NB-ARC domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NADH-ubiquinone oxidoreductase complex I subunit, putative

Species:

Leishmania major

UniProt:

Q4QD32_LEIMA

TriTrypDb:

LmjF.20.0120 , LMJLV39_200006300 , LMJSD75_200006200

Length:

556

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005747	mitochondrial respiratory chain complex I	4	2
GO:0030964	NADH dehydrogenase complex	3	2
GO:0032991	protein-containing complex	1	2
GO:0045271	respiratory chain complex I	4	2
GO:0098796	membrane protein complex	2	2
GO:0098798	mitochondrial protein-containing complex	2	2
GO:0098800	inner mitochondrial membrane protein complex	3	2
GO:0098803	respiratory chain complex	3	2
GO:1902494	catalytic complex	2	2
GO:1902495	transmembrane transporter complex	3	2
GO:1990204	oxidoreductase complex	3	2
GO:1990351	transporter complex	2	2

Expansion

Sequence features

Q4QD32

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD32

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	262	266	PF00656	0.504
CLV_C14_Caspase3-7	280	284	PF00656	0.434
CLV_NRD_NRD_1	124	126	PF00675	0.495
CLV_NRD_NRD_1	2	4	PF00675	0.647
CLV_NRD_NRD_1	348	350	PF00675	0.424
CLV_PCSK_KEX2_1	2	4	PF00082	0.667
CLV_PCSK_KEX2_1	234	236	PF00082	0.502
CLV_PCSK_KEX2_1	348	350	PF00082	0.424
CLV_PCSK_PC1ET2_1	234	236	PF00082	0.513
CLV_PCSK_SKI1_1	128	132	PF00082	0.411
CLV_PCSK_SKI1_1	229	233	PF00082	0.377
CLV_PCSK_SKI1_1	267	271	PF00082	0.476
CLV_PCSK_SKI1_1	389	393	PF00082	0.372
CLV_PCSK_SKI1_1	6	10	PF00082	0.701
DEG_APCC_DBOX_1	266	274	PF00400	0.488
DEG_Kelch_Keap1_1	15	20	PF01344	0.719
DEG_Nend_UBRbox_1	1	4	PF02207	0.726
DEG_SPOP_SBC_1	164	168	PF00917	0.561
DOC_CDC14_PxL_1	203	211	PF14671	0.441
DOC_CDC14_PxL_1	41	49	PF14671	0.546
DOC_CYCLIN_RxL_1	432	443	PF00134	0.405
DOC_CYCLIN_yCln2_LP_2	326	332	PF00134	0.549
DOC_MAPK_gen_1	123	133	PF00069	0.436
DOC_MAPK_gen_1	234	244	PF00069	0.547
DOC_MAPK_MEF2A_6	125	134	PF00069	0.419
DOC_MAPK_MEF2A_6	499	507	PF00069	0.555
DOC_PP1_RVXF_1	434	441	PF00149	0.398
DOC_PP2B_LxvP_1	477	480	PF13499	0.306
DOC_PP2B_LxvP_1	535	538	PF13499	0.551
DOC_USP7_MATH_1	110	114	PF00917	0.539
DOC_USP7_MATH_1	12	16	PF00917	0.677
DOC_USP7_MATH_1	180	184	PF00917	0.526
DOC_WW_Pin1_4	136	141	PF00397	0.522
DOC_WW_Pin1_4	171	176	PF00397	0.482
DOC_WW_Pin1_4	305	310	PF00397	0.540
DOC_WW_Pin1_4	377	382	PF00397	0.493
DOC_WW_Pin1_4	421	426	PF00397	0.568
LIG_14-3-3_CanoR_1	14	22	PF00244	0.693
LIG_14-3-3_CanoR_1	229	236	PF00244	0.474
LIG_14-3-3_CanoR_1	32	40	PF00244	0.383
LIG_14-3-3_CanoR_1	389	394	PF00244	0.412
LIG_14-3-3_CanoR_1	499	504	PF00244	0.432
LIG_14-3-3_CanoR_1	98	105	PF00244	0.406
LIG_BRCT_BRCA1_1	22	26	PF00533	0.699
LIG_BRCT_BRCA1_1	389	393	PF00533	0.419
LIG_BRCT_BRCA1_1	95	99	PF00533	0.440
LIG_Clathr_ClatBox_1	131	135	PF01394	0.391
LIG_FHA_1	239	245	PF00498	0.440
LIG_FHA_1	276	282	PF00498	0.453
LIG_FHA_1	372	378	PF00498	0.419
LIG_FHA_1	516	522	PF00498	0.391
LIG_FHA_2	260	266	PF00498	0.521
LIG_FHA_2	383	389	PF00498	0.480
LIG_LIR_Gen_1	151	162	PF02991	0.445
LIG_LIR_Gen_1	518	524	PF02991	0.397
LIG_LIR_Gen_1	60	66	PF02991	0.460
LIG_LIR_Gen_1	96	105	PF02991	0.409
LIG_LIR_LC3C_4	129	134	PF02991	0.461
LIG_LIR_Nem_3	197	203	PF02991	0.453
LIG_LIR_Nem_3	518	523	PF02991	0.372
LIG_LIR_Nem_3	60	65	PF02991	0.452
LIG_LIR_Nem_3	96	102	PF02991	0.414
LIG_NRP_CendR_1	553	556	PF00754	0.636
LIG_Pex14_1	409	413	PF04695	0.507
LIG_Pex14_1	516	520	PF04695	0.490
LIG_Pex14_2	307	311	PF04695	0.465
LIG_PTB_Apo_2	199	206	PF02174	0.479
LIG_PTB_Phospho_1	199	205	PF10480	0.480
LIG_SH2_CRK	42	46	PF00017	0.558
LIG_SH2_CRK	71	75	PF00017	0.523
LIG_SH2_PTP2	205	208	PF00017	0.417
LIG_SH2_SRC	478	481	PF00017	0.420
LIG_SH2_STAP1	413	417	PF00017	0.551
LIG_SH2_STAT5	154	157	PF00017	0.414
LIG_SH2_STAT5	205	208	PF00017	0.417
LIG_SH2_STAT5	478	481	PF00017	0.420
LIG_SH3_3	134	140	PF00018	0.401
LIG_SUMO_SIM_anti_2	129	136	PF11976	0.398
LIG_SUMO_SIM_anti_2	142	148	PF11976	0.431
LIG_SUMO_SIM_anti_2	484	491	PF11976	0.507
LIG_SUMO_SIM_anti_2	502	507	PF11976	0.586
LIG_SUMO_SIM_par_1	129	136	PF11976	0.398
LIG_SUMO_SIM_par_1	142	148	PF11976	0.431
LIG_SUMO_SIM_par_1	239	245	PF11976	0.424
LIG_SUMO_SIM_par_1	255	260	PF11976	0.186
LIG_TRAF2_1	33	36	PF00917	0.694
LIG_TRAF2_1	418	421	PF00917	0.586
LIG_TRAF2_1	508	511	PF00917	0.560
LIG_TYR_ITIM	203	208	PF00017	0.414
LIG_UBA3_1	437	442	PF00899	0.522
LIG_UBA3_1	519	526	PF00899	0.448
MOD_CDK_SPK_2	305	310	PF00069	0.540
MOD_CK1_1	148	154	PF00069	0.332
MOD_CK1_1	15	21	PF00069	0.682
MOD_CK1_1	176	182	PF00069	0.490
MOD_CK1_1	25	31	PF00069	0.713
MOD_CK1_1	34	40	PF00069	0.450
MOD_CK1_1	424	430	PF00069	0.507
MOD_CK1_1	465	471	PF00069	0.485
MOD_CK2_1	136	142	PF00069	0.517
MOD_CK2_1	14	20	PF00069	0.705
MOD_CK2_1	25	31	PF00069	0.683
MOD_CK2_1	461	467	PF00069	0.494
MOD_CK2_1	484	490	PF00069	0.501
MOD_Cter_Amidation	123	126	PF01082	0.461
MOD_GlcNHglycan	14	17	PF01048	0.715
MOD_GlcNHglycan	147	150	PF01048	0.537
MOD_GlcNHglycan	159	162	PF01048	0.490
MOD_GlcNHglycan	175	178	PF01048	0.330
MOD_GlcNHglycan	244	247	PF01048	0.481
MOD_GlcNHglycan	388	392	PF01048	0.385
MOD_GlcNHglycan	464	467	PF01048	0.422
MOD_GSK3_1	145	152	PF00069	0.394
MOD_GSK3_1	176	183	PF00069	0.477
MOD_GSK3_1	238	245	PF00069	0.452
MOD_GSK3_1	27	34	PF00069	0.699
MOD_GSK3_1	271	278	PF00069	0.386
MOD_GSK3_1	295	302	PF00069	0.527
MOD_GSK3_1	461	468	PF00069	0.447
MOD_GSK3_1	89	96	PF00069	0.445
MOD_N-GLC_1	162	167	PF02516	0.552
MOD_N-GLC_1	484	489	PF02516	0.530
MOD_NEK2_1	118	123	PF00069	0.471
MOD_NEK2_1	156	161	PF00069	0.401
MOD_NEK2_1	242	247	PF00069	0.416
MOD_NEK2_1	259	264	PF00069	0.486
MOD_NEK2_1	387	392	PF00069	0.396
MOD_NEK2_1	515	520	PF00069	0.342
MOD_NEK2_1	89	94	PF00069	0.526
MOD_NEK2_2	149	154	PF00069	0.325
MOD_NEK2_2	295	300	PF00069	0.540
MOD_PIKK_1	110	116	PF00454	0.540
MOD_PIKK_1	180	186	PF00454	0.481
MOD_PIKK_1	190	196	PF00454	0.534
MOD_PIKK_1	299	305	PF00454	0.525
MOD_PK_1	499	505	PF00069	0.519
MOD_PKA_2	31	37	PF00069	0.741
MOD_PKA_2	97	103	PF00069	0.423
MOD_Plk_1	188	194	PF00069	0.563
MOD_Plk_1	238	244	PF00069	0.548
MOD_Plk_1	259	265	PF00069	0.561
MOD_Plk_1	295	301	PF00069	0.526
MOD_Plk_1	484	490	PF00069	0.510
MOD_Plk_2-3	31	37	PF00069	0.741
MOD_Plk_2-3	484	490	PF00069	0.457
MOD_Plk_4	149	155	PF00069	0.446
MOD_Plk_4	195	201	PF00069	0.460
MOD_Plk_4	211	217	PF00069	0.460
MOD_Plk_4	246	252	PF00069	0.461
MOD_Plk_4	341	347	PF00069	0.434
MOD_Plk_4	389	395	PF00069	0.372
MOD_Plk_4	484	490	PF00069	0.517
MOD_Plk_4	515	521	PF00069	0.445
MOD_ProDKin_1	136	142	PF00069	0.528
MOD_ProDKin_1	171	177	PF00069	0.483
MOD_ProDKin_1	305	311	PF00069	0.556
MOD_ProDKin_1	377	383	PF00069	0.487
MOD_ProDKin_1	421	427	PF00069	0.560
MOD_SUMO_for_1	309	312	PF00179	0.582
MOD_SUMO_rev_2	546	555	PF00179	0.509
TRG_DiLeu_BaEn_1	127	132	PF01217	0.414
TRG_DiLeu_BaEn_1	142	147	PF01217	0.424
TRG_DiLeu_BaEn_1	433	438	PF01217	0.398
TRG_DiLeu_BaEn_4	510	516	PF01217	0.372
TRG_DiLeu_BaLyEn_6	204	209	PF01217	0.392
TRG_DiLeu_LyEn_5	36	41	PF01217	0.649
TRG_DiLeu_LyEn_5	433	438	PF01217	0.398
TRG_ENDOCYTIC_2	154	157	PF00928	0.387
TRG_ENDOCYTIC_2	205	208	PF00928	0.400
TRG_ENDOCYTIC_2	359	362	PF00928	0.486
TRG_ENDOCYTIC_2	71	74	PF00928	0.521
TRG_ER_diArg_1	1	3	PF00400	0.669
TRG_ER_diArg_1	347	349	PF00400	0.433
TRG_ER_diArg_1	66	69	PF00400	0.500
TRG_ER_diLys_1	553	556	PF00400	0.590
TRG_NES_CRM1_1	484	497	PF08389	0.492
TRG_Pf-PMV_PEXEL_1	229	233	PF00026	0.530
TRG_Pf-PMV_PEXEL_1	429	433	PF00026	0.500
TRG_Pf-PMV_PEXEL_1	513	517	PF00026	0.359
TRG_Pf-PMV_PEXEL_1	59	63	PF00026	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P560	Leptomonas seymouri	71%	100%
A0A0S4JGE1	Bodo saltans	37%	94%
A0A1X0NY36	Trypanosomatidae	44%	98%
A0A3S7WVT1	Leishmania donovani	94%	100%
A0A422N7U6	Trypanosoma rangeli	37%	100%
A4HBI0	Leishmania braziliensis	86%	100%
A4HYK2	Leishmania infantum	94%	100%
C9ZHV1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	98%
E9AUF2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	100%
V5BAF5	Trypanosoma cruzi	45%	99%