AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QD36_LEIMA

TriTrypDb:

LmjF.20.0080 , LMJLV39_200005700 , LMJSD75_200005700

Length:

671

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QD36

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD36

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	463	467	PF00656	0.412
CLV_NRD_NRD_1	116	118	PF00675	0.537
CLV_NRD_NRD_1	181	183	PF00675	0.362
CLV_NRD_NRD_1	253	255	PF00675	0.525
CLV_NRD_NRD_1	501	503	PF00675	0.380
CLV_NRD_NRD_1	580	582	PF00675	0.503
CLV_PCSK_KEX2_1	253	255	PF00082	0.515
CLV_PCSK_KEX2_1	501	503	PF00082	0.395
CLV_PCSK_KEX2_1	580	582	PF00082	0.436
CLV_PCSK_PC7_1	497	503	PF00082	0.373
CLV_PCSK_SKI1_1	130	134	PF00082	0.442
CLV_PCSK_SKI1_1	221	225	PF00082	0.553
CLV_PCSK_SKI1_1	253	257	PF00082	0.543
CLV_PCSK_SKI1_1	365	369	PF00082	0.582
CLV_PCSK_SKI1_1	497	501	PF00082	0.417
CLV_PCSK_SKI1_1	573	577	PF00082	0.631
CLV_PCSK_SKI1_1	597	601	PF00082	0.345
DOC_CKS1_1	314	319	PF01111	0.528
DOC_CKS1_1	381	386	PF01111	0.658
DOC_CKS1_1	399	404	PF01111	0.635
DOC_CKS1_1	533	538	PF01111	0.630
DOC_CKS1_1	593	598	PF01111	0.365
DOC_CYCLIN_yCln2_LP_2	388	394	PF00134	0.707
DOC_CYCLIN_yCln2_LP_2	473	479	PF00134	0.467
DOC_MAPK_gen_1	253	261	PF00069	0.520
DOC_MAPK_gen_1	505	513	PF00069	0.525
DOC_MAPK_gen_1	72	82	PF00069	0.379
DOC_MAPK_gen_1	96	105	PF00069	0.315
DOC_MAPK_HePTP_8	230	242	PF00069	0.426
DOC_MAPK_MEF2A_6	225	234	PF00069	0.365
DOC_MAPK_MEF2A_6	263	272	PF00069	0.501
DOC_MAPK_MEF2A_6	36	43	PF00069	0.417
DOC_MAPK_MEF2A_6	600	609	PF00069	0.417
DOC_MAPK_MEF2A_6	96	105	PF00069	0.315
DOC_PP1_RVXF_1	251	258	PF00149	0.524
DOC_PP1_RVXF_1	469	476	PF00149	0.373
DOC_USP7_MATH_1	120	124	PF00917	0.574
DOC_USP7_MATH_1	249	253	PF00917	0.481
DOC_USP7_MATH_1	467	471	PF00917	0.421
DOC_USP7_MATH_1	538	542	PF00917	0.551
DOC_USP7_UBL2_3	217	221	PF12436	0.625
DOC_USP7_UBL2_3	553	557	PF12436	0.679
DOC_USP7_UBL2_3	611	615	PF12436	0.500
DOC_USP7_UBL2_3	625	629	PF12436	0.565
DOC_WW_Pin1_4	165	170	PF00397	0.389
DOC_WW_Pin1_4	313	318	PF00397	0.574
DOC_WW_Pin1_4	321	326	PF00397	0.514
DOC_WW_Pin1_4	371	376	PF00397	0.597
DOC_WW_Pin1_4	380	385	PF00397	0.588
DOC_WW_Pin1_4	398	403	PF00397	0.726
DOC_WW_Pin1_4	532	537	PF00397	0.587
DOC_WW_Pin1_4	56	61	PF00397	0.383
DOC_WW_Pin1_4	592	597	PF00397	0.377
DOC_WW_Pin1_4	601	606	PF00397	0.345
DOC_WW_Pin1_4	84	89	PF00397	0.396
LIG_14-3-3_CanoR_1	174	179	PF00244	0.477
LIG_14-3-3_CanoR_1	253	258	PF00244	0.518
LIG_14-3-3_CanoR_1	295	303	PF00244	0.448
LIG_14-3-3_CanoR_1	343	351	PF00244	0.439
LIG_14-3-3_CanoR_1	365	375	PF00244	0.732
LIG_14-3-3_CanoR_1	429	438	PF00244	0.350
LIG_14-3-3_CanoR_1	6	12	PF00244	0.379
LIG_14-3-3_CanoR_1	75	81	PF00244	0.372
LIG_BRCT_BRCA1_1	123	127	PF00533	0.466
LIG_BRCT_BRCA1_1	454	458	PF00533	0.363
LIG_BRCT_BRCA1_1	514	518	PF00533	0.507
LIG_CaM_IQ_9	413	429	PF13499	0.620
LIG_Clathr_ClatBox_1	644	648	PF01394	0.369
LIG_CtBP_PxDLS_1	44	48	PF00389	0.428
LIG_eIF4E_1	344	350	PF01652	0.416
LIG_eIF4E_1	639	645	PF01652	0.308
LIG_FHA_1	142	148	PF00498	0.525
LIG_FHA_1	158	164	PF00498	0.406
LIG_FHA_1	198	204	PF00498	0.450
LIG_FHA_1	317	323	PF00498	0.455
LIG_FHA_1	345	351	PF00498	0.419
LIG_FHA_1	356	362	PF00498	0.666
LIG_FHA_1	411	417	PF00498	0.645
LIG_FHA_1	52	58	PF00498	0.385
LIG_FHA_1	602	608	PF00498	0.350
LIG_FHA_1	62	68	PF00498	0.348
LIG_FHA_1	629	635	PF00498	0.546
LIG_FHA_1	77	83	PF00498	0.367
LIG_FHA_2	593	599	PF00498	0.364
LIG_LIR_Apic_2	311	317	PF02991	0.582
LIG_LIR_Gen_1	10	19	PF02991	0.351
LIG_LIR_Gen_1	177	186	PF02991	0.559
LIG_LIR_Gen_1	297	308	PF02991	0.515
LIG_LIR_Gen_1	324	334	PF02991	0.473
LIG_LIR_Gen_1	478	487	PF02991	0.334
LIG_LIR_Gen_1	566	575	PF02991	0.601
LIG_LIR_Gen_1	640	647	PF02991	0.353
LIG_LIR_LC3C_4	152	155	PF02991	0.459
LIG_LIR_LC3C_4	346	351	PF02991	0.389
LIG_LIR_Nem_3	10	14	PF02991	0.356
LIG_LIR_Nem_3	177	181	PF02991	0.497
LIG_LIR_Nem_3	285	291	PF02991	0.572
LIG_LIR_Nem_3	297	303	PF02991	0.564
LIG_LIR_Nem_3	324	330	PF02991	0.470
LIG_LIR_Nem_3	478	482	PF02991	0.325
LIG_LIR_Nem_3	566	571	PF02991	0.591
LIG_LIR_Nem_3	640	644	PF02991	0.343
LIG_NBox_RRM_1	524	534	PF00076	0.499
LIG_PCNA_PIPBox_1	451	460	PF02747	0.394
LIG_PCNA_TLS_4	562	569	PF02747	0.531
LIG_Pex14_1	475	479	PF04695	0.323
LIG_PTB_Apo_2	629	636	PF02174	0.404
LIG_PTB_Phospho_1	629	635	PF10480	0.404
LIG_Rb_pABgroove_1	19	27	PF01858	0.359
LIG_SH2_CRK	178	182	PF00017	0.438
LIG_SH2_CRK	327	331	PF00017	0.489
LIG_SH2_CRK	635	639	PF00017	0.389
LIG_SH2_CRK	641	645	PF00017	0.274
LIG_SH2_GRB2like	620	623	PF00017	0.497
LIG_SH2_NCK_1	327	331	PF00017	0.480
LIG_SH2_SRC	620	623	PF00017	0.505
LIG_SH2_SRC	635	638	PF00017	0.382
LIG_SH2_SRC	639	642	PF00017	0.305
LIG_SH2_STAP1	11	15	PF00017	0.357
LIG_SH2_STAP1	327	331	PF00017	0.489
LIG_SH2_STAP1	639	643	PF00017	0.315
LIG_SH2_STAT5	107	110	PF00017	0.400
LIG_SH2_STAT5	344	347	PF00017	0.403
LIG_SH2_STAT5	503	506	PF00017	0.508
LIG_SH2_STAT5	620	623	PF00017	0.505
LIG_SH3_3	2	8	PF00018	0.406
LIG_SH3_3	232	238	PF00018	0.504
LIG_SH3_3	32	38	PF00018	0.400
LIG_SH3_3	372	378	PF00018	0.681
LIG_SH3_3	381	387	PF00018	0.649
LIG_SH3_3	396	402	PF00018	0.480
LIG_SH3_3	530	536	PF00018	0.619
LIG_SH3_5	633	637	PF00018	0.495
LIG_SUMO_SIM_anti_2	197	205	PF11976	0.351
LIG_SUMO_SIM_anti_2	241	246	PF11976	0.459
LIG_SUMO_SIM_anti_2	269	275	PF11976	0.350
LIG_TYR_ITIM	9	14	PF00017	0.361
MOD_CDC14_SPxK_1	87	90	PF00782	0.403
MOD_CDK_SPK_2	321	326	PF00069	0.369
MOD_CDK_SPK_2	592	597	PF00069	0.377
MOD_CDK_SPxK_1	84	90	PF00069	0.400
MOD_CK1_1	157	163	PF00069	0.384
MOD_CK1_1	168	174	PF00069	0.382
MOD_CK1_1	275	281	PF00069	0.470
MOD_CK1_1	312	318	PF00069	0.513
MOD_CK1_1	366	372	PF00069	0.567
MOD_CK1_1	395	401	PF00069	0.706
MOD_CK1_1	410	416	PF00069	0.637
MOD_CK1_1	432	438	PF00069	0.416
MOD_CK1_1	61	67	PF00069	0.356
MOD_CK1_1	628	634	PF00069	0.517
MOD_CK1_1	84	90	PF00069	0.400
MOD_CK2_1	188	194	PF00069	0.497
MOD_CK2_1	329	335	PF00069	0.451
MOD_CK2_1	408	414	PF00069	0.664
MOD_CK2_1	43	49	PF00069	0.424
MOD_CK2_1	443	449	PF00069	0.447
MOD_CK2_1	560	566	PF00069	0.570
MOD_CK2_1	592	598	PF00069	0.416
MOD_CMANNOS	318	321	PF00535	0.333
MOD_GlcNHglycan	118	121	PF01048	0.437
MOD_GlcNHglycan	123	126	PF01048	0.433
MOD_GlcNHglycan	156	159	PF01048	0.478
MOD_GlcNHglycan	331	334	PF01048	0.430
MOD_GlcNHglycan	365	368	PF01048	0.588
MOD_GlcNHglycan	375	378	PF01048	0.620
MOD_GlcNHglycan	394	397	PF01048	0.568
MOD_GlcNHglycan	410	413	PF01048	0.547
MOD_GlcNHglycan	540	543	PF01048	0.700
MOD_GlcNHglycan	546	549	PF01048	0.497
MOD_GlcNHglycan	577	580	PF01048	0.417
MOD_GSK3_1	112	119	PF00069	0.429
MOD_GSK3_1	170	177	PF00069	0.430
MOD_GSK3_1	236	243	PF00069	0.426
MOD_GSK3_1	249	256	PF00069	0.438
MOD_GSK3_1	308	315	PF00069	0.568
MOD_GSK3_1	321	328	PF00069	0.441
MOD_GSK3_1	440	447	PF00069	0.459
MOD_GSK3_1	467	474	PF00069	0.480
MOD_GSK3_1	49	56	PF00069	0.384
MOD_GSK3_1	556	563	PF00069	0.546
MOD_GSK3_1	583	590	PF00069	0.523
MOD_LATS_1	623	629	PF00433	0.552
MOD_N-GLC_1	130	135	PF02516	0.522
MOD_N-GLC_1	165	170	PF02516	0.389
MOD_N-GLC_1	275	280	PF02516	0.515
MOD_N-GLC_1	312	317	PF02516	0.608
MOD_N-GLC_1	355	360	PF02516	0.670
MOD_N-GLC_1	408	413	PF02516	0.646
MOD_N-GLC_1	506	511	PF02516	0.480
MOD_N-GLC_1	601	606	PF02516	0.362
MOD_NEK2_1	188	193	PF00069	0.416
MOD_NEK2_1	240	245	PF00069	0.407
MOD_NEK2_1	25	30	PF00069	0.372
MOD_NEK2_1	308	313	PF00069	0.547
MOD_NEK2_1	345	350	PF00069	0.508
MOD_NEK2_1	518	523	PF00069	0.484
MOD_NEK2_1	544	549	PF00069	0.650
MOD_NEK2_1	575	580	PF00069	0.542
MOD_NEK2_1	76	81	PF00069	0.370
MOD_NEK2_2	587	592	PF00069	0.413
MOD_PIKK_1	176	182	PF00454	0.346
MOD_PIKK_1	382	388	PF00454	0.654
MOD_PIKK_1	423	429	PF00454	0.626
MOD_PIKK_1	512	518	PF00454	0.419
MOD_PKA_1	253	259	PF00069	0.513
MOD_PKA_2	116	122	PF00069	0.418
MOD_PKA_2	253	259	PF00069	0.513
MOD_PKA_2	294	300	PF00069	0.504
MOD_PKA_2	309	315	PF00069	0.648
MOD_PKA_2	71	77	PF00069	0.380
MOD_Plk_1	130	136	PF00069	0.402
MOD_Plk_1	196	202	PF00069	0.488
MOD_Plk_1	25	31	PF00069	0.370
MOD_Plk_1	355	361	PF00069	0.703
MOD_Plk_4	325	331	PF00069	0.498
MOD_Plk_4	345	351	PF00069	0.451
MOD_Plk_4	432	438	PF00069	0.547
MOD_Plk_4	482	488	PF00069	0.367
MOD_Plk_4	53	59	PF00069	0.379
MOD_Plk_4	587	593	PF00069	0.378
MOD_Plk_4	76	82	PF00069	0.372
MOD_ProDKin_1	165	171	PF00069	0.388
MOD_ProDKin_1	313	319	PF00069	0.563
MOD_ProDKin_1	321	327	PF00069	0.511
MOD_ProDKin_1	371	377	PF00069	0.598
MOD_ProDKin_1	380	386	PF00069	0.588
MOD_ProDKin_1	398	404	PF00069	0.727
MOD_ProDKin_1	532	538	PF00069	0.589
MOD_ProDKin_1	56	62	PF00069	0.381
MOD_ProDKin_1	592	598	PF00069	0.368
MOD_ProDKin_1	601	607	PF00069	0.342
MOD_ProDKin_1	84	90	PF00069	0.400
MOD_SUMO_rev_2	110	120	PF00179	0.529
MOD_SUMO_rev_2	214	223	PF00179	0.577
MOD_SUMO_rev_2	441	446	PF00179	0.470
TRG_DiLeu_BaEn_2	563	569	PF01217	0.593
TRG_ENDOCYTIC_2	11	14	PF00928	0.361
TRG_ENDOCYTIC_2	178	181	PF00928	0.485
TRG_ENDOCYTIC_2	185	188	PF00928	0.484
TRG_ENDOCYTIC_2	288	291	PF00928	0.545
TRG_ENDOCYTIC_2	327	330	PF00928	0.482
TRG_ENDOCYTIC_2	641	644	PF00928	0.288
TRG_ENDOCYTIC_2	652	655	PF00928	0.298
TRG_ER_diArg_1	253	255	PF00400	0.515
TRG_ER_diArg_1	500	502	PF00400	0.370
TRG_Pf-PMV_PEXEL_1	225	229	PF00026	0.487
TRG_Pf-PMV_PEXEL_1	573	577	PF00026	0.640

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3N5	Leptomonas seymouri	83%	100%
A0A1X0NX92	Trypanosomatidae	34%	100%
A0A3Q8IEP3	Leishmania donovani	98%	100%
A0A422N7W1	Trypanosoma rangeli	34%	100%
A4HBH7	Leishmania braziliensis	93%	100%
C9ZHU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AGT8	Leishmania infantum	98%	100%
E9AUE8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
V5C0D6	Trypanosoma cruzi	33%	100%