Kelch domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

kelch domain-containing protein

Species:

Leishmania major

UniProt:

Q4QD23_LEIMA

TriTrypDb:

LmjF.20.0210 , LMJLV39_200007200 , LMJSD75_200007100

Length:

417

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QD23

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD23

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	147	149	PF00675	0.369
CLV_NRD_NRD_1	76	78	PF00675	0.454
CLV_NRD_NRD_1	79	81	PF00675	0.439
CLV_PCSK_KEX2_1	147	149	PF00082	0.369
CLV_PCSK_KEX2_1	76	78	PF00082	0.454
CLV_PCSK_SKI1_1	12	16	PF00082	0.681
CLV_PCSK_SKI1_1	408	412	PF00082	0.522
DEG_MDM2_SWIB_1	297	305	PF02201	0.448
DOC_CKS1_1	163	168	PF01111	0.469
DOC_CYCLIN_yCln2_LP_2	112	118	PF00134	0.310
DOC_CYCLIN_yCln2_LP_2	350	356	PF00134	0.480
DOC_PP1_RVXF_1	10	17	PF00149	0.484
DOC_PP2B_LxvP_1	350	353	PF13499	0.520
DOC_PP4_FxxP_1	361	364	PF00568	0.471
DOC_PP4_MxPP_1	35	38	PF00568	0.506
DOC_PP4_MxPP_1	88	91	PF00568	0.510
DOC_USP7_MATH_1	264	268	PF00917	0.279
DOC_USP7_MATH_1	288	292	PF00917	0.510
DOC_USP7_MATH_1	334	338	PF00917	0.410
DOC_USP7_MATH_1	83	87	PF00917	0.547
DOC_USP7_MATH_1	94	98	PF00917	0.410
DOC_WW_Pin1_4	111	116	PF00397	0.410
DOC_WW_Pin1_4	137	142	PF00397	0.534
DOC_WW_Pin1_4	162	167	PF00397	0.463
DOC_WW_Pin1_4	230	235	PF00397	0.354
DOC_WW_Pin1_4	33	38	PF00397	0.470
LIG_14-3-3_CanoR_1	130	134	PF00244	0.467
LIG_14-3-3_CanoR_1	250	255	PF00244	0.373
LIG_14-3-3_CanoR_1	269	275	PF00244	0.336
LIG_14-3-3_CanoR_1	335	339	PF00244	0.452
LIG_14-3-3_CanoR_1	374	381	PF00244	0.561
LIG_BIR_II_1	1	5	PF00653	0.493
LIG_BRCT_BRCA1_1	293	297	PF00533	0.472
LIG_BRCT_BRCA1_1	335	339	PF00533	0.371
LIG_eIF4E_1	48	54	PF01652	0.290
LIG_FHA_1	389	395	PF00498	0.645
LIG_FHA_2	195	201	PF00498	0.582
LIG_LIR_Apic_2	359	364	PF02991	0.431
LIG_LIR_Gen_1	128	139	PF02991	0.384
LIG_LIR_Gen_1	181	192	PF02991	0.407
LIG_LIR_Gen_1	278	288	PF02991	0.364
LIG_LIR_Gen_1	294	305	PF02991	0.396
LIG_LIR_Gen_1	50	56	PF02991	0.310
LIG_LIR_Nem_3	128	134	PF02991	0.372
LIG_LIR_Nem_3	15	21	PF02991	0.523
LIG_LIR_Nem_3	181	187	PF02991	0.392
LIG_LIR_Nem_3	253	257	PF02991	0.302
LIG_LIR_Nem_3	278	283	PF02991	0.377
LIG_LIR_Nem_3	294	300	PF02991	0.360
LIG_LIR_Nem_3	50	55	PF02991	0.310
LIG_LYPXL_SIV_4	330	338	PF13949	0.397
LIG_MLH1_MIPbox_1	293	297	PF16413	0.472
LIG_Pex14_2	16	20	PF04695	0.650
LIG_Pex14_2	297	301	PF04695	0.335
LIG_PTAP_UEV_1	165	170	PF05743	0.348
LIG_PTB_Apo_2	239	246	PF02174	0.290
LIG_PTB_Apo_2	63	70	PF02174	0.310
LIG_PTB_Phospho_1	63	69	PF10480	0.286
LIG_SH2_GRB2like	240	243	PF00017	0.310
LIG_SH2_PTP2	280	283	PF00017	0.420
LIG_SH2_SRC	118	121	PF00017	0.352
LIG_SH2_STAP1	118	122	PF00017	0.410
LIG_SH2_STAP1	270	274	PF00017	0.303
LIG_SH2_STAT3	107	110	PF00017	0.334
LIG_SH2_STAT3	367	370	PF00017	0.574
LIG_SH2_STAT5	160	163	PF00017	0.321
LIG_SH2_STAT5	176	179	PF00017	0.317
LIG_SH2_STAT5	220	223	PF00017	0.283
LIG_SH2_STAT5	280	283	PF00017	0.340
LIG_SH2_STAT5	296	299	PF00017	0.342
LIG_SH2_STAT5	331	334	PF00017	0.374
LIG_SH2_STAT5	52	55	PF00017	0.358
LIG_SH2_STAT5	69	72	PF00017	0.167
LIG_SH3_1	258	264	PF00018	0.497
LIG_SH3_3	138	144	PF00018	0.441
LIG_SH3_3	163	169	PF00018	0.480
LIG_SH3_3	258	264	PF00018	0.451
LIG_SUMO_SIM_anti_2	123	128	PF11976	0.304
LIG_SUMO_SIM_par_1	119	125	PF11976	0.412
LIG_TRAF2_1	410	413	PF00917	0.565
LIG_TYR_ITIM	116	121	PF00017	0.410
LIG_TYR_ITIM	174	179	PF00017	0.435
LIG_WW_3	89	93	PF00397	0.392
MOD_CK1_1	2	8	PF00069	0.572
MOD_CK1_1	212	218	PF00069	0.374
MOD_CK1_1	27	33	PF00069	0.574
MOD_CK1_1	291	297	PF00069	0.496
MOD_CK1_1	324	330	PF00069	0.324
MOD_CK1_1	393	399	PF00069	0.556
MOD_CK2_1	194	200	PF00069	0.644
MOD_CK2_1	393	399	PF00069	0.610
MOD_GlcNHglycan	211	214	PF01048	0.296
MOD_GlcNHglycan	24	27	PF01048	0.659
MOD_GlcNHglycan	266	269	PF01048	0.319
MOD_GlcNHglycan	323	326	PF01048	0.340
MOD_GlcNHglycan	367	370	PF01048	0.574
MOD_GlcNHglycan	375	378	PF01048	0.446
MOD_GlcNHglycan	96	99	PF01048	0.271
MOD_GSK3_1	125	132	PF00069	0.351
MOD_GSK3_1	208	215	PF00069	0.361
MOD_GSK3_1	246	253	PF00069	0.426
MOD_GSK3_1	291	298	PF00069	0.548
MOD_GSK3_1	329	336	PF00069	0.383
MOD_GSK3_1	365	372	PF00069	0.517
MOD_GSK3_1	72	79	PF00069	0.310
MOD_N-GLC_1	288	293	PF02516	0.512
MOD_NEK2_1	365	370	PF00069	0.505
MOD_NEK2_1	373	378	PF00069	0.506
MOD_NEK2_1	93	98	PF00069	0.390
MOD_NEK2_2	240	245	PF00069	0.290
MOD_NEK2_2	334	339	PF00069	0.375
MOD_NEK2_2	369	374	PF00069	0.600
MOD_PKA_1	76	82	PF00069	0.454
MOD_PKA_2	129	135	PF00069	0.472
MOD_PKA_2	264	270	PF00069	0.316
MOD_PKA_2	27	33	PF00069	0.638
MOD_PKA_2	334	340	PF00069	0.388
MOD_PKA_2	373	379	PF00069	0.580
MOD_PKA_2	388	394	PF00069	0.685
MOD_PKA_2	76	82	PF00069	0.366
MOD_Plk_1	12	18	PF00069	0.665
MOD_Plk_1	291	297	PF00069	0.514
MOD_Plk_1	348	354	PF00069	0.598
MOD_Plk_4	187	193	PF00069	0.542
MOD_Plk_4	200	206	PF00069	0.575
MOD_Plk_4	240	246	PF00069	0.302
MOD_Plk_4	27	33	PF00069	0.590
MOD_Plk_4	291	297	PF00069	0.496
MOD_Plk_4	334	340	PF00069	0.369
MOD_Plk_4	41	47	PF00069	0.325
MOD_ProDKin_1	111	117	PF00069	0.410
MOD_ProDKin_1	137	143	PF00069	0.527
MOD_ProDKin_1	162	168	PF00069	0.465
MOD_ProDKin_1	230	236	PF00069	0.354
MOD_ProDKin_1	33	39	PF00069	0.464
TRG_ENDOCYTIC_2	118	121	PF00928	0.349
TRG_ENDOCYTIC_2	160	163	PF00928	0.321
TRG_ENDOCYTIC_2	176	179	PF00928	0.317
TRG_ENDOCYTIC_2	280	283	PF00928	0.420
TRG_ENDOCYTIC_2	52	55	PF00928	0.407
TRG_ER_diArg_1	147	149	PF00400	0.369
TRG_ER_diArg_1	76	78	PF00400	0.454

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I272	Leptomonas seymouri	50%	100%
A0A0S4JFE6	Bodo saltans	33%	100%
A0A0S4KG66	Bodo saltans	23%	72%
A0A1X0NVZ5	Trypanosomatidae	23%	100%
A0A1X0NY29	Trypanosomatidae	41%	100%
A0A3S5H781	Leishmania donovani	94%	100%
A0A422NEH9	Trypanosoma rangeli	44%	100%
A0A422NWK7	Trypanosoma rangeli	22%	100%
A4HYL2	Leishmania infantum	94%	100%
C9ZHV9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	98%
E9AI75	Leishmania braziliensis	83%	100%
E9AUG1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	92%	100%
Q10AZ7	Oryza sativa subsp. japonica	23%	83%
Q3KRE6	Rattus norvegicus	25%	100%
Q58CV6	Bos taurus	25%	100%
Q6AYI2	Rattus norvegicus	25%	100%
Q8RY71	Arabidopsis thaliana	25%	100%
Q8VEM9	Mus musculus	25%	100%
Q9BQ90	Homo sapiens	26%	100%
Q9Y2U9	Homo sapiens	25%	100%
V5BAH1	Trypanosoma cruzi	23%	100%
V5DS74	Trypanosoma cruzi	43%	100%