Acetyltransf_13 domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ESCO acetyltransferase domain-containing protein

Species:

Leishmania major

UniProt:

Q4QD07_LEIMA

TriTrypDb:

LmjF.20.0346 , LMJLV39_200008700 , LMJSD75_200008600

Length:

310

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0000785	chromatin	2	2
GO:0005634	nucleus	5	2
GO:0005730	nucleolus	5	2
GO:0043226	organelle	2	2
GO:0043227	membrane-bounded organelle	3	2
GO:0043228	non-membrane-bounded organelle	3	2
GO:0043229	intracellular organelle	3	2
GO:0043231	intracellular membrane-bounded organelle	4	2
GO:0043232	intracellular non-membrane-bounded organelle	4	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

Q4QD07

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD07

Function

Biological processes
Term	Name	Level	Count
GO:0006996	organelle organization	4	10
GO:0007059	chromosome segregation	2	10
GO:0007062	sister chromatid cohesion	3	10
GO:0007064	mitotic sister chromatid cohesion	4	2
GO:0009987	cellular process	1	10
GO:0016043	cellular component organization	3	10
GO:0022402	cell cycle process	2	10
GO:0022414	reproductive process	1	10
GO:0045132	meiotic chromosome segregation	3	10
GO:0051276	chromosome organization	5	10
GO:0071840	cellular component organization or biogenesis	2	10
GO:0098813	nuclear chromosome segregation	3	10
GO:1903046	meiotic cell cycle process	2	10
GO:1903047	mitotic cell cycle process	3	10
GO:0000070	mitotic sister chromatid segregation	4	8
GO:0000819	sister chromatid segregation	4	8

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	10
GO:0008080	N-acetyltransferase activity	6	2
GO:0016407	acetyltransferase activity	5	10
GO:0016410	N-acyltransferase activity	5	2
GO:0016740	transferase activity	2	10
GO:0016746	acyltransferase activity	3	10
GO:0016747	acyltransferase activity, transferring groups other than amino-acyl groups	4	10
GO:0034212	peptide N-acetyltransferase activity	7	2
GO:0061733	peptide-lysine-N-acetyltransferase activity	3	2
GO:0140096	catalytic activity, acting on a protein	2	2

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	8	12	PF00656	0.709
CLV_C14_Caspase3-7	90	94	PF00656	0.522
CLV_NRD_NRD_1	297	299	PF00675	0.309
CLV_NRD_NRD_1	72	74	PF00675	0.715
CLV_PCSK_KEX2_1	101	103	PF00082	0.596
CLV_PCSK_KEX2_1	297	299	PF00082	0.331
CLV_PCSK_KEX2_1	74	76	PF00082	0.678
CLV_PCSK_PC1ET2_1	101	103	PF00082	0.505
CLV_PCSK_PC1ET2_1	74	76	PF00082	0.642
CLV_PCSK_PC7_1	70	76	PF00082	0.705
CLV_PCSK_SKI1_1	29	33	PF00082	0.480
DEG_SCF_FBW7_1	197	204	PF00400	0.520
DEG_SCF_FBW7_1	211	217	PF00400	0.407
DOC_CKS1_1	211	216	PF01111	0.505
DOC_MAPK_gen_1	256	265	PF00069	0.424
DOC_PP1_RVXF_1	245	251	PF00149	0.561
DOC_PP4_FxxP_1	193	196	PF00568	0.526
DOC_PP4_FxxP_1	276	279	PF00568	0.498
DOC_PP4_FxxP_1	285	288	PF00568	0.479
DOC_USP7_MATH_1	125	129	PF00917	0.480
DOC_USP7_MATH_1	16	20	PF00917	0.555
DOC_USP7_MATH_1	196	200	PF00917	0.716
DOC_USP7_MATH_1	214	218	PF00917	0.694
DOC_USP7_MATH_1	290	294	PF00917	0.591
DOC_WW_Pin1_4	128	133	PF00397	0.559
DOC_WW_Pin1_4	185	190	PF00397	0.572
DOC_WW_Pin1_4	197	202	PF00397	0.661
DOC_WW_Pin1_4	210	215	PF00397	0.417
DOC_WW_Pin1_4	238	243	PF00397	0.542
DOC_WW_Pin1_4	249	254	PF00397	0.492
DOC_WW_Pin1_4	30	35	PF00397	0.593
DOC_WW_Pin1_4	50	55	PF00397	0.595
LIG_14-3-3_CanoR_1	183	189	PF00244	0.614
LIG_FHA_1	202	208	PF00498	0.708
LIG_FHA_1	51	57	PF00498	0.578
LIG_FHA_1	58	64	PF00498	0.382
LIG_FHA_2	198	204	PF00498	0.708
LIG_FHA_2	6	12	PF00498	0.687
LIG_LIR_Gen_1	5	14	PF02991	0.492
LIG_LIR_Nem_3	19	24	PF02991	0.576
LIG_LIR_Nem_3	304	308	PF02991	0.505
LIG_LIR_Nem_3	5	10	PF02991	0.533
LIG_REV1ctd_RIR_1	64	74	PF16727	0.546
LIG_SH2_CRK	274	278	PF00017	0.597
LIG_SH2_STAP1	64	68	PF00017	0.437
LIG_SH2_STAT5	262	265	PF00017	0.424
LIG_SH2_STAT5	36	39	PF00017	0.580
LIG_SH3_3	28	34	PF00018	0.602
LIG_SUMO_SIM_par_1	216	223	PF11976	0.580
LIG_SUMO_SIM_par_1	59	65	PF11976	0.481
LIG_TYR_ITIM	260	265	PF00017	0.556
LIG_TYR_ITIM	272	277	PF00017	0.571
MOD_CDK_SPxxK_3	249	256	PF00069	0.591
MOD_CK1_1	108	114	PF00069	0.506
MOD_CK1_1	128	134	PF00069	0.301
MOD_CK1_1	157	163	PF00069	0.644
MOD_CK1_1	236	242	PF00069	0.565
MOD_CK1_1	252	258	PF00069	0.555
MOD_CK1_1	286	292	PF00069	0.508
MOD_CK1_1	91	97	PF00069	0.665
MOD_CK2_1	196	202	PF00069	0.659
MOD_GlcNHglycan	110	113	PF01048	0.571
MOD_GlcNHglycan	115	118	PF01048	0.534
MOD_GlcNHglycan	156	159	PF01048	0.710
MOD_GlcNHglycan	292	295	PF01048	0.391
MOD_GlcNHglycan	50	53	PF01048	0.639
MOD_GlcNHglycan	89	93	PF01048	0.715
MOD_GSK3_1	16	23	PF00069	0.374
MOD_GSK3_1	197	204	PF00069	0.710
MOD_GSK3_1	210	217	PF00069	0.740
MOD_GSK3_1	286	293	PF00069	0.531
MOD_GSK3_1	39	46	PF00069	0.528
MOD_GSK3_1	5	12	PF00069	0.711
MOD_NEK2_2	110	115	PF00069	0.469
MOD_OFUCOSY	212	218	PF10250	0.539
MOD_PKA_1	73	79	PF00069	0.609
MOD_PKA_2	105	111	PF00069	0.600
MOD_Plk_1	202	208	PF00069	0.698
MOD_Plk_2-3	5	11	PF00069	0.562
MOD_Plk_4	57	63	PF00069	0.459
MOD_ProDKin_1	128	134	PF00069	0.554
MOD_ProDKin_1	185	191	PF00069	0.583
MOD_ProDKin_1	197	203	PF00069	0.662
MOD_ProDKin_1	210	216	PF00069	0.415
MOD_ProDKin_1	238	244	PF00069	0.530
MOD_ProDKin_1	249	255	PF00069	0.492
MOD_ProDKin_1	30	36	PF00069	0.594
MOD_ProDKin_1	50	56	PF00069	0.584
TRG_ENDOCYTIC_2	182	185	PF00928	0.565
TRG_ENDOCYTIC_2	262	265	PF00928	0.556
TRG_ENDOCYTIC_2	274	277	PF00928	0.561
TRG_ENDOCYTIC_2	64	67	PF00928	0.427
TRG_ER_diArg_1	297	299	PF00400	0.531
TRG_NLS_MonoExtC_3	72	77	PF00514	0.676
TRG_NLS_MonoExtN_4	70	77	PF00514	0.709
TRG_NLS_MonoExtN_4	98	105	PF00514	0.593
TRG_Pf-PMV_PEXEL_1	22	26	PF00026	0.590

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4N8	Leptomonas seymouri	38%	100%
A0A1X0NWH5	Trypanosomatidae	31%	93%
A0A3S7WVV5	Leishmania donovani	87%	100%
A0A422MWP0	Trypanosoma rangeli	34%	100%
A4HYS2	Leishmania infantum	87%	100%
E9AI91	Leishmania braziliensis	71%	99%
E9AUH7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	100%
V5DS57	Trypanosoma cruzi	33%	100%