Enkurin domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Enkuring domain-containig protein

Species:

Leishmania major

UniProt:

Q4QD16_LEIMA

TriTrypDb:

LmjF.20.0270 , LMJLV39_200007900 , LMJSD75_200007800

Length:

367

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QD16

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD16

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	2
GO:0005515	protein binding	2	2
GO:0005516	calmodulin binding	3	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	173	177	PF00656	0.669
CLV_NRD_NRD_1	115	117	PF00675	0.603
CLV_NRD_NRD_1	220	222	PF00675	0.508
CLV_NRD_NRD_1	230	232	PF00675	0.509
CLV_NRD_NRD_1	291	293	PF00675	0.346
CLV_NRD_NRD_1	312	314	PF00675	0.302
CLV_NRD_NRD_1	96	98	PF00675	0.625
CLV_PCSK_FUR_1	243	247	PF00082	0.420
CLV_PCSK_KEX2_1	219	221	PF00082	0.513
CLV_PCSK_KEX2_1	245	247	PF00082	0.409
CLV_PCSK_KEX2_1	290	292	PF00082	0.375
CLV_PCSK_KEX2_1	314	316	PF00082	0.294
CLV_PCSK_KEX2_1	9	11	PF00082	0.511
CLV_PCSK_PC1ET2_1	219	221	PF00082	0.532
CLV_PCSK_PC1ET2_1	245	247	PF00082	0.423
CLV_PCSK_PC1ET2_1	314	316	PF00082	0.337
CLV_PCSK_PC1ET2_1	9	11	PF00082	0.511
CLV_PCSK_SKI1_1	199	203	PF00082	0.571
CLV_PCSK_SKI1_1	335	339	PF00082	0.522
CLV_PCSK_SKI1_1	73	77	PF00082	0.503
DEG_Nend_UBRbox_1	1	4	PF02207	0.516
DOC_ANK_TNKS_1	77	84	PF00023	0.515
DOC_CYCLIN_RxL_1	6	16	PF00134	0.449
DOC_MAPK_gen_1	331	340	PF00069	0.280
DOC_MAPK_MEF2A_6	321	330	PF00069	0.307
DOC_PP1_RVXF_1	7	14	PF00149	0.455
DOC_USP7_MATH_1	239	243	PF00917	0.307
DOC_USP7_MATH_1	363	367	PF00917	0.567
DOC_USP7_UBL2_3	113	117	PF12436	0.428
DOC_USP7_UBL2_3	32	36	PF12436	0.704
DOC_USP7_UBL2_3	357	361	PF12436	0.531
DOC_USP7_UBL2_3	94	98	PF12436	0.662
DOC_WW_Pin1_4	121	126	PF00397	0.574
DOC_WW_Pin1_4	234	239	PF00397	0.307
DOC_WW_Pin1_4	36	41	PF00397	0.689
LIG_14-3-3_CanoR_1	231	235	PF00244	0.497
LIG_14-3-3_CanoR_1	313	323	PF00244	0.343
LIG_Actin_WH2_2	83	99	PF00022	0.518
LIG_APCC_ABBA_1	338	343	PF00400	0.383
LIG_BIR_III_4	145	149	PF00653	0.596
LIG_BRCT_BRCA1_1	122	126	PF00533	0.727
LIG_FHA_2	107	113	PF00498	0.462
LIG_FHA_2	315	321	PF00498	0.430
LIG_FHA_2	57	63	PF00498	0.565
LIG_LIR_Apic_2	112	118	PF02991	0.551
LIG_LIR_Gen_1	56	61	PF02991	0.589
LIG_LIR_Nem_3	18	24	PF02991	0.498
LIG_LIR_Nem_3	38	44	PF02991	0.374
LIG_LIR_Nem_3	56	60	PF02991	0.450
LIG_REV1ctd_RIR_1	72	82	PF16727	0.632
LIG_SH2_CRK	115	119	PF00017	0.641
LIG_SH2_CRK	41	45	PF00017	0.592
LIG_SH2_PTP2	273	276	PF00017	0.419
LIG_SH2_STAP1	24	28	PF00017	0.492
LIG_SH2_STAP1	45	49	PF00017	0.553
LIG_SH2_STAP1	57	61	PF00017	0.507
LIG_SH2_STAT3	298	301	PF00017	0.282
LIG_SH2_STAT5	273	276	PF00017	0.393
LIG_SH2_STAT5	41	44	PF00017	0.546
LIG_SH2_STAT5	95	98	PF00017	0.616
LIG_SH3_3	49	55	PF00018	0.606
LIG_SUMO_SIM_par_1	208	214	PF11976	0.522
LIG_TRAF2_1	109	112	PF00917	0.571
LIG_TRAF2_1	257	260	PF00917	0.371
LIG_TRAF2_1	278	281	PF00917	0.361
LIG_UBA3_1	20	26	PF00899	0.548
LIG_WRC_WIRS_1	57	62	PF05994	0.524
MOD_CK1_1	16	22	PF00069	0.522
MOD_CK1_1	230	236	PF00069	0.552
MOD_CK1_1	306	312	PF00069	0.370
MOD_CK1_1	39	45	PF00069	0.652
MOD_CK1_1	56	62	PF00069	0.655
MOD_CK2_1	106	112	PF00069	0.462
MOD_CK2_1	230	236	PF00069	0.552
MOD_CK2_1	24	30	PF00069	0.545
MOD_CK2_1	254	260	PF00069	0.381
MOD_CK2_1	314	320	PF00069	0.334
MOD_CK2_1	32	38	PF00069	0.508
MOD_CK2_1	56	62	PF00069	0.567
MOD_GlcNHglycan	131	134	PF01048	0.658
MOD_GlcNHglycan	136	139	PF01048	0.626
MOD_GlcNHglycan	15	18	PF01048	0.513
MOD_GlcNHglycan	165	170	PF01048	0.734
MOD_GlcNHglycan	172	175	PF01048	0.713
MOD_GlcNHglycan	183	186	PF01048	0.554
MOD_GlcNHglycan	26	29	PF01048	0.494
MOD_GSK3_1	120	127	PF00069	0.693
MOD_GSK3_1	195	202	PF00069	0.636
MOD_GSK3_1	226	233	PF00069	0.504
MOD_GSK3_1	32	39	PF00069	0.628
MOD_N-GLC_1	121	126	PF02516	0.723
MOD_N-GLC_1	154	159	PF02516	0.620
MOD_NEK2_1	205	210	PF00069	0.460
MOD_NEK2_1	254	259	PF00069	0.307
MOD_NEK2_1	285	290	PF00069	0.319
MOD_PIKK_1	124	130	PF00454	0.674
MOD_PKA_1	314	320	PF00069	0.334
MOD_PKA_2	230	236	PF00069	0.493
MOD_PKA_2	314	320	PF00069	0.334
MOD_Plk_1	319	325	PF00069	0.339
MOD_Plk_4	16	22	PF00069	0.522
MOD_Plk_4	56	62	PF00069	0.528
MOD_ProDKin_1	121	127	PF00069	0.578
MOD_ProDKin_1	234	240	PF00069	0.307
MOD_ProDKin_1	36	42	PF00069	0.690
MOD_SUMO_for_1	244	247	PF00179	0.292
MOD_SUMO_rev_2	247	254	PF00179	0.397
MOD_SUMO_rev_2	256	263	PF00179	0.373
MOD_SUMO_rev_2	27	34	PF00179	0.564
MOD_SUMO_rev_2	6	16	PF00179	0.424
TRG_DiLeu_BaEn_1	281	286	PF01217	0.312
TRG_DiLeu_BaEn_2	249	255	PF01217	0.307
TRG_ENDOCYTIC_2	273	276	PF00928	0.419
TRG_ENDOCYTIC_2	41	44	PF00928	0.690
TRG_ENDOCYTIC_2	57	60	PF00928	0.432
TRG_ER_diArg_1	289	292	PF00400	0.435
TRG_ER_diArg_1	312	315	PF00400	0.319
TRG_NLS_MonoCore_2	218	223	PF00514	0.526
TRG_NLS_MonoCore_2	312	317	PF00514	0.419
TRG_NLS_MonoExtC_3	312	318	PF00514	0.419
TRG_NLS_MonoExtN_4	218	223	PF00514	0.576
TRG_Pf-PMV_PEXEL_1	246	250	PF00026	0.402

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IJA5	Leptomonas seymouri	54%	100%
A0A1X0NWL2	Trypanosomatidae	39%	96%
A0A3R7MDK6	Trypanosoma rangeli	37%	93%
A0A3R7RTB5	Trypanosoma rangeli	26%	100%
A0A3S5H782	Leishmania donovani	92%	100%
A4HYL9	Leishmania infantum	92%	100%
C9ZHT3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	38%	98%
E9AI83	Leishmania braziliensis	76%	100%
E9AUG8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	93%	100%
V5DS69	Trypanosoma cruzi	39%	93%