LeishMANIAdb
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MFS domain-containing protein

Quick info Annotations Function or PPIs Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:
MFS domain-containing protein
Gene product:
major facilitator superfamily, putative
Species:
Leishmania major
UniProt:
Q4QD06_LEIMA
TriTrypDb:
LmjF.20.0350 , LMJLV39_200008800 * , LMJSD75_200008700
Length:
730

Annotations

LeishMANIAdb annotations

A transporter protein family expanded in Kinetoplastids. Distantly similar to animal hem transporters (human FLVCR).

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 0, no: 12
NetGPI no yes: 0, no: 12
Cellular components
Term Name Level Count
GO:0016020 membrane 2 13
GO:0110165 cellular anatomical entity 1 13
GO:0020016 ciliary pocket 2 1

Expansion

Sequence features

Q4QD06
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD06

Function

Could not find GO biological_process term for this entry.
Molecular functions
Term Name Level Count
GO:0005215 transporter activity 1 12
GO:0022857 transmembrane transporter activity 2 12

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 321 325 PF00656 0.787
CLV_C14_Caspase3-7 650 654 PF00656 0.709
CLV_C14_Caspase3-7 709 713 PF00656 0.654
CLV_NRD_NRD_1 239 241 PF00675 0.612
CLV_NRD_NRD_1 368 370 PF00675 0.362
CLV_NRD_NRD_1 392 394 PF00675 0.338
CLV_NRD_NRD_1 588 590 PF00675 0.401
CLV_NRD_NRD_1 639 641 PF00675 0.586
CLV_NRD_NRD_1 666 668 PF00675 0.521
CLV_NRD_NRD_1 706 708 PF00675 0.432
CLV_NRD_NRD_1 81 83 PF00675 0.249
CLV_PCSK_KEX2_1 239 241 PF00082 0.597
CLV_PCSK_KEX2_1 368 370 PF00082 0.420
CLV_PCSK_KEX2_1 392 394 PF00082 0.337
CLV_PCSK_KEX2_1 588 590 PF00082 0.394
CLV_PCSK_KEX2_1 639 641 PF00082 0.582
CLV_PCSK_KEX2_1 666 668 PF00082 0.537
CLV_PCSK_KEX2_1 81 83 PF00082 0.249
CLV_PCSK_PC7_1 77 83 PF00082 0.249
CLV_PCSK_SKI1_1 362 366 PF00082 0.420
CLV_PCSK_SKI1_1 43 47 PF00082 0.435
CLV_PCSK_SKI1_1 682 686 PF00082 0.482
CLV_PCSK_SKI1_1 82 86 PF00082 0.249
DEG_Nend_UBRbox_3 1 3 PF02207 0.597
DEG_SPOP_SBC_1 168 172 PF00917 0.249
DOC_CDC14_PxL_1 97 105 PF14671 0.304
DOC_CKS1_1 126 131 PF01111 0.315
DOC_MAPK_gen_1 392 398 PF00069 0.448
DOC_MAPK_gen_1 456 466 PF00069 0.483
DOC_MAPK_JIP1_4 105 111 PF00069 0.249
DOC_MAPK_MEF2A_6 105 113 PF00069 0.249
DOC_MAPK_MEF2A_6 459 466 PF00069 0.488
DOC_PP1_SILK_1 94 99 PF00149 0.304
DOC_PP2B_LxvP_1 111 114 PF13499 0.304
DOC_PP2B_LxvP_1 161 164 PF13499 0.304
DOC_PP2B_LxvP_1 200 203 PF13499 0.460
DOC_PP2B_LxvP_1 481 484 PF13499 0.370
DOC_PP4_FxxP_1 162 165 PF00568 0.314
DOC_PP4_FxxP_1 199 202 PF00568 0.310
DOC_PP4_FxxP_1 205 208 PF00568 0.487
DOC_USP7_MATH_1 297 301 PF00917 0.720
DOC_USP7_MATH_1 92 96 PF00917 0.304
DOC_WW_Pin1_4 125 130 PF00397 0.315
DOC_WW_Pin1_4 343 348 PF00397 0.665
DOC_WW_Pin1_4 711 716 PF00397 0.705
LIG_14-3-3_CanoR_1 290 294 PF00244 0.714
LIG_14-3-3_CanoR_1 699 705 PF00244 0.617
LIG_Actin_WH2_2 83 100 PF00022 0.304
LIG_AP2alpha_2 11 13 PF02296 0.546
LIG_BIR_III_4 324 328 PF00653 0.648
LIG_BRCT_BRCA1_1 345 349 PF00533 0.689
LIG_Clathr_ClatBox_1 181 185 PF01394 0.304
LIG_deltaCOP1_diTrp_1 11 15 PF00928 0.534
LIG_eIF4E_1 458 464 PF01652 0.469
LIG_EVH1_1 625 629 PF00568 0.586
LIG_FHA_1 108 114 PF00498 0.277
LIG_FHA_1 126 132 PF00498 0.329
LIG_FHA_1 191 197 PF00498 0.304
LIG_FHA_1 383 389 PF00498 0.508
LIG_FHA_1 48 54 PF00498 0.276
LIG_FHA_2 172 178 PF00498 0.249
LIG_FHA_2 349 355 PF00498 0.741
LIG_FHA_2 376 382 PF00498 0.539
LIG_FHA_2 648 654 PF00498 0.693
LIG_FHA_2 704 710 PF00498 0.666
LIG_FHA_2 71 77 PF00498 0.304
LIG_LIR_Apic_2 204 208 PF02991 0.469
LIG_LIR_Apic_2 455 461 PF02991 0.530
LIG_LIR_Apic_2 518 524 PF02991 0.519
LIG_LIR_Gen_1 107 114 PF02991 0.272
LIG_LIR_Gen_1 175 186 PF02991 0.282
LIG_LIR_Gen_1 34 41 PF02991 0.273
LIG_LIR_Gen_1 378 387 PF02991 0.584
LIG_LIR_Gen_1 394 402 PF02991 0.331
LIG_LIR_Gen_1 411 420 PF02991 0.482
LIG_LIR_Gen_1 495 504 PF02991 0.321
LIG_LIR_Gen_1 57 68 PF02991 0.266
LIG_LIR_Nem_3 107 111 PF02991 0.272
LIG_LIR_Nem_3 11 16 PF02991 0.531
LIG_LIR_Nem_3 175 181 PF02991 0.282
LIG_LIR_Nem_3 185 191 PF02991 0.350
LIG_LIR_Nem_3 34 38 PF02991 0.238
LIG_LIR_Nem_3 365 370 PF02991 0.598
LIG_LIR_Nem_3 378 382 PF02991 0.537
LIG_LIR_Nem_3 385 390 PF02991 0.519
LIG_LIR_Nem_3 394 398 PF02991 0.337
LIG_LIR_Nem_3 411 415 PF02991 0.434
LIG_LIR_Nem_3 42 48 PF02991 0.235
LIG_LIR_Nem_3 495 499 PF02991 0.295
LIG_LIR_Nem_3 57 63 PF02991 0.226
LIG_NRP_CendR_1 728 730 PF00754 0.531
LIG_Pex14_2 178 182 PF04695 0.278
LIG_Pex14_2 349 353 PF04695 0.664
LIG_Pex14_2 496 500 PF04695 0.321
LIG_Rb_LxCxE_1 177 193 PF01857 0.272
LIG_SH2_CRK 35 39 PF00017 0.269
LIG_SH2_CRK 412 416 PF00017 0.350
LIG_SH2_CRK 60 64 PF00017 0.304
LIG_SH2_GRB2like 618 621 PF00017 0.561
LIG_SH2_NCK_1 35 39 PF00017 0.269
LIG_SH2_SRC 618 621 PF00017 0.561
LIG_SH2_STAP1 35 39 PF00017 0.269
LIG_SH2_STAP1 412 416 PF00017 0.350
LIG_SH2_STAP1 618 622 PF00017 0.576
LIG_SH2_STAT3 336 339 PF00017 0.675
LIG_SH2_STAT5 108 111 PF00017 0.276
LIG_SH2_STAT5 136 139 PF00017 0.469
LIG_SH2_STAT5 350 353 PF00017 0.744
LIG_SH2_STAT5 387 390 PF00017 0.529
LIG_SH2_STAT5 446 449 PF00017 0.336
LIG_SH2_STAT5 498 501 PF00017 0.385
LIG_SH2_STAT5 69 72 PF00017 0.312
LIG_SH3_3 229 235 PF00018 0.627
LIG_SH3_3 291 297 PF00018 0.656
LIG_SH3_3 623 629 PF00018 0.748
LIG_SUMO_SIM_par_1 164 172 PF11976 0.269
LIG_SUMO_SIM_par_1 540 545 PF11976 0.274
LIG_SUMO_SIM_par_1 563 569 PF11976 0.327
LIG_TRAF2_1 337 340 PF00917 0.765
LIG_TRAF2_1 656 659 PF00917 0.740
LIG_TYR_ITIM 33 38 PF00017 0.304
LIG_UBA3_1 476 482 PF00899 0.321
LIG_WRC_WIRS_1 376 381 PF05994 0.545
LIG_WRC_WIRS_1 493 498 PF05994 0.321
LIG_WW_2 628 631 PF00397 0.638
MOD_CK1_1 107 113 PF00069 0.225
MOD_CK1_1 171 177 PF00069 0.249
MOD_CK1_1 300 306 PF00069 0.757
MOD_CK1_1 37 43 PF00069 0.269
MOD_CK1_1 405 411 PF00069 0.341
MOD_CK1_1 545 551 PF00069 0.321
MOD_CK1_1 603 609 PF00069 0.554
MOD_CK1_1 647 653 PF00069 0.802
MOD_CK2_1 171 177 PF00069 0.249
MOD_CK2_1 263 269 PF00069 0.809
MOD_CK2_1 334 340 PF00069 0.773
MOD_CK2_1 375 381 PF00069 0.549
MOD_CK2_1 653 659 PF00069 0.722
MOD_CK2_1 70 76 PF00069 0.304
MOD_CK2_1 703 709 PF00069 0.670
MOD_GlcNHglycan 217 220 PF01048 0.502
MOD_GlcNHglycan 24 27 PF01048 0.276
MOD_GlcNHglycan 264 268 PF01048 0.586
MOD_GlcNHglycan 273 277 PF01048 0.616
MOD_GlcNHglycan 302 305 PF01048 0.461
MOD_GlcNHglycan 313 316 PF01048 0.583
MOD_GlcNHglycan 336 339 PF01048 0.605
MOD_GlcNHglycan 558 561 PF01048 0.571
MOD_GlcNHglycan 602 605 PF01048 0.474
MOD_GlcNHglycan 632 635 PF01048 0.506
MOD_GlcNHglycan 646 649 PF01048 0.549
MOD_GSK3_1 167 174 PF00069 0.249
MOD_GSK3_1 251 258 PF00069 0.754
MOD_GSK3_1 33 40 PF00069 0.304
MOD_GSK3_1 339 346 PF00069 0.725
MOD_GSK3_1 482 489 PF00069 0.359
MOD_GSK3_1 603 610 PF00069 0.606
MOD_N-GLC_1 310 315 PF02516 0.478
MOD_N-GLC_2 537 539 PF02516 0.321
MOD_NEK2_1 1 6 PF00069 0.583
MOD_NEK2_1 124 129 PF00069 0.304
MOD_NEK2_1 402 407 PF00069 0.321
MOD_NEK2_1 429 434 PF00069 0.234
MOD_NEK2_1 46 51 PF00069 0.277
MOD_NEK2_1 466 471 PF00069 0.288
MOD_NEK2_1 504 509 PF00069 0.321
MOD_NEK2_1 517 522 PF00069 0.532
MOD_NEK2_1 55 60 PF00069 0.317
MOD_NEK2_1 70 75 PF00069 0.315
MOD_PIKK_1 206 212 PF00454 0.679
MOD_PIKK_1 698 704 PF00454 0.613
MOD_PKA_1 666 672 PF00069 0.751
MOD_PKA_2 168 174 PF00069 0.240
MOD_PKA_2 289 295 PF00069 0.707
MOD_PKA_2 354 360 PF00069 0.649
MOD_PKA_2 666 672 PF00069 0.753
MOD_PKA_2 698 704 PF00069 0.645
MOD_Plk_1 517 523 PF00069 0.532
MOD_Plk_1 618 624 PF00069 0.553
MOD_Plk_2-3 246 252 PF00069 0.730
MOD_Plk_2-3 653 659 PF00069 0.722
MOD_Plk_4 1 7 PF00069 0.619
MOD_Plk_4 104 110 PF00069 0.269
MOD_Plk_4 362 368 PF00069 0.657
MOD_Plk_4 382 388 PF00069 0.427
MOD_Plk_4 405 411 PF00069 0.346
MOD_Plk_4 439 445 PF00069 0.323
MOD_Plk_4 466 472 PF00069 0.324
MOD_Plk_4 492 498 PF00069 0.337
MOD_Plk_4 537 543 PF00069 0.323
MOD_Plk_4 545 551 PF00069 0.324
MOD_Plk_4 55 61 PF00069 0.315
MOD_Plk_4 92 98 PF00069 0.304
MOD_ProDKin_1 125 131 PF00069 0.315
MOD_ProDKin_1 343 349 PF00069 0.666
MOD_ProDKin_1 711 717 PF00069 0.707
MOD_SUMO_rev_2 669 674 PF00179 0.656
TRG_DiLeu_BaLyEn_6 127 132 PF01217 0.315
TRG_DiLeu_BaLyEn_6 162 167 PF01217 0.304
TRG_DiLeu_BaLyEn_6 458 463 PF01217 0.502
TRG_ENDOCYTIC_2 108 111 PF00928 0.269
TRG_ENDOCYTIC_2 35 38 PF00928 0.300
TRG_ENDOCYTIC_2 350 353 PF00928 0.729
TRG_ENDOCYTIC_2 387 390 PF00928 0.529
TRG_ENDOCYTIC_2 412 415 PF00928 0.352
TRG_ENDOCYTIC_2 60 63 PF00928 0.281
TRG_ER_diArg_1 367 369 PF00400 0.573
TRG_ER_diArg_1 587 589 PF00400 0.582
TRG_ER_diArg_1 666 668 PF00400 0.703
TRG_ER_diArg_1 80 82 PF00400 0.449

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1I416 Leptomonas seymouri 64% 100%
A0A0N1IHM9 Leptomonas seymouri 26% 100%
A0A3Q8IBI9 Leishmania donovani 92% 100%
A0A3S5H541 Leishmania donovani 26% 100%
A4H3K8 Leishmania braziliensis 26% 100%
A4HRV1 Leishmania infantum 26% 100%
A4HYN7 Leishmania infantum 92% 100%
E9ACI6 Leishmania major 27% 100%
E9AI92 Leishmania braziliensis 70% 100%
E9AJS4 Leishmania mexicana (strain MHOM/GT/2001/U1103) 26% 100%
E9AUH8 Leishmania mexicana (strain MHOM/GT/2001/U1103) 86% 100%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS