Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QD26_LEIMA

TriTrypDb:

LmjF.20.0180 , LMJLV39_200006900 , LMJSD75_200006800

Length:

862

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QD26

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD26

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.719
CLV_C14_Caspase3-7	467	471	PF00656	0.459
CLV_C14_Caspase3-7	628	632	PF00656	0.492
CLV_NRD_NRD_1	209	211	PF00675	0.767
CLV_NRD_NRD_1	35	37	PF00675	0.637
CLV_NRD_NRD_1	408	410	PF00675	0.737
CLV_NRD_NRD_1	453	455	PF00675	0.569
CLV_NRD_NRD_1	478	480	PF00675	0.546
CLV_NRD_NRD_1	49	51	PF00675	0.443
CLV_NRD_NRD_1	569	571	PF00675	0.593
CLV_NRD_NRD_1	580	582	PF00675	0.500
CLV_NRD_NRD_1	622	624	PF00675	0.368
CLV_PCSK_FUR_1	207	211	PF00082	0.641
CLV_PCSK_KEX2_1	209	211	PF00082	0.777
CLV_PCSK_KEX2_1	322	324	PF00082	0.634
CLV_PCSK_KEX2_1	35	37	PF00082	0.626
CLV_PCSK_KEX2_1	408	410	PF00082	0.737
CLV_PCSK_KEX2_1	478	480	PF00082	0.546
CLV_PCSK_KEX2_1	569	571	PF00082	0.593
CLV_PCSK_KEX2_1	580	582	PF00082	0.500
CLV_PCSK_KEX2_1	622	624	PF00082	0.594
CLV_PCSK_PC1ET2_1	322	324	PF00082	0.634
CLV_PCSK_SKI1_1	319	323	PF00082	0.753
CLV_PCSK_SKI1_1	448	452	PF00082	0.738
CLV_PCSK_SKI1_1	479	483	PF00082	0.542
CLV_PCSK_SKI1_1	581	585	PF00082	0.519
CLV_Separin_Metazoa	32	36	PF03568	0.558
DEG_APCC_DBOX_1	133	141	PF00400	0.527
DEG_APCC_DBOX_1	478	486	PF00400	0.539
DEG_SIAH_1	421	429	PF03145	0.689
DOC_CKS1_1	802	807	PF01111	0.645
DOC_CYCLIN_RxL_1	130	142	PF00134	0.498
DOC_MAPK_gen_1	840	850	PF00069	0.406
DOC_MAPK_MEF2A_6	508	516	PF00069	0.364
DOC_MAPK_MEF2A_6	644	651	PF00069	0.467
DOC_PP2B_LxvP_1	390	393	PF13499	0.681
DOC_PP2B_LxvP_1	647	650	PF13499	0.511
DOC_USP7_MATH_1	114	118	PF00917	0.762
DOC_USP7_MATH_1	122	126	PF00917	0.633
DOC_USP7_MATH_1	265	269	PF00917	0.709
DOC_USP7_MATH_1	292	296	PF00917	0.737
DOC_USP7_MATH_1	302	306	PF00917	0.727
DOC_USP7_MATH_1	541	545	PF00917	0.532
DOC_USP7_MATH_1	564	568	PF00917	0.488
DOC_USP7_MATH_1	61	65	PF00917	0.732
DOC_USP7_MATH_1	626	630	PF00917	0.517
DOC_USP7_MATH_1	704	708	PF00917	0.572
DOC_USP7_MATH_1	739	743	PF00917	0.738
DOC_USP7_UBL2_3	853	857	PF12436	0.592
DOC_WW_Pin1_4	112	117	PF00397	0.733
DOC_WW_Pin1_4	194	199	PF00397	0.674
DOC_WW_Pin1_4	273	278	PF00397	0.758
DOC_WW_Pin1_4	285	290	PF00397	0.621
DOC_WW_Pin1_4	300	305	PF00397	0.692
DOC_WW_Pin1_4	327	332	PF00397	0.761
DOC_WW_Pin1_4	401	406	PF00397	0.775
DOC_WW_Pin1_4	418	423	PF00397	0.503
DOC_WW_Pin1_4	519	524	PF00397	0.665
DOC_WW_Pin1_4	708	713	PF00397	0.658
DOC_WW_Pin1_4	801	806	PF00397	0.653
DOC_WW_Pin1_4	84	89	PF00397	0.691
LIG_14-3-3_CanoR_1	148	156	PF00244	0.501
LIG_14-3-3_CanoR_1	210	219	PF00244	0.689
LIG_14-3-3_CanoR_1	400	405	PF00244	0.667
LIG_14-3-3_CanoR_1	440	446	PF00244	0.741
LIG_14-3-3_CanoR_1	504	508	PF00244	0.599
LIG_14-3-3_CanoR_1	558	566	PF00244	0.613
LIG_14-3-3_CanoR_1	672	678	PF00244	0.400
LIG_14-3-3_CanoR_1	757	763	PF00244	0.534
LIG_Actin_WH2_2	133	150	PF00022	0.550
LIG_AP2alpha_1	487	491	PF02296	0.602
LIG_BIR_II_1	1	5	PF00653	0.717
LIG_BRCT_BRCA1_1	603	607	PF00533	0.513
LIG_Clathr_ClatBox_1	847	851	PF01394	0.556
LIG_eIF4E_1	842	848	PF01652	0.531
LIG_FHA_1	133	139	PF00498	0.535
LIG_FHA_1	199	205	PF00498	0.719
LIG_FHA_1	294	300	PF00498	0.728
LIG_FHA_1	459	465	PF00498	0.659
LIG_FHA_1	573	579	PF00498	0.481
LIG_FHA_1	674	680	PF00498	0.489
LIG_FHA_1	696	702	PF00498	0.396
LIG_FHA_1	779	785	PF00498	0.573
LIG_FHA_1	833	839	PF00498	0.597
LIG_FHA_2	121	127	PF00498	0.741
LIG_FHA_2	311	317	PF00498	0.745
LIG_FHA_2	338	344	PF00498	0.706
LIG_FHA_2	484	490	PF00498	0.432
LIG_FHA_2	626	632	PF00498	0.484
LIG_GBD_Chelix_1	509	517	PF00786	0.579
LIG_LIR_Apic_2	81	86	PF02991	0.809
LIG_LIR_Gen_1	486	494	PF02991	0.488
LIG_LIR_Nem_3	142	147	PF02991	0.574
LIG_LIR_Nem_3	484	490	PF02991	0.524
LIG_LIR_Nem_3	604	610	PF02991	0.558
LIG_NRBOX	513	519	PF00104	0.354
LIG_Pex14_2	483	487	PF04695	0.613
LIG_Pex14_2	813	817	PF04695	0.430
LIG_PTAP_UEV_1	288	293	PF05743	0.630
LIG_PTAP_UEV_1	303	308	PF05743	0.654
LIG_REV1ctd_RIR_1	488	496	PF16727	0.619
LIG_SH2_CRK	144	148	PF00017	0.573
LIG_SH2_CRK	610	614	PF00017	0.355
LIG_SH2_CRK	83	87	PF00017	0.704
LIG_SH2_SRC	351	354	PF00017	0.555
LIG_SH2_STAP1	141	145	PF00017	0.444
LIG_SH2_STAP1	228	232	PF00017	0.654
LIG_SH2_STAT3	762	765	PF00017	0.558
LIG_SH2_STAT3	842	845	PF00017	0.547
LIG_SH2_STAT5	166	169	PF00017	0.506
LIG_SH2_STAT5	246	249	PF00017	0.758
LIG_SH3_1	286	292	PF00018	0.594
LIG_SH3_3	1	7	PF00018	0.592
LIG_SH3_3	113	119	PF00018	0.670
LIG_SH3_3	286	292	PF00018	0.650
LIG_SH3_3	301	307	PF00018	0.721
LIG_SH3_3	325	331	PF00018	0.746
LIG_SH3_3	686	692	PF00018	0.560
LIG_SH3_3	799	805	PF00018	0.569
LIG_SH3_3	817	823	PF00018	0.462
LIG_SH3_3	85	91	PF00018	0.725
LIG_SUMO_SIM_par_1	460	465	PF11976	0.586
LIG_SUMO_SIM_par_1	74	79	PF11976	0.614
LIG_TRAF2_1	186	189	PF00917	0.819
LIG_TRAF2_1	313	316	PF00917	0.746
LIG_TRAF2_1	350	353	PF00917	0.686
LIG_TRAF2_1	537	540	PF00917	0.576
LIG_UBA3_1	15	21	PF00899	0.595
LIG_WRC_WIRS_1	494	499	PF05994	0.562
MOD_CDC14_SPxK_1	522	525	PF00782	0.680
MOD_CDK_SPK_2	708	713	PF00069	0.658
MOD_CDK_SPxK_1	519	525	PF00069	0.669
MOD_CDK_SPxxK_3	401	408	PF00069	0.780
MOD_CDK_SPxxK_3	801	808	PF00069	0.653
MOD_CK1_1	103	109	PF00069	0.618
MOD_CK1_1	2	8	PF00069	0.761
MOD_CK1_1	227	233	PF00069	0.710
MOD_CK1_1	330	336	PF00069	0.615
MOD_CK1_1	444	450	PF00069	0.739
MOD_CK1_1	458	464	PF00069	0.466
MOD_CK1_1	472	478	PF00069	0.328
MOD_CK1_1	534	540	PF00069	0.632
MOD_CK1_1	562	568	PF00069	0.587
MOD_CK1_1	642	648	PF00069	0.573
MOD_CK1_1	719	725	PF00069	0.730
MOD_CK1_1	778	784	PF00069	0.583
MOD_CK1_1	81	87	PF00069	0.747
MOD_CK2_1	120	126	PF00069	0.751
MOD_CK2_1	194	200	PF00069	0.764
MOD_CK2_1	212	218	PF00069	0.484
MOD_CK2_1	310	316	PF00069	0.744
MOD_CK2_1	337	343	PF00069	0.710
MOD_CK2_1	534	540	PF00069	0.627
MOD_CK2_1	541	547	PF00069	0.492
MOD_CK2_1	757	763	PF00069	0.631
MOD_GlcNHglycan	181	184	PF01048	0.575
MOD_GlcNHglycan	214	217	PF01048	0.767
MOD_GlcNHglycan	304	307	PF01048	0.690
MOD_GlcNHglycan	332	335	PF01048	0.718
MOD_GlcNHglycan	395	398	PF01048	0.741
MOD_GlcNHglycan	432	435	PF01048	0.776
MOD_GlcNHglycan	457	460	PF01048	0.566
MOD_GlcNHglycan	543	546	PF01048	0.612
MOD_GlcNHglycan	57	60	PF01048	0.579
MOD_GlcNHglycan	603	606	PF01048	0.518
MOD_GlcNHglycan	628	631	PF01048	0.413
MOD_GlcNHglycan	693	696	PF01048	0.476
MOD_GlcNHglycan	702	705	PF01048	0.478
MOD_GlcNHglycan	820	823	PF01048	0.426
MOD_GlcNHglycan	83	86	PF01048	0.813
MOD_GSK3_1	128	135	PF00069	0.597
MOD_GSK3_1	184	191	PF00069	0.731
MOD_GSK3_1	194	201	PF00069	0.706
MOD_GSK3_1	208	215	PF00069	0.518
MOD_GSK3_1	265	272	PF00069	0.768
MOD_GSK3_1	298	305	PF00069	0.672
MOD_GSK3_1	469	476	PF00069	0.526
MOD_GSK3_1	673	680	PF00069	0.355
MOD_GSK3_1	691	698	PF00069	0.478
MOD_GSK3_1	700	707	PF00069	0.451
MOD_GSK3_1	719	726	PF00069	0.479
MOD_GSK3_1	74	81	PF00069	0.796
MOD_GSK3_1	757	764	PF00069	0.436
MOD_N-GLC_1	211	216	PF02516	0.696
MOD_N-GLC_1	293	298	PF02516	0.726
MOD_N-GLC_1	531	536	PF02516	0.516
MOD_N-GLC_1	818	823	PF02516	0.446
MOD_N-GLC_1	94	99	PF02516	0.736
MOD_NEK2_1	147	152	PF00069	0.570
MOD_NEK2_1	439	444	PF00069	0.572
MOD_NEK2_1	473	478	PF00069	0.606
MOD_NEK2_1	483	488	PF00069	0.478
MOD_NEK2_1	574	579	PF00069	0.530
MOD_NEK2_1	585	590	PF00069	0.457
MOD_NEK2_1	677	682	PF00069	0.493
MOD_NEK2_1	78	83	PF00069	0.756
MOD_NEK2_2	639	644	PF00069	0.644
MOD_OFUCOSY	528	535	PF10250	0.509
MOD_PIKK_1	147	153	PF00454	0.510
MOD_PIKK_1	311	317	PF00454	0.621
MOD_PIKK_1	375	381	PF00454	0.746
MOD_PIKK_1	559	565	PF00454	0.571
MOD_PIKK_1	696	702	PF00454	0.513
MOD_PIKK_1	731	737	PF00454	0.780
MOD_PIKK_1	761	767	PF00454	0.343
MOD_PK_1	508	514	PF00069	0.525
MOD_PKA_2	147	153	PF00069	0.523
MOD_PKA_2	208	214	PF00069	0.759
MOD_PKA_2	439	445	PF00069	0.794
MOD_PKA_2	503	509	PF00069	0.598
MOD_PKA_2	756	762	PF00069	0.639
MOD_Plk_1	128	134	PF00069	0.447
MOD_Plk_1	188	194	PF00069	0.808
MOD_Plk_1	469	475	PF00069	0.621
MOD_Plk_1	483	489	PF00069	0.339
MOD_Plk_1	531	537	PF00069	0.675
MOD_Plk_1	770	776	PF00069	0.532
MOD_Plk_1	832	838	PF00069	0.539
MOD_Plk_1	94	100	PF00069	0.732
MOD_Plk_2-3	120	126	PF00069	0.617
MOD_Plk_2-3	184	190	PF00069	0.759
MOD_Plk_4	103	109	PF00069	0.590
MOD_Plk_4	265	271	PF00069	0.746
MOD_Plk_4	483	489	PF00069	0.433
MOD_Plk_4	508	514	PF00069	0.584
MOD_Plk_4	574	580	PF00069	0.571
MOD_ProDKin_1	112	118	PF00069	0.732
MOD_ProDKin_1	194	200	PF00069	0.674
MOD_ProDKin_1	273	279	PF00069	0.760
MOD_ProDKin_1	285	291	PF00069	0.619
MOD_ProDKin_1	300	306	PF00069	0.691
MOD_ProDKin_1	327	333	PF00069	0.765
MOD_ProDKin_1	401	407	PF00069	0.777
MOD_ProDKin_1	418	424	PF00069	0.504
MOD_ProDKin_1	519	525	PF00069	0.669
MOD_ProDKin_1	708	714	PF00069	0.673
MOD_ProDKin_1	801	807	PF00069	0.647
MOD_ProDKin_1	84	90	PF00069	0.692
MOD_SUMO_for_1	643	646	PF00179	0.523
MOD_SUMO_rev_2	352	357	PF00179	0.661
MOD_SUMO_rev_2	711	720	PF00179	0.645
TRG_DiLeu_BaEn_1	547	552	PF01217	0.532
TRG_DiLeu_BaLyEn_6	133	138	PF01217	0.529
TRG_DiLeu_BaLyEn_6	682	687	PF01217	0.619
TRG_DiLeu_BaLyEn_6	833	838	PF01217	0.492
TRG_ENDOCYTIC_2	144	147	PF00928	0.576
TRG_ENDOCYTIC_2	488	491	PF00928	0.608
TRG_ENDOCYTIC_2	610	613	PF00928	0.350
TRG_ER_diArg_1	133	136	PF00400	0.525
TRG_ER_diArg_1	207	210	PF00400	0.754
TRG_ER_diArg_1	34	36	PF00400	0.636
TRG_ER_diArg_1	477	479	PF00400	0.536
TRG_ER_diArg_1	569	571	PF00400	0.595
TRG_ER_diArg_1	579	581	PF00400	0.461
TRG_ER_diArg_1	613	616	PF00400	0.370
TRG_ER_diArg_1	621	623	PF00400	0.333
TRG_ER_diArg_1	834	837	PF00400	0.539
TRG_Pf-PMV_PEXEL_1	245	250	PF00026	0.567
TRG_Pf-PMV_PEXEL_1	549	554	PF00026	0.477
TRG_Pf-PMV_PEXEL_1	558	563	PF00026	0.493

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NX86	Trypanosomatidae	23%	100%
A0A3Q8IBL2	Leishmania donovani	84%	100%
A4HYK9	Leishmania infantum	85%	100%
E9AI72	Leishmania braziliensis	57%	100%
E9AUF8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%