Plk_4	260	266	PF00069	0.676
MOD_ProDKin_1	228	234	PF00069	0.425
MOD_ProDKin_1	290	296	PF00069	0.630
MOD_ProDKin_1	44	50	PF00069	0.451
TRG_ENDOCYTIC_2	227	230	PF00928	0.403
TRG_ENDOCYTIC_2	275	278	PF00928	0.623
TRG_ER_diArg_1	166	168	PF00400	0.416
TRG_ER_diArg_1	248	250	PF00400	0.368
TRG_NES_CRM1_1	124	135	PF08389	0.409
TRG_Pf-PMV_PEXEL_1	160	164	PF00026	0.403
TRG_Pf-PMV_PEXEL_1	168	172	PF00026	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8A6	Leptomonas seymouri	79%	97%
A0A0S4JGQ4	Bodo saltans	54%	89%
A0A1X0P666	Trypanosomatidae	59%	100%
A0A3R7KT76	Trypanosoma rangeli	58%	100%
A0A3S7WVV0	Leishmania donovani	97%	100%
A4HAB1	Leishmania braziliensis	92%	90%
A4HYJ1	Leishmania infantum	97%	100%
D0A0W5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	55%	100%
E9ASB5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
V5AP17	Trypanosoma cruzi	57%	100%