Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QD24_LEIMA

TriTrypDb:

LmjF.20.0200 , LMJLV39_200007100 , LMJSD75_200007000

Length:

862

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QD24

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD24

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	127	131	PF00656	0.415
CLV_C14_Caspase3-7	76	80	PF00656	0.420
CLV_NRD_NRD_1	376	378	PF00675	0.543
CLV_NRD_NRD_1	393	395	PF00675	0.426
CLV_NRD_NRD_1	397	399	PF00675	0.445
CLV_NRD_NRD_1	538	540	PF00675	0.461
CLV_NRD_NRD_1	616	618	PF00675	0.330
CLV_NRD_NRD_1	696	698	PF00675	0.557
CLV_NRD_NRD_1	713	715	PF00675	0.331
CLV_PCSK_KEX2_1	206	208	PF00082	0.432
CLV_PCSK_KEX2_1	397	399	PF00082	0.447
CLV_PCSK_KEX2_1	696	698	PF00082	0.557
CLV_PCSK_KEX2_1	713	715	PF00082	0.331
CLV_PCSK_PC1ET2_1	206	208	PF00082	0.432
CLV_PCSK_SKI1_1	207	211	PF00082	0.373
CLV_PCSK_SKI1_1	342	346	PF00082	0.381
CLV_PCSK_SKI1_1	378	382	PF00082	0.522
CLV_PCSK_SKI1_1	617	621	PF00082	0.465
CLV_PCSK_SKI1_1	671	675	PF00082	0.395
CLV_PCSK_SKI1_1	855	859	PF00082	0.565
CLV_Separin_Metazoa	240	244	PF03568	0.509
DEG_APCC_DBOX_1	347	355	PF00400	0.441
DEG_Nend_Nbox_1	1	3	PF02207	0.441
DEG_SCF_FBW7_1	583	589	PF00400	0.389
DEG_SPOP_SBC_1	563	567	PF00917	0.507
DEG_SPOP_SBC_1	747	751	PF00917	0.537
DOC_CKS1_1	583	588	PF01111	0.518
DOC_CYCLIN_RxL_1	615	625	PF00134	0.332
DOC_CYCLIN_RxL_1	668	676	PF00134	0.387
DOC_CYCLIN_RxL_1	804	815	PF00134	0.382
DOC_CYCLIN_yCln2_LP_2	646	652	PF00134	0.535
DOC_MAPK_gen_1	135	143	PF00069	0.457
DOC_MAPK_gen_1	206	212	PF00069	0.435
DOC_MAPK_gen_1	214	223	PF00069	0.403
DOC_MAPK_gen_1	414	422	PF00069	0.391
DOC_MAPK_gen_1	539	548	PF00069	0.387
DOC_MAPK_MEF2A_6	135	143	PF00069	0.457
DOC_MAPK_MEF2A_6	360	368	PF00069	0.515
DOC_PP2B_LxvP_1	590	593	PF13499	0.447
DOC_USP7_MATH_1	11	15	PF00917	0.457
DOC_USP7_MATH_1	32	36	PF00917	0.583
DOC_USP7_MATH_1	384	388	PF00917	0.691
DOC_USP7_MATH_1	629	633	PF00917	0.442
DOC_USP7_MATH_1	683	687	PF00917	0.396
DOC_USP7_MATH_1	84	88	PF00917	0.444
DOC_USP7_MATH_1	857	861	PF00917	0.590
DOC_WW_Pin1_4	412	417	PF00397	0.415
DOC_WW_Pin1_4	495	500	PF00397	0.460
DOC_WW_Pin1_4	564	569	PF00397	0.527
DOC_WW_Pin1_4	582	587	PF00397	0.335
DOC_WW_Pin1_4	817	822	PF00397	0.403
DOC_WW_Pin1_4	836	841	PF00397	0.403
LIG_14-3-3_CanoR_1	107	111	PF00244	0.394
LIG_14-3-3_CanoR_1	220	224	PF00244	0.403
LIG_14-3-3_CanoR_1	316	322	PF00244	0.471
LIG_14-3-3_CanoR_1	342	351	PF00244	0.444
LIG_14-3-3_CanoR_1	360	368	PF00244	0.702
LIG_14-3-3_CanoR_1	597	606	PF00244	0.367
LIG_14-3-3_CanoR_1	658	668	PF00244	0.389
LIG_14-3-3_CanoR_1	714	722	PF00244	0.399
LIG_14-3-3_CanoR_1	796	804	PF00244	0.447
LIG_14-3-3_CanoR_1	807	812	PF00244	0.331
LIG_Actin_WH2_2	415	433	PF00022	0.345
LIG_Actin_WH2_2	94	109	PF00022	0.383
LIG_APCC_ABBA_1	462	467	PF00400	0.382
LIG_BH_BH3_1	33	49	PF00452	0.420
LIG_BRCT_BRCA1_1	108	112	PF00533	0.391
LIG_BRCT_BRCA1_1	13	17	PF00533	0.462
LIG_CSL_BTD_1	818	821	PF09270	0.407
LIG_deltaCOP1_diTrp_1	455	465	PF00928	0.451
LIG_deltaCOP1_diTrp_1	482	487	PF00928	0.370
LIG_DLG_GKlike_1	807	815	PF00625	0.453
LIG_EH1_1	825	833	PF00400	0.387
LIG_eIF4E_1	826	832	PF01652	0.380
LIG_FHA_1	188	194	PF00498	0.378
LIG_FHA_1	296	302	PF00498	0.528
LIG_FHA_1	304	310	PF00498	0.492
LIG_FHA_1	327	333	PF00498	0.499
LIG_FHA_1	49	55	PF00498	0.385
LIG_FHA_1	503	509	PF00498	0.539
LIG_FHA_1	549	555	PF00498	0.427
LIG_FHA_1	593	599	PF00498	0.404
LIG_FHA_1	641	647	PF00498	0.450
LIG_FHA_1	710	716	PF00498	0.406
LIG_FHA_1	722	728	PF00498	0.374
LIG_FHA_1	753	759	PF00498	0.360
LIG_FHA_1	837	843	PF00498	0.471
LIG_FHA_2	175	181	PF00498	0.441
LIG_FHA_2	254	260	PF00498	0.615
LIG_FHA_2	318	324	PF00498	0.542
LIG_FHA_2	38	44	PF00498	0.421
LIG_FHA_2	466	472	PF00498	0.458
LIG_FHA_2	758	764	PF00498	0.346
LIG_FHA_2	772	778	PF00498	0.382
LIG_FHA_2	811	817	PF00498	0.426
LIG_LIR_Apic_2	264	270	PF02991	0.605
LIG_LIR_Gen_1	163	174	PF02991	0.392
LIG_LIR_Gen_1	455	465	PF02991	0.429
LIG_LIR_Gen_1	486	494	PF02991	0.285
LIG_LIR_Gen_1	667	674	PF02991	0.352
LIG_LIR_Gen_1	704	715	PF02991	0.444
LIG_LIR_LC3C_4	331	336	PF02991	0.467
LIG_LIR_Nem_3	163	169	PF02991	0.381
LIG_LIR_Nem_3	455	461	PF02991	0.499
LIG_LIR_Nem_3	486	490	PF02991	0.280
LIG_LIR_Nem_3	667	672	PF02991	0.352
LIG_LIR_Nem_3	704	710	PF02991	0.424
LIG_LIR_Nem_3	816	822	PF02991	0.477
LIG_LYPXL_SIV_4	568	576	PF13949	0.445
LIG_NRBOX	313	319	PF00104	0.425
LIG_NRBOX	669	675	PF00104	0.383
LIG_NRBOX	760	766	PF00104	0.353
LIG_RPA_C_Fungi	10	22	PF08784	0.381
LIG_SH2_NCK_1	179	183	PF00017	0.367
LIG_SH2_SRC	826	829	PF00017	0.387
LIG_SH2_STAP1	569	573	PF00017	0.438
LIG_SH2_STAT5	233	236	PF00017	0.394
LIG_SH2_STAT5	493	496	PF00017	0.380
LIG_SH2_STAT5	561	564	PF00017	0.491
LIG_SH2_STAT5	641	644	PF00017	0.370
LIG_SH2_STAT5	669	672	PF00017	0.415
LIG_SH2_STAT5	826	829	PF00017	0.387
LIG_SH3_2	612	617	PF14604	0.312
LIG_SH3_3	606	612	PF00018	0.395
LIG_SH3_3	722	728	PF00018	0.439
LIG_SUMO_SIM_anti_2	418	424	PF11976	0.387
LIG_SUMO_SIM_anti_2	570	578	PF11976	0.431
LIG_SUMO_SIM_anti_2	759	766	PF11976	0.344
LIG_SUMO_SIM_par_1	317	323	PF11976	0.517
LIG_SUMO_SIM_par_1	53	58	PF11976	0.395
LIG_TRAF2_1	328	331	PF00917	0.497
LIG_TRAF2_1	480	483	PF00917	0.383
LIG_TRAF2_1	775	778	PF00917	0.453
LIG_WRC_WIRS_1	341	346	PF05994	0.366
LIG_WW_3	88	92	PF00397	0.463
MOD_CDK_SPK_2	412	417	PF00069	0.393
MOD_CDK_SPxxK_3	817	824	PF00069	0.391
MOD_CK1_1	152	158	PF00069	0.347
MOD_CK1_1	27	33	PF00069	0.556
MOD_CK1_1	279	285	PF00069	0.767
MOD_CK1_1	294	300	PF00069	0.467
MOD_CK1_1	310	316	PF00069	0.538
MOD_CK1_1	343	349	PF00069	0.361
MOD_CK1_1	35	41	PF00069	0.470
MOD_CK1_1	359	365	PF00069	0.416
MOD_CK1_1	387	393	PF00069	0.511
MOD_CK1_1	42	48	PF00069	0.389
MOD_CK1_1	450	456	PF00069	0.503
MOD_CK1_1	498	504	PF00069	0.575
MOD_CK1_1	511	517	PF00069	0.435
MOD_CK1_1	524	530	PF00069	0.490
MOD_CK1_1	60	66	PF00069	0.413
MOD_CK1_1	810	816	PF00069	0.429
MOD_CK2_1	234	240	PF00069	0.517
MOD_CK2_1	317	323	PF00069	0.517
MOD_CK2_1	477	483	PF00069	0.410
MOD_CK2_1	514	520	PF00069	0.469
MOD_CK2_1	771	777	PF00069	0.403
MOD_CK2_1	810	816	PF00069	0.429
MOD_DYRK1A_RPxSP_1	495	499	PF00069	0.447
MOD_GlcNHglycan	30	33	PF01048	0.500
MOD_GlcNHglycan	323	327	PF01048	0.487
MOD_GlcNHglycan	409	412	PF01048	0.591
MOD_GlcNHglycan	467	471	PF01048	0.612
MOD_GlcNHglycan	479	482	PF01048	0.455
MOD_GlcNHglycan	500	503	PF01048	0.584
MOD_GlcNHglycan	516	519	PF01048	0.408
MOD_GlcNHglycan	524	527	PF01048	0.564
MOD_GlcNHglycan	599	602	PF01048	0.365
MOD_GlcNHglycan	62	65	PF01048	0.540
MOD_GlcNHglycan	631	634	PF01048	0.458
MOD_GlcNHglycan	681	684	PF01048	0.389
MOD_GlcNHglycan	732	735	PF01048	0.440
MOD_GlcNHglycan	797	800	PF01048	0.453
MOD_GSK3_1	24	31	PF00069	0.630
MOD_GSK3_1	249	256	PF00069	0.608
MOD_GSK3_1	281	288	PF00069	0.646
MOD_GSK3_1	291	298	PF00069	0.617
MOD_GSK3_1	303	310	PF00069	0.607
MOD_GSK3_1	32	39	PF00069	0.571
MOD_GSK3_1	322	329	PF00069	0.523
MOD_GSK3_1	354	361	PF00069	0.553
MOD_GSK3_1	380	387	PF00069	0.549
MOD_GSK3_1	42	49	PF00069	0.316
MOD_GSK3_1	498	505	PF00069	0.720
MOD_GSK3_1	508	515	PF00069	0.520
MOD_GSK3_1	553	560	PF00069	0.458
MOD_GSK3_1	564	571	PF00069	0.417
MOD_GSK3_1	582	589	PF00069	0.342
MOD_GSK3_1	625	632	PF00069	0.536
MOD_GSK3_1	679	686	PF00069	0.398
MOD_GSK3_1	717	724	PF00069	0.408
MOD_GSK3_1	742	749	PF00069	0.522
MOD_GSK3_1	752	759	PF00069	0.354
MOD_GSK3_1	807	814	PF00069	0.409
MOD_NEK2_1	1	6	PF00069	0.416
MOD_NEK2_1	106	111	PF00069	0.384
MOD_NEK2_1	142	147	PF00069	0.374
MOD_NEK2_1	149	154	PF00069	0.344
MOD_NEK2_1	200	205	PF00069	0.346
MOD_NEK2_1	210	215	PF00069	0.392
MOD_NEK2_1	228	233	PF00069	0.464
MOD_NEK2_1	234	239	PF00069	0.473
MOD_NEK2_1	286	291	PF00069	0.690
MOD_NEK2_1	295	300	PF00069	0.505
MOD_NEK2_1	302	307	PF00069	0.432
MOD_NEK2_1	317	322	PF00069	0.444
MOD_NEK2_1	354	359	PF00069	0.408
MOD_NEK2_1	36	41	PF00069	0.503
MOD_NEK2_1	465	470	PF00069	0.474
MOD_NEK2_1	512	517	PF00069	0.524
MOD_NEK2_1	57	62	PF00069	0.423
MOD_NEK2_1	709	714	PF00069	0.374
MOD_NEK2_1	715	720	PF00069	0.423
MOD_NEK2_1	721	726	PF00069	0.373
MOD_NEK2_1	756	761	PF00069	0.312
MOD_NEK2_1	794	799	PF00069	0.481
MOD_NEK2_2	337	342	PF00069	0.437
MOD_PIKK_1	152	158	PF00454	0.396
MOD_PIKK_1	193	199	PF00454	0.474
MOD_PIKK_1	234	240	PF00454	0.504
MOD_PIKK_1	296	302	PF00454	0.528
MOD_PIKK_1	354	360	PF00454	0.588
MOD_PIKK_1	55	61	PF00454	0.462
MOD_PIKK_1	553	559	PF00454	0.390
MOD_PIKK_1	849	855	PF00454	0.597
MOD_PKA_2	106	112	PF00069	0.383
MOD_PKA_2	11	17	PF00069	0.432
MOD_PKA_2	219	225	PF00069	0.387
MOD_PKA_2	354	360	PF00069	0.504
MOD_PKA_2	538	544	PF00069	0.531
MOD_PKA_2	629	635	PF00069	0.422
MOD_PKA_2	659	665	PF00069	0.399
MOD_PKA_2	695	701	PF00069	0.419
MOD_PKA_2	795	801	PF00069	0.571
MOD_Plk_1	253	259	PF00069	0.621
MOD_Plk_1	282	288	PF00069	0.637
MOD_Plk_1	310	316	PF00069	0.442
MOD_Plk_1	387	393	PF00069	0.510
MOD_Plk_1	78	84	PF00069	0.397
MOD_Plk_1	815	821	PF00069	0.440
MOD_Plk_2-3	254	260	PF00069	0.615
MOD_Plk_2-3	447	453	PF00069	0.520
MOD_Plk_4	1	7	PF00069	0.524
MOD_Plk_4	180	186	PF00069	0.401
MOD_Plk_4	219	225	PF00069	0.482
MOD_Plk_4	229	235	PF00069	0.399
MOD_Plk_4	310	316	PF00069	0.620
MOD_Plk_4	387	393	PF00069	0.510
MOD_Plk_4	453	459	PF00069	0.614
MOD_Plk_4	641	647	PF00069	0.381
MOD_Plk_4	717	723	PF00069	0.483
MOD_Plk_4	752	758	PF00069	0.405
MOD_Plk_4	807	813	PF00069	0.376
MOD_ProDKin_1	412	418	PF00069	0.411
MOD_ProDKin_1	495	501	PF00069	0.472
MOD_ProDKin_1	564	570	PF00069	0.526
MOD_ProDKin_1	582	588	PF00069	0.341
MOD_ProDKin_1	817	823	PF00069	0.396
MOD_ProDKin_1	836	842	PF00069	0.398
TRG_AP2beta_CARGO_1	704	714	PF09066	0.434
TRG_DiLeu_BaEn_1	330	335	PF01217	0.523
TRG_DiLeu_BaEn_1	388	393	PF01217	0.453
TRG_DiLeu_BaLyEn_6	313	318	PF01217	0.423
TRG_DiLeu_BaLyEn_6	594	599	PF01217	0.370
TRG_DiLeu_BaLyEn_6	668	673	PF01217	0.315
TRG_ENDOCYTIC_2	669	672	PF00928	0.415
TRG_ER_diArg_1	137	140	PF00400	0.400
TRG_ER_diArg_1	658	661	PF00400	0.423
TRG_ER_diArg_1	713	715	PF00400	0.409
TRG_NLS_Bipartite_1	377	398	PF00514	0.438
TRG_NLS_MonoExtC_3	393	398	PF00514	0.455
TRG_Pf-PMV_PEXEL_1	417	421	PF00026	0.439
TRG_Pf-PMV_PEXEL_1	671	675	PF00026	0.374
TRG_Pf-PMV_PEXEL_1	691	695	PF00026	0.249
TRG_Pf-PMV_PEXEL_1	713	717	PF00026	0.405

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PBK8	Leptomonas seymouri	46%	100%
A0A3Q8IBG3	Leishmania donovani	89%	100%
A4HYL1	Leishmania infantum	89%	100%
E9AI74	Leishmania braziliensis	74%	100%
E9AUG0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%