Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF2946), putative

Species:

Leishmania major

UniProt:

Q4QD05_LEIMA

TriTrypDb:

LmjF.20.0360 , LMJLV39_200009100 , LMJSD75_200009000

Length:

315

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 24

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 16, no: 2
NetGPI	no	yes: 0, no: 18

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	17
GO:0110165	cellular anatomical entity	1	17

Expansion

Sequence features

Q4QD05

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD05

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	193	197	PF00656	0.449
CLV_C14_Caspase3-7	277	281	PF00656	0.692
CLV_PCSK_KEX2_1	2	4	PF00082	0.762
CLV_PCSK_KEX2_1	263	265	PF00082	0.441
CLV_PCSK_PC1ET2_1	2	4	PF00082	0.755
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.428
DEG_Nend_UBRbox_1	1	4	PF02207	0.679
DOC_CYCLIN_yClb1_LxF_4	110	116	PF00134	0.459
DOC_MAPK_gen_1	7	15	PF00069	0.515
DOC_MAPK_MEF2A_6	9	17	PF00069	0.409
DOC_WW_Pin1_4	1	6	PF00397	0.696
DOC_WW_Pin1_4	293	298	PF00397	0.774
LIG_14-3-3_CanoR_1	27	32	PF00244	0.188
LIG_14-3-3_CanoR_1	7	15	PF00244	0.421
LIG_Actin_WH2_2	112	128	PF00022	0.453
LIG_eIF4E_1	209	215	PF01652	0.450
LIG_FHA_1	172	178	PF00498	0.366
LIG_FHA_1	21	27	PF00498	0.416
LIG_FHA_1	8	14	PF00498	0.356
LIG_FHA_2	191	197	PF00498	0.408
LIG_FHA_2	275	281	PF00498	0.697
LIG_LIR_Gen_1	131	142	PF02991	0.473
LIG_LIR_Nem_3	114	120	PF02991	0.353
LIG_LIR_Nem_3	131	137	PF02991	0.467
LIG_LIR_Nem_3	179	183	PF02991	0.352
LIG_LIR_Nem_3	189	194	PF02991	0.413
LIG_NRBOX	13	19	PF00104	0.433
LIG_PCNA_yPIPBox_3	165	173	PF02747	0.444
LIG_Pex14_1	176	180	PF04695	0.299
LIG_SH2_CRK	117	121	PF00017	0.356
LIG_SH2_GRB2like	310	313	PF00017	0.607
LIG_SH2_NCK_1	310	314	PF00017	0.664
LIG_SH2_SRC	183	186	PF00017	0.494
LIG_SH2_STAP1	173	177	PF00017	0.308
LIG_SH2_STAP1	29	33	PF00017	0.335
LIG_SH2_STAT3	172	175	PF00017	0.431
LIG_SH2_STAT3	181	184	PF00017	0.455
LIG_SH2_STAT3	50	53	PF00017	0.306
LIG_SH2_STAT5	173	176	PF00017	0.332
LIG_SH2_STAT5	261	264	PF00017	0.618
LIG_SH2_STAT5	50	53	PF00017	0.333
LIG_SH3_3	189	195	PF00018	0.467
LIG_SUMO_SIM_anti_2	244	250	PF11976	0.421
LIG_SUMO_SIM_par_1	238	244	PF11976	0.354
LIG_SUMO_SIM_par_1	248	254	PF11976	0.271
MOD_CDC14_SPxK_1	4	7	PF00782	0.502
MOD_CDK_SPxK_1	1	7	PF00069	0.537
MOD_CK1_1	186	192	PF00069	0.612
MOD_CK1_1	56	62	PF00069	0.393
MOD_CK1_1	89	95	PF00069	0.497
MOD_CK2_1	157	163	PF00069	0.533
MOD_GlcNHglycan	138	141	PF01048	0.546
MOD_GlcNHglycan	37	40	PF01048	0.424
MOD_GlcNHglycan	54	58	PF01048	0.454
MOD_GlcNHglycan	69	72	PF01048	0.426
MOD_GlcNHglycan	91	94	PF01048	0.688
MOD_GSK3_1	186	193	PF00069	0.496
MOD_GSK3_1	3	10	PF00069	0.508
MOD_GSK3_1	63	70	PF00069	0.413
MOD_GSK3_1	89	96	PF00069	0.475
MOD_N-GLC_1	146	151	PF02516	0.645
MOD_N-GLC_1	97	102	PF02516	0.535
MOD_NEK2_1	20	25	PF00069	0.365
MOD_NEK2_2	121	126	PF00069	0.444
MOD_NEK2_2	302	307	PF00069	0.548
MOD_PIKK_1	171	177	PF00454	0.478
MOD_PIKK_1	216	222	PF00454	0.611
MOD_PIKK_1	284	290	PF00454	0.579
MOD_PK_1	27	33	PF00069	0.305
MOD_PKA_2	216	222	PF00069	0.557
MOD_PKA_2	89	95	PF00069	0.634
MOD_Plk_1	111	117	PF00069	0.372
MOD_Plk_1	146	152	PF00069	0.634
MOD_Plk_1	186	192	PF00069	0.588
MOD_Plk_1	302	308	PF00069	0.666
MOD_Plk_1	97	103	PF00069	0.607
MOD_Plk_2-3	274	280	PF00069	0.453
MOD_Plk_4	111	117	PF00069	0.408
MOD_Plk_4	146	152	PF00069	0.584
MOD_Plk_4	168	174	PF00069	0.409
MOD_Plk_4	186	192	PF00069	0.382
MOD_Plk_4	56	62	PF00069	0.315
MOD_ProDKin_1	1	7	PF00069	0.691
MOD_ProDKin_1	293	299	PF00069	0.729
TRG_ENDOCYTIC_2	117	120	PF00928	0.427
TRG_ENDOCYTIC_2	134	137	PF00928	0.456
TRG_Pf-PMV_PEXEL_1	222	226	PF00026	0.578

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P471	Leptomonas seymouri	67%	98%
A0A0N1I022	Leptomonas seymouri	34%	92%
A0A1X0NWG4	Trypanosomatidae	32%	87%
A0A1X0NWG7	Trypanosomatidae	34%	86%
A0A1X0NWG9	Trypanosomatidae	34%	87%
A0A1X0NXT1	Trypanosomatidae	34%	87%
A0A1X0NY10	Trypanosomatidae	31%	100%
A0A3Q8IBH3	Leishmania donovani	96%	98%
A0A3S5H4S6	Leishmania donovani	36%	95%
A4H335	Leishmania braziliensis	34%	95%
A4HRC3	Leishmania infantum	36%	95%
A4HYN5	Leishmania infantum	96%	98%
E9ABZ0	Leishmania major	35%	100%
E9AI94	Leishmania braziliensis	75%	100%
E9AJ87	Leishmania mexicana (strain MHOM/GT/2001/U1103)	34%	94%
E9AUH9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	94%	98%
V5DS51	Trypanosoma cruzi	33%	89%