LeishMANIAdb
  • Home
  • Browse
  • Manual
  • FAQ
  • Download

Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
Non-specific serine/threonine protein kinase
Gene product:
hypothetical protein, conserved
Species:
Leishmania major
UniProt:
Q4QD22_LEIMA
TriTrypDb:
LmjF.20.0220 , LMJLV39_200007400 * , LMJSD75_200007300
Length:
949

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 8
NetGPI no yes: 0, no: 8
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QD22
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD22

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 2 6 PF00656 0.537
CLV_C14_Caspase3-7 742 746 PF00656 0.444
CLV_C14_Caspase3-7 832 836 PF00656 0.499
CLV_MEL_PAP_1 602 608 PF00089 0.408
CLV_NRD_NRD_1 120 122 PF00675 0.432
CLV_NRD_NRD_1 174 176 PF00675 0.450
CLV_NRD_NRD_1 182 184 PF00675 0.406
CLV_NRD_NRD_1 187 189 PF00675 0.388
CLV_NRD_NRD_1 604 606 PF00675 0.476
CLV_NRD_NRD_1 727 729 PF00675 0.487
CLV_NRD_NRD_1 838 840 PF00675 0.449
CLV_NRD_NRD_1 95 97 PF00675 0.547
CLV_PCSK_FUR_1 725 729 PF00082 0.476
CLV_PCSK_KEX2_1 120 122 PF00082 0.432
CLV_PCSK_KEX2_1 174 176 PF00082 0.450
CLV_PCSK_KEX2_1 182 184 PF00082 0.406
CLV_PCSK_KEX2_1 187 189 PF00082 0.388
CLV_PCSK_KEX2_1 604 606 PF00082 0.476
CLV_PCSK_KEX2_1 727 729 PF00082 0.487
CLV_PCSK_KEX2_1 838 840 PF00082 0.449
CLV_PCSK_KEX2_1 95 97 PF00082 0.544
CLV_PCSK_PC7_1 183 189 PF00082 0.465
CLV_PCSK_SKI1_1 121 125 PF00082 0.410
CLV_PCSK_SKI1_1 158 162 PF00082 0.413
CLV_PCSK_SKI1_1 182 186 PF00082 0.466
CLV_PCSK_SKI1_1 192 196 PF00082 0.456
CLV_PCSK_SKI1_1 220 224 PF00082 0.402
CLV_PCSK_SKI1_1 420 424 PF00082 0.433
CLV_PCSK_SKI1_1 503 507 PF00082 0.371
CLV_PCSK_SKI1_1 55 59 PF00082 0.432
DEG_APCC_DBOX_1 204 212 PF00400 0.377
DEG_APCC_DBOX_1 219 227 PF00400 0.322
DEG_SCF_FBW7_1 618 623 PF00400 0.378
DEG_SCF_FBW7_2 381 388 PF00400 0.494
DEG_SIAH_1 660 668 PF03145 0.325
DEG_SPOP_SBC_1 541 545 PF00917 0.506
DOC_ANK_TNKS_1 173 180 PF00023 0.484
DOC_ANK_TNKS_1 452 459 PF00023 0.466
DOC_CKS1_1 382 387 PF01111 0.498
DOC_CYCLIN_RxL_1 187 199 PF00134 0.288
DOC_CYCLIN_RxL_1 217 224 PF00134 0.379
DOC_MAPK_HePTP_8 202 214 PF00069 0.296
DOC_MAPK_MEF2A_6 158 167 PF00069 0.412
DOC_MAPK_MEF2A_6 205 214 PF00069 0.527
DOC_MAPK_MEF2A_6 593 602 PF00069 0.417
DOC_MAPK_NFAT4_5 205 213 PF00069 0.367
DOC_MAPK_RevD_3 161 175 PF00069 0.430
DOC_PP2B_LxvP_1 357 360 PF13499 0.511
DOC_PP4_FxxP_1 782 785 PF00568 0.480
DOC_PP4_FxxP_1 803 806 PF00568 0.448
DOC_USP7_MATH_1 110 114 PF00917 0.422
DOC_USP7_MATH_1 177 181 PF00917 0.496
DOC_USP7_MATH_1 258 262 PF00917 0.450
DOC_USP7_MATH_1 410 414 PF00917 0.449
DOC_USP7_MATH_1 550 554 PF00917 0.561
DOC_USP7_MATH_1 581 585 PF00917 0.513
DOC_USP7_MATH_1 620 624 PF00917 0.419
DOC_USP7_MATH_1 63 67 PF00917 0.471
DOC_USP7_MATH_1 637 641 PF00917 0.351
DOC_USP7_MATH_1 723 727 PF00917 0.577
DOC_WW_Pin1_4 197 202 PF00397 0.452
DOC_WW_Pin1_4 259 264 PF00397 0.550
DOC_WW_Pin1_4 381 386 PF00397 0.533
DOC_WW_Pin1_4 40 45 PF00397 0.558
DOC_WW_Pin1_4 616 621 PF00397 0.444
DOC_WW_Pin1_4 684 689 PF00397 0.499
DOC_WW_Pin1_4 807 812 PF00397 0.454
LIG_14-3-3_CanoR_1 120 130 PF00244 0.356
LIG_14-3-3_CanoR_1 182 190 PF00244 0.375
LIG_14-3-3_CanoR_1 213 221 PF00244 0.383
LIG_14-3-3_CanoR_1 344 353 PF00244 0.376
LIG_14-3-3_CanoR_1 433 439 PF00244 0.528
LIG_14-3-3_CanoR_1 480 488 PF00244 0.444
LIG_14-3-3_CanoR_1 539 549 PF00244 0.491
LIG_14-3-3_CanoR_1 64 72 PF00244 0.377
LIG_14-3-3_CanoR_1 780 785 PF00244 0.445
LIG_14-3-3_CanoR_1 914 923 PF00244 0.521
LIG_14-3-3_CanoR_1 932 940 PF00244 0.293
LIG_BIR_II_1 1 5 PF00653 0.561
LIG_BIR_III_4 887 891 PF00653 0.589
LIG_CaM_NSCaTE_8 929 936 PF13499 0.477
LIG_Clathr_ClatBox_1 131 135 PF01394 0.421
LIG_Clathr_ClatBox_1 195 199 PF01394 0.379
LIG_eIF4E_1 674 680 PF01652 0.441
LIG_FHA_1 122 128 PF00498 0.389
LIG_FHA_1 241 247 PF00498 0.423
LIG_FHA_1 327 333 PF00498 0.411
LIG_FHA_1 362 368 PF00498 0.391
LIG_FHA_1 376 382 PF00498 0.359
LIG_FHA_1 425 431 PF00498 0.370
LIG_FHA_1 480 486 PF00498 0.499
LIG_FHA_1 522 528 PF00498 0.303
LIG_FHA_1 60 66 PF00498 0.532
LIG_FHA_1 617 623 PF00498 0.393
LIG_FHA_1 628 634 PF00498 0.593
LIG_FHA_1 673 679 PF00498 0.443
LIG_FHA_1 68 74 PF00498 0.287
LIG_FHA_1 685 691 PF00498 0.421
LIG_FHA_1 758 764 PF00498 0.522
LIG_FHA_1 790 796 PF00498 0.427
LIG_FHA_1 860 866 PF00498 0.463
LIG_FHA_2 18 24 PF00498 0.490
LIG_FHA_2 234 240 PF00498 0.447
LIG_FHA_2 264 270 PF00498 0.490
LIG_FHA_2 474 480 PF00498 0.328
LIG_FHA_2 566 572 PF00498 0.452
LIG_FHA_2 649 655 PF00498 0.385
LIG_FHA_2 740 746 PF00498 0.436
LIG_FHA_2 830 836 PF00498 0.482
LIG_FHA_2 893 899 PF00498 0.703
LIG_GBD_Chelix_1 649 657 PF00786 0.416
LIG_LIR_Apic_2 779 785 PF02991 0.442
LIG_LIR_Apic_2 800 806 PF02991 0.465
LIG_LIR_Gen_1 236 246 PF02991 0.454
LIG_LIR_Gen_1 311 322 PF02991 0.459
LIG_LIR_Gen_1 396 402 PF02991 0.456
LIG_LIR_Gen_1 476 485 PF02991 0.360
LIG_LIR_Gen_1 513 523 PF02991 0.374
LIG_LIR_Gen_1 623 633 PF02991 0.452
LIG_LIR_Gen_1 70 80 PF02991 0.330
LIG_LIR_Gen_1 874 881 PF02991 0.418
LIG_LIR_Gen_1 938 946 PF02991 0.480
LIG_LIR_Nem_3 236 241 PF02991 0.387
LIG_LIR_Nem_3 311 317 PF02991 0.454
LIG_LIR_Nem_3 396 401 PF02991 0.463
LIG_LIR_Nem_3 442 447 PF02991 0.598
LIG_LIR_Nem_3 476 481 PF02991 0.350
LIG_LIR_Nem_3 513 518 PF02991 0.364
LIG_LIR_Nem_3 623 629 PF02991 0.403
LIG_LIR_Nem_3 70 75 PF02991 0.388
LIG_LIR_Nem_3 779 784 PF02991 0.427
LIG_LIR_Nem_3 874 880 PF02991 0.408
LIG_LIR_Nem_3 938 943 PF02991 0.324
LIG_MYND_1 752 756 PF01753 0.272
LIG_NRBOX 129 135 PF00104 0.324
LIG_NRBOX 352 358 PF00104 0.458
LIG_NRBOX 480 486 PF00104 0.349
LIG_NRBOX 648 654 PF00104 0.451
LIG_NRBOX 739 745 PF00104 0.436
LIG_NRBOX 99 105 PF00104 0.450
LIG_PTAP_UEV_1 359 364 PF05743 0.413
LIG_PTAP_UEV_1 923 928 PF05743 0.438
LIG_PTB_Apo_2 74 81 PF02174 0.323
LIG_SH2_NCK_1 940 944 PF00017 0.324
LIG_SH2_PTP2 72 75 PF00017 0.402
LIG_SH2_SRC 569 572 PF00017 0.429
LIG_SH2_STAP1 674 678 PF00017 0.441
LIG_SH2_STAT5 107 110 PF00017 0.325
LIG_SH2_STAT5 450 453 PF00017 0.395
LIG_SH2_STAT5 674 677 PF00017 0.442
LIG_SH2_STAT5 72 75 PF00017 0.448
LIG_SH3_3 297 303 PF00018 0.477
LIG_SH3_3 357 363 PF00018 0.511
LIG_SH3_3 630 636 PF00018 0.562
LIG_SH3_3 760 766 PF00018 0.333
LIG_SH3_3 921 927 PF00018 0.440
LIG_Sin3_3 289 296 PF02671 0.420
LIG_SUMO_SIM_anti_2 70 77 PF11976 0.297
LIG_SUMO_SIM_anti_2 941 948 PF11976 0.319
LIG_SUMO_SIM_par_1 129 137 PF11976 0.337
LIG_SUMO_SIM_par_1 194 200 PF11976 0.424
LIG_TRAF2_1 26 29 PF00917 0.521
LIG_TRAF2_1 440 443 PF00917 0.494
LIG_TRAF2_1 568 571 PF00917 0.452
LIG_TRAF2_1 707 710 PF00917 0.605
LIG_TYR_ITSM 68 75 PF00017 0.277
LIG_Vh1_VBS_1 470 488 PF01044 0.374
LIG_WRC_WIRS_1 111 116 PF05994 0.377
MOD_CK1_1 113 119 PF00069 0.308
MOD_CK1_1 200 206 PF00069 0.560
MOD_CK1_1 375 381 PF00069 0.425
MOD_CK1_1 511 517 PF00069 0.294
MOD_CK1_1 542 548 PF00069 0.554
MOD_CK1_1 577 583 PF00069 0.560
MOD_CK1_1 638 644 PF00069 0.517
MOD_CK1_1 686 692 PF00069 0.563
MOD_CK1_1 787 793 PF00069 0.553
MOD_CK1_1 810 816 PF00069 0.485
MOD_CK1_1 827 833 PF00069 0.341
MOD_CK1_1 917 923 PF00069 0.488
MOD_CK2_1 150 156 PF00069 0.512
MOD_CK2_1 23 29 PF00069 0.499
MOD_CK2_1 233 239 PF00069 0.517
MOD_CK2_1 263 269 PF00069 0.532
MOD_CK2_1 320 326 PF00069 0.297
MOD_CK2_1 473 479 PF00069 0.309
MOD_CK2_1 486 492 PF00069 0.391
MOD_CK2_1 565 571 PF00069 0.434
MOD_CK2_1 648 654 PF00069 0.405
MOD_CK2_1 704 710 PF00069 0.585
MOD_CK2_1 788 794 PF00069 0.435
MOD_CK2_1 857 863 PF00069 0.450
MOD_GlcNHglycan 152 155 PF01048 0.507
MOD_GlcNHglycan 2 5 PF01048 0.546
MOD_GlcNHglycan 293 296 PF01048 0.413
MOD_GlcNHglycan 322 325 PF01048 0.304
MOD_GlcNHglycan 347 350 PF01048 0.401
MOD_GlcNHglycan 374 377 PF01048 0.504
MOD_GlcNHglycan 413 416 PF01048 0.505
MOD_GlcNHglycan 510 513 PF01048 0.537
MOD_GlcNHglycan 529 532 PF01048 0.420
MOD_GlcNHglycan 544 547 PF01048 0.533
MOD_GlcNHglycan 552 556 PF01048 0.426
MOD_GlcNHglycan 576 579 PF01048 0.526
MOD_GlcNHglycan 581 584 PF01048 0.514
MOD_GlcNHglycan 622 625 PF01048 0.468
MOD_GlcNHglycan 637 640 PF01048 0.499
MOD_GlcNHglycan 65 68 PF01048 0.394
MOD_GlcNHglycan 794 798 PF01048 0.482
MOD_GlcNHglycan 852 855 PF01048 0.573
MOD_GlcNHglycan 916 919 PF01048 0.443
MOD_GlcNHglycan 924 927 PF01048 0.435
MOD_GlcNHglycan 934 937 PF01048 0.314
MOD_GSK3_1 17 24 PF00069 0.490
MOD_GSK3_1 259 266 PF00069 0.490
MOD_GSK3_1 304 311 PF00069 0.492
MOD_GSK3_1 331 338 PF00069 0.486
MOD_GSK3_1 358 365 PF00069 0.391
MOD_GSK3_1 517 524 PF00069 0.363
MOD_GSK3_1 540 547 PF00069 0.577
MOD_GSK3_1 577 584 PF00069 0.592
MOD_GSK3_1 59 66 PF00069 0.444
MOD_GSK3_1 616 623 PF00069 0.442
MOD_GSK3_1 67 74 PF00069 0.424
MOD_GSK3_1 679 686 PF00069 0.413
MOD_GSK3_1 739 746 PF00069 0.438
MOD_GSK3_1 776 783 PF00069 0.454
MOD_GSK3_1 784 791 PF00069 0.407
MOD_GSK3_1 857 864 PF00069 0.395
MOD_GSK3_1 910 917 PF00069 0.419
MOD_NEK2_1 134 139 PF00069 0.362
MOD_NEK2_1 325 330 PF00069 0.599
MOD_NEK2_1 345 350 PF00069 0.373
MOD_NEK2_1 434 439 PF00069 0.494
MOD_NEK2_1 508 513 PF00069 0.443
MOD_NEK2_1 527 532 PF00069 0.396
MOD_NEK2_1 551 556 PF00069 0.343
MOD_NEK2_1 574 579 PF00069 0.508
MOD_NEK2_1 58 63 PF00069 0.421
MOD_NEK2_1 589 594 PF00069 0.287
MOD_NEK2_1 679 684 PF00069 0.429
MOD_NEK2_1 696 701 PF00069 0.449
MOD_NEK2_1 743 748 PF00069 0.415
MOD_NEK2_1 788 793 PF00069 0.342
MOD_NEK2_1 824 829 PF00069 0.324
MOD_NEK2_1 850 855 PF00069 0.363
MOD_NEK2_1 861 866 PF00069 0.431
MOD_NEK2_2 177 182 PF00069 0.491
MOD_PIKK_1 121 127 PF00454 0.425
MOD_PIKK_1 182 188 PF00454 0.407
MOD_PIKK_1 331 337 PF00454 0.483
MOD_PIKK_1 375 381 PF00454 0.425
MOD_PIKK_1 672 678 PF00454 0.448
MOD_PK_1 876 882 PF00069 0.368
MOD_PKA_1 182 188 PF00069 0.417
MOD_PKA_2 182 188 PF00069 0.386
MOD_PKA_2 212 218 PF00069 0.378
MOD_PKA_2 432 438 PF00069 0.518
MOD_PKA_2 479 485 PF00069 0.434
MOD_PKA_2 508 514 PF00069 0.389
MOD_PKA_2 63 69 PF00069 0.389
MOD_Plk_1 134 140 PF00069 0.394
MOD_Plk_1 34 40 PF00069 0.499
MOD_Plk_1 551 557 PF00069 0.400
MOD_Plk_1 793 799 PF00069 0.329
MOD_Plk_2-3 648 654 PF00069 0.385
MOD_Plk_4 134 140 PF00069 0.435
MOD_Plk_4 233 239 PF00069 0.472
MOD_Plk_4 242 248 PF00069 0.304
MOD_Plk_4 280 286 PF00069 0.363
MOD_Plk_4 648 654 PF00069 0.348
MOD_Plk_4 68 74 PF00069 0.388
MOD_Plk_4 739 745 PF00069 0.454
MOD_Plk_4 861 867 PF00069 0.400
MOD_Plk_4 876 882 PF00069 0.353
MOD_ProDKin_1 197 203 PF00069 0.462
MOD_ProDKin_1 259 265 PF00069 0.547
MOD_ProDKin_1 381 387 PF00069 0.539
MOD_ProDKin_1 40 46 PF00069 0.544
MOD_ProDKin_1 616 622 PF00069 0.441
MOD_ProDKin_1 684 690 PF00069 0.493
MOD_ProDKin_1 807 813 PF00069 0.447
MOD_SUMO_for_1 901 904 PF00179 0.434
TRG_DiLeu_BaEn_1 648 653 PF01217 0.426
TRG_DiLeu_BaLyEn_6 206 211 PF01217 0.435
TRG_DiLeu_BaLyEn_6 750 755 PF01217 0.292
TRG_ENDOCYTIC_2 478 481 PF00928 0.325
TRG_ENDOCYTIC_2 72 75 PF00928 0.402
TRG_ENDOCYTIC_2 940 943 PF00928 0.484
TRG_ER_diArg_1 174 176 PF00400 0.433
TRG_ER_diArg_1 181 183 PF00400 0.404
TRG_ER_diArg_1 603 605 PF00400 0.468
TRG_ER_diArg_1 725 728 PF00400 0.468
TRG_ER_diArg_1 837 839 PF00400 0.398
TRG_ER_diArg_1 95 97 PF00400 0.547
TRG_NES_CRM1_1 122 136 PF08389 0.360
TRG_NES_CRM1_1 479 492 PF08389 0.393
TRG_NES_CRM1_1 647 662 PF08389 0.399
TRG_Pf-PMV_PEXEL_1 121 125 PF00026 0.367
TRG_Pf-PMV_PEXEL_1 220 224 PF00026 0.469
TRG_Pf-PMV_PEXEL_1 720 724 PF00026 0.424
TRG_Pf-PMV_PEXEL_1 848 852 PF00026 0.372

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N0P4N6 Leptomonas seymouri 53% 100%
A0A3R7KCN8 Trypanosoma rangeli 28% 100%
A0A3S7WVU2 Leishmania donovani 93% 100%
A4HYL3 Leishmania infantum 93% 100%
E9AI76 Leishmania braziliensis 78% 100%
E9AUG2 Leishmania mexicana (strain MHOM/GT/2001/U1103) 90% 100%
V5BAE6 Trypanosoma cruzi 28% 100%

Download

Download
LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS