RING-type domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Leucine Rich repeats (2 copies), putative

Species:

Leishmania major

UniProt:

Q4QD45_LEIMA

TriTrypDb:

LmjF.19.1640 , LMJLV39_050018500 , LMJSD75_030005000

Length:

673

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 11
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	13
GO:0042995	cell projection	2	13
GO:0043226	organelle	2	13
GO:0043227	membrane-bounded organelle	3	13
GO:0110165	cellular anatomical entity	1	13
GO:0120025	plasma membrane bounded cell projection	3	13

Expansion

Sequence features

Q4QD45

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD45

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016787	hydrolase activity	2	3
GO:0005488	binding	1	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	159	163	PF00656	0.331
CLV_C14_Caspase3-7	305	309	PF00656	0.525
CLV_C14_Caspase3-7	348	352	PF00656	0.300
CLV_C14_Caspase3-7	53	57	PF00656	0.543
CLV_NRD_NRD_1	225	227	PF00675	0.435
CLV_NRD_NRD_1	659	661	PF00675	0.440
CLV_PCSK_KEX2_1	225	227	PF00082	0.537
CLV_PCSK_KEX2_1	659	661	PF00082	0.448
CLV_PCSK_SKI1_1	225	229	PF00082	0.463
CLV_PCSK_SKI1_1	377	381	PF00082	0.416
CLV_PCSK_SKI1_1	447	451	PF00082	0.484
CLV_PCSK_SKI1_1	70	74	PF00082	0.409
DEG_APCC_DBOX_1	69	77	PF00400	0.356
DEG_Nend_Nbox_1	1	3	PF02207	0.528
DEG_SPOP_SBC_1	19	23	PF00917	0.494
DOC_ANK_TNKS_1	58	65	PF00023	0.522
DOC_CDC14_PxL_1	331	339	PF14671	0.303
DOC_CDC14_PxL_1	514	522	PF14671	0.450
DOC_CDC14_PxL_1	583	591	PF14671	0.289
DOC_CYCLIN_RxL_1	273	282	PF00134	0.329
DOC_CYCLIN_RxL_1	377	390	PF00134	0.292
DOC_CYCLIN_RxL_1	518	529	PF00134	0.377
DOC_CYCLIN_yClb5_NLxxxL_5	404	413	PF00134	0.292
DOC_MAPK_gen_1	136	145	PF00069	0.399
DOC_MAPK_gen_1	225	232	PF00069	0.391
DOC_MAPK_gen_1	338	347	PF00069	0.312
DOC_MAPK_gen_1	354	364	PF00069	0.305
DOC_MAPK_gen_1	377	387	PF00069	0.322
DOC_MAPK_gen_1	444	454	PF00069	0.387
DOC_MAPK_MEF2A_6	167	174	PF00069	0.426
DOC_MAPK_MEF2A_6	225	234	PF00069	0.360
DOC_MAPK_NFAT4_5	225	233	PF00069	0.363
DOC_MIT_MIM_1	222	230	PF04212	0.369
DOC_PP2B_LxvP_1	196	199	PF13499	0.429
DOC_PP4_FxxP_1	320	323	PF00568	0.362
DOC_USP7_MATH_1	151	155	PF00917	0.442
DOC_USP7_MATH_1	19	23	PF00917	0.523
DOC_USP7_MATH_1	39	43	PF00917	0.513
DOC_USP7_MATH_1	48	52	PF00917	0.594
DOC_USP7_MATH_1	519	523	PF00917	0.509
DOC_USP7_UBL2_3	201	205	PF12436	0.376
DOC_WW_Pin1_4	29	34	PF00397	0.531
DOC_WW_Pin1_4	44	49	PF00397	0.540
DOC_WW_Pin1_4	506	511	PF00397	0.499
DOC_WW_Pin1_4	577	582	PF00397	0.291
DOC_WW_Pin1_4	623	628	PF00397	0.461
LIG_14-3-3_CanoR_1	167	173	PF00244	0.501
LIG_14-3-3_CanoR_1	255	263	PF00244	0.430
LIG_14-3-3_CanoR_1	285	291	PF00244	0.424
LIG_14-3-3_CanoR_1	344	353	PF00244	0.414
LIG_14-3-3_CanoR_1	414	419	PF00244	0.429
LIG_14-3-3_CanoR_1	5	9	PF00244	0.520
LIG_14-3-3_CanoR_1	553	560	PF00244	0.374
LIG_14-3-3_CanoR_1	629	638	PF00244	0.450
LIG_Actin_WH2_2	436	452	PF00022	0.345
LIG_Actin_WH2_2	599	615	PF00022	0.377
LIG_BIR_III_2	147	151	PF00653	0.433
LIG_BIR_III_2	270	274	PF00653	0.376
LIG_BIR_III_2	516	520	PF00653	0.443
LIG_BRCT_BRCA1_1	22	26	PF00533	0.547
LIG_DLG_GKlike_1	346	353	PF00625	0.357
LIG_DLG_GKlike_1	414	421	PF00625	0.323
LIG_FHA_1	107	113	PF00498	0.420
LIG_FHA_1	169	175	PF00498	0.662
LIG_FHA_1	264	270	PF00498	0.485
LIG_FHA_2	217	223	PF00498	0.394
LIG_FHA_2	30	36	PF00498	0.532
LIG_FHA_2	400	406	PF00498	0.458
LIG_FHA_2	433	439	PF00498	0.420
LIG_FHA_2	471	477	PF00498	0.342
LIG_FHA_2	478	484	PF00498	0.319
LIG_FHA_2	5	11	PF00498	0.489
LIG_Integrin_RGD_1	44	46	PF01839	0.530
LIG_LIR_Apic_2	318	323	PF02991	0.353
LIG_LIR_Apic_2	507	511	PF02991	0.383
LIG_LIR_Gen_1	476	485	PF02991	0.342
LIG_LIR_Nem_3	147	152	PF02991	0.427
LIG_LIR_Nem_3	476	482	PF02991	0.333
LIG_LIR_Nem_3	71	75	PF02991	0.401
LIG_LYPXL_yS_3	149	152	PF13949	0.423
LIG_SH2_CRK	508	512	PF00017	0.391
LIG_SH2_SRC	17	20	PF00017	0.531
LIG_SH2_STAP1	125	129	PF00017	0.344
LIG_SH2_STAT5	180	183	PF00017	0.486
LIG_SH2_STAT5	384	387	PF00017	0.459
LIG_SH2_STAT5	504	507	PF00017	0.368
LIG_SH2_STAT5	75	78	PF00017	0.537
LIG_SH3_3	210	216	PF00018	0.476
LIG_SUMO_SIM_anti_2	139	147	PF11976	0.339
LIG_SUMO_SIM_anti_2	555	564	PF11976	0.413
LIG_SUMO_SIM_anti_2	601	608	PF11976	0.403
LIG_SUMO_SIM_par_1	139	147	PF11976	0.318
LIG_SUMO_SIM_par_1	231	237	PF11976	0.340
LIG_SUMO_SIM_par_1	313	318	PF11976	0.312
LIG_SUMO_SIM_par_1	35	42	PF11976	0.537
LIG_SUMO_SIM_par_1	613	618	PF11976	0.415
LIG_TRAF2_1	300	303	PF00917	0.549
LIG_TRAF2_1	588	591	PF00917	0.276
LIG_TYR_ITIM	382	387	PF00017	0.292
LIG_WW_3	539	543	PF00397	0.376
MOD_CDC14_SPxK_1	626	629	PF00782	0.405
MOD_CDK_SPxK_1	623	629	PF00069	0.409
MOD_CK1_1	118	124	PF00069	0.431
MOD_CK1_1	168	174	PF00069	0.461
MOD_CK1_1	20	26	PF00069	0.534
MOD_CK1_1	297	303	PF00069	0.685
MOD_CK1_1	399	405	PF00069	0.397
MOD_CK1_1	417	423	PF00069	0.286
MOD_CK1_1	47	53	PF00069	0.691
MOD_CK1_1	470	476	PF00069	0.510
MOD_CK1_1	526	532	PF00069	0.520
MOD_CK1_1	555	561	PF00069	0.404
MOD_CK1_1	575	581	PF00069	0.340
MOD_CK1_1	601	607	PF00069	0.575
MOD_CK1_1	621	627	PF00069	0.327
MOD_CK2_1	297	303	PF00069	0.747
MOD_CK2_1	399	405	PF00069	0.446
MOD_CK2_1	4	10	PF00069	0.522
MOD_CK2_1	432	438	PF00069	0.528
MOD_CK2_1	489	495	PF00069	0.375
MOD_CK2_1	529	535	PF00069	0.444
MOD_CK2_1	630	636	PF00069	0.417
MOD_DYRK1A_RPxSP_1	623	627	PF00069	0.410
MOD_GlcNHglycan	104	107	PF01048	0.459
MOD_GlcNHglycan	139	142	PF01048	0.556
MOD_GlcNHglycan	153	156	PF01048	0.489
MOD_GlcNHglycan	303	307	PF01048	0.536
MOD_GlcNHglycan	331	334	PF01048	0.565
MOD_GlcNHglycan	409	412	PF01048	0.354
MOD_GlcNHglycan	453	457	PF01048	0.419
MOD_GlcNHglycan	491	494	PF01048	0.420
MOD_GlcNHglycan	607	610	PF01048	0.385
MOD_GSK3_1	100	107	PF00069	0.434
MOD_GSK3_1	13	20	PF00069	0.524
MOD_GSK3_1	21	28	PF00069	0.502
MOD_GSK3_1	297	304	PF00069	0.673
MOD_GSK3_1	4	11	PF00069	0.532
MOD_GSK3_1	432	439	PF00069	0.459
MOD_GSK3_1	44	51	PF00069	0.688
MOD_GSK3_1	489	496	PF00069	0.356
MOD_GSK3_1	519	526	PF00069	0.531
MOD_GSK3_1	555	562	PF00069	0.456
MOD_GSK3_1	571	578	PF00069	0.505
MOD_GSK3_1	601	608	PF00069	0.401
MOD_GSK3_1	617	624	PF00069	0.327
MOD_GSK3_1	64	71	PF00069	0.473
MOD_GSK3_1	663	670	PF00069	0.713
MOD_N-GLC_1	115	120	PF02516	0.361
MOD_N-GLC_1	407	412	PF02516	0.248
MOD_N-GLC_1	526	531	PF02516	0.357
MOD_N-GLC_1	572	577	PF02516	0.294
MOD_N-GLC_1	618	623	PF02516	0.468
MOD_N-GLC_2	549	551	PF02516	0.343
MOD_NEK2_1	100	105	PF00069	0.540
MOD_NEK2_1	137	142	PF00069	0.435
MOD_NEK2_1	165	170	PF00069	0.567
MOD_NEK2_1	263	268	PF00069	0.440
MOD_NEK2_1	301	306	PF00069	0.492
MOD_NEK2_1	315	320	PF00069	0.272
MOD_NEK2_1	385	390	PF00069	0.406
MOD_NEK2_1	430	435	PF00069	0.445
MOD_NEK2_1	477	482	PF00069	0.444
MOD_NEK2_1	523	528	PF00069	0.475
MOD_NEK2_1	560	565	PF00069	0.456
MOD_NEK2_1	571	576	PF00069	0.425
MOD_NEK2_1	617	622	PF00069	0.487
MOD_NEK2_1	652	657	PF00069	0.708
MOD_NEK2_1	663	668	PF00069	0.606
MOD_NEK2_1	68	73	PF00069	0.581
MOD_NEK2_2	207	212	PF00069	0.373
MOD_NEK2_2	493	498	PF00069	0.342
MOD_NEK2_2	572	577	PF00069	0.418
MOD_NEK2_2	64	69	PF00069	0.471
MOD_OFUCOSY	164	169	PF10250	0.409
MOD_PIKK_1	294	300	PF00454	0.600
MOD_PIKK_1	39	45	PF00454	0.502
MOD_PIKK_1	396	402	PF00454	0.298
MOD_PIKK_1	467	473	PF00454	0.442
MOD_PKA_2	254	260	PF00069	0.343
MOD_PKA_2	284	290	PF00069	0.542
MOD_PKA_2	345	351	PF00069	0.382
MOD_PKA_2	4	10	PF00069	0.522
MOD_PKA_2	552	558	PF00069	0.527
MOD_PKB_1	344	352	PF00069	0.306
MOD_Plk_1	165	171	PF00069	0.522
MOD_Plk_1	475	481	PF00069	0.333
MOD_Plk_1	483	489	PF00069	0.323
MOD_Plk_1	526	532	PF00069	0.364
MOD_Plk_1	555	561	PF00069	0.445
MOD_Plk_1	572	578	PF00069	0.451
MOD_Plk_1	601	607	PF00069	0.481
MOD_Plk_1	617	623	PF00069	0.399
MOD_Plk_1	64	70	PF00069	0.467
MOD_Plk_1	641	647	PF00069	0.608
MOD_Plk_4	22	28	PF00069	0.511
MOD_Plk_4	315	321	PF00069	0.491
MOD_Plk_4	436	442	PF00069	0.446
MOD_Plk_4	8	14	PF00069	0.547
MOD_ProDKin_1	29	35	PF00069	0.532
MOD_ProDKin_1	44	50	PF00069	0.542
MOD_ProDKin_1	506	512	PF00069	0.509
MOD_ProDKin_1	577	583	PF00069	0.296
MOD_ProDKin_1	623	629	PF00069	0.467
TRG_DiLeu_BaEn_1	259	264	PF01217	0.291
TRG_DiLeu_BaLyEn_6	578	583	PF01217	0.291
TRG_DiLeu_LyEn_5	248	253	PF01217	0.365
TRG_ENDOCYTIC_2	149	152	PF00928	0.483
TRG_ENDOCYTIC_2	384	387	PF00928	0.337
TRG_ENDOCYTIC_2	491	494	PF00928	0.369
TRG_ER_diArg_1	224	226	PF00400	0.564
TRG_ER_diArg_1	344	347	PF00400	0.331
TRG_ER_diArg_1	413	416	PF00400	0.292
TRG_ER_diArg_1	497	500	PF00400	0.340
TRG_ER_diArg_1	611	614	PF00400	0.382
TRG_Pf-PMV_PEXEL_1	226	231	PF00026	0.480
TRG_Pf-PMV_PEXEL_1	503	507	PF00026	0.357

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P921	Leptomonas seymouri	27%	82%
A0A1X0P1M5	Trypanosomatidae	24%	76%
A0A3Q8IAE2	Leishmania donovani	82%	100%
A4H3H4	Leishmania braziliensis	29%	69%
A4HCY0	Leishmania braziliensis	26%	100%
E9ACE9	Leishmania major	27%	67%
E9AG21	Leishmania infantum	27%	67%
E9AGT5	Leishmania infantum	81%	100%
E9AIU4	Leishmania braziliensis	26%	100%
E9AJN7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	28%	69%
Q4QJ80	Leishmania major	100%	100%