Nudix hydrolase domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, unknown function

Species:

Leishmania major

UniProt:

Q4QD02_LEIMA

TriTrypDb:

LmjF.20.0380 , LMJLV39_200009500 , LMJSD75_200009300

Length:

413

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 5
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

Q4QD02

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: Q4QD02

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0005488	binding	1	7
GO:0016787	hydrolase activity	2	7
GO:0043167	ion binding	2	7
GO:0043169	cation binding	3	7
GO:0046872	metal ion binding	4	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	155	159	PF00656	0.537
CLV_C14_Caspase3-7	398	402	PF00656	0.734
CLV_NRD_NRD_1	138	140	PF00675	0.602
CLV_NRD_NRD_1	277	279	PF00675	0.495
CLV_NRD_NRD_1	350	352	PF00675	0.613
CLV_PCSK_KEX2_1	138	140	PF00082	0.602
CLV_PCSK_KEX2_1	277	279	PF00082	0.517
CLV_PCSK_KEX2_1	350	352	PF00082	0.613
CLV_PCSK_KEX2_1	50	52	PF00082	0.470
CLV_PCSK_PC1ET2_1	50	52	PF00082	0.492
CLV_PCSK_SKI1_1	173	177	PF00082	0.742
CLV_PCSK_SKI1_1	31	35	PF00082	0.696
CLV_PCSK_SKI1_1	351	355	PF00082	0.517
CLV_PCSK_SKI1_1	95	99	PF00082	0.740
DEG_ODPH_VHL_1	288	301	PF01847	0.577
DOC_MAPK_gen_1	54	63	PF00069	0.441
DOC_MAPK_MEF2A_6	385	392	PF00069	0.529
DOC_MAPK_MEF2A_6	40	48	PF00069	0.579
DOC_MAPK_MEF2A_6	54	63	PF00069	0.415
DOC_PP2B_LxvP_1	288	291	PF13499	0.488
DOC_PP4_FxxP_1	355	358	PF00568	0.580
DOC_USP7_MATH_1	169	173	PF00917	0.722
DOC_USP7_MATH_1	184	188	PF00917	0.408
DOC_USP7_MATH_1	198	202	PF00917	0.439
DOC_USP7_MATH_1	217	221	PF00917	0.478
DOC_USP7_MATH_1	331	335	PF00917	0.725
DOC_USP7_UBL2_3	50	54	PF12436	0.519
DOC_WW_Pin1_4	194	199	PF00397	0.528
DOC_WW_Pin1_4	268	273	PF00397	0.429
DOC_WW_Pin1_4	315	320	PF00397	0.744
LIG_14-3-3_CanoR_1	11	17	PF00244	0.478
LIG_14-3-3_CanoR_1	173	178	PF00244	0.552
LIG_Actin_WH2_2	176	192	PF00022	0.519
LIG_BIR_II_1	1	5	PF00653	0.523
LIG_BRCT_BRCA1_1	282	286	PF00533	0.546
LIG_deltaCOP1_diTrp_1	146	152	PF00928	0.539
LIG_eIF4E_1	208	214	PF01652	0.452
LIG_FHA_1	13	19	PF00498	0.396
LIG_FHA_1	165	171	PF00498	0.675
LIG_FHA_1	290	296	PF00498	0.473
LIG_FHA_1	4	10	PF00498	0.566
LIG_FHA_1	76	82	PF00498	0.551
LIG_FHA_2	342	348	PF00498	0.738
LIG_FHA_2	396	402	PF00498	0.726
LIG_FHA_2	96	102	PF00498	0.691
LIG_IRF3_LxIS_1	264	271	PF10401	0.352
LIG_LIR_Apic_2	266	272	PF02991	0.477
LIG_LIR_Apic_2	371	377	PF02991	0.632
LIG_LIR_Gen_1	207	218	PF02991	0.478
LIG_LIR_Gen_1	292	301	PF02991	0.469
LIG_LIR_Gen_1	304	313	PF02991	0.497
LIG_LIR_Nem_3	207	213	PF02991	0.392
LIG_LIR_Nem_3	292	296	PF02991	0.459
LIG_LIR_Nem_3	304	308	PF02991	0.471
LIG_MYND_3	255	259	PF01753	0.621
LIG_Pex14_2	387	391	PF04695	0.679
LIG_Rb_LxCxE_1	333	348	PF01857	0.623
LIG_SH2_CRK	181	185	PF00017	0.426
LIG_SH2_CRK	210	214	PF00017	0.394
LIG_SH2_NCK_1	181	185	PF00017	0.426
LIG_SH2_NCK_1	74	78	PF00017	0.485
LIG_SH2_PTP2	62	65	PF00017	0.458
LIG_SH2_STAP1	205	209	PF00017	0.424
LIG_SH2_STAP1	210	214	PF00017	0.387
LIG_SH2_STAT5	208	211	PF00017	0.429
LIG_SH2_STAT5	293	296	PF00017	0.562
LIG_SH2_STAT5	361	364	PF00017	0.552
LIG_SH2_STAT5	374	377	PF00017	0.357
LIG_SH2_STAT5	62	65	PF00017	0.458
LIG_SH2_STAT5	80	83	PF00017	0.511
LIG_SH3_3	313	319	PF00018	0.718
LIG_SH3_3	4	10	PF00018	0.514
LIG_SUMO_SIM_anti_2	14	20	PF11976	0.458
LIG_TRAF2_1	110	113	PF00917	0.611
LIG_TRAF2_1	251	254	PF00917	0.670
LIG_TRFH_1	286	290	PF08558	0.491
LIG_WW_1	290	293	PF00397	0.585
MOD_CDK_SPK_2	194	199	PF00069	0.535
MOD_CK1_1	262	268	PF00069	0.519
MOD_CK1_1	304	310	PF00069	0.467
MOD_CK1_1	343	349	PF00069	0.634
MOD_CK2_1	107	113	PF00069	0.579
MOD_CK2_1	142	148	PF00069	0.471
MOD_CK2_1	234	240	PF00069	0.749
MOD_CK2_1	268	274	PF00069	0.548
MOD_CK2_1	341	347	PF00069	0.742
MOD_CK2_1	365	371	PF00069	0.575
MOD_CMANNOS	149	152	PF00535	0.611
MOD_Cter_Amidation	348	351	PF01082	0.627
MOD_GlcNHglycan	1	4	PF01048	0.565
MOD_GlcNHglycan	109	112	PF01048	0.699
MOD_GlcNHglycan	215	218	PF01048	0.623
MOD_GlcNHglycan	219	222	PF01048	0.663
MOD_GSK3_1	159	166	PF00069	0.734
MOD_GSK3_1	169	176	PF00069	0.589
MOD_GSK3_1	194	201	PF00069	0.467
MOD_GSK3_1	213	220	PF00069	0.388
MOD_GSK3_1	229	236	PF00069	0.537
MOD_GSK3_1	280	287	PF00069	0.509
MOD_GSK3_1	297	304	PF00069	0.482
MOD_NEK2_1	102	107	PF00069	0.694
MOD_NEK2_1	12	17	PF00069	0.462
MOD_NEK2_1	213	218	PF00069	0.600
MOD_NEK2_1	362	367	PF00069	0.691
MOD_NEK2_2	185	190	PF00069	0.592
MOD_OFUCOSY	231	238	PF10250	0.569
MOD_PIKK_1	230	236	PF00454	0.762
MOD_PIKK_1	96	102	PF00454	0.753
MOD_PKA_1	95	101	PF00069	0.716
MOD_PKA_2	198	204	PF00069	0.568
MOD_PKB_1	202	210	PF00069	0.363
MOD_Plk_4	12	18	PF00069	0.465
MOD_Plk_4	173	179	PF00069	0.563
MOD_Plk_4	204	210	PF00069	0.479
MOD_Plk_4	289	295	PF00069	0.475
MOD_Plk_4	331	337	PF00069	0.553
MOD_Plk_4	407	413	PF00069	0.728
MOD_ProDKin_1	194	200	PF00069	0.533
MOD_ProDKin_1	268	274	PF00069	0.436
MOD_ProDKin_1	315	321	PF00069	0.751
MOD_SUMO_rev_2	91	98	PF00179	0.661
TRG_DiLeu_BaEn_1	263	268	PF01217	0.505
TRG_DiLeu_BaLyEn_6	253	258	PF01217	0.636
TRG_ENDOCYTIC_2	210	213	PF00928	0.396
TRG_ENDOCYTIC_2	293	296	PF00928	0.520
TRG_ER_diArg_1	137	139	PF00400	0.577
TRG_ER_diArg_1	276	278	PF00400	0.503
TRG_ER_diArg_1	350	352	PF00400	0.671
TRG_Pf-PMV_PEXEL_1	127	131	PF00026	0.463

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IIQ0	Leptomonas seymouri	50%	100%
A0A3S7WVU6	Leishmania donovani	93%	100%
A4HYN2	Leishmania infantum	93%	100%
E9AI97	Leishmania braziliensis	74%	100%
E9AUI2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%