Leucine-rich repeat-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

leucine-rich repeat-containing protein

Species:

Leishmania major

UniProt:

Q4QD13_LEIMA

TriTrypDb:

LmjF.20.0300 , LMJLV39_200008200 , LMJSD75_200008100

Length:

311

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	2
GO:0005929	cilium	4	10
GO:0042995	cell projection	2	10
GO:0043226	organelle	2	10
GO:0043227	membrane-bounded organelle	3	10
GO:0110165	cellular anatomical entity	1	10
GO:0120025	plasma membrane bounded cell projection	3	10

Expansion

Sequence features

Q4QD13

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD13

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	214	218	PF00656	0.419
CLV_NRD_NRD_1	199	201	PF00675	0.412
CLV_NRD_NRD_1	282	284	PF00675	0.396
CLV_PCSK_KEX2_1	199	201	PF00082	0.450
CLV_PCSK_KEX2_1	282	284	PF00082	0.418
CLV_PCSK_KEX2_1	44	46	PF00082	0.587
CLV_PCSK_PC1ET2_1	44	46	PF00082	0.380
CLV_PCSK_SKI1_1	104	108	PF00082	0.298
CLV_PCSK_SKI1_1	177	181	PF00082	0.410
CLV_PCSK_SKI1_1	231	235	PF00082	0.328
CLV_PCSK_SKI1_1	270	274	PF00082	0.441
CLV_PCSK_SKI1_1	283	287	PF00082	0.276
CLV_PCSK_SKI1_1	44	48	PF00082	0.371
DEG_APCC_DBOX_1	52	60	PF00400	0.370
DEG_Nend_UBRbox_2	1	3	PF02207	0.560
DOC_MAPK_gen_1	101	111	PF00069	0.338
DOC_MAPK_gen_1	199	206	PF00069	0.514
DOC_MAPK_MEF2A_6	199	206	PF00069	0.384
DOC_PP1_RVXF_1	99	106	PF00149	0.347
DOC_USP7_MATH_1	126	130	PF00917	0.391
DOC_USP7_MATH_1	271	275	PF00917	0.286
DOC_USP7_UBL2_3	44	48	PF12436	0.371
DOC_WW_Pin1_4	19	24	PF00397	0.555
DOC_WW_Pin1_4	254	259	PF00397	0.372
DOC_WW_Pin1_4	298	303	PF00397	0.574
LIG_14-3-3_CanoR_1	104	110	PF00244	0.259
LIG_14-3-3_CanoR_1	62	71	PF00244	0.438
LIG_14-3-3_CanoR_1	93	99	PF00244	0.361
LIG_Actin_WH2_2	167	183	PF00022	0.321
LIG_Actin_WH2_2	91	106	PF00022	0.442
LIG_APCC_ABBA_1	234	239	PF00400	0.370
LIG_Clathr_ClatBox_1	163	167	PF01394	0.355
LIG_eIF4E_1	89	95	PF01652	0.328
LIG_FHA_1	240	246	PF00498	0.555
LIG_FHA_1	71	77	PF00498	0.420
LIG_FHA_2	63	69	PF00498	0.438
LIG_LIR_Apic_2	79	85	PF02991	0.361
LIG_LIR_Gen_1	49	59	PF02991	0.413
LIG_LIR_Nem_3	263	268	PF02991	0.420
LIG_LIR_Nem_3	274	280	PF02991	0.377
LIG_LIR_Nem_3	49	54	PF02991	0.422
LIG_LYPXL_yS_3	277	280	PF13949	0.427
LIG_NRBOX	229	235	PF00104	0.402
LIG_PCNA_PIPBox_1	153	162	PF02747	0.312
LIG_PDZ_Class_2	306	311	PF00595	0.472
LIG_Pex14_2	160	164	PF04695	0.406
LIG_Pex14_2	261	265	PF04695	0.425
LIG_PTAP_UEV_1	84	89	PF05743	0.339
LIG_SH2_CRK	51	55	PF00017	0.478
LIG_SH2_GRB2like	145	148	PF00017	0.311
LIG_SH2_SRC	238	241	PF00017	0.468
LIG_SH2_STAT5	115	118	PF00017	0.452
LIG_SH2_STAT5	145	148	PF00017	0.319
LIG_SH2_STAT5	162	165	PF00017	0.449
LIG_SH2_STAT5	194	197	PF00017	0.496
LIG_SH2_STAT5	260	263	PF00017	0.347
LIG_SH2_STAT5	264	267	PF00017	0.308
LIG_SH2_STAT5	89	92	PF00017	0.303
LIG_SH3_1	199	205	PF00018	0.474
LIG_SH3_1	82	88	PF00018	0.343
LIG_SH3_2	278	283	PF14604	0.441
LIG_SH3_3	199	205	PF00018	0.367
LIG_SH3_3	275	281	PF00018	0.448
LIG_SH3_3	296	302	PF00018	0.372
LIG_SH3_3	82	88	PF00018	0.343
LIG_SUMO_SIM_anti_2	209	214	PF11976	0.279
LIG_SUMO_SIM_anti_2	242	247	PF11976	0.403
LIG_SUMO_SIM_par_1	211	217	PF11976	0.312
LIG_SUMO_SIM_par_1	241	247	PF11976	0.319
LIG_SUMO_SIM_par_1	72	77	PF11976	0.415
LIG_TRAF2_1	131	134	PF00917	0.291
LIG_UBA3_1	94	101	PF00899	0.328
MOD_CDK_SPK_2	254	259	PF00069	0.372
MOD_CDK_SPxxK_3	19	26	PF00069	0.631
MOD_CK1_1	172	178	PF00069	0.543
MOD_CK1_1	188	194	PF00069	0.461
MOD_CK1_1	7	13	PF00069	0.539
MOD_CK2_1	19	25	PF00069	0.553
MOD_CK2_1	298	304	PF00069	0.357
MOD_CK2_1	62	68	PF00069	0.433
MOD_CMANNOS	34	37	PF00535	0.320
MOD_GlcNHglycan	128	131	PF01048	0.452
MOD_GlcNHglycan	13	16	PF01048	0.632
MOD_GlcNHglycan	273	276	PF01048	0.454
MOD_GSK3_1	120	127	PF00069	0.453
MOD_GSK3_1	298	305	PF00069	0.452
MOD_GSK3_1	4	11	PF00069	0.523
MOD_GSK3_1	58	65	PF00069	0.530
MOD_LATS_1	60	66	PF00433	0.432
MOD_NEK2_1	124	129	PF00069	0.445
MOD_NEK2_1	246	251	PF00069	0.361
MOD_NEK2_1	4	9	PF00069	0.576
MOD_NEK2_1	76	81	PF00069	0.350
MOD_NEK2_1	94	99	PF00069	0.269
MOD_NEK2_2	105	110	PF00069	0.355
MOD_PIKK_1	62	68	PF00454	0.490
MOD_PKA_1	44	50	PF00069	0.378
MOD_PKA_2	188	194	PF00069	0.478
MOD_PKA_2	44	50	PF00069	0.453
MOD_PKA_2	61	67	PF00069	0.345
MOD_Plk_1	133	139	PF00069	0.383
MOD_Plk_1	4	10	PF00069	0.637
MOD_Plk_4	120	126	PF00069	0.355
MOD_Plk_4	133	139	PF00069	0.348
MOD_Plk_4	208	214	PF00069	0.330
MOD_ProDKin_1	19	25	PF00069	0.554
MOD_ProDKin_1	254	260	PF00069	0.365
MOD_ProDKin_1	298	304	PF00069	0.572
TRG_DiLeu_BaEn_4	133	139	PF01217	0.360
TRG_DiLeu_BaLyEn_6	136	141	PF01217	0.301
TRG_ENDOCYTIC_2	277	280	PF00928	0.381
TRG_ENDOCYTIC_2	51	54	PF00928	0.414
TRG_ER_diArg_1	281	283	PF00400	0.399
TRG_NES_CRM1_1	102	112	PF08389	0.298
TRG_NES_CRM1_1	224	239	PF08389	0.398

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I4U2	Leptomonas seymouri	70%	75%
A0A3Q8IKD6	Leishmania donovani	94%	100%
A0A422NEI1	Trypanosoma rangeli	55%	74%
A4HYM2	Leishmania infantum	94%	100%
C9ZHT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	66%
E9AI86	Leishmania braziliensis	80%	100%
E9AUH1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%
V5BAD8	Trypanosoma cruzi	52%	76%