Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania major

UniProt:

Q4QD09_LEIMA

TriTrypDb:

LmjF.20.0340 , LMJLV39_200008600 , LMJSD75_200008500

Length:

389

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QD09

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD09

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	268	272	PF00656	0.499
CLV_NRD_NRD_1	212	214	PF00675	0.749
CLV_NRD_NRD_1	228	230	PF00675	0.543
CLV_PCSK_FUR_1	210	214	PF00082	0.683
CLV_PCSK_KEX2_1	209	211	PF00082	0.678
CLV_PCSK_KEX2_1	212	214	PF00082	0.689
CLV_PCSK_KEX2_1	228	230	PF00082	0.598
CLV_PCSK_PC1ET2_1	209	211	PF00082	0.655
CLV_PCSK_SKI1_1	337	341	PF00082	0.538
CLV_PCSK_SKI1_1	343	347	PF00082	0.467
DEG_Nend_UBRbox_3	1	3	PF02207	0.407
DOC_ANK_TNKS_1	157	164	PF00023	0.566
DOC_CKS1_1	380	385	PF01111	0.654
DOC_CKS1_1	92	97	PF01111	0.546
DOC_CYCLIN_yCln2_LP_2	328	334	PF00134	0.541
DOC_MAPK_gen_1	209	216	PF00069	0.717
DOC_MAPK_gen_1	340	350	PF00069	0.517
DOC_PIKK_1	253	261	PF02985	0.510
DOC_PP1_RVXF_1	132	139	PF00149	0.383
DOC_PP1_RVXF_1	63	70	PF00149	0.482
DOC_PP2B_LxvP_1	328	331	PF13499	0.538
DOC_PP2B_LxvP_1	351	354	PF13499	0.435
DOC_PP4_FxxP_1	377	380	PF00568	0.655
DOC_USP7_MATH_1	223	227	PF00917	0.730
DOC_USP7_MATH_1	32	36	PF00917	0.492
DOC_USP7_MATH_1	367	371	PF00917	0.605
DOC_WW_Pin1_4	229	234	PF00397	0.695
DOC_WW_Pin1_4	303	308	PF00397	0.434
DOC_WW_Pin1_4	370	375	PF00397	0.616
DOC_WW_Pin1_4	379	384	PF00397	0.630
DOC_WW_Pin1_4	91	96	PF00397	0.532
LIG_14-3-3_CanoR_1	363	372	PF00244	0.673
LIG_Actin_WH2_2	344	362	PF00022	0.530
LIG_FHA_1	380	386	PF00498	0.645
LIG_FHA_1	75	81	PF00498	0.566
LIG_FHA_2	137	143	PF00498	0.529
LIG_LIR_Gen_1	84	95	PF02991	0.549
LIG_LIR_LC3C_4	132	137	PF02991	0.493
LIG_LIR_Nem_3	119	125	PF02991	0.436
LIG_LIR_Nem_3	84	90	PF02991	0.543
LIG_MYND_1	376	380	PF01753	0.674
LIG_PAM2_1	145	157	PF00658	0.426
LIG_SH2_CRK	283	287	PF00017	0.495
LIG_SH2_STAP1	140	144	PF00017	0.594
LIG_SH2_STAP1	46	50	PF00017	0.623
LIG_SH2_STAT3	352	355	PF00017	0.443
LIG_SH2_STAT5	352	355	PF00017	0.525
LIG_SH3_3	156	162	PF00018	0.575
LIG_SH3_3	302	308	PF00018	0.443
LIG_SH3_3	324	330	PF00018	0.534
LIG_SH3_3	366	372	PF00018	0.630
LIG_SH3_3	377	383	PF00018	0.580
LIG_SH3_3	89	95	PF00018	0.450
LIG_SUMO_SIM_anti_2	240	248	PF11976	0.661
LIG_SUMO_SIM_par_1	286	291	PF11976	0.456
LIG_SUMO_SIM_par_1	75	81	PF11976	0.608
LIG_TRAF2_1	186	189	PF00917	0.672
MOD_CDK_SPK_2	384	389	PF00069	0.631
MOD_CK1_1	196	202	PF00069	0.746
MOD_CK1_1	224	230	PF00069	0.647
MOD_CK1_1	232	238	PF00069	0.625
MOD_CK1_1	248	254	PF00069	0.330
MOD_CK1_1	28	34	PF00069	0.476
MOD_CK1_1	370	376	PF00069	0.633
MOD_CK1_1	72	78	PF00069	0.541
MOD_CK2_1	136	142	PF00069	0.516
MOD_CK2_1	330	336	PF00069	0.562
MOD_GlcNHglycan	247	250	PF01048	0.594
MOD_GlcNHglycan	313	316	PF01048	0.568
MOD_GlcNHglycan	365	368	PF01048	0.630
MOD_GlcNHglycan	46	49	PF01048	0.666
MOD_GlcNHglycan	52	55	PF01048	0.607
MOD_GlcNHglycan	59	62	PF01048	0.346
MOD_GSK3_1	266	273	PF00069	0.479
MOD_GSK3_1	28	35	PF00069	0.479
MOD_GSK3_1	286	293	PF00069	0.343
MOD_GSK3_1	359	366	PF00069	0.522
MOD_GSK3_1	69	76	PF00069	0.467
MOD_NEK2_1	270	275	PF00069	0.466
MOD_NEK2_1	288	293	PF00069	0.346
MOD_NEK2_1	359	364	PF00069	0.582
MOD_NEK2_1	57	62	PF00069	0.445
MOD_NEK2_1	74	79	PF00069	0.371
MOD_PKA_1	44	50	PF00069	0.603
MOD_PKA_2	224	230	PF00069	0.664
MOD_PKA_2	28	34	PF00069	0.494
MOD_PKA_2	359	365	PF00069	0.566
MOD_PKA_2	69	75	PF00069	0.348
MOD_Plk_1	270	276	PF00069	0.497
MOD_Plk_1	83	89	PF00069	0.489
MOD_Plk_4	232	238	PF00069	0.632
MOD_ProDKin_1	229	235	PF00069	0.688
MOD_ProDKin_1	303	309	PF00069	0.444
MOD_ProDKin_1	370	376	PF00069	0.612
MOD_ProDKin_1	379	385	PF00069	0.630
MOD_ProDKin_1	91	97	PF00069	0.541
MOD_SUMO_rev_2	248	258	PF00179	0.558
MOD_SUMO_rev_2	260	268	PF00179	0.521
MOD_SUMO_rev_2	333	342	PF00179	0.556
TRG_DiLeu_BaEn_1	257	262	PF01217	0.497
TRG_DiLeu_BaLyEn_6	283	288	PF01217	0.467
TRG_ER_diArg_1	210	213	PF00400	0.751
TRG_ER_diArg_1	228	230	PF00400	0.649
TRG_NLS_MonoCore_2	208	213	PF00514	0.622
TRG_NLS_MonoExtC_3	208	213	PF00514	0.590
TRG_Pf-PMV_PEXEL_1	256	260	PF00026	0.508

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HWV5	Leptomonas seymouri	59%	95%
A0A3S7WVR4	Leishmania donovani	92%	100%
A4HYS0	Leishmania infantum	92%	100%
C9ZIA4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9AI90	Leishmania braziliensis	77%	100%
E9AUH5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	90%	100%
V5BVI5	Trypanosoma cruzi	30%	100%