ER membrane protein complex subunit 10

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transmembrane protein, putative

Species:

Leishmania major

UniProt:

Q4QD20_LEIMA

TriTrypDb:

LmjF.20.0240 , LMJLV39_200007600 , LMJSD75_200007500

Length:

261

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 8, no: 3
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

Q4QD20

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD20

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	117	121	PF00656	0.379
CLV_MEL_PAP_1	32	38	PF00089	0.559
CLV_NRD_NRD_1	189	191	PF00675	0.735
CLV_NRD_NRD_1	34	36	PF00675	0.524
CLV_PCSK_KEX2_1	217	219	PF00082	0.761
CLV_PCSK_KEX2_1	34	36	PF00082	0.524
CLV_PCSK_PC1ET2_1	217	219	PF00082	0.753
CLV_PCSK_SKI1_1	155	159	PF00082	0.689
CLV_PCSK_SKI1_1	237	241	PF00082	0.613
DOC_CKS1_1	106	111	PF01111	0.371
DOC_CYCLIN_yCln2_LP_2	182	188	PF00134	0.463
DOC_CYCLIN_yCln2_LP_2	247	253	PF00134	0.361
DOC_MAPK_DCC_7	179	188	PF00069	0.486
DOC_MAPK_MEF2A_6	169	176	PF00069	0.388
DOC_MAPK_MEF2A_6	242	251	PF00069	0.367
DOC_MAPK_MEF2A_6	6	14	PF00069	0.435
DOC_MAPK_NFAT4_5	242	250	PF00069	0.406
DOC_MAPK_RevD_3	21	35	PF00069	0.458
DOC_PP2B_LxvP_1	247	250	PF13499	0.361
DOC_USP7_MATH_1	118	122	PF00917	0.291
DOC_USP7_MATH_1	134	138	PF00917	0.357
DOC_USP7_MATH_1	99	103	PF00917	0.437
DOC_USP7_MATH_2	233	239	PF00917	0.460
DOC_USP7_UBL2_3	187	191	PF12436	0.529
DOC_USP7_UBL2_3	96	100	PF12436	0.491
DOC_WW_Pin1_4	105	110	PF00397	0.328
LIG_14-3-3_CanoR_1	212	220	PF00244	0.547
LIG_14-3-3_CanoR_1	52	61	PF00244	0.390
LIG_Actin_WH2_2	173	189	PF00022	0.464
LIG_BIR_II_1	1	5	PF00653	0.677
LIG_deltaCOP1_diTrp_1	39	48	PF00928	0.396
LIG_FHA_1	101	107	PF00498	0.413
LIG_FHA_1	121	127	PF00498	0.202
LIG_FHA_1	171	177	PF00498	0.390
LIG_FHA_1	187	193	PF00498	0.431
LIG_FHA_1	5	11	PF00498	0.522
LIG_FHA_2	199	205	PF00498	0.485
LIG_LIR_Gen_1	39	50	PF02991	0.370
LIG_LIR_Nem_3	3	8	PF02991	0.621
LIG_LIR_Nem_3	39	45	PF02991	0.355
LIG_REV1ctd_RIR_1	149	159	PF16727	0.486
LIG_SH2_STAT3	90	93	PF00017	0.431
LIG_SH2_STAT5	246	249	PF00017	0.379
LIG_SH2_STAT5	30	33	PF00017	0.319
LIG_SH3_3	103	109	PF00018	0.384
LIG_SH3_4	96	103	PF00018	0.483
LIG_SUMO_SIM_anti_2	7	13	PF11976	0.445
LIG_SUMO_SIM_par_1	102	108	PF11976	0.421
LIG_SUMO_SIM_par_1	120	128	PF11976	0.237
LIG_TRAF2_1	233	236	PF00917	0.506
LIG_TRAF2_1	91	94	PF00917	0.399
LIG_TYR_ITIM	192	197	PF00017	0.491
LIG_WRC_WIRS_1	45	50	PF05994	0.347
MOD_CK1_1	146	152	PF00069	0.435
MOD_CK1_1	51	57	PF00069	0.367
MOD_CK2_1	198	204	PF00069	0.483
MOD_CK2_1	35	41	PF00069	0.429
MOD_GSK3_1	101	108	PF00069	0.352
MOD_GSK3_1	40	47	PF00069	0.365
MOD_GSK3_1	48	55	PF00069	0.327
MOD_GSK3_1	6	13	PF00069	0.416
MOD_NEK2_1	10	15	PF00069	0.380
MOD_NEK2_1	17	22	PF00069	0.371
MOD_NEK2_1	186	191	PF00069	0.470
MOD_NEK2_1	4	9	PF00069	0.525
MOD_NEK2_1	48	53	PF00069	0.335
MOD_PIKK_1	24	30	PF00454	0.387
MOD_PIKK_1	52	58	PF00454	0.459
MOD_PIKK_1	60	66	PF00454	0.373
MOD_PKA_2	51	57	PF00069	0.379
MOD_PKA_2	59	65	PF00069	0.385
MOD_Plk_1	162	168	PF00069	0.351
MOD_Plk_1	235	241	PF00069	0.410
MOD_Plk_1	40	46	PF00069	0.411
MOD_Plk_1	67	73	PF00069	0.423
MOD_Plk_4	101	107	PF00069	0.363
MOD_Plk_4	108	114	PF00069	0.306
MOD_Plk_4	120	126	PF00069	0.251
MOD_Plk_4	136	142	PF00069	0.289
MOD_Plk_4	251	257	PF00069	0.365
MOD_Plk_4	26	32	PF00069	0.330
MOD_Plk_4	6	12	PF00069	0.389
MOD_ProDKin_1	105	111	PF00069	0.330
MOD_SUMO_rev_2	117	124	PF00179	0.450
MOD_SUMO_rev_2	202	209	PF00179	0.448
TRG_DiLeu_BaEn_2	234	240	PF01217	0.453
TRG_DiLeu_BaEn_4	235	241	PF01217	0.448
TRG_DiLeu_BaEn_4	74	80	PF01217	0.380
TRG_ENDOCYTIC_2	194	197	PF00928	0.404
TRG_ENDOCYTIC_2	246	249	PF00928	0.357
TRG_ER_diArg_1	34	36	PF00400	0.324
TRG_NLS_Bipartite_1	190	211	PF00514	0.381
TRG_NLS_MonoExtC_3	189	195	PF00514	0.524
TRG_NLS_MonoExtN_4	187	194	PF00514	0.529

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCK3	Leptomonas seymouri	67%	100%
A0A0S4J8Z8	Bodo saltans	30%	100%
A0A1X0NWH6	Trypanosomatidae	44%	96%
A0A3R7KYG2	Trypanosoma rangeli	38%	93%
A0A3S7WVR1	Leishmania donovani	96%	100%
A4HYL5	Leishmania infantum	96%	100%
C9ZHW3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	97%
E9AI78	Leishmania braziliensis	79%	100%
E9AUG4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	95%	100%
V5BQW5	Trypanosoma cruzi	37%	94%