Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QD25_LEIMA

TriTrypDb:

LmjF.20.0190 , LMJLV39_200007000 , LMJSD75_200006900

Length:

202

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QD25

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD25

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	180	184	PF00656	0.617
CLV_NRD_NRD_1	140	142	PF00675	0.621
CLV_NRD_NRD_1	170	172	PF00675	0.563
CLV_NRD_NRD_1	2	4	PF00675	0.682
CLV_NRD_NRD_1	62	64	PF00675	0.689
CLV_PCSK_FUR_1	2	6	PF00082	0.577
CLV_PCSK_KEX2_1	140	142	PF00082	0.705
CLV_PCSK_KEX2_1	170	172	PF00082	0.541
CLV_PCSK_KEX2_1	177	179	PF00082	0.478
CLV_PCSK_KEX2_1	2	4	PF00082	0.731
CLV_PCSK_KEX2_1	61	63	PF00082	0.771
CLV_PCSK_PC1ET2_1	177	179	PF00082	0.501
CLV_PCSK_PC1ET2_1	4	6	PF00082	0.606
CLV_PCSK_SKI1_1	39	43	PF00082	0.561
DEG_Nend_UBRbox_1	1	4	PF02207	0.638
DEG_SPOP_SBC_1	44	48	PF00917	0.739
DOC_SPAK_OSR1_1	80	84	PF12202	0.424
DOC_USP7_MATH_1	17	21	PF00917	0.624
DOC_USP7_MATH_1	45	49	PF00917	0.689
DOC_USP7_MATH_1	57	61	PF00917	0.688
DOC_USP7_MATH_1	66	70	PF00917	0.685
DOC_USP7_UBL2_3	155	159	PF12436	0.607
DOC_WW_Pin1_4	52	57	PF00397	0.733
LIG_14-3-3_CanoR_1	132	139	PF00244	0.695
LIG_14-3-3_CanoR_1	3	9	PF00244	0.577
LIG_14-3-3_CanoR_1	39	45	PF00244	0.657
LIG_14-3-3_CanoR_1	61	66	PF00244	0.733
LIG_14-3-3_CterR_2	198	202	PF00244	0.714
LIG_BIR_III_4	76	80	PF00653	0.472
LIG_BRCT_BRCA1_1	153	157	PF00533	0.533
LIG_BRCT_BRCA1_2	153	159	PF00533	0.379
LIG_deltaCOP1_diTrp_1	168	172	PF00928	0.485
LIG_FHA_1	33	39	PF00498	0.571
LIG_FHA_1	8	14	PF00498	0.561
LIG_FHA_1	86	92	PF00498	0.577
LIG_FHA_2	126	132	PF00498	0.743
LIG_LIR_Gen_1	151	157	PF02991	0.548
LIG_LIR_Nem_3	151	156	PF02991	0.498
LIG_LIR_Nem_3	168	172	PF02991	0.378
LIG_MAD2	188	196	PF02301	0.418
LIG_PCNA_PIPBox_1	24	33	PF02747	0.524
LIG_Pex14_2	149	153	PF04695	0.438
LIG_RPA_C_Fungi	166	178	PF08784	0.510
LIG_SH2_STAP1	146	150	PF00017	0.519
LIG_SH2_STAT5	8	11	PF00017	0.613
LIG_TRAF2_1	96	99	PF00917	0.611
LIG_WRC_WIRS_1	67	72	PF05994	0.608
MOD_CK1_1	151	157	PF00069	0.541
MOD_CK1_1	173	179	PF00069	0.587
MOD_CK1_1	48	54	PF00069	0.716
MOD_CK1_1	7	13	PF00069	0.616
MOD_CK2_1	125	131	PF00069	0.749
MOD_CK2_1	52	58	PF00069	0.727
MOD_GlcNHglycan	133	136	PF01048	0.807
MOD_GlcNHglycan	172	175	PF01048	0.548
MOD_GlcNHglycan	191	194	PF01048	0.389
MOD_GlcNHglycan	51	54	PF01048	0.788
MOD_GlcNHglycan	85	88	PF01048	0.575
MOD_GSK3_1	144	151	PF00069	0.572
MOD_GSK3_1	3	10	PF00069	0.607
MOD_GSK3_1	39	46	PF00069	0.655
MOD_GSK3_1	48	55	PF00069	0.666
MOD_GSK3_1	57	64	PF00069	0.574
MOD_N-GLC_2	16	18	PF02516	0.410
MOD_NEK2_1	148	153	PF00069	0.438
MOD_NEK2_1	49	54	PF00069	0.754
MOD_PKA_1	170	176	PF00069	0.566
MOD_PKA_1	3	9	PF00069	0.674
MOD_PKA_1	61	67	PF00069	0.686
MOD_PKA_2	131	137	PF00069	0.729
MOD_PKA_2	170	176	PF00069	0.628
MOD_PKA_2	4	10	PF00069	0.560
MOD_PKA_2	61	67	PF00069	0.713
MOD_Plk_4	144	150	PF00069	0.463
MOD_Plk_4	26	32	PF00069	0.548
MOD_Plk_4	4	10	PF00069	0.663
MOD_Plk_4	45	51	PF00069	0.605
MOD_ProDKin_1	52	58	PF00069	0.734
MOD_SUMO_rev_2	173	179	PF00179	0.495
MOD_SUMO_rev_2	20	30	PF00179	0.618
TRG_DiLeu_BaEn_1	181	186	PF01217	0.561
TRG_ENDOCYTIC_2	146	149	PF00928	0.450
TRG_ER_diArg_1	1	3	PF00400	0.745
TRG_ER_diArg_1	139	141	PF00400	0.693
TRG_ER_diArg_1	169	171	PF00400	0.565
TRG_ER_diArg_1	61	63	PF00400	0.703
TRG_ER_diArg_1	78	81	PF00400	0.505
TRG_NLS_MonoExtN_4	2	7	PF00514	0.712

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWU9	Leptomonas seymouri	33%	100%
A0A1X0NWM2	Trypanosomatidae	26%	100%
A0A3Q8IBI0	Leishmania donovani	92%	100%
A0A422NEH1	Trypanosoma rangeli	29%	100%
A4HYL0	Leishmania infantum	90%	100%
E9AI73	Leishmania braziliensis	63%	67%
E9AUF9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%