Leucine-rich repeat-containing protein 75B

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine-rich repeat-containing protein

Species:

Leishmania major

UniProt:

Q4QD27_LEIMA

TriTrypDb:

LmjF.20.0170 , LMJLV39_200006800 , LMJSD75_200006700

Length:

340

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	12
GO:0042995	cell projection	2	12
GO:0043226	organelle	2	12
GO:0043227	membrane-bounded organelle	3	12
GO:0110165	cellular anatomical entity	1	12
GO:0120025	plasma membrane bounded cell projection	3	12

Expansion

Sequence features

Q4QD27

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD27

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005509	calcium ion binding	5	1
GO:0043167	ion binding	2	1
GO:0043169	cation binding	3	1
GO:0046872	metal ion binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.425
CLV_NRD_NRD_1	292	294	PF00675	0.505
CLV_NRD_NRD_1	4	6	PF00675	0.579
CLV_PCSK_KEX2_1	149	151	PF00082	0.542
CLV_PCSK_KEX2_1	244	246	PF00082	0.460
CLV_PCSK_KEX2_1	292	294	PF00082	0.512
CLV_PCSK_KEX2_1	4	6	PF00082	0.579
CLV_PCSK_PC1ET2_1	149	151	PF00082	0.570
CLV_PCSK_PC1ET2_1	244	246	PF00082	0.487
CLV_PCSK_SKI1_1	162	166	PF00082	0.382
CLV_PCSK_SKI1_1	244	248	PF00082	0.370
CLV_Separin_Metazoa	188	192	PF03568	0.488
DEG_Nend_Nbox_1	1	3	PF02207	0.351
DEG_SCF_FBW7_1	326	333	PF00400	0.495
DEG_SCF_FBW7_1	6	13	PF00400	0.528
DEG_SPOP_SBC_1	298	302	PF00917	0.424
DOC_CYCLIN_yCln2_LP_2	331	337	PF00134	0.561
DOC_MAPK_gen_1	109	118	PF00069	0.453
DOC_MAPK_HePTP_8	106	118	PF00069	0.392
DOC_MAPK_MEF2A_6	109	118	PF00069	0.395
DOC_USP7_MATH_1	10	14	PF00917	0.473
DOC_USP7_MATH_1	19	23	PF00917	0.335
DOC_USP7_UBL2_3	205	209	PF12436	0.466
DOC_WW_Pin1_4	121	126	PF00397	0.276
DOC_WW_Pin1_4	148	153	PF00397	0.511
DOC_WW_Pin1_4	326	331	PF00397	0.474
DOC_WW_Pin1_4	6	11	PF00397	0.483
LIG_14-3-3_CanoR_1	245	250	PF00244	0.350
LIG_14-3-3_CanoR_1	293	303	PF00244	0.558
LIG_14-3-3_CanoR_1	55	60	PF00244	0.468
LIG_APCC_ABBA_1	199	204	PF00400	0.476
LIG_BRCT_BRCA1_1	57	61	PF00533	0.453
LIG_Clathr_ClatBox_1	227	231	PF01394	0.469
LIG_Clathr_ClatBox_1	249	253	PF01394	0.265
LIG_deltaCOP1_diTrp_1	304	308	PF00928	0.324
LIG_EH1_1	223	231	PF00400	0.458
LIG_FHA_1	194	200	PF00498	0.465
LIG_FHA_1	298	304	PF00498	0.379
LIG_FHA_2	232	238	PF00498	0.447
LIG_FHA_2	27	33	PF00498	0.444
LIG_FHA_2	299	305	PF00498	0.510
LIG_LIR_Gen_1	183	192	PF02991	0.513
LIG_LIR_Gen_1	204	215	PF02991	0.433
LIG_LIR_Gen_1	22	33	PF02991	0.531
LIG_LIR_Gen_1	220	229	PF02991	0.260
LIG_LIR_Gen_1	302	313	PF02991	0.327
LIG_LIR_Nem_3	183	189	PF02991	0.549
LIG_LIR_Nem_3	204	210	PF02991	0.426
LIG_LIR_Nem_3	22	28	PF02991	0.549
LIG_LIR_Nem_3	220	224	PF02991	0.262
LIG_LIR_Nem_3	302	308	PF02991	0.317
LIG_LIR_Nem_3	70	75	PF02991	0.447
LIG_NRBOX	224	230	PF00104	0.451
LIG_SH2_PTP2	115	118	PF00017	0.385
LIG_SH2_STAT3	73	76	PF00017	0.384
LIG_SH2_STAT5	115	118	PF00017	0.473
LIG_SH2_STAT5	160	163	PF00017	0.439
LIG_SH2_STAT5	264	267	PF00017	0.453
LIG_SH2_STAT5	310	313	PF00017	0.379
LIG_SH2_STAT5	37	40	PF00017	0.346
LIG_SH2_STAT5	65	68	PF00017	0.362
LIG_SH2_STAT5	73	76	PF00017	0.353
LIG_SH2_STAT5	94	97	PF00017	0.440
LIG_SH3_1	150	156	PF00018	0.555
LIG_SH3_3	13	19	PF00018	0.436
LIG_SH3_3	150	156	PF00018	0.521
LIG_SH3_3	251	257	PF00018	0.518
LIG_SH3_3	308	314	PF00018	0.482
LIG_SUMO_SIM_par_1	225	231	PF11976	0.422
LIG_TYR_ITIM	113	118	PF00017	0.380
MOD_CK1_1	121	127	PF00069	0.424
MOD_CK1_1	193	199	PF00069	0.492
MOD_CK1_1	280	286	PF00069	0.563
MOD_CK1_1	67	73	PF00069	0.460
MOD_CK2_1	181	187	PF00069	0.509
MOD_CK2_1	231	237	PF00069	0.445
MOD_CK2_1	330	336	PF00069	0.628
MOD_CK2_1	87	93	PF00069	0.362
MOD_GlcNHglycan	12	15	PF01048	0.513
MOD_GlcNHglycan	120	123	PF01048	0.518
MOD_GlcNHglycan	177	180	PF01048	0.419
MOD_GlcNHglycan	183	186	PF01048	0.450
MOD_GlcNHglycan	192	195	PF01048	0.380
MOD_GlcNHglycan	20	24	PF01048	0.443
MOD_GlcNHglycan	88	92	PF01048	0.461
MOD_GlcNHglycan	97	100	PF01048	0.465
MOD_GSK3_1	138	145	PF00069	0.409
MOD_GSK3_1	177	184	PF00069	0.388
MOD_GSK3_1	231	238	PF00069	0.447
MOD_GSK3_1	27	34	PF00069	0.450
MOD_GSK3_1	294	301	PF00069	0.520
MOD_GSK3_1	326	333	PF00069	0.620
MOD_GSK3_1	6	13	PF00069	0.531
MOD_N-GLC_1	67	72	PF02516	0.338
MOD_NEK2_1	108	113	PF00069	0.425
MOD_NEK2_1	118	123	PF00069	0.424
MOD_NEK2_1	167	172	PF00069	0.388
MOD_NEK2_1	181	186	PF00069	0.463
MOD_NEK2_1	190	195	PF00069	0.447
MOD_NEK2_1	31	36	PF00069	0.370
MOD_NEK2_2	160	165	PF00069	0.487
MOD_PIKK_1	37	43	PF00454	0.481
MOD_PKA_2	108	114	PF00069	0.385
MOD_PKA_2	118	124	PF00069	0.417
MOD_PKA_2	190	196	PF00069	0.519
MOD_PKA_2	280	286	PF00069	0.563
MOD_Plk_1	235	241	PF00069	0.431
MOD_Plk_1	285	291	PF00069	0.463
MOD_Plk_1	298	304	PF00069	0.293
MOD_Plk_1	67	73	PF00069	0.341
MOD_Plk_2-3	231	237	PF00069	0.530
MOD_Plk_2-3	299	305	PF00069	0.352
MOD_Plk_4	177	183	PF00069	0.453
MOD_Plk_4	55	61	PF00069	0.404
MOD_Plk_4	67	73	PF00069	0.347
MOD_ProDKin_1	121	127	PF00069	0.273
MOD_ProDKin_1	148	154	PF00069	0.518
MOD_ProDKin_1	326	332	PF00069	0.479
MOD_ProDKin_1	6	12	PF00069	0.485
TRG_ENDOCYTIC_2	115	118	PF00928	0.385
TRG_ER_diArg_1	292	294	PF00400	0.525
TRG_ER_diArg_1	4	7	PF00400	0.554
TRG_Pf-PMV_PEXEL_1	162	166	PF00026	0.510

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDI3	Leptomonas seymouri	60%	85%
A0A0S4JE69	Bodo saltans	35%	90%
A0A1X0NWJ3	Trypanosomatidae	43%	90%
A0A3S5H780	Leishmania donovani	96%	100%
A0A422MW34	Trypanosoma rangeli	39%	90%
A0A422NVZ8	Trypanosoma rangeli	28%	68%
A4HYK8	Leishmania infantum	95%	100%
C9ZHV7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	89%
E9AI71	Leishmania braziliensis	81%	91%
E9AUF7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	91%
V5BQX0	Trypanosoma cruzi	41%	80%