Guanine nucleotide-binding protein subunit beta-like protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

wd40 repeat domain-containing protein

Species:

Leishmania major

UniProt:

Q4QD28_LEIMA

TriTrypDb:

LmjF.20.0160 , LMJLV39_200006700 , LMJSD75_200006600

Length:

805

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005815	microtubule organizing center	2	2
GO:0036064	ciliary basal body	3	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QD28

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD28

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	201	205	PF00656	0.604
CLV_C14_Caspase3-7	448	452	PF00656	0.690
CLV_C14_Caspase3-7	479	483	PF00656	0.728
CLV_C14_Caspase3-7	504	508	PF00656	0.670
CLV_C14_Caspase3-7	579	583	PF00656	0.771
CLV_C14_Caspase3-7	601	605	PF00656	0.615
CLV_NRD_NRD_1	112	114	PF00675	0.560
CLV_NRD_NRD_1	122	124	PF00675	0.478
CLV_NRD_NRD_1	492	494	PF00675	0.655
CLV_NRD_NRD_1	499	501	PF00675	0.743
CLV_NRD_NRD_1	580	582	PF00675	0.691
CLV_NRD_NRD_1	586	588	PF00675	0.670
CLV_PCSK_KEX2_1	112	114	PF00082	0.560
CLV_PCSK_KEX2_1	122	124	PF00082	0.478
CLV_PCSK_KEX2_1	492	494	PF00082	0.630
CLV_PCSK_KEX2_1	499	501	PF00082	0.597
CLV_PCSK_KEX2_1	580	582	PF00082	0.691
CLV_PCSK_KEX2_1	655	657	PF00082	0.563
CLV_PCSK_KEX2_1	662	664	PF00082	0.598
CLV_PCSK_KEX2_1	784	786	PF00082	0.619
CLV_PCSK_PC1ET2_1	655	657	PF00082	0.556
CLV_PCSK_PC1ET2_1	662	664	PF00082	0.608
CLV_PCSK_PC1ET2_1	784	786	PF00082	0.503
CLV_PCSK_PC7_1	576	582	PF00082	0.642
CLV_PCSK_SKI1_1	259	263	PF00082	0.500
CLV_PCSK_SKI1_1	381	385	PF00082	0.514
CLV_PCSK_SKI1_1	442	446	PF00082	0.617
CLV_PCSK_SKI1_1	478	482	PF00082	0.729
CLV_PCSK_SKI1_1	628	632	PF00082	0.563
CLV_PCSK_SKI1_1	656	660	PF00082	0.554
CLV_PCSK_SKI1_1	721	725	PF00082	0.567
DEG_APCC_DBOX_1	121	129	PF00400	0.516
DEG_APCC_DBOX_1	130	138	PF00400	0.391
DEG_APCC_DBOX_1	380	388	PF00400	0.507
DEG_APCC_DBOX_1	477	485	PF00400	0.649
DEG_Nend_Nbox_1	1	3	PF02207	0.657
DEG_SPOP_SBC_1	75	79	PF00917	0.655
DOC_ANK_TNKS_1	499	506	PF00023	0.692
DOC_CYCLIN_RxL_1	439	448	PF00134	0.642
DOC_MAPK_FxFP_2	363	366	PF00069	0.517
DOC_MAPK_gen_1	564	572	PF00069	0.718
DOC_MAPK_gen_1	784	793	PF00069	0.501
DOC_MAPK_MEF2A_6	285	292	PF00069	0.436
DOC_MAPK_MEF2A_6	326	335	PF00069	0.462
DOC_MAPK_MEF2A_6	566	574	PF00069	0.676
DOC_MAPK_RevD_3	565	581	PF00069	0.573
DOC_PP4_FxxP_1	363	366	PF00568	0.517
DOC_USP7_MATH_1	196	200	PF00917	0.523
DOC_USP7_MATH_1	343	347	PF00917	0.472
DOC_USP7_MATH_1	503	507	PF00917	0.728
DOC_USP7_MATH_1	542	546	PF00917	0.667
DOC_USP7_MATH_1	706	710	PF00917	0.572
DOC_WW_Pin1_4	307	312	PF00397	0.740
DOC_WW_Pin1_4	71	76	PF00397	0.670
DOC_WW_Pin1_4	77	82	PF00397	0.648
LIG_14-3-3_CanoR_1	104	109	PF00244	0.548
LIG_14-3-3_CanoR_1	321	330	PF00244	0.492
LIG_14-3-3_CanoR_1	620	630	PF00244	0.440
LIG_14-3-3_CanoR_1	707	711	PF00244	0.670
LIG_14-3-3_CanoR_1	726	734	PF00244	0.330
LIG_14-3-3_CanoR_1	757	767	PF00244	0.549
LIG_APCC_ABBA_1	154	159	PF00400	0.487
LIG_BIR_III_4	218	222	PF00653	0.627
LIG_BIR_III_4	470	474	PF00653	0.653
LIG_BRCT_BRCA1_1	361	365	PF00533	0.487
LIG_BRCT_BRCA1_1	672	676	PF00533	0.588
LIG_Clathr_ClatBox_1	222	226	PF01394	0.603
LIG_DLG_GKlike_1	104	111	PF00625	0.399
LIG_FAT_LD_1	533	541	PF03623	0.717
LIG_FHA_1	187	193	PF00498	0.470
LIG_FHA_1	245	251	PF00498	0.509
LIG_FHA_1	277	283	PF00498	0.457
LIG_FHA_1	292	298	PF00498	0.446
LIG_FHA_1	322	328	PF00498	0.535
LIG_FHA_1	398	404	PF00498	0.686
LIG_FHA_2	185	191	PF00498	0.469
LIG_FHA_2	211	217	PF00498	0.577
LIG_FHA_2	241	247	PF00498	0.427
LIG_FHA_2	411	417	PF00498	0.770
LIG_FHA_2	519	525	PF00498	0.657
LIG_FHA_2	549	555	PF00498	0.735
LIG_FHA_2	728	734	PF00498	0.643
LIG_FHA_2	738	744	PF00498	0.462
LIG_FHA_2	98	104	PF00498	0.627
LIG_LIR_Apic_2	273	278	PF02991	0.491
LIG_LIR_Apic_2	362	366	PF02991	0.512
LIG_LIR_Apic_2	42	48	PF02991	0.580
LIG_LIR_Gen_1	133	141	PF02991	0.514
LIG_LIR_Gen_1	185	196	PF02991	0.459
LIG_LIR_Gen_1	246	256	PF02991	0.546
LIG_LIR_Gen_1	485	496	PF02991	0.549
LIG_LIR_Gen_1	761	771	PF02991	0.400
LIG_LIR_Gen_1	80	91	PF02991	0.569
LIG_LIR_Nem_3	103	109	PF02991	0.592
LIG_LIR_Nem_3	133	139	PF02991	0.434
LIG_LIR_Nem_3	185	191	PF02991	0.459
LIG_LIR_Nem_3	246	252	PF02991	0.561
LIG_LIR_Nem_3	262	268	PF02991	0.348
LIG_LIR_Nem_3	28	33	PF02991	0.516
LIG_LIR_Nem_3	485	491	PF02991	0.540
LIG_LIR_Nem_3	761	767	PF02991	0.415
LIG_LIR_Nem_3	80	86	PF02991	0.572
LIG_NRBOX	440	446	PF00104	0.704
LIG_PALB2_WD40_1	788	796	PF16756	0.500
LIG_Pex14_2	30	34	PF04695	0.599
LIG_Pex14_2	359	363	PF04695	0.446
LIG_SH2_CRK	265	269	PF00017	0.601
LIG_SH2_CRK	275	279	PF00017	0.396
LIG_SH2_CRK	83	87	PF00017	0.528
LIG_SH2_NCK_1	83	87	PF00017	0.606
LIG_SH2_PTP2	249	252	PF00017	0.550
LIG_SH2_SRC	157	160	PF00017	0.617
LIG_SH2_SRC	249	252	PF00017	0.529
LIG_SH2_STAP1	26	30	PF00017	0.524
LIG_SH2_STAP1	83	87	PF00017	0.606
LIG_SH2_STAT3	523	526	PF00017	0.654
LIG_SH2_STAT5	249	252	PF00017	0.550
LIG_SH3_3	11	17	PF00018	0.533
LIG_SH3_3	134	140	PF00018	0.569
LIG_SUMO_SIM_anti_2	557	564	PF11976	0.731
LIG_SUMO_SIM_par_1	193	199	PF11976	0.430
LIG_SUMO_SIM_par_1	239	247	PF11976	0.454
LIG_SUMO_SIM_par_1	328	334	PF11976	0.456
LIG_TRAF2_1	156	159	PF00917	0.463
LIG_TRAF2_1	413	416	PF00917	0.779
LIG_TRAF2_1	712	715	PF00917	0.579
LIG_TYR_ITAM	246	268	PF00017	0.325
LIG_TYR_ITSM	245	252	PF00017	0.527
LIG_UBA3_1	2	11	PF00899	0.574
LIG_WRC_WIRS_1	749	754	PF05994	0.657
MOD_CK1_1	107	113	PF00069	0.506
MOD_CK1_1	325	331	PF00069	0.483
MOD_CK1_1	334	340	PF00069	0.494
MOD_CK1_1	404	410	PF00069	0.532
MOD_CK1_1	545	551	PF00069	0.697
MOD_CK1_1	632	638	PF00069	0.658
MOD_CK1_1	670	676	PF00069	0.665
MOD_CK1_1	77	83	PF00069	0.650
MOD_CK2_1	184	190	PF00069	0.491
MOD_CK2_1	195	201	PF00069	0.474
MOD_CK2_1	210	216	PF00069	0.597
MOD_CK2_1	410	416	PF00069	0.711
MOD_CK2_1	511	517	PF00069	0.727
MOD_CK2_1	518	524	PF00069	0.620
MOD_CK2_1	540	546	PF00069	0.702
MOD_CK2_1	548	554	PF00069	0.625
MOD_CK2_1	671	677	PF00069	0.612
MOD_CK2_1	756	762	PF00069	0.629
MOD_GlcNHglycan	198	201	PF01048	0.650
MOD_GlcNHglycan	207	210	PF01048	0.732
MOD_GlcNHglycan	256	259	PF01048	0.643
MOD_GlcNHglycan	315	318	PF01048	0.588
MOD_GlcNHglycan	345	348	PF01048	0.614
MOD_GlcNHglycan	367	370	PF01048	0.563
MOD_GlcNHglycan	405	409	PF01048	0.754
MOD_GlcNHglycan	470	474	PF01048	0.730
MOD_GlcNHglycan	691	695	PF01048	0.549
MOD_GlcNHglycan	71	74	PF01048	0.601
MOD_GlcNHglycan	743	748	PF01048	0.544
MOD_GSK3_1	126	133	PF00069	0.462
MOD_GSK3_1	2	9	PF00069	0.642
MOD_GSK3_1	240	247	PF00069	0.481
MOD_GSK3_1	321	328	PF00069	0.500
MOD_GSK3_1	334	341	PF00069	0.465
MOD_GSK3_1	388	395	PF00069	0.533
MOD_GSK3_1	397	404	PF00069	0.486
MOD_GSK3_1	406	413	PF00069	0.704
MOD_GSK3_1	433	440	PF00069	0.580
MOD_GSK3_1	541	548	PF00069	0.678
MOD_GSK3_1	628	635	PF00069	0.605
MOD_GSK3_1	64	71	PF00069	0.796
MOD_GSK3_1	667	674	PF00069	0.596
MOD_N-GLC_1	540	545	PF02516	0.687
MOD_N-GLC_1	644	649	PF02516	0.432
MOD_NEK2_1	1	6	PF00069	0.693
MOD_NEK2_1	217	222	PF00069	0.576
MOD_NEK2_1	264	269	PF00069	0.615
MOD_NEK2_1	313	318	PF00069	0.581
MOD_NEK2_1	359	364	PF00069	0.463
MOD_NEK2_1	397	402	PF00069	0.652
MOD_NEK2_1	433	438	PF00069	0.584
MOD_NEK2_1	487	492	PF00069	0.588
MOD_NEK2_1	540	545	PF00069	0.559
MOD_NEK2_1	654	659	PF00069	0.671
MOD_NEK2_1	682	687	PF00069	0.556
MOD_NEK2_1	76	81	PF00069	0.690
MOD_NEK2_2	706	711	PF00069	0.589
MOD_NEK2_2	748	753	PF00069	0.640
MOD_PIKK_1	397	403	PF00454	0.666
MOD_PIKK_1	406	412	PF00454	0.630
MOD_PIKK_1	6	12	PF00454	0.643
MOD_PIKK_1	632	638	PF00454	0.680
MOD_PIKK_1	682	688	PF00454	0.555
MOD_PIKK_1	727	733	PF00454	0.644
MOD_PKA_1	580	586	PF00069	0.712
MOD_PKA_2	130	136	PF00069	0.493
MOD_PKA_2	325	331	PF00069	0.573
MOD_PKA_2	359	365	PF00069	0.492
MOD_PKA_2	580	586	PF00069	0.790
MOD_PKA_2	706	712	PF00069	0.663
MOD_PKA_2	756	762	PF00069	0.498
MOD_PKB_1	412	420	PF00069	0.672
MOD_Plk_1	259	265	PF00069	0.601
MOD_Plk_1	545	551	PF00069	0.751
MOD_Plk_1	628	634	PF00069	0.554
MOD_Plk_1	670	676	PF00069	0.588
MOD_Plk_1	778	784	PF00069	0.529
MOD_Plk_2-3	511	517	PF00069	0.749
MOD_Plk_2-3	671	677	PF00069	0.586
MOD_Plk_2-3	737	743	PF00069	0.625
MOD_Plk_4	104	110	PF00069	0.496
MOD_Plk_4	359	365	PF00069	0.501
MOD_Plk_4	392	398	PF00069	0.603
MOD_Plk_4	511	517	PF00069	0.727
MOD_Plk_4	518	524	PF00069	0.641
MOD_Plk_4	671	677	PF00069	0.586
MOD_Plk_4	695	701	PF00069	0.643
MOD_Plk_4	737	743	PF00069	0.597
MOD_ProDKin_1	307	313	PF00069	0.742
MOD_ProDKin_1	71	77	PF00069	0.667
MOD_SUMO_for_1	694	697	PF00179	0.518
MOD_SUMO_rev_2	447	452	PF00179	0.527
TRG_DiLeu_BaEn_1	532	537	PF01217	0.633
TRG_DiLeu_BaEn_1	558	563	PF01217	0.730
TRG_DiLeu_BaEn_4	558	564	PF01217	0.732
TRG_DiLeu_BaEn_4	614	620	PF01217	0.606
TRG_DiLeu_BaLyEn_6	309	314	PF01217	0.670
TRG_ENDOCYTIC_2	157	160	PF00928	0.617
TRG_ENDOCYTIC_2	249	252	PF00928	0.537
TRG_ENDOCYTIC_2	265	268	PF00928	0.366
TRG_ENDOCYTIC_2	430	433	PF00928	0.662
TRG_ENDOCYTIC_2	83	86	PF00928	0.535
TRG_ER_diArg_1	111	113	PF00400	0.442
TRG_ER_diArg_1	121	123	PF00400	0.506
TRG_ER_diArg_1	13	16	PF00400	0.562
TRG_ER_diArg_1	491	493	PF00400	0.643
TRG_ER_diArg_1	563	566	PF00400	0.728
TRG_Pf-PMV_PEXEL_1	617	622	PF00026	0.683
TRG_Pf-PMV_PEXEL_1	726	731	PF00026	0.646

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HVC8	Leptomonas seymouri	40%	99%
A0A3Q8IKB9	Leishmania donovani	92%	100%
A4HBI4	Leishmania braziliensis	73%	100%
A4HYK7	Leishmania infantum	93%	100%
E9AUF6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%