LeishMANIAdb
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Putative GIPL galf transferase

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
Putative GIPL galf transferase
Gene product:
GIPL galf transferase, putative
Species:
Leishmania major
UniProt:
Q4QD44_LEIMA
TriTrypDb:
LmjF.05.1230 , LMJLV39_320048000 * , LMJSD75_320048400 *
Length:
599

Annotations

LeishMANIAdb annotations

A large family of glycosyltransferases expanded in parazitic kinetoplastids (and even more in T cruzi). Localization: ER (by homology)

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 11
NetGPI no yes: 0, no: 11
Cellular components
Term Name Level Count
GO:0005886 plasma membrane 3 2
GO:0016020 membrane 2 7
GO:0110165 cellular anatomical entity 1 7

Expansion

Sequence features

Q4QD44
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD44

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0003824 catalytic activity 1 12
GO:0016740 transferase activity 2 12
GO:0016757 glycosyltransferase activity 3 6

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 183 187 PF00656 0.311
CLV_C14_Caspase3-7 303 307 PF00656 0.350
CLV_MEL_PAP_1 234 240 PF00089 0.457
CLV_NRD_NRD_1 1 3 PF00675 0.459
CLV_NRD_NRD_1 236 238 PF00675 0.522
CLV_NRD_NRD_1 486 488 PF00675 0.631
CLV_NRD_NRD_1 494 496 PF00675 0.568
CLV_NRD_NRD_1 72 74 PF00675 0.728
CLV_PCSK_KEX2_1 236 238 PF00082 0.494
CLV_PCSK_KEX2_1 486 488 PF00082 0.606
CLV_PCSK_KEX2_1 494 496 PF00082 0.572
CLV_PCSK_KEX2_1 72 74 PF00082 0.744
CLV_PCSK_SKI1_1 151 155 PF00082 0.566
CLV_PCSK_SKI1_1 340 344 PF00082 0.645
CLV_PCSK_SKI1_1 411 415 PF00082 0.535
CLV_PCSK_SKI1_1 486 490 PF00082 0.668
CLV_PCSK_SKI1_1 588 592 PF00082 0.570
CLV_PCSK_SKI1_1 73 77 PF00082 0.708
DEG_APCC_DBOX_1 410 418 PF00400 0.303
DEG_APCC_DBOX_1 486 494 PF00400 0.364
DEG_Nend_UBRbox_1 1 4 PF02207 0.635
DEG_SCF_FBW7_1 111 116 PF00400 0.449
DEG_SPOP_SBC_1 80 84 PF00917 0.503
DOC_CKS1_1 108 113 PF01111 0.472
DOC_CKS1_1 191 196 PF01111 0.300
DOC_MAPK_DCC_7 20 28 PF00069 0.457
DOC_MAPK_gen_1 11 19 PF00069 0.626
DOC_MAPK_HePTP_8 17 29 PF00069 0.457
DOC_MAPK_MEF2A_6 185 192 PF00069 0.325
DOC_MAPK_MEF2A_6 20 29 PF00069 0.457
DOC_MAPK_MEF2A_6 346 354 PF00069 0.457
DOC_MAPK_NFAT4_5 185 193 PF00069 0.276
DOC_PP4_FxxP_1 105 108 PF00568 0.487
DOC_PP4_FxxP_1 470 473 PF00568 0.426
DOC_USP7_MATH_1 113 117 PF00917 0.477
DOC_USP7_MATH_1 125 129 PF00917 0.470
DOC_USP7_MATH_1 54 58 PF00917 0.470
DOC_USP7_MATH_1 71 75 PF00917 0.478
DOC_USP7_MATH_2 98 104 PF00917 0.492
DOC_USP7_UBL2_3 520 524 PF12436 0.409
DOC_WW_Pin1_4 107 112 PF00397 0.465
DOC_WW_Pin1_4 190 195 PF00397 0.296
DOC_WW_Pin1_4 395 400 PF00397 0.353
DOC_WW_Pin1_4 465 470 PF00397 0.418
DOC_WW_Pin1_4 73 78 PF00397 0.577
DOC_WW_Pin1_4 92 97 PF00397 0.487
LIG_14-3-3_CanoR_1 14 20 PF00244 0.597
LIG_14-3-3_CanoR_1 2 8 PF00244 0.668
LIG_14-3-3_CanoR_1 365 371 PF00244 0.375
LIG_14-3-3_CanoR_1 411 420 PF00244 0.304
LIG_14-3-3_CanoR_1 487 493 PF00244 0.381
LIG_14-3-3_CanoR_1 72 76 PF00244 0.551
LIG_BIR_III_2 186 190 PF00653 0.304
LIG_BIR_III_4 106 110 PF00653 0.462
LIG_BIR_III_4 402 406 PF00653 0.332
LIG_BIR_III_4 543 547 PF00653 0.358
LIG_deltaCOP1_diTrp_1 273 279 PF00928 0.284
LIG_deltaCOP1_diTrp_1 433 443 PF00928 0.403
LIG_FHA_1 110 116 PF00498 0.456
LIG_FHA_1 194 200 PF00498 0.347
LIG_FHA_1 225 231 PF00498 0.324
LIG_FHA_1 35 41 PF00498 0.292
LIG_FHA_1 356 362 PF00498 0.424
LIG_FHA_1 404 410 PF00498 0.348
LIG_FHA_1 535 541 PF00498 0.436
LIG_FHA_1 76 82 PF00498 0.493
LIG_FHA_2 128 134 PF00498 0.527
LIG_FHA_2 269 275 PF00498 0.297
LIG_FHA_2 301 307 PF00498 0.309
LIG_FHA_2 367 373 PF00498 0.360
LIG_FHA_2 570 576 PF00498 0.405
LIG_FHA_2 62 68 PF00498 0.475
LIG_FHA_2 88 94 PF00498 0.494
LIG_Integrin_RGD_1 304 306 PF01839 0.541
LIG_LIR_Apic_2 102 108 PF02991 0.499
LIG_LIR_Apic_2 468 473 PF02991 0.415
LIG_LIR_Apic_2 557 563 PF02991 0.383
LIG_LIR_Gen_1 150 159 PF02991 0.383
LIG_LIR_Gen_1 522 533 PF02991 0.428
LIG_LIR_Nem_3 198 204 PF02991 0.410
LIG_LIR_Nem_3 326 332 PF02991 0.405
LIG_LIR_Nem_3 347 352 PF02991 0.435
LIG_LIR_Nem_3 387 393 PF02991 0.399
LIG_LIR_Nem_3 422 428 PF02991 0.447
LIG_LIR_Nem_3 433 439 PF02991 0.347
LIG_LIR_Nem_3 455 460 PF02991 0.390
LIG_LIR_Nem_3 522 528 PF02991 0.483
LIG_LYPXL_yS_3 349 352 PF13949 0.441
LIG_Pex14_2 201 205 PF04695 0.301
LIG_Pex14_2 439 443 PF04695 0.360
LIG_SH2_CRK 215 219 PF00017 0.332
LIG_SH2_CRK 500 504 PF00017 0.438
LIG_SH2_NCK_1 368 372 PF00017 0.346
LIG_SH2_NCK_1 460 464 PF00017 0.375
LIG_SH2_STAP1 332 336 PF00017 0.379
LIG_SH2_STAP1 484 488 PF00017 0.431
LIG_SH2_STAT3 217 220 PF00017 0.339
LIG_SH2_STAT3 555 558 PF00017 0.424
LIG_SH2_STAT5 204 207 PF00017 0.345
LIG_SH2_STAT5 217 220 PF00017 0.379
LIG_SH2_STAT5 368 371 PF00017 0.340
LIG_SH2_STAT5 393 396 PF00017 0.402
LIG_SH2_STAT5 419 422 PF00017 0.369
LIG_SH2_STAT5 424 427 PF00017 0.387
LIG_SH2_STAT5 492 495 PF00017 0.493
LIG_SH2_STAT5 8 11 PF00017 0.613
LIG_SH3_1 357 363 PF00018 0.346
LIG_SH3_2 360 365 PF14604 0.335
LIG_SH3_2 68 73 PF14604 0.473
LIG_SH3_3 105 111 PF00018 0.470
LIG_SH3_3 347 353 PF00018 0.461
LIG_SH3_3 357 363 PF00018 0.348
LIG_SH3_3 65 71 PF00018 0.514
LIG_SH3_3 93 99 PF00018 0.480
LIG_SUMO_SIM_par_1 188 193 PF11976 0.358
LIG_SUMO_SIM_par_1 405 410 PF11976 0.318
LIG_TRAF2_1 271 274 PF00917 0.271
LIG_TRAF2_1 572 575 PF00917 0.404
LIG_TYR_ITIM 213 218 PF00017 0.293
LIG_UBA3_1 191 200 PF00899 0.299
LIG_WRC_WIRS_1 525 530 PF05994 0.391
MOD_CK1_1 116 122 PF00069 0.492
MOD_CK1_1 43 49 PF00069 0.439
MOD_CK1_1 561 567 PF00069 0.416
MOD_CK1_1 57 63 PF00069 0.455
MOD_CK1_1 586 592 PF00069 0.369
MOD_CK1_1 6 12 PF00069 0.632
MOD_CK1_1 79 85 PF00069 0.524
MOD_CK2_1 127 133 PF00069 0.482
MOD_CK2_1 268 274 PF00069 0.286
MOD_CK2_1 327 333 PF00069 0.377
MOD_CK2_1 569 575 PF00069 0.410
MOD_CK2_1 61 67 PF00069 0.478
MOD_CK2_1 87 93 PF00069 0.498
MOD_DYRK1A_RPxSP_1 73 77 PF00069 0.472
MOD_GlcNHglycan 115 118 PF01048 0.702
MOD_GlcNHglycan 240 243 PF01048 0.494
MOD_GlcNHglycan 255 258 PF01048 0.497
MOD_GlcNHglycan 346 349 PF01048 0.627
MOD_GlcNHglycan 376 379 PF01048 0.644
MOD_GlcNHglycan 414 417 PF01048 0.463
MOD_GlcNHglycan 45 48 PF01048 0.664
MOD_GlcNHglycan 56 59 PF01048 0.700
MOD_GlcNHglycan 574 578 PF01048 0.638
MOD_GlcNHglycan 78 81 PF01048 0.710
MOD_GlcNHglycan 83 86 PF01048 0.691
MOD_GSK3_1 109 116 PF00069 0.523
MOD_GSK3_1 2 9 PF00069 0.670
MOD_GSK3_1 34 41 PF00069 0.327
MOD_GSK3_1 403 410 PF00069 0.407
MOD_GSK3_1 48 55 PF00069 0.462
MOD_GSK3_1 524 531 PF00069 0.422
MOD_GSK3_1 554 561 PF00069 0.408
MOD_GSK3_1 569 576 PF00069 0.411
MOD_GSK3_1 57 64 PF00069 0.505
MOD_GSK3_1 71 78 PF00069 0.507
MOD_GSK3_1 81 88 PF00069 0.463
MOD_N-GLC_1 327 332 PF02516 0.572
MOD_N-GLC_1 482 487 PF02516 0.620
MOD_N-GLC_1 528 533 PF02516 0.642
MOD_N-GLC_1 558 563 PF02516 0.573
MOD_NEK2_1 1 6 PF00069 0.647
MOD_NEK2_1 238 243 PF00069 0.318
MOD_NEK2_1 39 44 PF00069 0.507
MOD_NEK2_1 412 417 PF00069 0.395
MOD_NEK2_1 523 528 PF00069 0.466
MOD_NEK2_1 549 554 PF00069 0.408
MOD_NEK2_1 573 578 PF00069 0.453
MOD_NEK2_2 15 20 PF00069 0.579
MOD_NEK2_2 34 39 PF00069 0.235
MOD_PIKK_1 554 560 PF00454 0.389
MOD_PK_1 3 9 PF00069 0.631
MOD_PKA_1 2 8 PF00069 0.617
MOD_PKA_2 1 7 PF00069 0.627
MOD_PKA_2 120 126 PF00069 0.463
MOD_PKA_2 366 372 PF00069 0.394
MOD_PKA_2 374 380 PF00069 0.448
MOD_PKA_2 493 499 PF00069 0.396
MOD_PKA_2 561 567 PF00069 0.454
MOD_PKA_2 71 77 PF00069 0.538
MOD_Plk_1 126 132 PF00069 0.470
MOD_Plk_1 225 231 PF00069 0.326
MOD_Plk_1 327 333 PF00069 0.385
MOD_Plk_1 528 534 PF00069 0.405
MOD_Plk_1 564 570 PF00069 0.450
MOD_Plk_1 99 105 PF00069 0.489
MOD_Plk_2-3 100 106 PF00069 0.474
MOD_Plk_2-3 127 133 PF00069 0.462
MOD_Plk_4 100 106 PF00069 0.488
MOD_Plk_4 127 133 PF00069 0.500
MOD_Plk_4 3 9 PF00069 0.610
MOD_Plk_4 327 333 PF00069 0.377
MOD_Plk_4 34 40 PF00069 0.306
MOD_Plk_4 488 494 PF00069 0.384
MOD_Plk_4 534 540 PF00069 0.391
MOD_ProDKin_1 107 113 PF00069 0.463
MOD_ProDKin_1 190 196 PF00069 0.300
MOD_ProDKin_1 395 401 PF00069 0.360
MOD_ProDKin_1 465 471 PF00069 0.423
MOD_ProDKin_1 73 79 PF00069 0.577
MOD_ProDKin_1 92 98 PF00069 0.485
MOD_SUMO_for_1 135 138 PF00179 0.443
TRG_DiLeu_BaEn_4 574 580 PF01217 0.414
TRG_DiLeu_BaLyEn_6 186 191 PF01217 0.314
TRG_DiLeu_BaLyEn_6 240 245 PF01217 0.283
TRG_DiLeu_BaLyEn_6 357 362 PF01217 0.335
TRG_ENDOCYTIC_2 215 218 PF00928 0.416
TRG_ENDOCYTIC_2 349 352 PF00928 0.443
TRG_ENDOCYTIC_2 500 503 PF00928 0.465
TRG_ENDOCYTIC_2 525 528 PF00928 0.445
TRG_ENDOCYTIC_2 587 590 PF00928 0.378
TRG_ER_diArg_1 236 238 PF00400 0.296
TRG_ER_diArg_1 247 250 PF00400 0.243
TRG_ER_diArg_1 337 340 PF00400 0.419
TRG_ER_diArg_1 365 368 PF00400 0.474
TRG_ER_diArg_1 385 388 PF00400 0.321
TRG_ER_diArg_1 493 495 PF00400 0.399
TRG_ER_diArg_1 71 73 PF00400 0.515
TRG_NES_CRM1_1 160 172 PF08389 0.328
TRG_Pf-PMV_PEXEL_1 571 575 PF00026 0.612

Homologs

Protein Taxonomy Sequence identity Coverage
A0A3Q8IHI5 Leishmania donovani 84% 91%
A0A3S5H7D9 Leishmania donovani 27% 100%
A0A3S7WZK8 Leishmania donovani 26% 100%
A4HDU8 Leishmania braziliensis 24% 100%
A4HL36 Leishmania braziliensis 62% 100%
A4I143 Leishmania infantum 27% 100%
E9AHM5 Leishmania infantum 84% 100%
E9B3H7 Leishmania mexicana (strain MHOM/GT/2001/U1103) 75% 100%
E9B3L0 Leishmania mexicana (strain MHOM/GT/2001/U1103) 28% 100%
Q4Q9D9 Leishmania major 26% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2024 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS