Leucine_Rich_repeat_-_putative

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Nucleolar protein 49, putative

Species:

Leishmania major

UniProt:

Q4QD11_LEIMA

TriTrypDb:

LmjF.20.0320 , LMJLV39_200008400 , LMJSD75_200008300

Length:

630

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Cellular components
Term	Name	Level	Count
GO:0005654	nucleoplasm	2	2
GO:0005730	nucleolus	5	2
GO:0005737	cytoplasm	2	2
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	2
GO:0043226	organelle	2	7
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0097014	ciliary plasm	5	2
GO:0099568	cytoplasmic region	3	2
GO:0110165	cellular anatomical entity	1	7
GO:0005929	cilium	4	5
GO:0042995	cell projection	2	5
GO:0043227	membrane-bounded organelle	3	5
GO:0120025	plasma membrane bounded cell projection	3	5

Expansion

Sequence features

Q4QD11

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	231	235	PF00656	0.704
CLV_C14_Caspase3-7	245	249	PF00656	0.562
CLV_C14_Caspase3-7	516	520	PF00656	0.599
CLV_C14_Caspase3-7	551	555	PF00656	0.529
CLV_NRD_NRD_1	263	265	PF00675	0.644
CLV_NRD_NRD_1	267	269	PF00675	0.616
CLV_NRD_NRD_1	301	303	PF00675	0.443
CLV_NRD_NRD_1	320	322	PF00675	0.270
CLV_NRD_NRD_1	382	384	PF00675	0.417
CLV_NRD_NRD_1	49	51	PF00675	0.297
CLV_NRD_NRD_1	535	537	PF00675	0.634
CLV_NRD_NRD_1	539	541	PF00675	0.620
CLV_NRD_NRD_1	573	575	PF00675	0.615
CLV_NRD_NRD_1	597	599	PF00675	0.731
CLV_PCSK_FUR_1	264	268	PF00082	0.554
CLV_PCSK_KEX2_1	262	264	PF00082	0.808
CLV_PCSK_KEX2_1	266	268	PF00082	0.612
CLV_PCSK_KEX2_1	301	303	PF00082	0.509
CLV_PCSK_KEX2_1	382	384	PF00082	0.417
CLV_PCSK_KEX2_1	539	541	PF00082	0.696
CLV_PCSK_KEX2_1	573	575	PF00082	0.615
CLV_PCSK_KEX2_1	597	599	PF00082	0.731
CLV_PCSK_PC1ET2_1	262	264	PF00082	0.648
CLV_PCSK_PC1ET2_1	597	599	PF00082	0.731
CLV_PCSK_PC7_1	263	269	PF00082	0.574
CLV_PCSK_SKI1_1	26	30	PF00082	0.358
CLV_PCSK_SKI1_1	302	306	PF00082	0.446
CLV_PCSK_SKI1_1	336	340	PF00082	0.405
CLV_PCSK_SKI1_1	576	580	PF00082	0.619
DEG_APCC_DBOX_1	335	343	PF00400	0.390
DOC_CYCLIN_RxL_1	23	31	PF00134	0.348
DOC_CYCLIN_RxL_1	316	329	PF00134	0.377
DOC_CYCLIN_RxL_1	47	55	PF00134	0.352
DOC_CYCLIN_yCln2_LP_2	128	134	PF00134	0.374
DOC_CYCLIN_yCln2_LP_2	307	313	PF00134	0.368
DOC_MAPK_gen_1	262	271	PF00069	0.578
DOC_MAPK_gen_1	301	307	PF00069	0.458
DOC_MAPK_gen_1	316	325	PF00069	0.507
DOC_MAPK_gen_1	32	38	PF00069	0.356
DOC_MAPK_gen_1	382	392	PF00069	0.377
DOC_MAPK_gen_1	438	448	PF00069	0.454
DOC_MAPK_gen_1	573	579	PF00069	0.617
DOC_MAPK_RevD_3	18	33	PF00069	0.368
DOC_USP7_MATH_1	102	106	PF00917	0.330
DOC_USP7_MATH_1	217	221	PF00917	0.527
DOC_USP7_MATH_1	37	41	PF00917	0.406
DOC_USP7_MATH_1	584	588	PF00917	0.697
DOC_USP7_UBL2_3	478	482	PF12436	0.531
DOC_WW_Pin1_4	127	132	PF00397	0.351
DOC_WW_Pin1_4	2	7	PF00397	0.486
DOC_WW_Pin1_4	278	283	PF00397	0.618
DOC_WW_Pin1_4	289	294	PF00397	0.587
DOC_WW_Pin1_4	420	425	PF00397	0.545
DOC_WW_Pin1_4	530	535	PF00397	0.682
DOC_WW_Pin1_4	60	65	PF00397	0.297
DOC_WW_Pin1_4	600	605	PF00397	0.759
LIG_14-3-3_CanoR_1	160	169	PF00244	0.598
LIG_14-3-3_CanoR_1	321	326	PF00244	0.345
LIG_14-3-3_CanoR_1	513	521	PF00244	0.598
LIG_Actin_WH2_2	332	348	PF00022	0.406
LIG_FHA_1	186	192	PF00498	0.363
LIG_FHA_1	201	207	PF00498	0.439
LIG_FHA_1	23	29	PF00498	0.435
LIG_FHA_2	137	143	PF00498	0.569
LIG_FHA_2	409	415	PF00498	0.533
LIG_IRF3_LxIS_1	365	371	PF10401	0.352
LIG_IRF3_LxIS_1	93	99	PF10401	0.318
LIG_LIR_Gen_1	312	320	PF02991	0.381
LIG_LIR_Gen_1	99	106	PF02991	0.384
LIG_LIR_Nem_3	312	317	PF02991	0.373
LIG_LIR_Nem_3	99	103	PF02991	0.379
LIG_PCNA_PIPBox_1	436	445	PF02747	0.424
LIG_PCNA_yPIPBox_3	193	201	PF02747	0.396
LIG_PCNA_yPIPBox_3	436	447	PF02747	0.424
LIG_PCNA_yPIPBox_3	614	627	PF02747	0.604
LIG_PTB_Apo_2	369	376	PF02174	0.414
LIG_PTB_Apo_2	94	101	PF02174	0.379
LIG_SH2_STAT3	386	389	PF00017	0.396
LIG_SH2_STAT5	386	389	PF00017	0.396
LIG_SH3_3	33	39	PF00018	0.367
LIG_SH3_3	554	560	PF00018	0.602
LIG_SH3_3	601	607	PF00018	0.612
LIG_SUMO_SIM_anti_2	91	97	PF11976	0.331
LIG_SUMO_SIM_par_1	187	192	PF11976	0.354
LIG_SUMO_SIM_par_1	309	315	PF11976	0.366
LIG_SUMO_SIM_par_1	366	371	PF11976	0.353
LIG_UBA3_1	439	447	PF00899	0.436
LIG_UBA3_1	81	86	PF00899	0.243
LIG_WRC_WIRS_1	116	121	PF05994	0.282
LIG_WRC_WIRS_1	180	185	PF05994	0.415
MOD_CDC14_SPxK_1	533	536	PF00782	0.657
MOD_CDK_SPxK_1	530	536	PF00069	0.666
MOD_CDK_SPxxK_3	530	537	PF00069	0.665
MOD_CK1_1	162	168	PF00069	0.574
MOD_CK1_1	192	198	PF00069	0.361
MOD_CK1_1	377	383	PF00069	0.395
MOD_CK1_1	425	431	PF00069	0.613
MOD_CK1_1	485	491	PF00069	0.563
MOD_CK1_1	508	514	PF00069	0.781
MOD_CK2_1	136	142	PF00069	0.560
MOD_CK2_1	309	315	PF00069	0.366
MOD_CK2_1	323	329	PF00069	0.376
MOD_CK2_1	408	414	PF00069	0.517
MOD_CK2_1	468	474	PF00069	0.544
MOD_CK2_1	490	496	PF00069	0.611
MOD_Cter_Amidation	252	255	PF01082	0.669
MOD_GlcNHglycan	164	167	PF01048	0.562
MOD_GlcNHglycan	220	223	PF01048	0.593
MOD_GlcNHglycan	240	243	PF01048	0.724
MOD_GlcNHglycan	248	251	PF01048	0.802
MOD_GlcNHglycan	258	261	PF01048	0.587
MOD_GlcNHglycan	275	279	PF01048	0.519
MOD_GlcNHglycan	325	328	PF01048	0.350
MOD_GlcNHglycan	425	428	PF01048	0.684
MOD_GlcNHglycan	461	464	PF01048	0.485
MOD_GlcNHglycan	470	473	PF01048	0.604
MOD_GlcNHglycan	486	490	PF01048	0.477
MOD_GlcNHglycan	516	519	PF01048	0.691
MOD_GlcNHglycan	53	57	PF01048	0.272
MOD_GlcNHglycan	542	545	PF01048	0.736
MOD_GlcNHglycan	586	589	PF01048	0.652
MOD_GlcNHglycan	627	630	PF01048	0.548
MOD_GlcNHglycan	88	91	PF01048	0.356
MOD_GSK3_1	154	161	PF00069	0.584
MOD_GSK3_1	185	192	PF00069	0.376
MOD_GSK3_1	234	241	PF00069	0.671
MOD_GSK3_1	274	281	PF00069	0.747
MOD_GSK3_1	419	426	PF00069	0.660
MOD_GSK3_1	508	515	PF00069	0.693
MOD_GSK3_1	559	566	PF00069	0.585
MOD_GSK3_1	584	591	PF00069	0.626
MOD_GSK3_1	60	67	PF00069	0.289
MOD_GSK3_1	621	628	PF00069	0.537
MOD_N-GLC_1	96	101	PF02516	0.320
MOD_NEK2_1	1	6	PF00069	0.570
MOD_NEK2_1	109	114	PF00069	0.377
MOD_NEK2_1	12	17	PF00069	0.448
MOD_NEK2_1	158	163	PF00069	0.518
MOD_NEK2_1	28	33	PF00069	0.285
MOD_NEK2_1	323	328	PF00069	0.381
MOD_NEK2_1	368	373	PF00069	0.348
MOD_NEK2_1	374	379	PF00069	0.381
MOD_NEK2_1	52	57	PF00069	0.297
MOD_NEK2_1	621	626	PF00069	0.537
MOD_NEK2_1	81	86	PF00069	0.311
MOD_NEK2_1	88	93	PF00069	0.443
MOD_NEK2_1	96	101	PF00069	0.303
MOD_PKA_1	321	327	PF00069	0.367
MOD_PKA_2	159	165	PF00069	0.621
MOD_PKA_2	192	198	PF00069	0.395
MOD_PKA_2	218	224	PF00069	0.652
MOD_PKA_2	256	262	PF00069	0.653
MOD_PKA_2	315	321	PF00069	0.423
MOD_PKA_2	512	518	PF00069	0.673
MOD_PKB_1	319	327	PF00069	0.337
MOD_Plk_1	109	115	PF00069	0.314
MOD_Plk_1	96	102	PF00069	0.410
MOD_Plk_2-3	14	20	PF00069	0.403
MOD_Plk_2-3	226	232	PF00069	0.707
MOD_Plk_4	185	191	PF00069	0.347
MOD_Plk_4	309	315	PF00069	0.366
MOD_Plk_4	559	565	PF00069	0.586
MOD_Plk_4	91	97	PF00069	0.331
MOD_ProDKin_1	127	133	PF00069	0.358
MOD_ProDKin_1	2	8	PF00069	0.473
MOD_ProDKin_1	278	284	PF00069	0.618
MOD_ProDKin_1	289	295	PF00069	0.578
MOD_ProDKin_1	420	426	PF00069	0.544
MOD_ProDKin_1	530	536	PF00069	0.683
MOD_ProDKin_1	60	66	PF00069	0.297
MOD_ProDKin_1	600	606	PF00069	0.756
TRG_DiLeu_BaLyEn_6	128	133	PF01217	0.417
TRG_DiLeu_BaLyEn_6	393	398	PF01217	0.475
TRG_DiLeu_BaLyEn_6	435	440	PF01217	0.434
TRG_ENDOCYTIC_2	177	180	PF00928	0.364
TRG_ER_diArg_1	266	268	PF00400	0.559
TRG_ER_diArg_1	381	383	PF00400	0.415
TRG_ER_diArg_1	572	574	PF00400	0.609
TRG_NES_CRM1_1	315	329	PF08389	0.378
TRG_NLS_MonoExtC_3	535	540	PF00514	0.705
TRG_NLS_MonoExtN_4	252	258	PF00514	0.668
TRG_NLS_MonoExtN_4	534	540	PF00514	0.701
TRG_Pf-PMV_PEXEL_1	385	389	PF00026	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4N9	Leptomonas seymouri	55%	98%
A0A3Q8IBM2	Leishmania donovani	92%	100%
A4HYR8	Leishmania infantum	92%	100%
E9AI88	Leishmania braziliensis	73%	100%
E9AUH3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	89%	100%