Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QD17_LEIMA

TriTrypDb:

LmjF.20.0265 , LMJLV39_200007800 , LMJSD75_200007700

Length:

262

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QD17

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD17

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0016853	isomerase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	243	245	PF00675	0.602
CLV_NRD_NRD_1	255	257	PF00675	0.597
CLV_NRD_NRD_1	92	94	PF00675	0.608
CLV_PCSK_FUR_1	253	257	PF00082	0.695
CLV_PCSK_KEX2_1	245	247	PF00082	0.593
CLV_PCSK_KEX2_1	255	257	PF00082	0.695
CLV_PCSK_KEX2_1	26	28	PF00082	0.515
CLV_PCSK_KEX2_1	92	94	PF00082	0.614
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.709
CLV_PCSK_PC1ET2_1	26	28	PF00082	0.515
CLV_PCSK_SKI1_1	175	179	PF00082	0.464
CLV_PCSK_SKI1_1	238	242	PF00082	0.507
CLV_PCSK_SKI1_1	27	31	PF00082	0.566
DEG_APCC_DBOX_1	189	197	PF00400	0.493
DEG_APCC_DBOX_1	26	34	PF00400	0.534
DEG_SPOP_SBC_1	98	102	PF00917	0.619
DOC_AGCK_PIF_1	86	91	PF00069	0.462
DOC_CDC14_PxL_1	91	99	PF14671	0.481
DOC_MAPK_DCC_7	26	35	PF00069	0.570
DOC_MAPK_gen_1	113	123	PF00069	0.579
DOC_PP1_RVXF_1	81	87	PF00149	0.506
DOC_PP2B_LxvP_1	186	189	PF13499	0.499
DOC_PP2B_LxvP_1	239	242	PF13499	0.470
DOC_USP7_MATH_1	108	112	PF00917	0.642
DOC_USP7_MATH_1	71	75	PF00917	0.560
DOC_USP7_UBL2_3	147	151	PF12436	0.504
DOC_WW_Pin1_4	104	109	PF00397	0.620
DOC_WW_Pin1_4	133	138	PF00397	0.535
DOC_WW_Pin1_4	256	261	PF00397	0.594
LIG_14-3-3_CanoR_1	116	122	PF00244	0.657
LIG_14-3-3_CanoR_1	190	194	PF00244	0.475
LIG_14-3-3_CanoR_1	253	262	PF00244	0.595
LIG_14-3-3_CanoR_1	3	9	PF00244	0.593
LIG_AP2alpha_1	146	150	PF02296	0.460
LIG_BIR_III_2	129	133	PF00653	0.561
LIG_eIF4E_1	159	165	PF01652	0.433
LIG_FHA_1	166	172	PF00498	0.441
LIG_FHA_1	40	46	PF00498	0.590
LIG_FHA_1	99	105	PF00498	0.669
LIG_FHA_2	153	159	PF00498	0.498
LIG_FHA_2	190	196	PF00498	0.494
LIG_IRF3_LxIS_1	117	124	PF10401	0.594
LIG_LIR_Apic_2	7	12	PF02991	0.665
LIG_LIR_Gen_1	209	219	PF02991	0.484
LIG_LIR_Nem_3	209	215	PF02991	0.470
LIG_LIR_Nem_3	34	38	PF02991	0.553
LIG_LIR_Nem_3	85	89	PF02991	0.496
LIG_Pex14_2	146	150	PF04695	0.423
LIG_SH2_STAT5	159	162	PF00017	0.530
LIG_SH2_STAT5	89	92	PF00017	0.565
LIG_SH3_3	100	106	PF00018	0.606
LIG_Sin3_3	174	181	PF02671	0.334
LIG_WW_3	241	245	PF00397	0.578
MOD_CDK_SPK_2	256	261	PF00069	0.594
MOD_CK1_1	107	113	PF00069	0.638
MOD_CK1_1	206	212	PF00069	0.388
MOD_CK1_1	228	234	PF00069	0.623
MOD_CK1_1	39	45	PF00069	0.552
MOD_CK1_1	99	105	PF00069	0.626
MOD_CK2_1	246	252	PF00069	0.626
MOD_CK2_1	71	77	PF00069	0.721
MOD_CK2_1	99	105	PF00069	0.604
MOD_DYRK1A_RPxSP_1	133	137	PF00069	0.503
MOD_DYRK1A_RPxSP_1	256	260	PF00069	0.539
MOD_GlcNHglycan	152	155	PF01048	0.590
MOD_GlcNHglycan	38	41	PF01048	0.636
MOD_GlcNHglycan	50	53	PF01048	0.370
MOD_GlcNHglycan	59	62	PF01048	0.481
MOD_GlcNHglycan	74	77	PF01048	0.595
MOD_GSK3_1	104	111	PF00069	0.639
MOD_GSK3_1	115	122	PF00069	0.607
MOD_GSK3_1	146	153	PF00069	0.556
MOD_GSK3_1	184	191	PF00069	0.515
MOD_GSK3_1	203	210	PF00069	0.319
MOD_GSK3_1	224	231	PF00069	0.585
MOD_GSK3_1	34	41	PF00069	0.562
MOD_GSK3_1	44	51	PF00069	0.610
MOD_GSK3_1	59	66	PF00069	0.422
MOD_GSK3_1	93	100	PF00069	0.639
MOD_N-GLC_1	72	77	PF02516	0.561
MOD_NEK2_1	115	120	PF00069	0.626
MOD_NEK2_1	121	126	PF00069	0.594
MOD_NEK2_1	138	143	PF00069	0.420
MOD_NEK2_1	146	151	PF00069	0.547
MOD_NEK2_1	164	169	PF00069	0.292
MOD_NEK2_1	207	212	PF00069	0.527
MOD_NEK2_1	224	229	PF00069	0.433
MOD_NEK2_1	36	41	PF00069	0.569
MOD_NEK2_1	97	102	PF00069	0.623
MOD_NEK2_2	189	194	PF00069	0.360
MOD_NEK2_2	21	26	PF00069	0.625
MOD_PIKK_1	138	144	PF00454	0.495
MOD_PIKK_1	2	8	PF00454	0.592
MOD_PK_1	119	125	PF00069	0.591
MOD_PKA_1	246	252	PF00069	0.619
MOD_PKA_1	255	261	PF00069	0.594
MOD_PKA_2	115	121	PF00069	0.657
MOD_PKA_2	165	171	PF00069	0.447
MOD_PKA_2	189	195	PF00069	0.480
MOD_PKA_2	2	8	PF00069	0.640
MOD_PKA_2	254	260	PF00069	0.525
MOD_PKB_1	244	252	PF00069	0.606
MOD_PKB_1	253	261	PF00069	0.592
MOD_Plk_1	138	144	PF00069	0.482
MOD_Plk_1	203	209	PF00069	0.565
MOD_Plk_1	225	231	PF00069	0.524
MOD_Plk_4	207	213	PF00069	0.371
MOD_Plk_4	225	231	PF00069	0.605
MOD_Plk_4	31	37	PF00069	0.560
MOD_Plk_4	4	10	PF00069	0.594
MOD_Plk_4	44	50	PF00069	0.438
MOD_Plk_4	82	88	PF00069	0.667
MOD_Plk_4	93	99	PF00069	0.555
MOD_ProDKin_1	104	110	PF00069	0.621
MOD_ProDKin_1	133	139	PF00069	0.524
MOD_ProDKin_1	256	262	PF00069	0.565
TRG_ENDOCYTIC_2	212	215	PF00928	0.486
TRG_ER_diArg_1	243	246	PF00400	0.595
TRG_ER_diArg_1	253	256	PF00400	0.586
TRG_ER_diArg_1	91	93	PF00400	0.567

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0NX71	Trypanosomatidae	26%	100%
A0A3Q8IDI2	Leishmania donovani	92%	100%
A4HYL8	Leishmania infantum	92%	100%
E9AI82	Leishmania braziliensis	68%	100%
E9AUG7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BQY8	Trypanosoma cruzi	33%	98%