Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

WD domain, G-beta repeat, putative

Species:

Leishmania major

UniProt:

Q4QD42_LEIMA

TriTrypDb:

LmjF.20.0020 , LMJLV39_200005100 , LMJSD75_200005100

Length:

410

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	2
GO:0005656	nuclear pre-replicative complex	3	2
GO:0005730	nucleolus	5	2
GO:0005840	ribosome	5	6
GO:0032991	protein-containing complex	1	6
GO:0032993	protein-DNA complex	2	2
GO:0036387	pre-replicative complex	3	2
GO:0043226	organelle	2	6
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	6
GO:0043229	intracellular organelle	3	6
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	6
GO:0097344	Rix1 complex	2	2
GO:0110165	cellular anatomical entity	1	6
GO:0140513	nuclear protein-containing complex	2	2
GO:1990904	ribonucleoprotein complex	2	6

Expansion

Sequence features

Q4QD42

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD42

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	2
GO:0006259	DNA metabolic process	4	2
GO:0006260	DNA replication	5	2
GO:0006261	DNA-templated DNA replication	6	2
GO:0006364	rRNA processing	8	2
GO:0006396	RNA processing	6	2
GO:0006725	cellular aromatic compound metabolic process	3	2
GO:0006807	nitrogen compound metabolic process	2	2
GO:0008152	metabolic process	1	2
GO:0009987	cellular process	1	2
GO:0016070	RNA metabolic process	5	2
GO:0016072	rRNA metabolic process	7	2
GO:0034470	ncRNA processing	7	2
GO:0034641	cellular nitrogen compound metabolic process	3	2
GO:0034660	ncRNA metabolic process	6	2
GO:0043170	macromolecule metabolic process	3	2
GO:0044237	cellular metabolic process	2	2
GO:0044238	primary metabolic process	2	2
GO:0044260	obsolete cellular macromolecule metabolic process	3	2
GO:0046483	heterocycle metabolic process	3	2
GO:0071704	organic substance metabolic process	2	2
GO:0090304	nucleic acid metabolic process	4	2
GO:1901360	organic cyclic compound metabolic process	3	2

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.553
CLV_C14_Caspase3-7	243	247	PF00656	0.530
CLV_C14_Caspase3-7	374	378	PF00656	0.643
CLV_NRD_NRD_1	355	357	PF00675	0.578
CLV_NRD_NRD_1	400	402	PF00675	0.508
CLV_PCSK_KEX2_1	355	357	PF00082	0.586
CLV_PCSK_KEX2_1	359	361	PF00082	0.579
CLV_PCSK_KEX2_1	400	402	PF00082	0.561
CLV_PCSK_PC1ET2_1	359	361	PF00082	0.650
CLV_PCSK_PC7_1	355	361	PF00082	0.697
CLV_PCSK_SKI1_1	155	159	PF00082	0.339
CLV_PCSK_SKI1_1	198	202	PF00082	0.563
CLV_PCSK_SKI1_1	224	228	PF00082	0.478
CLV_PCSK_SKI1_1	297	301	PF00082	0.478
CLV_PCSK_SKI1_1	356	360	PF00082	0.663
CLV_PCSK_SKI1_1	66	70	PF00082	0.453
DEG_APCC_DBOX_1	9	17	PF00400	0.536
DEG_Nend_Nbox_1	1	3	PF02207	0.368
DOC_ANK_TNKS_1	22	29	PF00023	0.544
DOC_CDC14_PxL_1	272	280	PF14671	0.305
DOC_MAPK_gen_1	362	370	PF00069	0.705
DOC_PP2B_LxvP_1	254	257	PF13499	0.633
DOC_USP7_MATH_1	122	126	PF00917	0.504
DOC_USP7_MATH_1	128	132	PF00917	0.492
DOC_USP7_MATH_1	240	244	PF00917	0.655
DOC_USP7_MATH_1	282	286	PF00917	0.419
DOC_WW_Pin1_4	261	266	PF00397	0.503
DOC_WW_Pin1_4	301	306	PF00397	0.541
DOC_WW_Pin1_4	35	40	PF00397	0.497
DOC_WW_Pin1_4	66	71	PF00397	0.477
LIG_14-3-3_CanoR_1	198	203	PF00244	0.569
LIG_14-3-3_CanoR_1	343	349	PF00244	0.644
LIG_Clathr_ClatBox_1	13	17	PF01394	0.456
LIG_DCNL_PONY_1	1	4	PF03556	0.491
LIG_FHA_1	16	22	PF00498	0.419
LIG_FHA_1	183	189	PF00498	0.485
LIG_FHA_1	208	214	PF00498	0.439
LIG_FHA_1	30	36	PF00498	0.335
LIG_FHA_1	67	73	PF00498	0.336
LIG_FHA_1	81	87	PF00498	0.475
LIG_FHA_1	91	97	PF00498	0.482
LIG_FHA_2	127	133	PF00498	0.482
LIG_FHA_2	199	205	PF00498	0.453
LIG_FHA_2	279	285	PF00498	0.460
LIG_Integrin_isoDGR_2	295	297	PF01839	0.505
LIG_NRP_CendR_1	409	410	PF00754	0.671
LIG_PTAP_UEV_1	272	277	PF05743	0.325
LIG_SH2_CRK	37	41	PF00017	0.542
LIG_SH2_NCK_1	37	41	PF00017	0.509
LIG_SH2_SRC	233	236	PF00017	0.610
LIG_SH2_SRC	25	28	PF00017	0.529
LIG_SH3_1	270	276	PF00018	0.472
LIG_SH3_2	334	339	PF14604	0.659
LIG_SH3_3	270	276	PF00018	0.427
LIG_SH3_3	331	337	PF00018	0.601
LIG_SUMO_SIM_par_1	12	18	PF11976	0.466
LIG_SUMO_SIM_par_1	209	215	PF11976	0.419
LIG_SUMO_SIM_par_1	387	393	PF11976	0.458
LIG_TRAF2_1	380	383	PF00917	0.594
LIG_TYR_ITIM	35	40	PF00017	0.523
LIG_Vh1_VBS_1	72	90	PF01044	0.564
MOD_CDC14_SPxK_1	304	307	PF00782	0.543
MOD_CDK_SPxK_1	301	307	PF00069	0.550
MOD_CK1_1	131	137	PF00069	0.500
MOD_CK1_1	182	188	PF00069	0.486
MOD_CK1_1	274	280	PF00069	0.535
MOD_CK1_1	38	44	PF00069	0.511
MOD_CK1_1	57	63	PF00069	0.250
MOD_CK2_1	126	132	PF00069	0.475
MOD_CK2_1	278	284	PF00069	0.458
MOD_Cter_Amidation	353	356	PF01082	0.498
MOD_DYRK1A_RPxSP_1	66	70	PF00069	0.546
MOD_GlcNHglycan	100	103	PF01048	0.496
MOD_GlcNHglycan	120	123	PF01048	0.128
MOD_GlcNHglycan	257	260	PF01048	0.574
MOD_GlcNHglycan	273	276	PF01048	0.461
MOD_GlcNHglycan	284	287	PF01048	0.224
MOD_GlcNHglycan	405	408	PF01048	0.545
MOD_GlcNHglycan	56	59	PF01048	0.475
MOD_GSK3_1	118	125	PF00069	0.470
MOD_GSK3_1	159	166	PF00069	0.508
MOD_GSK3_1	178	185	PF00069	0.328
MOD_GSK3_1	274	281	PF00069	0.483
MOD_GSK3_1	72	79	PF00069	0.469
MOD_GSK3_1	86	93	PF00069	0.506
MOD_N-GLC_1	90	95	PF02516	0.341
MOD_NEK2_1	104	109	PF00069	0.523
MOD_NEK2_1	126	131	PF00069	0.468
MOD_NEK2_1	163	168	PF00069	0.482
MOD_NEK2_1	171	176	PF00069	0.437
MOD_NEK2_1	278	283	PF00069	0.447
MOD_NEK2_1	54	59	PF00069	0.416
MOD_NEK2_1	64	69	PF00069	0.371
MOD_NEK2_1	72	77	PF00069	0.374
MOD_NEK2_2	90	95	PF00069	0.398
MOD_PIKK_1	15	21	PF00454	0.549
MOD_PIKK_1	219	225	PF00454	0.457
MOD_PIKK_1	342	348	PF00454	0.613
MOD_PIKK_1	38	44	PF00454	0.489
MOD_PIKK_1	57	63	PF00454	0.267
MOD_PIKK_1	76	82	PF00454	0.492
MOD_PKA_1	403	409	PF00069	0.614
MOD_PKA_2	342	348	PF00069	0.634
MOD_PKB_1	401	409	PF00069	0.598
MOD_Plk_1	122	128	PF00069	0.485
MOD_Plk_1	131	137	PF00069	0.493
MOD_Plk_1	214	220	PF00069	0.438
MOD_Plk_4	122	128	PF00069	0.465
MOD_Plk_4	166	172	PF00069	0.513
MOD_Plk_4	17	23	PF00069	0.466
MOD_Plk_4	214	220	PF00069	0.438
MOD_Plk_4	274	280	PF00069	0.489
MOD_Plk_4	80	86	PF00069	0.503
MOD_Plk_4	90	96	PF00069	0.504
MOD_ProDKin_1	261	267	PF00069	0.501
MOD_ProDKin_1	301	307	PF00069	0.550
MOD_ProDKin_1	35	41	PF00069	0.503
MOD_ProDKin_1	66	72	PF00069	0.363
TRG_DiLeu_BaLyEn_6	306	311	PF01217	0.506
TRG_ENDOCYTIC_2	37	40	PF00928	0.542
TRG_ER_diArg_1	147	150	PF00400	0.583
TRG_ER_diArg_1	400	403	PF00400	0.542
TRG_NES_CRM1_1	140	151	PF08389	0.329

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVD5	Leptomonas seymouri	66%	98%
A0A0S4IM90	Bodo saltans	31%	88%
A0A1X0NWV7	Trypanosomatidae	36%	91%
A0A3S7WVV8	Leishmania donovani	93%	100%
A0A422N846	Trypanosoma rangeli	37%	96%
A4HBH0	Leishmania braziliensis	84%	100%
A4HYJ4	Leishmania infantum	93%	100%
C9ZHT7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	93%
E8NHN2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	23%	100%
E9AUE1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	98%
P62884	Leishmania infantum	23%	100%
Q0D0X6	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	24%	92%
Q0P593	Bos taurus	22%	99%
Q3SZD4	Bos taurus	24%	95%
Q499N3	Rattus norvegicus	26%	95%
Q4Q7Y7	Leishmania major	23%	100%
Q4R8E7	Macaca fascicularis	22%	99%
Q5BLX8	Rattus norvegicus	25%	100%
Q5XGE2	Xenopus tropicalis	22%	80%
Q61FW2	Caenorhabditis briggsae	24%	70%
Q6C953	Yarrowia lipolytica (strain CLIB 122 / E 150)	24%	96%
Q76LS6	Leishmania donovani	23%	100%
Q8N136	Homo sapiens	21%	99%
Q9BRX9	Homo sapiens	25%	100%
Q9M3B4	Arabidopsis thaliana	25%	94%