AAA domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QD36_LEIMA

TriTrypDb:

LmjF.20.0080 , LMJLV39_200005700 , LMJSD75_200005700

Length:

671

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

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Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

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Expansion

Sequence features

Q4QD36

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD36

Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	463	467	PF00656	0.412
CLV_NRD_NRD_1	116	118	PF00675	0.537
CLV_NRD_NRD_1	181	183	PF00675	0.362
CLV_NRD_NRD_1	253	255	PF00675	0.525
CLV_NRD_NRD_1	501	503	PF00675	0.380
CLV_NRD_NRD_1	580	582	PF00675	0.503
CLV_PCSK_KEX2_1	253	255	PF00082	0.515
CLV_PCSK_KEX2_1	501	503	PF00082	0.395
CLV_PCSK_KEX2_1	580	582	PF00082	0.436
CLV_PCSK_PC7_1	497	503	PF00082	0.373

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I3N5	Leptomonas seymouri	83%	100%
A0A1X0NX92	Trypanosomatidae	34%	100%
A0A3Q8IEP3	Leishmania donovani	98%	100%
A0A422N7W1	Trypanosoma rangeli	34%	100%
A4HBH7	Leishmania braziliensis	93%	100%
C9ZHU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9AGT8	Leishmania infantum	98%	100%
E9AUE8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	98%	100%
V5C0D6	Trypanosoma cruzi	33%	100%

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